Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3WKO5)

Drug Name
AG490 Drug Info
Synonyms
(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; 133550-30-8; AG-490; Tyrphostin B42; Tyrphostin AG 490; AG 490; (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; Tyrphostin AG490; tyrphostin AG-490; AG-490 (Tyrphostin B42); alpha-Cyano-(3,4-dihydroxy)-N-benzylcinnamide; N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; 134036-52-5; (2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; CHEMBL56543; (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; (2E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(PHENYLMETHYL)-2-PROPENAMIDE; SMR001230665
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Terminated [1]
Renal transplantation NE84 Terminated [1]
Cross-matching ID
PubChem CID
5328779
ChEBI ID
CHEBI:131968
CAS Number
CAS 133550-30-8
TTD Drug ID
DM3WKO5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Janus kinase 2 (JAK-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [7]
Baricitinib DM4ONW5 Rheumatoid arthritis FA20 Approved [8]
Ruxolitinib DM7Q98D Essential thrombocythemia 3B63.1Z Approved [9]
Pacritinib DM1T6ZN Myelofibrosis 2A20.2 Approved [10]
Fedratinib DM4ZBK6 Myelofibrosis 2A20.2 Approved [11]
ITF2357 DMFZBNE Duchenne dystrophy 8C70 Phase 3 [12]
XL019 DMJ6F5C Solid tumour/cancer 2A00-2F9Z Phase 3 [12]
Cerdulatinib DMSCR2H B-cell lymphoma 2A86 Phase 2 [13]
CTP-543 DM3SYOK Alopecia ED70 Phase 2 [14]
INCB039110 DMD9RV3 Malignant neoplasm 2A00-2F9Z Phase 2 [15]
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Drug(s) Targeting Janus kinase 3 (JAK-3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [16]
Ritlecitinib DMYKNME Alopecia areata ED70.2 Approved [17]
ASP-015K DMZ1UOI Psoriasis vulgaris EA90 Phase 3 [18]
VX-509 DM2U3MX Rheumatoid arthritis FA20 Phase 2/3 [8]
Cerdulatinib DMSCR2H B-cell lymphoma 2A86 Phase 2 [17]
ATI-501 DMTY6OF Alopecia ED70 Phase 2 [19]
ATI-502 DM8NODR Alopecia ED70 Phase 2 [20]
TD-8236 DMTOMJN Asthma CA23 Phase 2 [21]
ALXN2075 DM1BSD8 Non-hodgkin lymphoma 2B33.5 Phase 1/2 [22]
SNA-125 DM8L1GJ Atopic dermatitis EA80 Phase 1 [17]
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Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [23]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [28]
Estrone DM5T6US Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [31]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [32]
Gefitinib DM15F0X Colon adenocarcinoma Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [35]
Etretinate DM2CZFA Keratosis ED56 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [37]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [38]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Gefitinib DM15F0X Colon adenocarcinoma Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [48]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [52]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [53]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [55]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [59]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [60]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [61]
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Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [66]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [67]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [68]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [69]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [70]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Gefitinib DM15F0X Colon adenocarcinoma Approved [73]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Selenium DM25CGV N. A. N. A. Approved [76]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [77]
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Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Selenium DM25CGV N. A. N. A. Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
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Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Gefitinib DM15F0X Colon adenocarcinoma Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [88]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [91]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [92]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [93]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [94]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [98]
Selenium DM25CGV N. A. N. A. Approved [76]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [99]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [48]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [101]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [103]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [104]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [106]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [52]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [108]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [109]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [110]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Meloxicam DM2AR7L Arthritis FA20 Approved [112]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [113]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [35]
Selenium DM25CGV N. A. N. A. Approved [76]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [115]
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [116]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [117]
Quercetin DM3NC4M Obesity 5B81 Approved [118]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [119]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [60]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [109]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [120]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [122]
Quercetin DM3NC4M Obesity 5B81 Approved [123]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [125]
Ethacrynic acid DM60QMR Edema MG29 Approved [126]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [127]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [108]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [128]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [129]
Quercetin DM3NC4M Obesity 5B81 Approved [130]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [133]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [134]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Inhibitor [2]
Janus kinase 3 (JAK-3) TTT7PJU JAK3_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [5]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [4]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Gene/Protein Processing [4]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [5]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Gene/Protein Processing [6]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Gene/Protein Processing [6]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [4]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [5]

References

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34 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
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41 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
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43 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
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46 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
47 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
48 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
49 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
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