General Information of Drug (ID: DMPC1J7)

Drug Name
Clofibrate Drug Info
Synonyms
Amotril; Angiokapsul; Anparton; Antilipid; Antilipide; Apolan; Arterioflexin; Arterosol; Artevil; Ateculon; Ateriosan; Athebrate; Atheromide; Atheropront; Athromidin; Atrolen; Atromid; Atromida; Atromidin; Atrovis; Azionyl; Bioscleran; Bresit; CPIB; Cartagyl; Chlorfenisate; Chlorphenisate; Cinnarizin; Citiflus; Claripex; Cloberat; Clobrat; Clofar; Clofibate; Clofibram; Clofibrat; Clofibrato; Clofibratum; Clofinit; Clofipront; Delipid; Deliva; ELPI; EPIB; Fibralem; Gerastop; Hyclorate; Klofibrat; Klofiran; Levatrom; Lipamid; Lipavil; Lipavlon; Lipidsenker; Lipofacton; Lipomid; Liponorm; Liporeduct; Liporil; Liposid; Liprin; Liprinal; Lobetrin; Miscleron; Misclerone; Miskleron; Negalip; Normalip; Normat; Normet; Normolipol; Novofibrate; Persantinat; Recolip; Regardin; Regelan; Robigram; Scrobin; Serofinex; Serotinex; Skerolip; Sklerepmexe; Sklero; Sklerolip; Skleromex; Skleromexe; Ticlobran; Xyduril; Yoclo; Amotril S; Atromid S; Claripex CPIB; Clofibrato [Spanish]; Dura clofibrat; Ethyl chlorophenoxyisobutyrate; Ethyl clofibrate; Regelan N; Vincamin compositum; AY 61123; C 6643; Lipide 500; Oxan 600; AY-61123; Athranid-wirkstoff; Atromid-S; BML2-F02; Chlorophenoxyisobutyrate, Ethyl; Clobren-5F; Clobren-SF; Clofibrate (CLOF); Clofibrato [INN-Spanish]; Clofibratum [INN-Latin]; Clofibric Acid, Ethyl Ester; Ethyl p-chlorophenoxyisobutyrate; Ethyl para-chlorophenoxyisobutyrate; Neo-Atomid; Neo-Atromid; Sklero-Tablinen; Sklero-tablinene; Sklero-tabuls; ATROMID-S (TN); Atromid-S (TN); Atromid-S, Clofibrate; Ethyl alpha-p-chlorophenoxyisobutyrate; Clofibrate (JP15/USP/INN); Clofibrate [USAN:INN:BAN:JAN]; Ethyl 2-(4-chlorophenoxy)isobutyrate; Ethyl 2-(p-chlorophenoxy)isobutyrate; Ethyl alpha-(4-chlorophenoxy)isobutyrate; Ethyl alpha-(p-chlorophenoxy)isobutyrate; Ethyl-alpha-p-chlorophenoxy-isobutyrate
Indication
Disease Entry ICD 11 Status REF
Dysbetalipoproteinemia 5C80.2 Approved [1]
Therapeutic Class
Antilipemic Agents
Cross-matching ID
PubChem CID
2796
ChEBI ID
CHEBI:3750
CAS Number
CAS 637-07-0
TTD Drug ID
DMPC1J7
INTEDE Drug ID
DR0347

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Preclinical Drug(s)
Drug(s) Targeting Lipoprotein lipase (LPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [16]
AMT-011 DM8QIRN Blood forming organ disorder JB64.1 Phase 3 [17]
Ibrolipim DMOPWSX Hyperlipidaemia 5C80 Phase 2 [18]
WS-070117 DMYNIG5 Hyperlipidaemia 5C80 Investigative [17]
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [20]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [28]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [34]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [36]
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Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [28]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [37]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Metronidazole DMTIVEN Abscess Approved [40]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [41]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [43]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [44]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [45]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [46]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [34]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [47]
Estrone DM5T6US Acne vulgaris ED80 Approved [48]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [49]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [50]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [51]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [90]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [91]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [92]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [93]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [94]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Ethacrynic acid DM60QMR Edema MG29 Approved [96]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [97]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [98]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [99]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [52]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [53]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [55]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [56]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [57]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [58]
Propranolol DM79NTF Angina pectoris BA40 Approved [59]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [62]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [63]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [64]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [65]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [66]
Ethacrynic acid DM60QMR Edema MG29 Approved [67]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [68]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [69]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [70]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [71]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [73]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Verapamil DMA7PEW Angina pectoris BA40 Approved [74]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [75]
Estrone DM5T6US Acne vulgaris ED80 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [78]
Verapamil DMA7PEW Angina pectoris BA40 Approved [37]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [79]
Estrone DM5T6US Acne vulgaris ED80 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [81]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [82]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [83]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [84]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [85]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [72]
Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [86]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [89]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [86]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [86]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [86]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [86]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [88]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [104]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [105]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [106]
Leflunomide DMR8ONJ Arthritis FA20 Approved [107]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [108]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [109]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [110]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [12]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Fluoxetine DM3PD2C Bipolar depression Approved [113]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [88]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [114]
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Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [115]
Haloperidol DM96SE0 Delirium Approved [12]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [116]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [119]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [120]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Epinephrine DM3KJBC Acute asthma CA23 Approved [122]
Quercetin DM3NC4M Obesity 5B81 Approved [123]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [125]
Prednisone DM2HG4X Acute asthma CA23 Approved [126]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [126]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [127]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [128]
Epinephrine DM3KJBC Acute asthma CA23 Approved [129]
Quercetin DM3NC4M Obesity 5B81 Approved [130]
Fluoxetine DM3PD2C Bipolar depression Approved [113]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [131]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [11]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [132]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [132]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [133]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [11]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [132]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [134]
Gefitinib DM15F0X Colon adenocarcinoma Approved [11]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [135]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [11]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Fluoxetine DM3PD2C Bipolar depression Approved [113]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [88]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [138]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [139]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [140]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [141]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [142]
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Drug(s) Affected By Ceruloplasmin (CP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [145]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [146]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [149]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Ampicillin DMHWE7P Acute epiglottitis Approved [100]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [151]
Gefitinib DM15F0X Colon adenocarcinoma Approved [152]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [153]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [154]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [155]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [156]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Selenium DM25CGV N. A. N. A. Approved [159]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [160]
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Drug(s) Affected By Plasminogen (PLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [163]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [164]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [165]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [148]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [166]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [167]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [168]
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Drug(s) Affected By Antithrombin-III (SERPINC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [169]
Prednisone DM2HG4X Acute asthma CA23 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Testosterone enanthate DMB6871 N. A. N. A. Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Aminocaproic Acid DMFGND4 Bleeding disorder GA20-GA21 Approved [170]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [172]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [9]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [173]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [157]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [174]
Gefitinib DM15F0X Colon adenocarcinoma Approved [175]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [176]
Selenium DM25CGV N. A. N. A. Approved [177]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [178]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [179]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [180]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
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Drug(s) Affected By Pro-glucagon (GCG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [181]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Metoclopramide DMFA5MY Nausea MD90 Approved [182]
Orlistat DMRJSP8 Obesity 5B81 Approved [183]
Gatifloxacin DMSL679 Acute gonococcal cervicitis Approved [184]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [185]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [186]
geraniol DMS3CBD Discovery agent N.A. Investigative [187]
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Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Epinephrine DM3KJBC Acute asthma CA23 Approved [189]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [190]
Fructose DM43AN2 Vomiting MD90 Approved [191]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [181]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [192]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [193]
Propranolol DM79NTF Angina pectoris BA40 Approved [194]
Testosterone DM7HUNW Hot flushes GA30 Approved [195]
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Drug(s) Affected By Apolipoprotein A-I (APOA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [196]
Quercetin DM3NC4M Obesity 5B81 Approved [197]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [88]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [198]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [199]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [200]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [201]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [202]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [203]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [165]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [12]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [204]
Diazepam DM08E9O Alcohol withdrawal Approved [205]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [112]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [207]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [208]
Methotrexate DM2TEOL Anterior urethra cancer Approved [209]
Quercetin DM3NC4M Obesity 5B81 Approved [210]
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Drug(s) Affected By Serotransferrin (TF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [211]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [212]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [215]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [216]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [164]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [218]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [219]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [220]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [212]
Selenium DM25CGV N. A. N. A. Approved [177]
Etretinate DM2CZFA Keratosis ED56 Approved [221]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [222]
Methotrexate DM2TEOL Anterior urethra cancer Approved [223]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [225]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [157]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [88]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [226]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [227]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [228]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [229]
Testosterone DM7HUNW Hot flushes GA30 Approved [230]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [231]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [232]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [212]
Methotrexate DM2TEOL Anterior urethra cancer Approved [233]
Quercetin DM3NC4M Obesity 5B81 Approved [225]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [234]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [235]
Estrone DM5T6US Acne vulgaris ED80 Approved [232]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [236]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [237]
Testosterone DM7HUNW Hot flushes GA30 Approved [230]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [238]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Selenium DM25CGV N. A. N. A. Approved [177]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [240]
Methotrexate DM2TEOL Anterior urethra cancer Approved [223]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [241]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [242]
Quercetin DM3NC4M Obesity 5B81 Approved [225]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [226]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [243]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [244]
Gefitinib DM15F0X Colon adenocarcinoma Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [246]
Selenium DM25CGV N. A. N. A. Approved [159]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [247]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [248]
Methotrexate DM2TEOL Anterior urethra cancer Approved [249]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [250]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [252]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [219]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [174]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [253]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Methotrexate DM2TEOL Anterior urethra cancer Approved [255]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [224]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [256]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [257]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [258]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [259]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [260]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [261]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [262]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [263]
Gefitinib DM15F0X Colon adenocarcinoma Approved [264]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [265]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [266]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Selenium DM25CGV N. A. N. A. Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [223]
Quercetin DM3NC4M Obesity 5B81 Approved [225]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [234]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [267]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [268]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [269]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [271]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [226]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [12]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [272]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [273]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [274]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [142]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [275]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [275]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [276]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [275]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [275]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [276]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [277]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caveolin-1 (CAV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [278]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [244]
Gefitinib DM15F0X Colon adenocarcinoma Approved [264]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [279]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [280]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [281]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [282]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [283]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [284]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [285]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [286]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [287]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [288]
Testosterone DM7HUNW Hot flushes GA30 Approved [230]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [289]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [290]
Quercetin DM3NC4M Obesity 5B81 Approved [291]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Artemether DM48QOT Malaria 1F40-1F45 Approved [292]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [293]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [294]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [295]
Estrone DM5T6US Acne vulgaris ED80 Approved [296]
Leflunomide DMR8ONJ Arthritis FA20 Approved [297]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [298]
Fructose DM43AN2 Vomiting MD90 Approved [299]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [300]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [301]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [145]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [276]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [302]
Leflunomide DMR8ONJ Arthritis FA20 Approved [107]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [303]
Testosterone DM7HUNW Hot flushes GA30 Approved [230]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [230]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [271]
Capsaicin DMGMF6V Back pain ME84.Z Approved [304]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [305]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [164]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [244]
Quercetin DM3NC4M Obesity 5B81 Approved [307]
Testosterone DM7HUNW Hot flushes GA30 Approved [308]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [309]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [310]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [311]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [312]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [313]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CREB-binding protein (CREBBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [314]
Quercetin DM3NC4M Obesity 5B81 Approved [225]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [315]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [316]
Testosterone DM7HUNW Hot flushes GA30 Approved [317]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [318]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [319]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [320]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [321]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [314]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [303]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [164]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [322]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [323]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [324]
BENZOQUINONE DMNBA0G Discovery agent N.A. Investigative [325]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Lipoprotein lipase (LPL) TTOF3WZ LIPL_HUMAN Activator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [4]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [4]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [4]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [5]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [4]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [4]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [4]
Lauric acid omega-hydroxylase (CYP4A11) DE2XQGW CP4AB_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Gene/Protein Processing [7]
Albumin (ALB) OTVMM513 ALBU_HUMAN Gene/Protein Processing [8]
Antithrombin-III (SERPINC1) OTDFATG0 ANT3_HUMAN Gene/Protein Processing [9]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Protein Interaction/Cellular Processes [10]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [11]
Carnitine O-acetyltransferase (CRAT) OTSCLZ04 CACP_HUMAN Drug Response [12]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Gene/Protein Processing [13]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Gene/Protein Processing [14]
Ceruloplasmin (CP) OTM8JE4Y CERU_HUMAN Gene/Protein Processing [8]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Drug Response [15]

References

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23 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
24 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
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32 PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
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36 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
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39 Psychotropic drug interactions with valproate. Clin Neuropharmacol. 2005 Mar-Apr;28(2):96-101.
40 The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94.
41 Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95.
42 CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine delta-5'(1')iminium ion. J Pharmacol Exp Ther. 2012 Nov;343(2):307-15.
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44 Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74.
45 Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism. 2007 Jul;56(7):887-94.
46 Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. J Med Chem. 1994 Mar 18;37(6):860-7.
47 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
48 A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clin Chem Lab Med. 2005;43(7):702-6.
49 Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):157-72.
50 Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J. 1998 Apr 1;331 ( Pt 1):273-81.
51 Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Curr Drug Metab. 2007 Aug;8(6):554-62.
52 Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemother Pharmacol. 1993;32(6):491-5.
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