Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA0WEK)

• Drug Name: Coprexa Drug Info
• Synonyms: Tetrathiomolybdate

Indication

Disease Entry	ICD 11	Status	REF
Neurological disorder	6B60	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 5245480
  ChEBI ID: CHEBI:30703
  CAS Number: CAS 16330-92-0
  TTD Drug ID: DMA0WEK

Molecule-Related Drug Atlas

Drug(s) Targeting Superoxide dismutase Cu-Zn (SOD Cu-Zn)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tofersen	DM0AEDT	Amyotrophic lateral sclerosis	8B60.0	Approved	[5]
Tempol	DMUQH78	Spinal cord injury	ND51.2	Phase 2	[6]
Superoxide dismutase	DMSWPA6	Myocardial infarction	BA41-BA43	Phase 2	[7]
Midismase	DMGCRKY	Cerebral infarction	8B11.5Z	Phase 2	[8]
Methoxyestradiol	DMHSL87	N. A.	N. A.	Phase 2	[9]
ATN-224	DMQJ5DV	Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]
PC-SOD	DMUHDX3	Interstitial lung disease	CB0Z	Phase 2	[8]
APN-201	DMV7Q6X	Dermatitis	EA80-EA89	Phase 1/2	[10]
EUK-189	DMY9ZAS	Skin burns	ME65.0	Phase 1	[11]
AEOL-10150	DM13YRT	Multiple sclerosis	8A40	Preclinical	[12]

Drug(s) Affected By Angiopoietin-2 (ANGPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[18]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[19]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[20]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[21]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Ketoprofen	DMRKXPT	Bursitis		Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Haloperidol	DM96SE0	Delirium		Approved	[23]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[36]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[42]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[43]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[47]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[50]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[54]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[56]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[59]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[61]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[62]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[65]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[68]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[71]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[73]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[74]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[75]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[76]

Drug(s) Affected By Cytochrome c oxidase subunit 5B, mitochondrial (COX5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[78]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[83]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[86]

Drug(s) Affected By Integrin beta-4 (ITGB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[87]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[100]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[106]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[107]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[75]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[113]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[114]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[117]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[118]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[119]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[75]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[111]

Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[121]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[16]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By Aquaporin-1 (AQP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[133]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[134]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[135]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[136]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[138]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[140]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[144]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[146]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[150]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[151]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[152]

Drug(s) Affected By Type-2 angiotensin II receptor (AGTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[156]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[158]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[159]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[163]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[166]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[168]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[169]

Drug(s) Affected By Bcl-2-like protein 2 (BCL2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[172]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[173]

Drug(s) Affected By CREB/ATF bZIP transcription factor (CREBZF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[178]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[16]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[94]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[142]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]

Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[184]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[187]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]

Drug(s) Affected By Immunoglobulin lambda-like polypeptide 5 (IGLL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[188]

Drug(s) Affected By Unconventional myosin-If (MYO1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[184]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[190]

Drug(s) Affected By Leukocyte-specific transcript 1 protein (LST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Bortezomib	DMNO38U	Leukemia		Approved	[192]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[193]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[191]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[194]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]

Drug(s) Affected By Claudin-4 (CLDN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[198]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[200]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[16]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]

Drug(s) Affected By Copper chaperone for superoxide dismutase (CCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[28]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[202]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[203]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]

Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[204]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[206]

Drug(s) Affected By Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[207]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Ceruloplasmin (CP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[210]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[96]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[213]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[214]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[215]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[216]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[217]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[218]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Selenium	DM25CGV	N. A.	N. A.	Approved	[221]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[222]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[223]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[219]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[223]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[225]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]

Drug(s) Affected By Immunoglobulin J chain (JCHAIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[228]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[229]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[167]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[106]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[194]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[106]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[230]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[231]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[232]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[234]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[235]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[239]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[243]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[244]

Drug(s) Affected By Cystatin-B (CSTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[253]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[254]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[258]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[259]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[260]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[262]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[263]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[264]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[265]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[268]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[269]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[272]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[270]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[270]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[273]

Drug(s) Affected By Fibroblast growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[275]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[271]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]

Drug(s) Affected By Lithostathine-1-alpha (REG1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[230]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[270]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[277]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[280]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[282]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[283]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[284]

Drug(s) Affected By Serine protease 1 (PRSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[285]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[286]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[287]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[290]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[291]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[292]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[293]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[294]

Drug(s) Affected By Matrix Gla protein (MGP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[169]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[298]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase C (PTPRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[301]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[303]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]

Drug(s) Affected By Keratin, type I cytoskeletal 19 (KRT19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[184]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[211]

Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[305]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[106]

Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[50]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[308]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[169]

Drug(s) Affected By Tumor-associated calcium signal transducer 2 (TACSTD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[271]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[272]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]

Drug(s) Affected By Serglycin (SRGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[309]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[310]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[231]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[311]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[312]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[158]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[313]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[314]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[16]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[268]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[158]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[315]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[316]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[318]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[319]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Selenium	DM25CGV	N. A.	N. A.	Approved	[320]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[321]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[322]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[324]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[325]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[328]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[303]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[329]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[330]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[331]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[332]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[333]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[320]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[151]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[334]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[335]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[336]

Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[337]
Cinoxacin	DM4EWNS	Urinary tract infection	GC08	Approved	[337]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[337]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[337]

Drug(s) Affected By fMet-Leu-Phe receptor (FPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[338]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[339]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[340]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[341]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[342]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[344]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[347]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[348]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[349]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[350]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[353]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[355]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]

Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[357]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[273]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[358]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[359]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[360]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[76]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[344]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[362]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[321]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[363]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[332]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[365]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[28]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[16]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[268]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[366]

Drug(s) Affected By Copper-transporting ATPase 2 (ATP7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[367]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[50]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[280]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[210]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[280]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[369]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[370]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[371]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[372]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[373]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[283]

Drug(s) Affected By Myeloid cell nuclear differentiation antigen (MNDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[375]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[376]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[88]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[377]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[378]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[379]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[380]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[381]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[342]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[350]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[363]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[382]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[384]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[385]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[387]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[258]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[388]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[389]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[390]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[391]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[392]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[393]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[394]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[395]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[20]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[167]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[211]

Drug(s) Affected By Claudin-18 (CLDN18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]

Drug(s) Affected By Hemoglobin subunit beta (HBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[398]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Voxelotor	DMCS6M5	Sickle-cell disorder	3A51	Approved	[399]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[400]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[401]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[402]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[403]

Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[184]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[280]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[405]

Drug(s) Affected By Interferon-induced transmembrane protein 2 (IFITM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[187]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[406]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[407]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[406]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[408]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[406]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[407]

Drug(s) Affected By Transcription factor Sp3 (SP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[292]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[410]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[411]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[412]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[413]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]

Drug(s) Affected By Trefoil factor 3 (TFF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[414]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[415]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[416]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[414]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[417]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[68]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[393]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[73]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[418]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[323]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[151]

Drug(s) Affected By Laminin subunit beta-3 (LAMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[419]

Drug(s) Affected By Cytochrome c oxidase copper chaperone (COX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[420]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[417]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[417]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[417]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[417]

Drug(s) Affected By Insulin-like growth factor-binding protein 7 (IGFBP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[421]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[50]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[169]

Drug(s) Affected By Rapamycin-insensitive companion of mTOR (RICTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[422]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[376]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[423]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[303]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[422]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[424]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[425]

Drug(s) Affected By Regulatory-associated protein of mTOR (RPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[192]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[426]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[193]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[425]

Drug(s) Affected By Retinoic acid-induced protein 3 (GPRC5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[184]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[427]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[280]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[428]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[429]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[430]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[308]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By ERO1-like protein alpha (ERO1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[20]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[431]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[280]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By Granulocyte colony-stimulating factor receptor (CSF3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[432]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[338]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[303]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[433]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[23]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[432]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[434]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[435]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]

Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[436]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[432]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[106]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[437]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[192]

Drug(s) Affected By Immortalization up-regulated protein (C19ORF33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[80]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[16]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[96]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[438]

Drug(s) Affected By Rho family-interacting cell polarization regulator 2 (RIPOR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[309]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[439]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[440]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[80]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[441]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[16]

Drug(s) Affected By Protein SLC31A2 (SLC31A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[442]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[319]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[444]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[294]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Superoxide dismutase Cu-Zn (SOD Cu-Zn)	TT6RVLG	SODC_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[2]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Protein Interaction/Cellular Processes	[3]
Angiopoietin-2 (ANGPT2)	OTEQK65P	ANGP2_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[2]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Aquaporin-1 (AQP1)	OTX5MYX9	AQP1_HUMAN	Gene/Protein Processing	[4]
Bcl-2-like protein 2 (BCL2L2)	OTMKVO0J	B2CL2_HUMAN	Gene/Protein Processing	[4]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Gene/Protein Processing	[4]
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)	OTREV92I	CEAM5_HUMAN	Gene/Protein Processing	[2]
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)	OTQOUHVK	CEAM6_HUMAN	Gene/Protein Processing	[2]

References

• [1] Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
• [2] Copper deprivation enhances the chemosensitivity of pancreatic cancer to rapamycin by mTORC1/2 inhibition. Chem Biol Interact. 2023 Sep 1;382:110546. doi: 10.1016/j.cbi.2023.110546. Epub 2023 Jun 7.
• [3] The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region. Ann N Y Acad Sci. 2004 Dec;1035:34-48. doi: 10.1196/annals.1332.003.
• [4] Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms. Microvasc Res. 2009 May;77(3):314-26.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] The superoxide dismutase mimetic, tempol, reduces the bioavailability of nitric oxide and does not alter L-NAME-induced hypertension in rats. Basic Clin Pharmacol Toxicol. 2005 Jul;97(1):29-34.
• [7] Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase: a novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant.Artif Cells Blood Substit Immobil Biotechnol.2011 Jun;39(3):127-36.
• [8] A lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis
• [9] Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor. J Biol Chem. 2003 Jan 3;278(1):407-14.
• [10] Peyronie's disease: a critical appraisal of current diagnosis and treatment. Int J Impot Res. 2008 Sep-Oct;20(5):445-59.
• [11] Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008;30(2):271-90.
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