Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5F24X)

Drug Name
Crocin Drug Info
Cross-matching ID
PubChem CID
5281233
TTD Drug ID
DM5F24X
VARIDT Drug ID
DR01664

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [6]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [8]
Folic Acid DMEMBJC Colorectal carcinoma Approved [9]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [8]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [8]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [10]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [8]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [11]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [13]
Gefitinib DM15F0X Colon adenocarcinoma Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [16]
Etretinate DM2CZFA Keratosis ED56 Approved [17]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [18]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [19]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein P2 (FOXP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Folic Acid DMEMBJC Colorectal carcinoma Approved [26]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [27]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [28]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [29]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [30]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [31]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [36]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [39]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [40]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Gefitinib DM15F0X Colon adenocarcinoma Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [48]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [16]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [55]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [56]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [55]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [63]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [67]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [70]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [61]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [71]
Paclitaxel DMLB81S Breast carcinoma Approved [72]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [73]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [63]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone enanthate DMB6871 N. A. N. A. Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [77]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [78]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [28]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [79]
OXYBENZONE DMMZYX6 Discovery agent N.A. Investigative [80]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [2]
Forkhead box protein P2 (FOXP2) OTVX6A59 FOXP2_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [2]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [2]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [2]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [4]
Protein sprouty homolog 2 (SPRY2) OTH0CRCZ SPY2_HUMAN Gene/Protein Processing [3]
Tyrosine-protein phosphatase non-receptor type 4 (PTPN4) OT6SXU5Y PTN4_HUMAN Gene/Protein Processing [5]

References

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2 Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells FTC-133 through the inhibition of STAT/JAK signaling pathway. J Biochem Mol Toxicol. 2021 Jan;35(1):e22608. doi: 10.1002/jbt.22608. Epub 2020 Sep 4.
3 Crocin suppresses breast cancer cell proliferation by down-regulating tumor promoter miR-122-5p and up-regulating tumor suppressors FOXP2 and SPRY2. Environ Toxicol. 2023 Jul;38(7):1597-1608. doi: 10.1002/tox.23789. Epub 2023 Mar 29.
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29 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
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37 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
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39 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
40 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
41 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
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70 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
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74 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
75 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
76 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
77 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
78 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
79 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
80 Chromatin modifiers: A new class of pollutants with potential epigenetic effects revealed by in vitro assays and transcriptomic analyses. Toxicology. 2023 Jan 15;484:153413. doi: 10.1016/j.tox.2022.153413. Epub 2022 Dec 26.