Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5F24X)

Drug Name
Crocin Drug Info
Cross-matching ID
PubChem CID
5281233
TTD Drug ID
DM5F24X
VARIDT Drug ID
DR01664

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [4]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [6]
Folic Acid DMEMBJC Colorectal carcinoma Approved [7]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [6]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [6]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [8]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [6]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [9]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [10]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [11]
Gefitinib DM15F0X Colon adenocarcinoma Approved [12]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [13]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [14]
Etretinate DM2CZFA Keratosis ED56 Approved [15]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [16]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [17]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
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Drug(s) Affected By Forkhead box protein P2 (FOXP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [24]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [25]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [26]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [27]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [28]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [29]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [30]
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Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [34]
Leflunomide DMR8ONJ Arthritis FA20 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [37]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [38]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Gefitinib DM15F0X Colon adenocarcinoma Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [45]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [46]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [47]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [50]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [51]
Fructose DM43AN2 Vomiting MD90 Approved [52]
Ketoprofen DMRKXPT Bursitis Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Haloperidol DM96SE0 Delirium Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [62]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [63]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
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Drug(s) Affected By N-myc proto-oncogene protein (MYCN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [74]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [75]
Menthol DMG2KW7 Back pain ME84.Z Approved [76]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [77]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [78]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [68]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [82]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [14]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [86]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [87]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [86]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [88]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [91]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [92]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [94]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Verapamil DMA7PEW Angina pectoris BA40 Approved [95]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [96]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [97]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [97]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [100]
Gefitinib DM15F0X Colon adenocarcinoma Approved [101]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Selenium DM25CGV N. A. N. A. Approved [104]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [46]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [105]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [106]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [107]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [109]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [111]
Gefitinib DM15F0X Colon adenocarcinoma Approved [112]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [115]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [107]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [116]
Paclitaxel DMLB81S Breast carcinoma Approved [117]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [118]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [106]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [119]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [109]
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Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone enanthate DMB6871 N. A. N. A. Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [122]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [26]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [66]
OXYBENZONE DMMZYX6 Discovery agent N.A. Investigative [123]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [124]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [125]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [97]
Gefitinib DM15F0X Colon adenocarcinoma Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [128]
Selenium DM25CGV N. A. N. A. Approved [104]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [129]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [46]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [130]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [131]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [132]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [133]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [134]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [135]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [136]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [138]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [139]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [140]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [141]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [142]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [143]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [144]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [145]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [146]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [147]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [148]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [149]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [150]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [151]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [96]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [152]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [14]
Meloxicam DM2AR7L Arthritis FA20 Approved [154]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [155]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [156]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [91]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [149]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Verapamil DMA7PEW Angina pectoris BA40 Approved [95]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [157]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [152]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Meloxicam DM2AR7L Arthritis FA20 Approved [158]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [87]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [159]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [160]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [161]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [119]
Gefitinib DM15F0X Colon adenocarcinoma Approved [162]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [163]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [14]
Selenium DM25CGV N. A. N. A. Approved [104]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [155]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [2]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [2]
Catalase (CAT) OTHEBX9R CATA_HUMAN Gene/Protein Processing [2]
Forkhead box protein P2 (FOXP2) OTVX6A59 FOXP2_HUMAN Gene/Protein Processing [3]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [2]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [2]

References

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2 Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells FTC-133 through the inhibition of STAT/JAK signaling pathway. J Biochem Mol Toxicol. 2021 Jan;35(1):e22608. doi: 10.1002/jbt.22608. Epub 2020 Sep 4.
3 Crocin suppresses breast cancer cell proliferation by down-regulating tumor promoter miR-122-5p and up-regulating tumor suppressors FOXP2 and SPRY2. Environ Toxicol. 2023 Jul;38(7):1597-1608. doi: 10.1002/tox.23789. Epub 2023 Mar 29.
4 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
5 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
6 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
7 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
8 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
9 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
10 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
11 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
12 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
13 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
14 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
15 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
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17 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
18 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
19 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
20 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
21 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
22 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
23 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
24 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
25 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
26 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
27 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
28 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
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