Details of Disease

General Information of Disease (ID: DISDQFDI)

Disease Name Acute leukaemia
Synonyms stem cell leukaemia (disease); stem cell leukemia (disease); stem cell leukaemia; leukemia, acute, X-linked; stem cell leukemia; acute leukemia; acute leukaemia (disease); acute leukemia (disease)
Disease Class 2A60: Acute myeloid leukaemia
Definition
A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).
Disease Hierarchy
DISNAKFL: Leukemia
DISBV50J: Acute disease
DISDQFDI: Acute leukaemia
ICD Code
ICD-11
ICD-11: 2A60
ICD-10
ICD-10: C91-C95
ICD-9
ICD-9: 204-208
Expand ICD-9
2.04E+14
Disease Identifiers
MONDO ID
MONDO_0010643
UMLS CUI
C0085669
MedGen ID
43225
HPO ID
HP:0002488
SNOMED CT ID
24072005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CD19 specific CAR T cells DMGDK9C Phase 1/2 CAR T Cell Therapy [1]
ONO-7475 DMV6GX7 Phase 1/2 Small molecular drug [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 71 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CYP2B6 TTMH124 Limited Genetic Variation [4]
ETS1 TTTGPSD Limited Altered Expression [5]
RUNX1 TTWIN3H Limited Genetic Variation [6]
SCT TTOBVIN Limited Biomarker [7]
TERF1 TT1Y6J2 Limited Altered Expression [8]
STC1 TTDLUER Disputed Altered Expression [9]
ABCC1 TTOI92F moderate Biomarker [10]
NPM1 TTHBS98 moderate Biomarker [11]
PAX5 TTA4REJ moderate Altered Expression [6]
ABCC3 TTVLG21 Strong Altered Expression [12]
ANXA8 TTSW16P Strong Altered Expression [13]
ARAF TT5TURO Strong Genetic Variation [14]
ATRAID TTFLIKM Strong Altered Expression [15]
CALR TTUZ7OA Strong Genetic Variation [16]
CASP5 TTWR48J Strong Genetic Variation [17]
CD200 TT0BE68 Strong Biomarker [18]
CD22 TTM6QSK Strong Altered Expression [19]
CD33 TTJVYO3 Strong Biomarker [20]
CD34 TTZAVYN Strong Altered Expression [21]
CD38 TTPURFN Strong Genetic Variation [22]
CD6 TTMF6KC Strong Altered Expression [23]
CDA TTQ12RK Strong Altered Expression [24]
CDH5 TTXLCFO Strong Posttranslational Modification [25]
CDKN2C TTBRUGA Strong Biomarker [26]
CSF3R TTC70AJ Strong Genetic Variation [27]
CTSG TTQAJF1 Strong Altered Expression [28]
DLL1 TT9CFQD Strong Biomarker [29]
DOT1L TTSZ8T1 Strong Biomarker [30]
EPHA7 TTAHTVG Strong Posttranslational Modification [31]
FER TTRA9G0 Strong Genetic Variation [32]
FGF4 TTCEKVZ Strong Genetic Variation [33]
FGF8 TTIUF3J Strong Altered Expression [34]
FLT3 TTGJCWZ Strong Biomarker [35]
GGH TTZJRL0 Strong Posttranslational Modification [36]
HDC TTV9GOF Strong Biomarker [37]
IFNAR2 TTMQB37 Strong Biomarker [38]
IGFBP7 TTUQ01B Strong Altered Expression [39]
KDM1A TTNR0UQ Strong Biomarker [40]
KDM4C TTV8CRH Strong Biomarker [41]
KDM5A TTIG67W Strong Biomarker [42]
KIR2DL1 TT4UXPE Strong Biomarker [43]
KMT2A TT1GNDM Strong Genetic Variation [44]
MPL TTIHYA4 Strong Genetic Variation [16]
MPO TTVCZPI Strong Biomarker [45]
MYB TT8V13P Strong Altered Expression [46]
NAAA TTMN4HY Strong Biomarker [47]
NGFR TTEDJN4 Strong Altered Expression [48]
NOP2 TTBLG3H Strong Biomarker [49]
NR0B2 TT25A9Q Strong Altered Expression [50]
P2RY8 TT84EWY Strong Altered Expression [51]
PIM2 TT69J2Z Strong Altered Expression [52]
PRG4 TTSKF4V Strong Genetic Variation [53]
PSMB6 TT8EPLT Strong Biomarker [29]
PTP4A2 TT1MHKD Strong Altered Expression [54]
PTPN6 TT369M5 Strong Altered Expression [50]
PTPRC TTUS45N Strong Altered Expression [55]
RARG TT1Q3IE Strong Biomarker [56]
SLC12A3 TTP362L Strong Biomarker [57]
STYK1 TTRMCYJ Strong Biomarker [58]
TCF3 TTULOD8 Strong Altered Expression [48]
THPO TTCG5PE Strong Altered Expression [59]
TRIM24 TT9Q7AE Strong Biomarker [60]
WDR5 TT7OFWB Strong Genetic Variation [61]
WEE1 TTJFOAL Strong Biomarker [62]
WT1 TTZ8UT4 Strong Altered Expression [63]
ABCB4 TTJUXV6 Definitive Biomarker [64]
CCNA2 TTAMQ62 Definitive Altered Expression [65]
CCR7 TT2GIDQ Definitive Biomarker [66]
CD19 TTW640A Definitive Biomarker [67]
MME TT5TKPM Definitive Biomarker [20]
PLA2R1 TTHKW7D Definitive Posttranslational Modification [68]
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⏷ Show the Full List of 71 DTT(s)
This Disease Is Related to 3 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCB5 DTKVEXO Strong Biomarker [69]
SLC29A2 DTW78DQ Strong Biomarker [70]
SLCO6A1 DTIFXNS Strong Genetic Variation [71]
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This Disease Is Related to 6 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CYP1A1 DE6OQ3W Limited Genetic Variation [72]
ABO DESIA7R Strong Biomarker [73]
FPGS DECWT2V Strong Altered Expression [74]
GSTM1 DEYZEJA Strong Genetic Variation [75]
SULT2A1 DE0P6LK Strong Genetic Variation [33]
GSTT1 DE3PKUG Definitive Genetic Variation [71]
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⏷ Show the Full List of 6 DME(s)
This Disease Is Related to 163 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
A2ML1 OTWNUXIS Limited Altered Expression [76]
ABI1 OT5H4M62 Limited Altered Expression [77]
AK6 OT84OHHP Limited Altered Expression [78]
BAALC OTUZSRVF Limited Genetic Variation [79]
CBFB OTIAC6W4 Limited Genetic Variation [80]
CCDC28A OTSWUMXT Limited Biomarker [81]
CEBPZ OT11BATG Limited Genetic Variation [82]
CNTNAP1 OT5Y03EU Limited Altered Expression [83]
CUL2 OTPF83PG Limited Genetic Variation [84]
ELL OTCBN5LF Limited Biomarker [85]
FIP1L1 OTF91GTL Limited Biomarker [86]
HLA-E OTX1CTFB Limited Altered Expression [87]
HOXA9 OTKNK5H0 Limited Altered Expression [88]
HOXD13 OTWSC8TF Limited Biomarker [89]
IL3 OT0CQ35N Limited Biomarker [90]
MLIP OTMT7AII Limited Altered Expression [78]
MLLT6 OTOC9OGX Limited Genetic Variation [91]
MOS OTNMQPFJ Limited Biomarker [92]
MRPL28 OT4LUTZU Limited Biomarker [93]
MYH11 OTVNVWY3 Limited Genetic Variation [82]
NNAT OTNRLO7G Limited Genetic Variation [94]
NUP98 OTNT12G2 Limited Biomarker [95]
NXT1 OT0VO6AY Limited Biomarker [93]
PPP1R13L OTNCPLWE Limited Altered Expression [96]
RALGAPB OTY8CGA3 Limited Altered Expression [76]
SUB1 OTK71JYU Limited Biomarker [93]
TAF15 OTNE038N Limited Altered Expression [97]
TFR2 OTMYCCEO Limited Genetic Variation [98]
TP53BP2 OTOWJ2Y4 Limited Altered Expression [99]
LETMD1 OTZTZ4RD Disputed Biomarker [100]
CDKN2B OTAG24N1 moderate Biomarker [93]
GATA1 OTX1R7O1 moderate Altered Expression [101]
MSH3 OTD3YPVL moderate Biomarker [10]
ACTR1A OT1QAU16 Strong Genetic Variation [102]
ADRM1 OTOU4EY6 Strong Biomarker [103]
AFF2 OTMF1PZW Strong Genetic Variation [104]
AFF3 OTR0705Z Strong Biomarker [105]
AFM OTPOR8IO Strong Altered Expression [106]
AGFG2 OTXQZHCR Strong Biomarker [56]
AKAP12 OTCVRDDX Strong Altered Expression [107]
ANGPTL1 OTXIN6V5 Strong Genetic Variation [102]
ANKHD1 OTVYQ7ZL Strong Altered Expression [108]
ANKRD26 OT2ENKKV Strong Genetic Variation [109]
AP5M1 OTDLWEBL Strong Genetic Variation [110]
APAF1 OTJWIVY0 Strong Posttranslational Modification [111]
APOBEC2 OT4CCS0Q Strong Genetic Variation [102]
ARFRP1 OTP1OV78 Strong Genetic Variation [102]
ARID5B OTUQ4CQY Strong Genetic Variation [112]
ASPG OT5E2EKR Strong Altered Expression [113]
ATAD1 OTJ02XFL Strong Genetic Variation [114]
BCL11B OT8KKCVJ Strong Genetic Variation [115]
BCL2L10 OTYXQJ3I Strong Posttranslational Modification [116]
BIRC6 OTCQJAB0 Strong Altered Expression [117]
BTBD8 OT3A3RD7 Strong Genetic Variation [118]
BTN3A1 OTGZADIX Strong Biomarker [119]
C4BPA OTHNH6Y8 Strong Biomarker [120]
CALM2 OTNYA92F Strong Biomarker [121]
CD1C OT4XINUJ Strong Biomarker [122]
CD200R1 OT65Q9M6 Strong Biomarker [123]
CD79A OTOJC8DV Strong Altered Expression [6]
CDH9 OTV9N5XK Strong Genetic Variation [124]
CDX2 OTCG4TSY Strong Altered Expression [125]
CDX4 OTD1SQKM Strong Altered Expression [126]
CEBPE OTKZA25M Strong Genetic Variation [127]
CHMP5 OTQWZL6R Strong Altered Expression [128]
CLDN5 OTUX60YO Strong Biomarker [129]
CRYL1 OT0SJSJM Strong Genetic Variation [130]
CT45A2 OT9X9KTC Strong Biomarker [131]
CYTH1 OTYH9NRJ Strong Biomarker [70]
DMTF1 OTDKO9OO Strong Genetic Variation [132]
DUSP7 OT6Z5AHP Strong Biomarker [133]
EBF1 OTZ61YYH Strong Genetic Variation [134]
EEF1E1 OTRA6XOB Strong Altered Expression [15]
ERG OTOTX9VU Strong Biomarker [135]
ETV6 OTCZMG61 Strong Biomarker [136]
EVPL OTZIAFEK Strong Altered Expression [137]
FANCC OTTIDM3P Strong Posttranslational Modification [138]
FANCL OTJC7QPQ Strong Posttranslational Modification [138]
FOXO4 OT90X9LN Strong Genetic Variation [139]
FRYL OTBN3XHN Strong Genetic Variation [140]
FZD6 OTBCPII8 Strong Biomarker [124]
FZR1 OT0WGWZS Strong Biomarker [141]
GNA15 OTFYRZGV Strong Altered Expression [142]
GSTK1 OTDNGWAF Strong Genetic Variation [71]
GTF2A1L OTDQHVAI Strong Altered Expression [106]
HACD1 OTEC7EP7 Strong Biomarker [118]
HCLS1 OTX7WGYN Strong Altered Expression [48]
HEMGN OTZPYUOY Strong Altered Expression [143]
HLX OT7DTH46 Strong Altered Expression [144]
HOXB4 OTH1HRW5 Strong Biomarker [145]
HPSE2 OTGEPP8V Strong Posttranslational Modification [146]
HTN3 OTEUXA81 Strong Genetic Variation [33]
ID4 OTPMJ39I Strong Posttranslational Modification [147]
IRX3 OTLJ48FG Strong Biomarker [148]
LAMA1 OTQZMP86 Strong Biomarker [149]
LAMTOR1 OTIBJBW9 Strong Altered Expression [15]
LDB1 OT20EAPR Strong Altered Expression [150]
LITAF OTT5JX1F Strong Altered Expression [151]
LMO1 OTB59SKB Strong Altered Expression [150]
LYL1 OTCNOV1M Strong Biomarker [152]
MAFK OTZJUE4P Strong Altered Expression [15]
MARCKSL1 OT13J2FM Strong Altered Expression [153]
MECOM OTP983W8 Strong Biomarker [66]
MEF2D OT7CEIG0 Strong Altered Expression [154]
MEIS1 OTH9DKAD Strong Biomarker [155]
MLF1 OTC5BKHU Strong Altered Expression [156]
MLF2 OTU3B4WU Strong Genetic Variation [157]
MLLT10 OTURMDV7 Strong Biomarker [44]
MLLT11 OTG5RVHC Strong Genetic Variation [158]
MLLT3 OTXH4DDG Strong Biomarker [159]
MTX1 OTLSDNZO Strong Genetic Variation [160]
MXD1 OTS5CTHX Strong Biomarker [161]
NBN OT73B5MD Strong Genetic Variation [162]
NCOA2 OTMQFPBB Strong Biomarker [41]
NCOR1 OT04XNOU Strong Genetic Variation [163]
NOL3 OT1K0L0D Strong Biomarker [164]
NR2F2 OTJFS67N Strong Genetic Variation [102]
NSRP1 OTOXZJUV Strong Altered Expression [165]
NSUN5 OTBN7RS8 Strong Biomarker [49]
NXF2 OTJS5KTH Strong Biomarker [166]
OPN1LW OTFNUZ7O Strong Genetic Variation [167]
PAG1 OTFOJUIQ Strong Genetic Variation [167]
PARN OTTG4PE3 Strong Biomarker [168]
PBX1 OTORABGO Strong Biomarker [26]
PCBP4 OTDLL4NB Strong Genetic Variation [167]
PCM1 OTFM133C Strong Biomarker [169]
PICALM OTQVRPMQ Strong Genetic Variation [22]
PRAM1 OTZN3DWD Strong Altered Expression [28]
PRB1 OTV0SYMD Strong Biomarker [170]
PTPRA OTZA82J1 Strong Biomarker [171]
RAB3A OT2GIUO5 Strong Biomarker [124]
RBM15 OT8ZPGWF Strong Altered Expression [172]
RGPD2 OTMUZ0HX Strong Biomarker [56]
RIMS2 OTQASWDH Strong Biomarker [124]
RPS27A OTIIGGZ2 Strong Altered Expression [173]
RUNX1T1 OT30DED5 Strong Biomarker [174]
RYK OTZ3WWZH Strong Biomarker [175]
SEPTIN9 OT1VMRFQ Strong Genetic Variation [53]
SERPINB6 OT7G55IK Strong Biomarker [118]
SETDB2 OTBVVP9Q Strong Biomarker [26]
SIGLEC7 OTNDLURR Strong Altered Expression [48]
SMARCA5 OT5GR4Z2 Strong Biomarker [176]
SNAP91 OTE3EXWZ Strong Biomarker [121]
SOCS6 OT2O5ZBK Strong Altered Expression [50]
SORBS1 OTWH8762 Strong Biomarker [118]
STIL OT9799VN Strong Biomarker [177]
STON1 OT2HPUAI Strong Altered Expression [106]
SV2B OTAO5WIU Strong Biomarker [178]
TAF8 OTWWGCHV Strong Altered Expression [39]
TAL1 OTX4K6QZ Strong Genetic Variation [179]
TCHP OTVDMHSY Strong Biomarker [180]
TESC OTI8C76M Strong Biomarker [57]
TINF2 OT861N2N Strong Altered Expression [181]
TLX3 OTBUHHK3 Strong Genetic Variation [182]
TMEM132D OTV6I4Z0 Strong Genetic Variation [183]
TPPP2 OTI3WA6X Strong Altered Expression [15]
TRIB1 OTPEO17G Strong Altered Expression [156]
AFF1 OTT2C78E Definitive Genetic Variation [184]
AVEN OTGIN5YK Definitive Altered Expression [185]
FANCB OTMZTXB5 Definitive Biomarker [186]
IKZF1 OTCW1FKL Definitive Biomarker [112]
MLLT1 OT41UZU5 Definitive Biomarker [187]
SORL1 OTQ8FFNS Definitive Biomarker [188]
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⏷ Show the Full List of 163 DOT(s)

References

1 ClinicalTrials.gov (NCT02028455) A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD19 for Relapsed/Refractory CD19+ Leukemia
2 ClinicalTrials.gov (NCT03176277) A Study of ONO-7475 in Patients With Acute Leukemias. U.S. National Institutes of Health.
3 Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
4 Effects of cytochrome P450 family 3 subfamily A member5 gene polymorphisms on daunorubicin metabolism and adverse reactions in patients with acute leukemia.Mol Med Rep. 2017 Jun;15(6):3493-3498. doi: 10.3892/mmr.2017.6470. Epub 2017 Apr 12.
5 MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia.Leuk Res. 2013 Jun;37(6):647-56. doi: 10.1016/j.leukres.2013.02.019. Epub 2013 Mar 20.
6 RUNX1 Mutations Can Lead to Aberrant Expression of CD79a and PAX5 in Acute Myelogenous Leukemias: A Potential Diagnostic Pitfall.Pathobiology. 2019;86(2-3):162-166. doi: 10.1159/000493688. Epub 2018 Nov 5.
7 Predicted indirectly recognizable HLA epitopes are not associated with clinical outcomes after haploidentical hematopoietic stem cell transplantation.Hum Immunol. 2018 Feb;79(2):117-121. doi: 10.1016/j.humimm.2017.11.004. Epub 2017 Nov 16.
8 Impaired telomere regulation mechanism by TRF1 (telomere-binding protein), but not TRF2 expression, in acute leukemia cells.Int J Oncol. 2001 Mar;18(3):593-8. doi: 10.3892/ijo.18.3.593.
9 Stanniocalcin1 gene expression in patients with acute leukemia: impact on response to therapy and disease outcome.Int J Lab Hematol. 2016 Feb;38(1):81-9. doi: 10.1111/ijlh.12445. Epub 2015 Nov 7.
10 Expression of genes related to multiple drug resistance and apoptosis in acute leukemia: response to induction chemotherapy.Exp Mol Pathol. 2012 Feb;92(1):44-9. doi: 10.1016/j.yexmp.2011.09.004. Epub 2011 Oct 19.
11 NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblastic leukemia and their expression level affects patient outcome.J Transl Med. 2018 Aug 20;16(1):232. doi: 10.1186/s12967-018-1608-2.
12 Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia.Blood. 1995 Jan 1;85(1):186-93.
13 Regulation of the expression of annexin VIII in acute promyelocytic leukemia.Blood. 1994 Jul 1;84(1):279-86.
14 Mutational analysis of the ARAF gene in human cancers.APMIS. 2005 Jan;113(1):54-7. doi: 10.1111/j.1600-0463.2005.apm1130108.x.
15 Homozygous deletions of cyclin-dependent kinase inhibitor genes, p16(INK4A) and p18, in childhood T cell lineage acute lymphoblastic leukemias.Leukemia. 1996 Feb;10(2):255-60.
16 Progress in elucidation of molecular pathophysiology of myeloproliferative neoplasms and its application to therapeutic decisions.Int J Hematol. 2020 Feb;111(2):182-191. doi: 10.1007/s12185-019-02778-9. Epub 2019 Nov 18.
17 Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndrome.Mol Cancer Res. 2005 May;3(5):251-60. doi: 10.1158/1541-7786.MCR-04-0182.
18 Clinical impact of CD200 expression in patients with acute myeloid leukemia and correlation with other molecular prognostic factors.Oncotarget. 2015 Oct 6;6(30):30212-21. doi: 10.18632/oncotarget.4901.
19 Fc epsilon RI and CD22 mRNA are expressed in early B-lineage and myeloid leukemia cell lines.Leuk Res. 2003 Feb;27(2):173-82. doi: 10.1016/s0145-2126(02)00086-3.
20 Immunophenotypic profile of acute leukemia: critical analysis and insights gained at a tertiary care center in India.Cytometry B Clin Cytom. 2009 May;76(3):199-205. doi: 10.1002/cyto.b.20451.
21 CD34 expression and the outcome of nucleophosmin 1-mutated acute myeloid leukemia.Ann Hematol. 2016 Dec;95(12):1949-1954. doi: 10.1007/s00277-016-2811-y. Epub 2016 Sep 5.
22 PICALM-MLLT10 acute myeloid leukemia: a French cohort of 18 patients.Leuk Res. 2012 Nov;36(11):1365-9. doi: 10.1016/j.leukres.2012.07.008. Epub 2012 Aug 5.
23 Prospective gene expression analysis accurately subtypes acute leukaemia in children and establishes a commonality between hyperdiploidy and t(12;21) in acute lymphoblastic leukaemia.Br J Haematol. 2005 Jul;130(1):26-35. doi: 10.1111/j.1365-2141.2005.05545.x.
24 Myeloprotection by cytidine deaminase gene transfer in antileukemic therapy.Neoplasia. 2013 Mar;15(3):239-48. doi: 10.1593/neo.121954.
25 E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia.Clin Cancer Res. 2000 Nov;6(11):4243-8.
26 SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression.Cell Rep. 2018 Apr 24;23(4):1166-1177. doi: 10.1016/j.celrep.2018.03.124.
27 CSF3R Mutations are frequently associated with abnormalities of RUNX1, CBFB, CEBPA, and NPM1 genes in acute myeloid leukemia.Cancer. 2018 Aug;124(16):3329-3338. doi: 10.1002/cncr.31586. Epub 2018 Jun 22.
28 Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences.Blood. 1997 Jan 15;89(2):376-87.
29 Lineage commitment in biphenotypic acute leukemia.Leukemia. 1993 Jun;7(6):919-27.
30 Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches.J Comput Aided Mol Des. 2018 Mar;32(3):435-458. doi: 10.1007/s10822-018-0096-z. Epub 2018 Jan 15.
31 ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias.Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14442-7. doi: 10.1073/pnas.0703211104. Epub 2007 Aug 28.
32 Prognostic significance of foetal-like tyrosine kinase 3 mutation in Egyptian children with acute leukaemia.Int J Lab Hematol. 2009 Jun;31(3):320-6. doi: 10.1111/j.1751-553X.2008.01039.x. Epub 2008 Mar 10.
33 Genomic clone of hst with transforming activity from a patient with acute leukemia.Biochem Biophys Res Commun. 1987 Feb 13;142(3):1019-24. doi: 10.1016/0006-291x(87)91516-6.
34 Expression of the fetal-oncogenic fibroblast growth factor-8/17/18 subfamily in human hematopoietic tumors.Biochem Biophys Res Commun. 2005 Sep 30;335(3):843-9. doi: 10.1016/j.bbrc.2005.07.153.
35 Isavuconazole therapy in an FLT3 mutated acute myeloid leukemia patient receiving midostaurin: A case report.J Oncol Pharm Pract. 2019 Jun;25(4):987-989. doi: 10.1177/1078155218764257. Epub 2018 Mar 20.
36 Methylation level of CpG islands in GGH gene promoter in pediatric acute leukemia.PLoS One. 2017 Mar 9;12(3):e0173472. doi: 10.1371/journal.pone.0173472. eCollection 2017.
37 Impact of fluoroquinolone prophylaxis during neutropenia on bloodstream infection: Data from a surveillance program in 8755 patients receiving high-dose chemotherapy for haematologic malignancies between 2009 and 2014.J Infect. 2018 Jul;77(1):68-74. doi: 10.1016/j.jinf.2018.05.004. Epub 2018 Jun 6.
38 Expression of the IFNAR1 chain of type 1 interferon receptor in benign cells protects against progression of acute leukemia.Leuk Lymphoma. 2018 Jan;59(1):171-177. doi: 10.1080/10428194.2017.1319053. Epub 2017 May 15.
39 TAF-I deficiency inhibits proliferation and promotes apoptosis by rescuing PP2A and inhibiting the AKT/GSK-3 pathway in leukemic cells.Exp Ther Med. 2019 Nov;18(5):3801-3808. doi: 10.3892/etm.2019.8012. Epub 2019 Sep 17.
40 ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.Cancer Cell. 2018 Mar 12;33(3):495-511.e12. doi: 10.1016/j.ccell.2018.02.002. Epub 2018 Mar 1.
41 Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.Cancer Cell. 2016 Jan 11;29(1):32-48. doi: 10.1016/j.ccell.2015.12.007.
42 Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene.Genes Chromosomes Cancer. 2006 May;45(5):437-46. doi: 10.1002/gcc.20308.
43 Influence of Differently Licensed KIR2DL1-Positive Natural Killer Cells in Transplant Recipients with Acute Leukemia: A Japanese National Registry Study.Biol Blood Marrow Transplant. 2016 Mar;22(3):423-31. doi: 10.1016/j.bbmt.2015.09.029. Epub 2015 Oct 9.
44 Acute leukemias harboring KMT2A/MLLT10 fusion: a 10-year experience from a single genomics laboratory.Genes Chromosomes Cancer. 2019 Aug;58(8):567-577. doi: 10.1002/gcc.22741. Epub 2019 Mar 19.
45 Acute myeloid/T-lymphoblastic leukaemia (AMTL): a distinct category of acute leukaemias with common pathogenesis in need of improved therapy.Br J Haematol. 2018 Mar;180(6):919-924. doi: 10.1111/bjh.15129. Epub 2018 Feb 14.
46 A correlation analysis of miRNA?4a and its predicted target genes in leukemia.Mol Med Rep. 2014 Apr;9(4):1283-8. doi: 10.3892/mmr.2014.1931. Epub 2014 Feb 3.
47 Analytical performance of automated platelet counts and impact on platelet transfusion guidance in patients with acute leukemia.Scand J Clin Lab Invest. 2019 May;79(3):160-166. doi: 10.1080/00365513.2019.1576100. Epub 2019 Feb 14.
48 Expression of the p75 neurotrophin receptor in acute leukaemia.Br J Haematol. 2005 Oct;131(1):67-70. doi: 10.1111/j.1365-2141.2005.05717.x.
49 E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia.Leukemia. 2008 Apr;22(4):723-9. doi: 10.1038/sj.leu.2405084. Epub 2008 Jan 10.
50 Expression of SHP-1 and SOCS6 in patients with acute leukemia and their clinical implication.Onco Targets Ther. 2017 Mar 29;10:1915-1920. doi: 10.2147/OTT.S131537. eCollection 2017.
51 Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening.Leuk Lymphoma. 2007 May;48(5):978-86. doi: 10.1080/10428190701225882.
52 Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation.Leukemia. 2008 Jan;22(1):78-86. doi: 10.1038/sj.leu.2404988. Epub 2007 Oct 18.
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54 Overexpression of PTP4A3 in ETV6-RUNX1 acute lymphoblastic leukemia.Leuk Res. 2017 Mar;54:1-6. doi: 10.1016/j.leukres.2016.12.005. Epub 2016 Dec 26.
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