Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7APNJ)

Drug Name
Zomepirac Drug Info
Synonyms
ZOMEPIRAC SODIUM; Zomepirac sodium [USAN:USP]; UNII-Y0185WZ209; McN-2783-21-98; Y0185WZ209; 64092-49-5; Zomepirac sodium dihydrate; 1H-Pyrrole-2-acetic acid, 5-(4-chlorobenzoyl)-1,4-dimethyl-, sodium salt, dihydrate; Zomepirac sodium (USAN); CHEMBL3989403; DTXSID60214282; ZJXLSCXDGPDZOL-UHFFFAOYSA-M; D06382; Sodium 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetate dihydrate; Sodium 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetate Dihydrate
Indication
Disease Entry ICD 11 Status REF
Pain MG30-MG3Z Withdrawn from market [1]
Cross-matching ID
PubChem CID
5733
ChEBI ID
CHEBI:35859
CAS Number
CAS 33369-31-2
TTD Drug ID
DM7APNJ
INTEDE Drug ID
DR1736

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase (COX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [9]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [10]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [11]
Dexibuprofen DMFYBD0 Ankylosing spondylitis FA92.0 Approved [12]
Ketorolac DMI4EL5 Postoperative inflammation 1A00-CA43.1 Approved [13]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [14]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [15]
Aceclofenac DMZDF0B Inflammation 1A00-CA43.1 Approved [16]
Lornoxicam DMYZFXN Migraine 8A80 Approved [17]
Morniflumate DM9UTDE Otitis media AA80-AB0Z Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [20]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [28]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [5]
Diazepam DM08E9O Alcohol withdrawal Approved [29]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [30]
Desogestrel DM27U4Y Contraception QA21 Approved [30]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [5]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [5]
Diazepam DM08E9O Alcohol withdrawal Approved [29]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [35]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [5]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [5]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [38]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [40]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [5]
Diazepam DM08E9O Alcohol withdrawal Approved [29]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [5]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [42]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [43]
Ethacrynic acid DM60QMR Edema MG29 Approved [41]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [5]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [45]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [51]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [52]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [53]
Diazepam DM08E9O Alcohol withdrawal Approved [54]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [55]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [56]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [57]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [61]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [62]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [63]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [66]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [68]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [69]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [63]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [73]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [45]
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Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [77]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [78]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [79]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [4]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [5]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [5]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [5]
Dehydrogenase/reductase SDR family member 11 (DHRS11) OTU3J0ZL DHR11_HUMAN Gene/Protein Processing [6]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Gene/Protein Processing [7]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [7]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [7]
UDP-glucuronosyltransferase 2B7 OT2Q71VQ UD2B7_HUMAN Biotransformations [8]

References

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