Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC8J6F)

Drug Name

METHYLTHIOADENOSINE Drug Info

Synonyms

5'-Deoxy-5'-methylthioadenosine; 2457-80-9; Methylthioadenosine; 5'-S-methyl-5'-thioadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-DEOXY-5'-METHYLTHIOADENOSINE; (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol; Thiomethyladenosine; Vitamin L2; ADENOSINE, 5'-S-METHYL-5'-THIO-; 5'-S-Methylthioadenosine; MTA; S-methyl-5'-thioadenosine; Vitamin L(sub 2); UNII-634Z2VK3UQ; 5'-Deoxy(methylthio)adenosine; 5'-Deoxy-5'-Methylthioadenosine

Indication

Disease Entry	ICD 11	Status	REF
Multiple sclerosis	8A40	Terminated	[1]

Cross-matching ID

PubChem CID: 439176
ChEBI ID: CHEBI:17509
CAS Number: CAS 2457-80-9
TTD Drug ID: DMC8J6F
INTEDE Drug ID: DR2066

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting Adenosine A3 receptor (ADORA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IB-MECA	DM9G5XD	Psoriasis vulgaris	EA90	Phase 3	[8]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[9]
NITD609	DMQHBSX	Malaria	1F40-1F45	Phase 2	[10]
CF102	DMP56WJ	Hepatocellular carcinoma	2C12.02	Phase 2	[11]
SCH-442416	DMQ2K1V	N. A.	N. A.	Phase 1	[12]
AST-004	DM5WMG7	Stroke	8B20	Phase 1	[13]
BEMESETRON	DMSPJX9	N. A.	N. A.	Discontinued in Phase 3	[14]
BAY 60-6583	DMTEJV1	Myocardial ischemia	BA6Z	Preclinical	[15]
CF602	DM0ULO2	Inflammation	1A00-CA43.1	Preclinical	[11]
CF502	DMQSJ20	Inflammation	1A00-CA43.1	Preclinical	[11]
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Drug(s) Targeting S-methyl-5'-thioadenosine phosphorylase (MTAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
5'-Deoxy-5'-(Methylthio)-Tubercidin	DMR28HG	Discovery agent	N.A.	Investigative	[3]
Formycin	DMWG0P3	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Adenosine A2a receptor (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[16]
Istradefylline	DM20VSK	Parkinson disease	8A00.0	Approved	[17]
Regadenoson	DM76VHG	Radionuclide imaging	N.A.	Approved	[18]
Tozadenant	DMATC14	Parkinson disease	8A00.0	Phase 3	[19]
Binodenoson	DMVHF8G	Hypertension	BA00-BA04	Phase 3	[20]
Apadenoson	DMD8QTC	Coronary artery disease	BA80	Phase 3	[21]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[9]
Dexefaroxan	DMTY4KN	Parkinson disease	8A00.0	Phase 2	[22]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[23]
BIIB014	DMH7RJ1	Parkinson disease	8A00.0	Phase 2	[24]
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Drug(s) Targeting Adenosine A2b receptor (ADORA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[25]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[25]
A295	DM55GO2	Aggressive cancer	2A00-2F9Z	IND submitted	[26]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[9]
YT-146	DM3YVKQ	Hypertension	BA00-BA04	Phase 2	[27]
AB928	DMDOXMN	Metastatic colorectal cancer	2B91	Phase 1/2	[28]
KF-17837	DMQ6DLZ	Parkinson disease	8A00.0	Phase 1	[29]
Xanthine	DMFBOQ7	Apnea	MD11.0	Phase 1	[30]
CVT-6883	DMY84TW	Asthma	CA23	Phase 1	[31]
PBF-1129	DMOPGXM	Non-small-cell lung cancer	2C25.Y	Phase 1	[28]
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Drug(s) Targeting Adenosine A1 receptor (ADORA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[16]
Rolofylline	DMSZPR3	Heart failure	BD10-BD13	Phase 3	[32]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[9]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[23]
SELODENOSON	DMQM3IX	Cardiac arrhythmias	BC9Z	Phase 2	[33]
Apaxifylline	DMQMV9F	Cognitive impairment	6D71	Phase 2	[34]
SLV320	DM867BJ	Heart failure	BD10-BD13	Phase 2	[35]
DTI-0009	DMV84OK	Atrial fibrillation	BC81.3	Phase 2	[33]
Capadenoson	DMYWO62	Atrial fibrillation	BC81.3	Phase 2	[36]
BAY 1067197	DM4JGNH	Heart failure	BD10-BD13	Phase 2	[37]
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Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[38]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[39]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[40]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[47]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[50]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[54]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[55]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[61]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[62]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[63]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[65]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
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Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[76]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[77]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[78]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[79]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[82]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[84]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[85]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[86]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[88]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[85]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[94]
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Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[48]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[95]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[96]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[106]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[110]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A1 receptor (ADORA1)	TTK25J1	AA1R_HUMAN	Inhibitor	[2]
Adenosine A2a receptor (ADORA2A)	TTM2AOE	AA2AR_HUMAN	Inhibitor	[2]
Adenosine A2b receptor (ADORA2B)	TTNE7KG	AA2BR_HUMAN	Inhibitor	[2]
Adenosine A3 receptor (ADORA3)	TTJFY5U	AA3R_HUMAN	Inhibitor	[2]
S-methyl-5'-thioadenosine phosphorylase (MTAP)	TTDBX7N	MTAP_HUMAN	Inhibitor	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
S-adenosylhomocysteine nucleosidase (mtnN)	DE1DR6Y	MTNN_KLEPN	Substrate	[4]
S-methyl-5'-thioadenosine phosphorylase (MTAP)	DEXHBCR	MTAP_HUMAN	Substrate	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[6]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[7]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Gene/Protein Processing	[7]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Protein Interaction/Cellular Processes	[6]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Protein Interaction/Cellular Processes	[6]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[6]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Post-Translational Modifications	[6]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Post-Translational Modifications	[6]

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