Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3WQNY)

Drug Name	4-Hydroxybenzoicacid Drug Info
Cross-matching ID	PubChem CID 135 ChEBI ID CHEBI:30763 CAS Number CAS 99-96-7 TTD Drug ID DM3WQNY

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[6]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[7]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[8]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[9]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[10]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[11]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[12]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[13]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[14]
Budipine	DMODHQI	Migraine	8A80	Approved	[15]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[16]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[17]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[18]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
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Drug(s) Affected By Aldo-keto reductase family 1 member C4 (AKR1C4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[2]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[27]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[25]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[25]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[29]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[30]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[32]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[25]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[33]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[33]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[32]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[32]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[42]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[32]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[44]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[45]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[43]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[32]
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Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[46]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[52]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[53]
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Drug(s) Affected By Biotin--protein ligase (HLCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[3]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[59]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[60]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[54]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member C4 (AKR1C4)	OTW2MMOF	AK1C4_HUMAN	Gene/Protein Processing	[2]
Biotin--protein ligase (HLCS)	OTPDUX30	BPL1_HUMAN	Gene/Protein Processing	[3]
Leptin (LEP)	OT5Q7ODW	LEP_HUMAN	Gene/Protein Processing	[4]
Sulfotransferase 1A1 (SULT1A1)	OT0K7JIE	ST1A1_HUMAN	Gene/Protein Processing	[5]

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