Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4SJ5Y)

• Drug Name: Acetic Acid, Glacial Drug Info
• Synonyms: ethanoic acid; 64-19-7; Ethylic acid; Acetic acid glacial; Acetic acid, glacial; Methanecarboxylic acid; Glacial acetic acid; Vinegar acid; Acetasol; Acide acetique; Essigsaeure; Aci-jel; Azijnzuur; Vinegar; Kyselina octova; Acido acetico; Octowy kwas; Pyroligneous acid; HOAc; Azijnzuur [Dutch]; Ethanoic acid monomer; acetyl alcohol; Aceticum acidum; Essigsaeure [German]; ethoic acid; Caswell No 003; Otic Tridesilon; Octowy kwas [Polish]; Otic Domeboro; Acetic acid (natural); Kyselina octova [Czech]; Acide acetique [French]; Orlex; Vosol; Acetic Acid 025% In Plastic Container

Indication

Disease Entry	ICD 11	Status	REF
infection in the ear canal	AA0Y	Approved	[1]

• Therapeutic Class: Antiinfective Agents
• Cross-matching ID:
  PubChem CID: 176
  ChEBI ID: CHEBI:15366
  CAS Number: CAS 64-19-7
  TTD Drug ID: DM4SJ5Y
  INTEDE Drug ID: DR0038

Molecule-Related Drug Atlas

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[5]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[6]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[7]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[9]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[10]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[11]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[12]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[13]

Drug(s) Affected By Activator of apoptosis harakiri (HRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Methamphetamine	DMPM4SK	Anxiety		Approved	[22]

Drug(s) Affected By Transcription factor E2F3 (E2F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By Programmed cell death protein 5 (PDCD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[29]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[36]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[37]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Selenium	DM25CGV	N. A.	N. A.	Approved	[43]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[44]

Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[55]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[58]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]

Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[64]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[65]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Death-associated protein kinase 3 (DAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[75]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[78]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]

Drug(s) Affected By HMG box-containing protein 1 (HBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]

Drug(s) Affected By DnaJ homolog subfamily B member 6 (DNAJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[95]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[89]

Drug(s) Affected By Large neutral amino acids transporter small subunit 3 (SLC43A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[99]

Drug(s) Affected By E3 SUMO-protein ligase PIAS1 (PIAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[101]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[102]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[67]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[103]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Glutaminase kidney isoform, mitochondrial (GLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[86]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]

Drug(s) Affected By Elongator complex protein 1 (ELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[110]

Drug(s) Affected By RCC1 and BTB domain-containing protein 2 (RCBTB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[114]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[115]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[116]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[79]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[86]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[66]

Drug(s) Affected By NAD kinase (NADK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Bortezomib	DMNO38U	Leukemia		Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[67]

Drug(s) Affected By Heat shock 70 kDa protein 4L (HSPA4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[123]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[29]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[127]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[128]
Ketoprofen	DMRKXPT	Bursitis		Approved	[110]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[158]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[159]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[160]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[162]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[158]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[159]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[170]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[171]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[172]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[175]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[176]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]

Drug(s) Affected By Alpha-enolase (ENO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[182]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Protein disulfide-isomerase (P4HB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[183]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[184]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]

Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[188]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[189]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[190]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Selenium	DM25CGV	N. A.	N. A.	Approved	[193]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[194]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]

Drug(s) Affected By Metallothionein 1H-like protein 1 (MT1HL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[198]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[115]
Lead acetate	DML0GZ2	Discovery agent	N.A.	Investigative	[199]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[200]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[201]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[202]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[203]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[204]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[158]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[205]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[210]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[110]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[216]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[217]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[218]

Drug(s) Affected By Neurofibromin (NF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[120]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[220]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Selenium	DM25CGV	N. A.	N. A.	Approved	[225]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[226]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[227]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[228]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[206]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[230]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]

Drug(s) Affected By Calnexin (CANX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[85]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[235]

Drug(s) Affected By Cell division cycle protein 27 homolog (CDC27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[37]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[238]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]

Drug(s) Affected By High affinity cationic amino acid transporter 1 (SLC7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[239]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 8 (TNFSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[240]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[241]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[242]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[243]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[244]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]

Drug(s) Affected By Glycogen debranching enzyme (AGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[247]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[249]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[201]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[41]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[250]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[255]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[256]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[257]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[258]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[259]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[261]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[262]

Drug(s) Affected By Neutral amino acid transporter A (SLC1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[66]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[66]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[263]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[171]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[264]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[266]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[267]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[268]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[269]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[270]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[274]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[275]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[276]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[277]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[278]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[183]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[282]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[283]

Drug(s) Affected By Transcription activator BRG1 (SMARCA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]

Drug(s) Affected By Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Bortezomib	DMNO38U	Leukemia		Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[101]

Drug(s) Affected By Monocarboxylate transporter 1 (SLC16A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[282]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[282]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[285]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[287]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]

Drug(s) Affected By Selenoprotein W (SELENOW)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[288]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[289]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[80]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By Metallothionein-1H (MT1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[158]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[162]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[294]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[295]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[298]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[299]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[300]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[301]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[176]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]

Drug(s) Affected By Transcription factor RelB (RELB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[305]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[306]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[244]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[34]

Drug(s) Affected By Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[307]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[308]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[310]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[309]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[311]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[312]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[313]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[314]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[316]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[317]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[230]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[315]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Cell division cycle protein 16 homolog (CDC16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[316]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]

Drug(s) Affected By FAS-associated death domain protein (FADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Selenium	DM25CGV	N. A.	N. A.	Approved	[319]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[321]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[292]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[323]

Drug(s) Affected By DnaJ homolog subfamily C member 3 (DNAJC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[324]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[315]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[325]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[75]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[329]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[216]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[332]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]

Drug(s) Affected By Cullin-3 (CUL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[334]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[235]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[337]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[76]

Drug(s) Affected By Core-binding factor subunit beta (CBFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[341]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[316]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[80]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[342]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[344]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]

Drug(s) Affected By Helicase-like transcription factor (HLTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[315]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[345]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[346]

Drug(s) Affected By Protein RRP5 homolog (PDCD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[316]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[347]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[347]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 2 (NR1D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[324]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[308]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[348]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[349]

Drug(s) Affected By Metal cation symporter ZIP14 (SLC39A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[324]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[353]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[353]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[354]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[355]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[356]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[357]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[358]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[359]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[360]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[62]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[66]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[123]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]

Drug(s) Affected By S-adenosylmethionine sensor upstream of mTORC1 (BMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[362]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[363]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[364]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[14]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[365]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[367]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[64]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[365]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[315]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]

Drug(s) Affected By Cyclin-J (CCNJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[344]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[368]

Drug(s) Affected By Rho GTPase-activating protein 17 (ARHGAP17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[369]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[362]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[244]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[116]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[370]

Drug(s) Affected By Cell division cycle-associated protein 2 (CDCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[287]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]

Drug(s) Affected By Interferon regulatory factor 2-binding protein 2 (IRF2BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[308]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[316]

Drug(s) Affected By Homeodomain-interacting protein kinase 1 (HIPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[371]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]

Drug(s) Affected By T-cell activation Rho GTPase-activating protein (TAGAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[372]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[349]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[369]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[373]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[244]

Drug(s) Affected By Protein PHTF2 (PHTF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[362]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[374]

Drug(s) Affected By TNFAIP3-interacting protein 2 (TNIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[375]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[244]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[116]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[68]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[68]

Drug(s) Affected By Alanine aminotransferase 2 (GPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]

Drug(s) Affected By General transcription factor 3C polypeptide 2 (GTF3C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Bortezomib	DMNO38U	Leukemia		Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[377]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[68]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[68]

Drug(s) Affected By DNA-binding death effector domain-containing protein 2 (DEDD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Bortezomib	DMNO38U	Leukemia		Approved	[378]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[379]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[368]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[362]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[380]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]

Drug(s) Affected By Protein FAM162A (FAM162A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[66]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]

Drug(s) Affected By Probable G-protein coupled receptor 146 (GPR146)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[368]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[381]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[116]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[382]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[383]

Drug(s) Affected By Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[385]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[372]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[308]

Drug(s) Affected By Sodium-coupled neutral amino acid symporter 2 (SLC38A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[357]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[386]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[274]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[64]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]

Drug(s) Affected By Cell division cycle 5-like protein (CDC5L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[387]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[388]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[389]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[103]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[68]

Drug(s) Affected By Myeloid differentiation primary response protein MyD88 (MYD88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]

Drug(s) Affected By Cyclin-dependent kinase 19 (CDK19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[236]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[368]

Drug(s) Affected By Serine/threonine-protein kinase D2 (PRKD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[349]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[376]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[316]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[362]

Drug(s) Affected By Egl nine homolog 1 (EGLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[123]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]

Drug(s) Affected By MOB kinase activator 1A (MOB1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[236]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[389]

Drug(s) Affected By Zinc transporter ZIP9 (SLC39A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[391]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[350]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[26]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[87]

Drug(s) Affected By Fas apoptotic inhibitory molecule 1 (FAIM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[392]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[287]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[357]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[248]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[275]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]

Drug(s) Affected By NADH-cytochrome b5 reductase 1 (CYB5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[235]
Bortezomib	DMNO38U	Leukemia		Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[236]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[110]

Drug(s) Affected By Zinc transporter ZIP10 (SLC39A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[395]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[395]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[395]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[396]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[397]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[395]

Drug(s) Affected By Nischarin (NISCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[399]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[68]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[400]

Drug(s) Affected By Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[316]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[402]

Drug(s) Affected By Lysine-specific demethylase 3A (KDM3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[403]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[66]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[396]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[3]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]

Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[405]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[405]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[406]
Bortezomib	DMNO38U	Leukemia		Approved	[407]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[256]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[410]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[411]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[412]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[413]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[396]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[414]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[189]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[415]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[416]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[417]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[418]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[396]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[419]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[419]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[110]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[420]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[421]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[424]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[425]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[194]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[427]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[428]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[426]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[429]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[430]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[431]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[432]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[433]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[433]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[434]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[137]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[435]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[436]
Selenium	DM25CGV	N. A.	N. A.	Approved	[437]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[282]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[396]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[282]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[438]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[439]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[440]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[189]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[205]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[191]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[395]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[441]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[395]

Drug(s) Affected By Interleukin-7 (IL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[442]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[442]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[443]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[444]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[445]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[446]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[447]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[450]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[451]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[452]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[453]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[110]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[262]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[454]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[455]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[456]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[457]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[458]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[459]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[461]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[462]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[463]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[418]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[131]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[464]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[465]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[466]

Drug(s) Affected By Reelin (RELN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[467]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[369]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]

Drug(s) Affected By Histone deacetylase 2 (HDAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[468]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[470]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[471]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[99]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[472]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[473]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[474]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[475]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[476]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]

Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[477]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[478]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[85]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2E1 (CYP2E1) Main DME	DEVDYN7	CP2E1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Gene/Protein Processing	[3]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)	OTQYEXL2	F264_HUMAN	Gene/Protein Processing	[3]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[3]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[3]
Activator of apoptosis harakiri (HRK)	OTR4GWJ0	HRK_HUMAN	Gene/Protein Processing	[3]
Alanine aminotransferase 2 (GPT2)	OTS5VF7N	ALAT2_HUMAN	Gene/Protein Processing	[3]
Alpha-enolase (ENO1)	OTB1KWJS	ENOA_HUMAN	Gene/Protein Processing	[3]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[3]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[3]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Gene/Protein Processing	[3]

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