Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7C8YV)

Drug Name
Plicamycin Drug Info
Synonyms A-2371; NSC24559; PA-144; MTM A; AC1O3EQZ; CHEMBL413720; SCHEMBL14066059; NSC-24559; AKOS030213136; EC-7071; CCG-208236; NCGC00160390-01; NCI60_004287; AB01273958-01
Indication
Disease Entry ICD 11 Status REF
Hypercalcaemia 5B91.0 Approved [1]
Testicular cancer 2C80 Approved [1]
Solid tumour/cancer 2A00-2F9Z Withdrawn from market [2]
Lung cancer 2C25.0 Investigative [3]
Ovarian cancer 2C73 Investigative [3]
Cross-matching ID
PubChem CID
163659
ChEBI ID
CHEBI:31856
CAS Number
CAS 18378-89-7
TTD Drug ID
DM7C8YV
VARIDT Drug ID
DR01174

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [11]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [11]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [15]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [16]
Testosterone DM7HUNW Hot flushes GA30 Approved [17]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [18]
Leflunomide DMR8ONJ Arthritis FA20 Approved [19]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [20]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [21]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [22]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [25]
Ethacrynic acid DM60QMR Edema MG29 Approved [26]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [27]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [28]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [29]
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Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [32]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [33]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [38]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [39]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [21]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [41]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Estrone DM5T6US Acne vulgaris ED80 Approved [43]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [44]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [45]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [46]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [47]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [48]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Gefitinib DM15F0X Colon adenocarcinoma Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [52]
Etretinate DM2CZFA Keratosis ED56 Approved [53]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [54]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [55]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [63]
Paclitaxel DMLB81S Breast carcinoma Approved [64]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
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Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [71]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [15]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [76]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [77]
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Drug(s) Affected By Transcription factor Sp1 (SP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [84]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [85]
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Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [90]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [91]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [76]
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Drug(s) Affected By Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [94]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [95]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Fructose DM43AN2 Vomiting MD90 Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [93]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [100]
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Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [101]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [102]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [102]
Leflunomide DMR8ONJ Arthritis FA20 Approved [19]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [104]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
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Drug(s) Affected By Transcription factor Sp3 (SP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Leflunomide DMR8ONJ Arthritis FA20 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Promegestone DMK4S8I Gynecological disease GA6Z Approved [5]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [107]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [108]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [109]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [110]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [111]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [112]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [113]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [117]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [119]
Ethacrynic acid DM60QMR Edema MG29 Approved [120]
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Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8 (EPS8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Leflunomide DMR8ONJ Arthritis FA20 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [76]
Benzatropine DMF7EXL Parkinsonian disorder Approved [121]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [122]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [123]
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Drug(s) Affected By TNFAIP3-interacting protein 1 (TNIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [124]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [125]
Arsenic DMTL2Y1 N. A. N. A. Approved [126]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [127]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [110]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [128]
Methotrexate DM2TEOL Anterior urethra cancer Approved [129]
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Drug(s) Affected By Sphingomyelin phosphodiesterase 3 (SMPD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [123]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [109]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [131]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [132]
Urethane DM7NSI0 N. A. N. A. Phase 4 [133]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [109]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
RNA synthesis (hRNA synth) TTX2AYW NOUNIPROTAC Modulator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Gene/Protein Processing [5]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [6]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [7]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [7]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [6]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [6]
Epidermal growth factor receptor kinase substrate 8 (EPS8) OTZ6ES6V EPS8_HUMAN Gene/Protein Processing [8]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Gene/Protein Processing [9]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [10]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Gene/Protein Processing [8]

References

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49 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
50 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
51 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
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