Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM2R1N)

• Drug Name: all-trans-4-oxo-retinoic acid Drug Info
• Synonyms: 4-oxoretinoic acid; Ro 12-4824

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6437063
  ChEBI ID: CHEBI:80656
  CAS Number: CAS 38030-57-8
  TTD Drug ID: DMM2R1N

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-2C (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[6]
Dihydroergocristine	DM5SQ1G	Alcohol dependence	6C40.2	Approved	[7]
Brimonidine	DMQLT4N	Ocular hypertension	9C61.01	Approved	[8]
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[9]
Amezinium	DM6I2WQ	Hypotension	BA20-BA21	Approved	[10]
Propylhexedrine	DMTBW2O	Obesity	5B81	Approved	[11]
Tetrahydrozoline	DMT57WC	Ocular disease	1F00.1Z	Approved	[12]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[13]
Xylometazoline	DMKV32D	Allergic rhinitis	CA08.0	Phase 4	[14]
TNX-102	DMO1234	Fibromyalgia	MG30.01	Phase 3	[15]

Drug(s) Targeting RAR-related orphan receptor-beta (RORB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9598431, 5	DMXGF56	N. A.	N. A.	Patented	[16]
US9598431, 2	DMILY1P	N. A.	N. A.	Patented	[16]
US9598431, 1	DMRVQ5Z	N. A.	N. A.	Patented	[16]

Drug(s) Affected By AH receptor-interacting protein (AIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[29]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[30]

Drug(s) Affected By Suppressor of cytokine signaling 2 (SOCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[37]

Drug(s) Affected By Suppressor of cytokine signaling 1 (SOCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[40]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Lomustine	DMMWSUL	Brain cancer	2A00	Approved	[41]

Drug(s) Affected By Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[45]

Drug(s) Affected By RNA/RNP complex-1-interacting phosphatase (DUSP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[51]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[52]

Drug(s) Affected By Keratin, type II cytoskeletal 75 (KRT75)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[59]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[60]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[61]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[62]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[68]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[70]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[71]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[75]
Fructose	DM43AN2	Vomiting	MD90	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[79]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[77]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[77]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[80]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[77]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[87]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[88]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[91]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[92]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[96]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[97]

Drug(s) Affected By Keratin, type I cytoskeletal 14 (KRT14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[101]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[102]
Methamphetamine	DMPM4SK	Anxiety		Approved	[103]

Drug(s) Affected By Keratin, type II cytoskeletal 6A (KRT6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[107]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[109]

Drug(s) Affected By Lysosomal acid glucosylceramidase (GBA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Afegostat	DMRWSKX	Gaucher disease	5C56.0Y	Discontinued in Phase 2	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[112]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[113]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[118]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]

Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[121]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]

Drug(s) Affected By Apolipoprotein D (APOD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[129]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[130]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[132]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[134]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[135]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[135]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[140]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]

Drug(s) Affected By Fibroblast growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[145]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]

Drug(s) Affected By Neurofilament light polypeptide (NEFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]

Drug(s) Affected By Keratin, type I cytoskeletal 19 (KRT19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]

Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[129]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Haloperidol	DM96SE0	Delirium		Approved	[154]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[157]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[158]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[159]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[160]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[163]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[166]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[171]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[172]

Drug(s) Affected By Collagen alpha-1(VI) chain (COL6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[174]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]

Drug(s) Affected By Creatine kinase B-type (CKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]

Drug(s) Affected By Integrin alpha-4 (ITGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[129]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[178]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[179]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]

Drug(s) Affected By Keratin, type I cytoskeletal 10 (KRT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[183]

Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[102]

Drug(s) Affected By Glutamine synthetase (GLUL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[185]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[186]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[190]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[127]

Drug(s) Affected By Keratin, type I cytoskeletal 15 (KRT15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[29]

Drug(s) Affected By Filaggrin (FLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[192]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[146]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]

Drug(s) Affected By Cornifin-B (SPRR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[195]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[196]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase K (TGM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[196]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[185]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[203]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]

Drug(s) Affected By Protein S100-A1 (S100A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[146]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[204]

Drug(s) Affected By Laminin subunit alpha-2 (LAMA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[205]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[207]

Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[208]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[209]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[210]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[211]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[212]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[213]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[214]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]

Drug(s) Affected By Collagen alpha-2(VIII) chain (COL8A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[215]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[216]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[217]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[207]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[32]

Drug(s) Affected By Protein S100-A7 (S100A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[146]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[195]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[113]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[218]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[219]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[220]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[199]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[222]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[223]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[225]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[124]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[226]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[229]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[231]

Drug(s) Affected By Serpin B9 (SERPINB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[233]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]

Drug(s) Affected By Monocarboxylate transporter 1 (SLC16A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[234]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[235]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[236]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]

Drug(s) Affected By Epithelial membrane protein 1 (EMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]

Drug(s) Affected By Microfibrillar-associated protein 2 (MFAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[240]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[241]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[245]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[246]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[247]

Drug(s) Affected By Small ribosomal subunit protein uS15 (RPS13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[249]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[204]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[250]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[112]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[251]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[252]

Drug(s) Affected By Thymosin beta-4 (TMSB4X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[45]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[240]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[253]
Indomethacin	DMSC4A7	Bursitis		Approved	[254]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[255]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[256]

Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[40]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[258]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[259]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[261]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[262]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[263]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[156]

Drug(s) Affected By Fatty acid-binding protein 5 (FABP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[264]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[174]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[240]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[266]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[267]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[268]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[269]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[270]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[270]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[270]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[270]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[270]

Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[182]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]

Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[273]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[274]

Drug(s) Affected By Desmocollin-1 (DSC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[121]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[92]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[92]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[276]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[92]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]

Drug(s) Affected By Chromobox protein homolog 3 (CBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Bortezomib	DMNO38U	Leukemia		Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[183]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 2 (EIF4EBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[277]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[278]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[279]

Drug(s) Affected By Interleukin-10 receptor subunit alpha (IL10RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[129]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[215]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[183]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[281]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[282]

Drug(s) Affected By Fas-activated serine/threonine kinase (FASTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[192]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[283]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Bortezomib	DMNO38U	Leukemia		Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[183]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[154]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[278]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[284]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[285]

Drug(s) Affected By Growth factor receptor-bound protein 7 (GRB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[121]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[284]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[286]

Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[29]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[29]

Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[29]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[29]

Drug(s) Affected By Protein FAM3C (FAM3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[287]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[281]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[284]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[288]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[160]

Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[291]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF5 (RNF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[284]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[292]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[17]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[262]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[170]

Drug(s) Affected By Growth/differentiation factor 2 (GDF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[298]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[299]

Drug(s) Affected By Laminin subunit gamma-3 (LAMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[133]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[300]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[302]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]

Drug(s) Affected By Homeobox protein Meis1 (MEIS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[5]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[5]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]

Drug(s) Affected By Homeobox protein Meis2 (MEIS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[304]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[305]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[5]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[5]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[163]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[307]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[308]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[309]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[310]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[311]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[312]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[316]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[317]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[318]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[182]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[319]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[129]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[193]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[5]

Drug(s) Affected By Collagen alpha-2(IV) chain (COL4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[320]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[5]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[88]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[321]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[29]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[29]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[305]

Drug(s) Affected By Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[324]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[305]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[326]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[327]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[5]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[329]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[330]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[332]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[334]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[336]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[337]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[338]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[339]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[340]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[341]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[342]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[344]
Fructose	DM43AN2	Vomiting	MD90	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[302]

Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[345]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[324]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[346]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]

Drug(s) Affected By Retinoic acid receptor responder protein 1 (RARRES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[347]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[348]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[5]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[5]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[240]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[143]

Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[349]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[349]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[349]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[349]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[349]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[349]

Drug(s) Affected By Hepatocyte nuclear factor 3-alpha (FOXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[351]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[339]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[45]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[5]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[5]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[352]

Drug(s) Affected By Mucin-5AC (MUC5AC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]
Selenium	DM25CGV	N. A.	N. A.	Approved	[354]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[355]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[356]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[5]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[357]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[5]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[358]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[359]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[360]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[361]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[362]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[363]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[364]

Drug(s) Affected By Transcription factor GATA-6 (GATA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[365]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[5]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[5]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[133]
Indomethacin	DMSC4A7	Bursitis		Approved	[366]

Drug(s) Affected By Phospholipase A and acyltransferase 4 (PLAAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[367]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[129]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[5]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]

Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[368]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[369]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[368]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[274]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[371]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[368]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[372]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[215]

Drug(s) Affected By Retinoic acid receptor gamma (RARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[373]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[374]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[305]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[205]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[133]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[376]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[377]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[378]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[379]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[380]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[381]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[382]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[383]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[384]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[385]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[386]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[387]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[388]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[389]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[390]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[391]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[388]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[392]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[389]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[388]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[393]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[394]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[393]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[394]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[395]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[393]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[393]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[393]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[396]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[397]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[398]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[386]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[399]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[389]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[388]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[388]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[400]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[401]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[402]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[403]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Antagonist	[2]
RAR-related orphan receptor-beta (RORB)	TTGB2LZ	RORB_HUMAN	Antagonist	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
AH receptor-interacting protein (AIP)	OTDJ3OSV	AIP_HUMAN	Gene/Protein Processing	[4]
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Gene/Protein Processing	[4]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Gene/Protein Processing	[4]
Apolipoprotein D (APOD)	OTT77XW8	APOD_HUMAN	Gene/Protein Processing	[4]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[5]
Cellular retinoic acid-binding protein 2 (CRABP2)	OTY01V9G	RABP2_HUMAN	Gene/Protein Processing	[5]
Chromobox protein homolog 3 (CBX3)	OTOP9RLD	CBX3_HUMAN	Gene/Protein Processing	[4]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[5]
Collagen alpha-1(VI) chain (COL6A1)	OTYKSCOB	CO6A1_HUMAN	Gene/Protein Processing	[4]
Collagen alpha-2(IV) chain (COL4A2)	OTJK1LKN	CO4A2_HUMAN	Gene/Protein Processing	[5]

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