Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN4CV5)

Drug Name
Calcidiol Drug Info
Synonyms
Calcifediolum; Calcifidiol; Delakmin; VDY; Calcifediol anhydrous; BML2-E02; Calcifediolum [INN-Latin]; Ro 8-8892; U-32070E; (1R,3Z)-3-[(2E)-2-[(1R,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol; (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol; (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol; (3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol; (3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol; (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol; (5Z,7E)-9,10-Seco-5,7,10(19)-cholestatrien-3beta,25-diol; 25(OH)D3; 25-(OH)Vitamin D3; 25-Hydroxycholecalciferol; 25-Hydroxycholecalciferol (Calcifediol); 25-Hydroxycholescalciferol; 25-Hydroxyvitamin D; 25-Hydroxyvitamin D3 monohydrate; 25-hydroxyvitamin D3; 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL; 5,6-cis-25-Hydroxyvitamin D3; 5,6-trans-25-Hydroxycholescalciferol; 5,6-trans-9,10-Seco-5,7,10(19)-cholestatrien-3beta,25-diol; 9,10-Secocholesta-5,7,10(19)-triene-3beta,25-diol
Indication
Disease Entry ICD 11 Status REF
Hypophosphatemia Approved [1]
Renal osteodystrophy Approved [2]
Rickets 5B57 Approved [3]
Vitamin D deficiency 5B57 Approved [4]
Autosomal dominant hypocalcemia 5A50.0Y Investigative [5]
Therapeutic Class
Vitamins
Cross-matching ID
PubChem CID
5283731
ChEBI ID
CHEBI:17933
CAS Number
CAS 19356-17-3
TTD Drug ID
DMN4CV5
INTEDE Drug ID
DR0259
ACDINA Drug ID
D00089

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Vitamin D3 receptor (VDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [6]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [12]
Doxercalciferol DM6FG1P Chronic kidney disease GB61 Approved [13]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [14]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [15]
Dihydrotachysterol DMFB97P Hypocalcemia 5B5K.1 Approved [16]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [17]
Paricalcitol DMYBV3G Hyperparathyroidism 5A51 Approved [18]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [19]
S-06911 DMAYTIH Osteoporosis FB83.0 Phase 3 [20]
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Drug(s) Metabolized By Vitamin D(3) 24-hydroxylase (CYP24A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [21]
Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [22]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [29]
Testosterone DM7HUNW Hot flushes GA30 Approved [30]
Leflunomide DMR8ONJ Arthritis FA20 Approved [31]
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Drug(s) Affected By 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [34]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [37]
Arsenic DMTL2Y1 N. A. N. A. Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
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Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [41]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [47]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [50]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [51]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [54]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Verapamil DMA7PEW Angina pectoris BA40 Approved [56]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [57]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
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Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [62]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [63]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [64]
Meloxicam DM2AR7L Arthritis FA20 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Epinephrine DM3KJBC Acute asthma CA23 Approved [68]
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Drug(s) Affected By Integrin-binding sialoprotein (IBSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [10]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [70]
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [71]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [72]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [73]
GSK2816126 DMJDVW4 Solid tumour/cancer 2A00-2F9Z Phase 1 [74]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [75]
EUGENOL DM7US1H Discovery agent N.A. Patented [76]
alpha-ketoglutaric acid DM5LFYN Discovery agent N.A. Investigative [77]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [78]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [84]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [87]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [89]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Etretinate DM2CZFA Keratosis ED56 Approved [92]
Prednisone DM2HG4X Acute asthma CA23 Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [94]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [95]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [51]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Verapamil DMA7PEW Angina pectoris BA40 Approved [56]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [97]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [98]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Meloxicam DM2AR7L Arthritis FA20 Approved [65]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [94]
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Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [48]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [104]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [106]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [107]
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Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
Epinephrine DM3KJBC Acute asthma CA23 Approved [110]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [111]
Fructose DM43AN2 Vomiting MD90 Approved [112]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [114]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [115]
Propranolol DM79NTF Angina pectoris BA40 Approved [116]
Testosterone DM7HUNW Hot flushes GA30 Approved [117]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vitamin D3 receptor (VDR) TTK59TV VDR_HUMAN Antagonist [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Vitamin D(3) 24-hydroxylase (CYP24A1) DEFI12S CP24A_HUMAN Substrate [7]
Calcidiol 1-monooxygenase (CYP27B1) DE3FYEM CP27B_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Gene/Protein Processing [9]
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1) OTTK98BH CP27B_HUMAN Biotransformations [10]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Gene/Protein Processing [10]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [10]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [10]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [10]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [10]
Insulin (INS) OTZ85PDU INS_HUMAN Protein Interaction/Cellular Processes [11]
Integrin-binding sialoprotein (IBSP) OT29944Y SIAL_HUMAN Gene/Protein Processing [10]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Gene/Protein Processing [10]

References

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55 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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