General Information of Drug (ID: DMVZL26)

Drug Name
3,4-Dihydroxycinnamic Acid Drug Info
Synonyms
Caffeic acid; caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 3-(3,4-dihydroxyphenyl)acrylic acid; 501-16-6; (E)-3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; trans-caffeic acid; trans-Caffeate; 3,4-Dihydroxy-trans-cinnamate; 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-; Cinnamic acid, 3,4-dihydroxy-; 3-(3,4-Dihydroxyphenyl)propenoic acid; UNII-U2S3A33KVM; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene
Indication
Disease Entry ICD 11 Status REF
Thrombocytopenia 3B64 Phase 4 [1]
Cross-matching ID
PubChem CID
689043
ChEBI ID
CHEBI:16433
CAS Number
CAS 331-39-5
TTD Drug ID
DMVZL26

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [12]
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [13]
Silymarin DMXBYQR N. A. N. A. Phase 4 [14]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [15]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [16]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [17]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [18]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [19]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [20]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [21]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Anti-MIF antibodies DM8EKSV Autoimmune diabetes 5A10 Phase 4 [22]
ISO-1 DMDB7KU N. A. N. A. Phase 1 [23]
COR100140 DMN0GTR Inflammation 1A00-CA43.1 Preclinical [24]
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE DMPSOIF Discovery agent N.A. Investigative [25]
4-hydroxyphenylpyruvic acid DM0564K Discovery agent N.A. Investigative [25]
AVP-13546 DMDTONZ Autoimmune disease 4A40-4A45 Investigative [26]
AVP-13748 DMBNDYK Autoimmune disease 4A40-4A45 Investigative [26]
4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME DM7WPGN Discovery agent N.A. Investigative [25]
NAPQI DM8F5LR Autoimmune disease 4A40-4A45 Investigative [26]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [32]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [33]
EXISULIND DMBY56U Colorectal cancer 2B91.Z Phase 3 [34]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [35]
CP-461 DMEYMTX Inflammatory bowel disease DD72 Phase 2 [36]
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Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [11]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Fructose DM43AN2 Vomiting MD90 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
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Drug(s) Affected By Norrin (NDP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [48]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [49]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [50]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [46]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [46]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [51]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [52]
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Drug(s) Affected By Myeloperoxidase (MPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dapsone DM4LT8A Acne vulgaris ED80 Approved [39]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [39]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [10]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [55]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [58]
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Drug(s) Affected By Amine oxidase A (MAOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [63]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
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Drug(s) Affected By Amine oxidase B (MAOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [70]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
BENZYL BENZOATE DMDPYI5 Infestations of lice and scabies 1G00.Z Approved [5]
Linezolid DMGFPU2 Bacteremia 1A73 Approved [72]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [74]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [77]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [78]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [83]
Paclitaxel DMLB81S Breast carcinoma Approved [84]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [85]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [87]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [88]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [94]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [39]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [100]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [101]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [102]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [103]
Ethanol DMDRQZU Chronic pain MG30 Approved [104]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [33]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [107]
CERC-801 DM3SZ7P N. A. N. A. Phase 2 [108]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [52]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [109]
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Drug(s) Affected By Biotin--protein ligase (HLCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [6]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [100]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [111]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [112]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [113]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [114]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [115]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [110]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [116]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [117]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [113]
Methylene blue DMJAPE7 Acquired methemoglobinemia 3A93 Approved [118]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [117]
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Drug(s) Affected By Sulfotransferase 1C2 (SULT1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Panobinostat DM58WKG Chronic graft versus host disease Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [119]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [114]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [120]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [122]
Minoxidil DMA2Z4F Alopecia ED70 Approved [123]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
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Drug(s) Affected By Sulfotransferase 1A2 (SULT1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Panobinostat DM58WKG Chronic graft versus host disease Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
Folic Acid DMEMBJC Colorectal carcinoma Approved [130]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [114]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
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Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ethanol DMDRQZU Chronic pain MG30 Approved [132]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [133]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [134]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [135]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [124]
Epinephrine DM3KJBC Acute asthma CA23 Approved [123]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [123]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [7]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [7]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [7]
Modafinil DMYILBE Malignant glioma 2A00.0 Approved [136]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [7]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [2]
Macrophage migration inhibitory factor (MIF) TT2AST1 MIF_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
6-phosphogluconate dehydrogenase, decarboxylating (PGD) OTVG296F 6PGD_HUMAN Gene/Protein Processing [4]
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Gene/Protein Processing [5]
Amine oxidase B (MAOB) OTTDFM1O AOFB_HUMAN Gene/Protein Processing [5]
Biotin--protein ligase (HLCS) OTPDUX30 BPL1_HUMAN Gene/Protein Processing [6]
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Biotransformations [7]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [8]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Gene/Protein Processing [4]
Glutaminase kidney isoform, mitochondrial (GLS) OTGOZG2M GLSK_HUMAN Gene/Protein Processing [9]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Gene/Protein Processing [10]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Gene/Protein Processing [11]

References

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3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4 Investigation of the effects of some phenolic compounds on the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from human erythrocytes. J Biochem Mol Toxicol. 2014 Nov;28(11):510-4. doi: 10.1002/jbt.21592. Epub 2014 Aug 6.
5 Combining initro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45.
6 Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. J Nutr Biochem. 2015 Nov;26(11):1379-84. doi: 10.1016/j.jnutbio.2015.07.004. Epub 2015 Jul 26.
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8 Do wine polyphenols modulate p53 gene expression in human cancer cell lines?. Clin Biochem. 2001 Jul;34(5):415-20. doi: 10.1016/s0009-9120(01)00246-6.
9 Metformin and caffeic acid regulate metabolic reprogramming in human cervical carcinoma SiHa/HTB-35ells and augment anticancer activity of Cisplatin via cell cycle regulation. Food Chem Toxicol. 2017 Aug;106(Pt A):260-272.
10 Differentiation between stoichiometric and anticatalytic antioxidant properties of benzoic acid analogues: a structure/redox potential relationship study. Chem Biol Interact. 2013 Nov 25;206(2):194-203.
11 A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide. 2005 Mar;12(2):97-104.
12 5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9. Neurol Res. 2009 Oct;31(8):848-52.
13 Inhibition of leukotriene formation by diethylcarbamazine modifies the acid-base balance in the rabbits with blast injuries of the lungs. Vojnosanit Pregl. 1999 May-Jun;56(3):243-7.
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20 Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. Bioorg Med Chem. 2013 May 1;21(9):2551-9.
21 Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36.
22 Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the beta-Sheet Structure of MIF. J Biol Chem. 2012 March 2; 287(10): 7446-7455.
23 The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82.
24 Cortical Pty Ltd Presents MIF Antagonist Data at World Congress on Inflammation. Cortical Pty Ltd. 2005.
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26 MIF in autoimmunity and novel therapeutic approaches. Autoimmun Rev. 2009 Jan;8(3):244-9.
27 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. J Natl Cancer Inst. 2000 Jul 19;92(14):1136-42.
28 Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells. Chem Biol Interact. 2018 Oct 1;294:158-166.
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30 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
31 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
32 The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells. Cancer Res. 2004 Dec 1;64(23):8778-81.
33 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
34 GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells. Cancer Res. 2002 Feb 15;62(4):1178-83.
35 Evaluation of the antioxidative properties of lipoxygenase inhibitors. Pharmacol Rep. 2012;64(5):1179-88.
36 Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. Cancer Res. 2005 Sep 15;65(18):8442-7.
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