Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3JFIH)

Drug Name
Vancomycin Drug Info
Synonyms Vancomycin (oral, MRSA), AuricX; Vancomycin (oral/pill, MSRA); Vancomycin (oral/pill, MSRA), AuricX/SRI International
Indication
Disease Entry ICD 11 Status REF
Bacteremia 1A73 Approved [1]
Bacterial endocarditis Approved [1]
Clostridioides difficile infection 1A04 Approved [1]
Methicillin-resistant staphylococci infection 1A00-1A09 Approved [2]
Neonatal sepsis Approved [1]
Staphylococcal pneumonia Approved [1]
Staphylococcus aureus infection Approved [1]
MRSA infection 1D01.0Y Investigative [3]
Skin infection 1F28-1G0Z Investigative [1]
Cross-matching ID
PubChem CID
14969
ChEBI ID
CHEBI:28001
CAS Number
CAS 1404-90-6
TTD Drug ID
DM3JFIH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By VanA ligase (vanA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [4]
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [4]
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [4]
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [5]
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [6]
Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [13]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [14]
Allopurinol DMLPAOB Gout FA25 Approved [15]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [16]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [17]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [18]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [12]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [19]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [20]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [22]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [23]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [26]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [27]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [28]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [29]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [30]
Testosterone DM7HUNW Hot flushes GA30 Approved [31]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [12]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [32]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ethosuximide DMDZ9LT Epilepsy 8A60-8A68 Approved [12]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [34]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [35]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [36]
Bortezomib DMNO38U Leukemia Approved [37]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [12]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [12]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [40]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [12]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [12]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [12]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
VanA ligase (vanA) DEOFMQ7 Q0WYK7_ENTFL Substrate [4]
VanA ligase (vanA) DEO97D6 VANA_ENTFC Substrate [4]
VanA ligase (vanA) DEN6VO0 A0A376GZ73_ENTGA Substrate [5]
VanA ligase (vanA) DEO8E75 A0A437UFE2_ENTAV Substrate [4]
VanA ligase (vanA) DESOXHP A0A4U9YK96_ENTCA Substrate [6] , [5]
VanB ligase (vanB) DER7KFQ VANB_ENTFA Substrate [4]
VanB ligase (vanB) DE27YVU Q58F99_ENTFC Substrate [4]
VanG ligase (vanG) DEPN8F9 A0A076YRI6_STRAG Substrate [7]
VanC2 ligase (vanC) DEIF4P9 VANC_ENTGA Substrate [8]
D-alanylalanine synthetase (ddl) DE035GU A0A1Q6S944_9FIRM Substrate [7]
VanB ligase (vanB) DEMDEJ8 Q58F99_ENTFC Substrate [9]
VanB ligase (vanB) DE2GMEK Q58F99_ENTFC Substrate [9]
VanC2 ligase (vanC) DEH73ZC Q47720_ENTCA Substrate [10]
VanG ligase (vanG) DEPH3S7 A0A076ZC24_STRAP Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [11]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Gene/Protein Processing [12]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Gene/Protein Processing [12]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Gene/Protein Processing [12]

References

1 Vancomycin FDA Label
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
4 Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71.
5 Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob Agents Chemother. 1994 Jul;38(7):1675-7.
6 vanA in Enterococcus faecium, Enterococcus faecalis, and Enterococcus casseliflavus detected in French cattle. Foodborne Pathog Dis. 2009 Nov;6(9):1107-11.
7 vanG element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus. mBio. 2014 Jul 22;5(4):e01386-14.
8 Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance. Gene. 1992 Mar 1;112(1):53-8.
9 vanI: a novel D-Ala-D-Lac vancomycin resistance gene cluster found in Desulfitobacterium hafniense. Microb Biotechnol. 2014 Sep;7(5):456-66.
10 Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10040-4.
11 [Successful treatment of MRSA-associated glomerulonephritis with antibiotic therapy]. Nihon Jinzo Gakkai Shi. 2003;45(1):37-41.
12 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
13 Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations. Pharmacogenomics. 2008 Oct;9(10):1543-6. doi: 10.2217/14622416.9.10.1543.
14 Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics. 2010 Mar;11(3):349-56. doi: 10.2217/pgs.09.162.
15 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4134-9. doi: 10.1073/pnas.0409500102. Epub 2005 Mar 2.
16 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
17 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
18 HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese. Epilepsia. 2013 Jul;54(7):1307-14. doi: 10.1111/epi.12217. Epub 2013 May 20.
19 Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet. 2002 Mar 30;359(9312):1121-2. doi: 10.1016/S0140-6736(02)08158-8.
20 HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet. 2009 Jul;41(7):816-9. doi: 10.1038/ng.379. Epub 2009 May 31.
21 HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity. PLoS One. 2013 Jul 9;8(7):e68111. doi: 10.1371/journal.pone.0068111. Print 2013.
22 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
23 C-Reactive protein levels over time and cardiovascular risk in HIV-infected individuals suppressed on an indinavir-based regimen: AIDS Clinical Trials Group 5056s. AIDS. 2004 Dec 3;18(18):2434-7.
24 Simvastatin combined with ramipril treatment in hypercholesterolemic patients. Hypertension. 2004 Aug;44(2):180-5. doi: 10.1161/01.HYP.0000133310.42762.25. Epub 2004 Jun 7.
25 The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007 Feb 28;557(2-3):221-9.
26 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
27 Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Sci Immunol. 2020 Jun 5;5(48):eabd0110. doi: 10.1126/sciimmunol.abd0110. Epub 2020 Jun 5.
28 The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. Curr Med Res Opin. 1975;3(5):286-97. doi: 10.1185/03007997509114779.
29 Intractable insomnia after cessation of treatment with thalidomide. Gastroenterology. 2001 May;120(6):1567-8. doi: 10.1053/gast.2001.24495.
30 Effects of hormone treatment on hemostasis variables. Climacteric. 2007 Oct;10 Suppl 2:32-7. doi: 10.1080/13697130701598548.
31 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
32 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
33 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
34 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
35 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
36 Chromosomal radiosensitivity in two cell lineages derived from clinically radiosensitive cancer patients. Clin Cancer Res. 2005 Sep 1;11(17):6352-8. doi: 10.1158/1078-0432.CCR-04-1931.
37 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
38 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
39 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
40 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
41 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.