Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVXFYE)

Drug Name
Vinorelbine Drug Info
Synonyms
Eunades; Exelbine; NVB; Navelbine; Vinorelbin; Vinorelbina; Vinorelbinum; Navelbine base; Vinorelbina [Spanish]; Vinorelbine Ditartarate; Vinorelbine ditartrate; Vinorelbine tartrate; Vinorelbinum [Latin]; KW 2307; KW 2307 base; ANX-530; KW-2307; Navelbine (TN); SDP-012; Vinorelbine (INN); Vinorelbine [INN:BAN]; Aspidospermidine-3-carboxylic acid; Nor-5'-anhydrovinblastine; Methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate; Methyl (2b,3b,4b,5a,12b,19a)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
Indication
Disease Entry ICD 11 Status REF
Advanced cancer 2A00-2F9Z Approved [1]
Lung cancer 2C25.0 Approved [1]
Non-small-cell lung cancer 2C25.Y Approved [1]
Solid tumour/cancer 2A00-2F9Z Approved [2]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
5311497
ChEBI ID
CHEBI:480999
CAS Number
CAS 71486-22-1
TTD Drug ID
DMVXFYE
VARIDT Drug ID
DR01343
INTEDE Drug ID
DR1696

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tubulin (TUB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [15]
Cabazitaxel DMPAZHC Breast cancer 2C60-2C65 Approved [16]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
Ixabepilone DM2OZ3G Breast cancer 2C60-2C65 Approved [16]
Eribulin DM1DX4Q Breast cancer 2C60-2C65 Approved [16]
Epothilon DMITJRU Ovarian cancer 2C73 Phase 3 [18]
DOLASTATIN-10 DMDUV1S Solid tumour/cancer 2A00-2F9Z Phase 2 [19]
BMS-188797 DML1CK2 Solid tumour/cancer 2A00-2F9Z Phase 2 [20]
Indibulin DM6OFJ8 Advanced sarcoma 2A60-2C35 Phase 2 [21]
Soblidotin DMO4EYX Solid tumour/cancer 2A00-2F9Z Phase 2 [22]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [23]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Folic Acid DMEMBJC Colorectal carcinoma Approved [26]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [31]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [38]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [6]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [39]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [38]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [41]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [42]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [43]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [44]
Propranolol DM79NTF Angina pectoris BA40 Approved [45]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [46]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [47]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [48]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [50]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [51]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [53]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Prednisone DM2HG4X Acute asthma CA23 Approved [58]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [64]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [65]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [67]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [71]
Prednisone DM2HG4X Acute asthma CA23 Approved [72]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [73]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
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Drug(s) Affected By Vitamin K-dependent protein C (PROC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Desogestrel DM27U4Y Contraception QA21 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [79]
Testosterone enanthate DMB6871 N. A. N. A. Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Clozapine DMFC71L Schizophrenia 6A20 Approved [82]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [83]
Clomipramine DMINRKW Depression 6A70-6A7Z Approved [84]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [85]
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Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Selenium DM25CGV N. A. N. A. Approved [88]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [11]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Panobinostat DM58WKG Chronic graft versus host disease Approved [92]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [94]
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Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [95]
Panobinostat DM58WKG Chronic graft versus host disease Approved [92]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [97]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [98]
Paclitaxel DMLB81S Breast carcinoma Approved [99]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [85]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [100]
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Drug(s) Affected By Splicing factor 45 (RBM17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [103]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [98]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [12]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [12]
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Drug(s) Affected By Equilibrative nucleoside transporter 1 (SLC29A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [107]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [108]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [110]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [111]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [112]
Testosterone DM7HUNW Hot flushes GA30 Approved [113]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
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Drug(s) Affected By Nucleophosmin (NPM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Etretinate DM2CZFA Keratosis ED56 Approved [115]
Methotrexate DM2TEOL Anterior urethra cancer Approved [11]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Testosterone DM7HUNW Hot flushes GA30 Approved [113]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tubulin (TUB) TTML2WA NOUNIPROTAC Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Gene/Protein Processing [7]
Epithelial cell adhesion molecule (EPCAM) OTHBZK5X EPCAM_HUMAN Gene/Protein Processing [8]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Drug Response [9]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Gene/Protein Processing [10]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Drug Response [11]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Gene/Protein Processing [7]
Splicing factor 45 (RBM17) OT9ROJCL SPF45_HUMAN Drug Response [12]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Gene/Protein Processing [13]
Vitamin K-dependent protein C (PROC) OTGVH484 PROC_HUMAN Gene/Protein Processing [14]

References

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56 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
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64 p16 loss facilitate hydroquinone-induced malignant transformation of TK6 cells through promoting cell proliferation and accelerating the cell cycle progression. Environ Toxicol. 2021 Aug;36(8):1591-1599. doi: 10.1002/tox.23155. Epub 2021 May 1.
65 Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells. Acta Oncol. 2008;47(6):1062-70.
66 Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
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