Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML0DBV)

Drug Name
ABT-737 Drug Info
Synonyms
ABT-737; 852808-04-9; ABT 737; ABT737; UNII-Z5NFR173NV; Z5NFR173NV; 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide; CHEMBL376408; C42H45ClN6O5S2; 4-{4-[(4'-Chlorobiphenyl-2-Yl)methyl]piperazin-1-Yl}-N-{[4-({(1r)-3-(Dimethylamino)-1-[(Phenylthio)methyl]propyl}amino)-3-Nitrophenyl]sulfonyl}benzamide
Cross-matching ID
PubChem CID
11228183
CAS Number
CAS 852808-04-9
TTD Drug ID
DML0DBV
VARIDT Drug ID
DR01411

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Apoptosis regulator Bcl-2 (BCL-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MCI-186 DM8ZHP1 Amyotrophic lateral sclerosis 8B60.0 Approved [10]
Taxol DMUOT9V Breast cancer 2C60-2C65 Approved [11]
GDC-0199 DMH0QKA Chronic lymphocytic leukaemia 2A82.0 Approved [12]
ABT-263 DMNE56X Myelofibrosis 2A20.2 Phase 3 [13]
Taxol/Paraplatin/Herceptin DML6GAN Breast cancer 2C60-2C65 Phase 3 [14]
Oblimersen DM7KI4E Melanoma 2C30 Phase 3 [15]
RG7601 DMDVAFP Chronic lymphocytic leukaemia 2A82.0 Phase 3 [12]
Thymoquinone DMVDTR2 Polycystic ovarian syndrome 5A80.1 Phase 2/3 [16]
Obatoclax DMPF9ZM Solid tumour/cancer 2A00-2F9Z Phase 2 [17]
PI-88/Taxotere DM4FIWC Solid tumour/cancer 2A00-2F9Z Phase 2 [18]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [26]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [28]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [29]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [30]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [33]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [34]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [35]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [38]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [39]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [40]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [43]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [44]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [45]
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Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [46]
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [51]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [53]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [54]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [55]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [59]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [60]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [62]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [63]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [64]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [65]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [33]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [69]
Meloxicam DM2AR7L Arthritis FA20 Approved [70]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [71]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [72]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [26]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [45]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [73]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [67]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Meloxicam DM2AR7L Arthritis FA20 Approved [76]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [77]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [80]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [87]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [80]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
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Drug(s) Affected By Homeobox protein NANOG (NANOG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Panobinostat DM58WKG Chronic graft versus host disease Approved [97]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [99]
Testosterone DM7HUNW Hot flushes GA30 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [34]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [105]
Quercetin DM3NC4M Obesity 5B81 Approved [106]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [108]
Ethacrynic acid DM60QMR Edema MG29 Approved [109]
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Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [73]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Leflunomide DMR8ONJ Arthritis FA20 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [113]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [114]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [115]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [110]
Menthol DMG2KW7 Back pain ME84.Z Approved [116]
Capsaicin DMGMF6V Back pain ME84.Z Approved [117]
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Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [122]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [123]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [124]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [110]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Apoptosis regulator Bcl-2 (BCL-2) TTJGNVC BCL2_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Protein Interaction/Cellular Processes [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Drug Response [3]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Drug Response [4]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [6]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [6]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [7]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [8]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Gene/Protein Processing [9]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Drug Response [3]

References

1 Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem. 2007 Feb 22;50(4):641-62.
2 The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochem Biophys Res Commun. 2011 May 6;408(2):344-9.
3 Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88. doi: 10.1016/j.ccr.2006.10.006.
4 The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737. J Biol Chem. 2013 Mar 8;288(10):6980-90. doi: 10.1074/jbc.M112.414177. Epub 2013 Jan 22.
5 Apoptosis induces Bcl-XS and cleaved Bcl-XL in chronic lymphocytic leukaemia. Biochem Biophys Res Commun. 2011 Feb 18;405(3):480-5. doi: 10.1016/j.bbrc.2011.01.057. Epub 2011 Jan 20.
6 The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs. Mol Pharmacol. 2010 Mar;77(3):483-94. doi: 10.1124/mol.109.060780. Epub 2009 Dec 28.
7 Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells. Autophagy. 2010 Feb;6(2):256-69. doi: 10.4161/auto.6.2.11124. Epub 2010 Feb 6.
8 Para-tertiary butyl catechol (PTBC), an industrial antioxidant induces human platelet apoptosis. Environ Toxicol. 2019 Mar;34(3):262-270. doi: 10.1002/tox.22681. Epub 2018 Nov 21.
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11 Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res. 2009 Sep 1;69(17):6906-14.
12 ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8.
13 Clinical pipeline report, company report or official report of Roche (2009).
14 Two concurrent phase II trials of paclitaxel/carboplatin/trastuzumab (weekly or every-3-week schedule) as first-line therapy in women with HER2-overexpressing metastatic breast cancer: NCCTG study 983252. Clin Breast Cancer. 2005 Dec;6(5):425-32.
15 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
16 Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197.
17 Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.
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19 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
20 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
21 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
22 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
23 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
24 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
25 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
26 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
27 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
28 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
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31 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
32 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
33 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
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38 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
39 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
40 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
41 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
42 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
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44 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
45 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
46 Effect of menstrual cycle and hormonal treatment on ki-67 and bcl-2 expression and adenomyosis. Gynecol Endocrinol. 2005 Mar;20(3):127-31. doi: 10.1080/09513590400021086.
47 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
48 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
49 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
50 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
51 An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
52 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
53 Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ Toxicol Pharmacol. 2016 Jul;45:212-21.
54 Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
55 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
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