Details of Disease

General Information of Disease (ID: DIS882XU)

Disease Name Adult T-cell leukemia/lymphoma
Synonyms
adult T cell lymphoma/leukemia; adult T-cell lymphoma/leukemia; adult T-cell leukemia/lymphoma (HTLV-1 positive); HTLV-1 associated adult T-cell lymphoma/leukemia; HTLV-I associated adult T-cell leukemia/lymphoma; adult T-cell lymphoma; T-cell leukaemia of adults; adult T-cell leukaemia; adult T-cell leukemia; adult T-cell leukemia/lymphoma; T-cell leukemia of adults; ATLL
Definition
A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus type 1 (HTLV-1), adult T-cell leukemia/lymphoma is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa.
Disease Hierarchy
DISN5C4M: Human T-lymphotropic virus 1 infectious disease
DISJ6YIF: T-cell leukaemia
DISO0SN0: Retrovirus infection
DISSXRTQ: T-cell lymphoma
DISMPOPT: Virus associated tumor
DISK8IZR: Adult lymphoma
DIS882XU: Adult T-cell leukemia/lymphoma
Disease Identifiers
MONDO ID
MONDO_0019471
MESH ID
D015459
UMLS CUI
C0023493
MedGen ID
44128
Orphanet ID
86875
SNOMED CT ID
110007008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Lenalidomide DM6Q7U4 Approved Small molecular drug [1]
Thalidomide DM70BU5 Approved Small molecular drug [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 81 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
IL4 TTLGTKB Limited Biomarker [3]
STAT3 TTHJT3X Limited Genetic Variation [4]
SERPINH1 TTPSWQG Disputed Biomarker [5]
TCL1A TTUKRDV Disputed Biomarker [6]
TXN TTZJ5U9 Disputed Biomarker [7]
CCR7 TT2GIDQ moderate Biomarker [8]
CD28 TTQ13FT moderate Biomarker [8]
CD80 TT89Z17 moderate Biomarker [9]
CSNK1A1 TTFQEMX moderate Biomarker [8]
CSNK2A1 TTER6YH moderate Biomarker [8]
CTLA4 TTI2S1D moderate Biomarker [8]
GPR183 TTME5YJ moderate Biomarker [8]
HNRNPA2B1 TT8UPW6 moderate Biomarker [8]
ICOS TTE5VP6 moderate Biomarker [8]
IFNA2 TTSIUJ9 moderate Therapeutic [10]
RTN4 TT7GXMU moderate Biomarker [11]
ANK1 TTKFPMH Strong Biomarker [12]
APOBEC3G TTP96KH Strong Genetic Variation [13]
BIRC5 TTTPU1G Strong Altered Expression [14]
BMP6 TT07RIB Strong Posttranslational Modification [15]
BUB1 TT78309 Strong Biomarker [16]
CCL22 TTBTWI1 Strong Biomarker [17]
CCR4 TT7HQD0 Strong Altered Expression [18]
CCR9 TTIPS8B Strong Altered Expression [19]
CD3G TTV3XPL Strong Altered Expression [20]
CD5 TTEGYK1 Strong Biomarker [21]
CD52 TTQT5S9 Strong Altered Expression [14]
CD58 TT5KSBY Strong Biomarker [22]
CD70 TTNCIE0 Strong Altered Expression [23]
CD86 TT53XHB Strong Altered Expression [24]
CD9 TTZEIBV Strong Biomarker [25]
CES1 TTMF541 Strong Biomarker [26]
CREB1 TTH4AN3 Strong Altered Expression [27]
CTAG1A TTE5ITK Strong Altered Expression [28]
FCGRT TTKLPHO Strong Biomarker [29]
FOSL2 TT689IR Strong Altered Expression [30]
FOXP3 TT1X3QF Strong Altered Expression [31]
FUT4 TTNV1KZ Strong Altered Expression [32]
FYN TT2B9KF Strong Biomarker [33]
GATA3 TT45KOB Strong Biomarker [8]
GSTO1 TTWO3SH Strong Altered Expression [34]
HAL TTXQOZW Strong Genetic Variation [35]
HDAC8 TTT6LFV Strong Altered Expression [30]
IFNL3 TTRF4Q2 Strong Altered Expression [36]
IKZF2 TTKT5NV Strong Biomarker [8]
IL21R TTZO9B0 Strong Biomarker [37]
ITGAL TT48WR6 Strong Altered Expression [38]
ITGB2 TTIJWR7 Strong Altered Expression [38]
ITGB7 TTLT9XQ Strong Altered Expression [39]
JAK3 TTT7PJU Strong Biomarker [40]
JUN TTS7IR5 Strong Biomarker [41]
LCK TT860QF Strong Genetic Variation [42]
LCT TTA0OSE Strong Altered Expression [43]
LMO2 TTFX379 Strong Biomarker [44]
LOXL2 TTFSUHX Strong Genetic Variation [45]
MTAP TTDBX7N Strong Biomarker [46]
MYB TT8V13P Strong Altered Expression [47]
PIM3 TTCGOIN Strong Biomarker [48]
PLCG1 TT6T4JI Strong Biomarker [49]
PMS1 TTX1ISF Strong Altered Expression [50]
PRKCB TTYPXQF Strong Genetic Variation [51]
PRMT5 TTR1D7X Strong Altered Expression [52]
PSMD10 TT2H4LN Strong Altered Expression [34]
PTPN13 TT405FP Strong Altered Expression [53]
REL TT1ZCTH Strong Biomarker [54]
RORC TTGV6LY Strong Altered Expression [55]
SELL TT2IYXF Strong Biomarker [56]
SRPK1 TTU3WV6 Strong Biomarker [57]
SYK TT2HUPM Strong Biomarker [41]
TDP1 TT64IHJ Strong Biomarker [58]
TERF2 TT5XSLT Strong Biomarker [59]
TNFRSF4 TTL31H0 Strong Altered Expression [60]
TNFRSF8 TT2GM5R Strong Biomarker [61]
TNFSF11 TT9E8HR Strong Altered Expression [62]
TRB TT84HCW Strong Genetic Variation [63]
TRBC1 TT1DHW2 Strong Genetic Variation [63]
USP44 TTJLTNM Strong Altered Expression [64]
WNK1 TTJ9UMX Strong Altered Expression [31]
XPO1 TTCJUR4 Strong Altered Expression [65]
CNTN2 TT2Z1WB Definitive Genetic Variation [66]
THBS1 TTKI0H1 Definitive Biomarker [67]
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⏷ Show the Full List of 81 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC44A1 DT3I2SU Strong Biomarker [68]
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This Disease Is Related to 2 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
APRT DE2MV1R Disputed Biomarker [69]
SCLY DEH4TD6 Strong Biomarker [70]
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This Disease Is Related to 121 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CCR10 OT7ZWSSD Limited Biomarker [71]
ATN1 OTNZFLKY Disputed Biomarker [72]
CDKN2B OTAG24N1 Disputed Biomarker [73]
MFAP1 OTZN4FT3 Disputed Biomarker [69]
TCL1B OT4CSO39 Disputed Biomarker [6]
CARD11 OTRCTLYC moderate Biomarker [8]
CSNK2B OT2WW7R1 moderate Biomarker [8]
TP73 OT0LUO47 moderate Biomarker [8]
ADAM11 OTPTVW5W Strong Biomarker [74]
ADAM21 OTGBAVYU Strong Biomarker [75]
AKAP13 OTOZAR14 Strong Altered Expression [76]
AMFR OTQRX7LC Strong Biomarker [77]
ASCC2 OT3B204T Strong Biomarker [78]
ASZ1 OTLM93UO Strong Biomarker [79]
ATL1 OTR2788Y Strong Genetic Variation [80]
ATL2 OT93AUOO Strong Biomarker [68]
ATL3 OTQVFKMV Strong Biomarker [81]
AZI2 OT61Q7Q8 Strong Altered Expression [30]
BATF OT9VSD2D Strong Altered Expression [82]
BCAP31 OTKSACR4 Strong Altered Expression [34]
BCL11B OT8KKCVJ Strong Altered Expression [83]
CADM4 OT0TFMFE Strong Biomarker [84]
CCL1 OT23NON8 Strong Biomarker [85]
CD151 OTF3UZS7 Strong Altered Expression [86]
CD3D OTRBLP0R Strong Altered Expression [87]
CENPV OTPQ0KT9 Strong Biomarker [88]
CFDP1 OTXY7J96 Strong Biomarker [89]
CHP1 OTHTXN1A Strong Biomarker [25]
CLDN10 OT2CVAKY Strong Altered Expression [90]
CLEC11A OT9KBH7C Strong Altered Expression [76]
CNKSR3 OTXP4QH8 Strong Biomarker [91]
CNOT3 OT4D5Z9L Strong Biomarker [92]
CTAG1B OTIQGW6U Strong Altered Expression [28]
DLG1 OTCRZYWT Strong Biomarker [93]
DNALI1 OTTB3L8N Strong Altered Expression [34]
DNTT OTFSEF12 Strong Altered Expression [94]
DSTN OTMXO4YB Strong Altered Expression [95]
E2F4 OTB3JFH4 Strong Genetic Variation [96]
EIF4G2 OTEO98CR Strong Biomarker [89]
EPC1 OT3Q25ND Strong Biomarker [97]
ERVW-1 OTWV8DXJ Strong Biomarker [98]
FEZF2 OTU4TXIW Strong Biomarker [99]
FOXN2 OTBPLTCM Strong Biomarker [100]
GBP2 OTVU4G07 Strong Biomarker [101]
GEMIN4 OTX7402E Strong Biomarker [89]
GORASP1 OTQS91S7 Strong Altered Expression [31]
GOSR1 OTX8TMVU Strong Altered Expression [34]
GPHN OTAKK1SV Strong Genetic Variation [12]
GZMM OTEC5CWT Strong Genetic Variation [102]
HERPUD1 OT9EROL6 Strong Biomarker [103]
IFNA1 OTPMKY0L Strong Biomarker [104]
IFT172 OT12DW08 Strong Biomarker [105]
IL2RG OTRZ3OMY Strong Altered Expression [106]
IRF4 OT1DHQ1P Strong Biomarker [54]
JUND OTNKACJD Strong Biomarker [41]
KRT7 OTLT3JFN Strong Biomarker [70]
LBX1 OTQJHICM Strong Biomarker [107]
LGALS9 OT7MF91K Strong Biomarker [108]
LMO1 OTB59SKB Strong Biomarker [109]
LORICRIN OTFRPVEO Strong Genetic Variation [45]
MAGI1 OTMV4ASV Strong Biomarker [91]
MAP4K5 OTUFGLXE Strong Altered Expression [30]
MRPL28 OT4LUTZU Strong Biomarker [73]
MSH3 OTD3YPVL Strong Biomarker [50]
MVP OTJGHJRB Strong Altered Expression [110]
NCKIPSD OT24UORN Strong Biomarker [111]
NDRG2 OT5L6KD7 Strong Altered Expression [52]
NFE2L1 OT1QHOS2 Strong Altered Expression [58]
NOG OTGRHHPG Strong Biomarker [112]
NOX5 OTHTH59G Strong Biomarker [113]
NRF1 OTOXWNV8 Strong Altered Expression [58]
NRK OTGR01FF Strong Altered Expression [114]
NRSN1 OT1KKXC8 Strong Biomarker [25]
NSFL1C OTIKQF3U Strong Altered Expression [76]
NXT1 OT0VO6AY Strong Biomarker [73]
OAS3 OT6E5FYS Strong Biomarker [78]
PDLIM2 OTEURRPD Strong Biomarker [115]
PIAS3 OT3TWH9R Strong Altered Expression [116]
PLEK OTB73XXA Strong Altered Expression [76]
PLVAP OTAQGWYA Strong Altered Expression [117]
POLD4 OTG578YH Strong Biomarker [111]
POLE4 OTCMWUT6 Strong Biomarker [111]
POLK OTKZ38JH Strong Genetic Variation [51]
POT1 OTNBXJCQ Strong Altered Expression [118]
PRDM16 OT0BGA27 Strong Altered Expression [119]
PSMD2 OT6HZHN7 Strong Biomarker [89]
PTPA OTRGFOI7 Strong Biomarker [52]
PTPRA OTZA82J1 Strong Biomarker [120]
PWWP3A OTXQVL4U Strong Biomarker [121]
RAB4A OT7BL9WW Strong Biomarker [122]
RBL2 OTBQSOE6 Strong Biomarker [123]
RGS1 OTGXJYMG Strong Biomarker [124]
RPL17 OTTYMPS6 Strong Biomarker [125]
SACM1L OT6ORKTD Strong Biomarker [126]
SART3 OTC1AM7S Strong Biomarker [78]
SPOCK3 OTYSOOO7 Strong Altered Expression [127]
SPTAN1 OT6VY3A3 Strong Biomarker [128]
STAMBPL1 OTI4CYTF Strong Biomarker [129]
SUB1 OTK71JYU Strong Biomarker [73]
SUGP1 OT7W0EB8 Strong Altered Expression [130]
SYT1 OTVTPOI6 Strong Altered Expression [31]
TAL2 OTSK1E88 Strong Biomarker [70]
TARS1 OT0PWST5 Strong Biomarker [95]
TBPL1 OT4I143E Strong Biomarker [59]
TBPL2 OTDEC1KO Strong Altered Expression [131]
THUMPD1 OTKU8KWH Strong Genetic Variation [132]
TIGAR OTR7NMRJ Strong Biomarker [133]
TINF2 OT861N2N Strong Altered Expression [118]
TLX1 OTVN0MNW Strong Altered Expression [134]
TLX2 OTPFAUM8 Strong Biomarker [107]
TM9SF3 OTBISJZQ Strong Biomarker [135]
TMED2 OTBLO7RW Strong Biomarker [25]
TMED5 OT70W1J8 Strong Altered Expression [34]
TMED9 OTYGAQS0 Strong Biomarker [136]
TOX OTE8BL5Z Strong Biomarker [137]
TPPP OTCFMSUF Strong Biomarker [136]
CADM1 OTRWG9QS Definitive Altered Expression [76]
HBZ OTMHGFSS Definitive Biomarker [62]
SUPT7L OTZJCPN1 Definitive Biomarker [49]
TAL1 OTX4K6QZ Definitive Biomarker [138]
TLX3 OTBUHHK3 Definitive Genetic Variation [139]
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⏷ Show the Full List of 121 DOT(s)

References

1 Lenalidomide FDA Label
2 Thalidomide FDA Label
3 The combination of arsenic, interferon-alpha, and zidovudine restores an "immunocompetent-like" cytokine expression profile in patients with adult T-cell leukemia lymphoma.Retrovirology. 2013 Aug 20;10:91. doi: 10.1186/1742-4690-10-91.
4 Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T-cell leukemia/lymphoma.Cancer Sci. 2019 Sep;110(9):2982-2991. doi: 10.1111/cas.14114. Epub 2019 Jul 23.
5 Involvement of molecular mimicry between human T-cell leukemia virus type 1 gp46 and osteoprotegerin in induction of hypercalcemia.Cancer Sci. 2009 Mar;100(3):490-6. doi: 10.1111/j.1349-7006.2008.01061.x. Epub 2008 Dec 24.
6 The role of TCL1 in human T-cell leukemia.Oncogene. 2001 Sep 10;20(40):5638-43. doi: 10.1038/sj.onc.1204596.
7 Cell Signaling with Extracellular Thioredoxin and Thioredoxin-Like Proteins: Insight into Their Mechanisms of Action.Oxid Med Cell Longev. 2017;2017:8475125. doi: 10.1155/2017/8475125. Epub 2017 Sep 12.
8 Integrated molecular analysis of adult T cell leukemia/lymphoma.Nat Genet. 2015 Nov;47(11):1304-15. doi: 10.1038/ng.3415. Epub 2015 Oct 5.
9 Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade.J Virol. 2000 Jan;74(1):428-35. doi: 10.1128/jvi.74.1.428-435.2000.
10 Emodin and DHA potently increase arsenic trioxide interferon-alpha-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1.Blood. 2007 Feb 15;109(4):1653-9. doi: 10.1182/blood-2006-04-015537. Epub 2006 Oct 31.
11 Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma.Int J Cancer. 2006 Oct 1;119(7):1648-53. doi: 10.1002/ijc.22011.
12 Rapid isolation of viral integration site reveals frequent integration of HTLV-1 into expressed loci.J Hum Genet. 2004;49(3):154-165. doi: 10.1007/s10038-004-0126-7. Epub 2004 Feb 26.
13 APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo.J Virol. 2010 Jul;84(14):7278-87. doi: 10.1128/JVI.02239-09. Epub 2010 May 12.
14 Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia.Blood. 2013 Mar 14;121(11):2029-37. doi: 10.1182/blood-2012-05-427773. Epub 2013 Jan 15.
15 Promoter methylation of the bone morphogenetic protein-6 gene in association with adult T-cell leukemia.Int J Cancer. 2008 Oct 15;123(8):1824-31. doi: 10.1002/ijc.23749.
16 Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma.Cancer Lett. 2000 Oct 1;158(2):141-50. doi: 10.1016/s0304-3835(00)00512-7.
17 Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma.J Exp Med. 2014 Dec 15;211(13):2497-505. doi: 10.1084/jem.20140987. Epub 2014 Dec 8.
18 Population Pharmacokinetic Modeling of Mogamulizumab in Adults With Cutaneous T-Cell Lymphoma or Adult T-Cell Lymphoma.J Clin Pharmacol. 2020 Jan;60(1):58-66. doi: 10.1002/jcph.1564. Epub 2019 Dec 16.
19 Expression of CCR9 in HTLV-1+ T cells and ATL cells expressing Tax.Int J Cancer. 2007 Apr 1;120(7):1591-7. doi: 10.1002/ijc.22483.
20 Human T cell leukemia virus type I prevents cell surface expression of the T cell receptor through down-regulation of the CD3-gamma, -delta, -epsilon, and -zeta genes.J Immunol. 1990 Oct 1;145(7):2297-303.
21 Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma.Blood. 1983 Jan;61(1):192-9.
22 Molecular Pathology of Adult T-Cell Leukemia/Lymphoma.Oncology. 2015;89 Suppl 1:7-15. doi: 10.1159/000431058. Epub 2015 Nov 10.
23 Clinical significance of CD70 expression on T cells in human T-lymphotropic virus type-1 carriers and adult T cell leukemia/ lymphoma patients.Leuk Lymphoma. 2016;57(3):685-91. doi: 10.3109/10428194.2015.1063140. Epub 2015 Jul 25.
24 An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T cell leukemia virus type 1.AIDS Res Hum Retroviruses. 2013 Sep;29(9):1273-85. doi: 10.1089/aid.2013.0054. Epub 2013 Jul 19.
25 Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells.Cancer Lett. 1984 Sep;24(2):129-39. doi: 10.1016/0304-3835(84)90128-9.
26 Synthesis of New N1Arylpiperazine Substituted Xanthine Derivatives and Evaluation of their Antioxidant and Cytotoxic Effects.Anticancer Agents Med Chem. 2019;19(4):528-537. doi: 10.2174/1871520619666190121155651.
27 Transcriptional activation of the interleukin-21 gene and its receptor gene by human T-cell leukemia virus type 1 Tax in human T-cells.J Biol Chem. 2009 Sep 18;284(38):25501-11. doi: 10.1074/jbc.M109.010959. Epub 2009 Jul 17.
28 Prevalence of plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status.Virol J. 2017 Jul 17;14(1):130. doi: 10.1186/s12985-017-0802-9.
29 Cytogenetic implication in adult T-cell leukemia. A hypothesis of leukemogenesis.Cancer Genet Cytogenet. 1991 Jan;51(1):131-6. doi: 10.1016/0165-4608(91)90019-q.
30 SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma.Blood. 2013 May 2;121(18):3640-9. doi: 10.1182/blood-2012-07-441022. Epub 2013 Mar 12.
31 Detection of human T lymphotropic virus type-I bZIP factor and tax in the salivary glands of Sjgren's syndrome patients.Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):51-60. Epub 2018 Mar 20.
32 Transcriptional regulation of expression of carbohydrate ligands for cell adhesion molecules in the selectin family.Adv Exp Med Biol. 2001;491:267-78. doi: 10.1007/978-1-4615-1267-7_18.
33 Enhancer profiling identifies critical cancer genes and characterizes cell identity in adult T-cell leukemia.Blood. 2017 Nov 23;130(21):2326-2338. doi: 10.1182/blood-2017-06-792184. Epub 2017 Oct 4.
34 Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo.Retrovirology. 2008 May 12;5:38. doi: 10.1186/1742-4690-5-38.
35 Detection of human T-lymphotropic virus type-I DNA and mRNA in the lymph nodes; using polymerase chain reaction in situ hybridization (PCR/ISH) and reverse transcription (RT-PCR/ISH).Int J Cancer. 1996 Mar 28;66(1):18-23. doi: 10.1002/(SICI)1097-0215(19960328)66:1<18::AID-IJC4>3.0.CO;2-1.
36 HTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: virus and host gene expressions.BMC Cancer. 2018 Dec 22;18(1):1287. doi: 10.1186/s12885-018-5209-5.
37 Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells.Br J Haematol. 2005 Jan;128(2):169-76. doi: 10.1111/j.1365-2141.2004.05255.x.
38 Tetramethylpyrazine inhibits phytohemagglutinin-induced upregulation of ICAM-1 and LFA-1 mediated leukocyte adhesion.Clin Hemorheol Microcirc. 2000;23(2-4):145-51.
39 Identification of an adhesion molecule expressed on adult T cell leukemia cells derived from a patient with gastrointestinal involvement: implication for a possible role of integrin beta 7 in leukemic cell infiltration into intestinal mucosa.J Clin Immunol. 1999 May;19(3):186-93. doi: 10.1023/a:1020507828066.
40 CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.Blood. 2011 Feb 10;117(6):1938-46. doi: 10.1182/blood-2010-09-305425. Epub 2010 Nov 24.
41 Anti-adult Tcell leukemia/lymphoma activity of cerdulatinib, a dual SYK/JAK kinase inhibitor.Int J Oncol. 2018 Oct;53(4):1681-1690. doi: 10.3892/ijo.2018.4513. Epub 2018 Aug 1.
42 Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia.J Exp Med. 1991 Oct 1;174(4):867-73. doi: 10.1084/jem.174.4.867.
43 Synthesis of proteins in Escherichia coli immunoreactive with sera from individuals infected with human T-cell leukemia virus type I.Mol Cell Probes. 1988 Mar;2(1):39-46. doi: 10.1016/0890-8508(88)90042-4.
44 LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.PLoS One. 2014 Jan 21;9(1):e85883. doi: 10.1371/journal.pone.0085883. eCollection 2014.
45 Mechanism of leukemogenesis by human T-cell leukemia virus types I and II: role of the lor gene.Cancer Detect Prev. 1987;10(5-6):411-24.
46 Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL).Leukemia. 2002 Sep;16(9):1799-807. doi: 10.1038/sj.leu.2402570.
47 Dysregulation of c-Myb Pathway by Aberrant Expression of Proto-oncogene MYB Provides the Basis for Malignancy in Adult T-cell Leukemia/lymphoma Cells.Clin Cancer Res. 2016 Dec 1;22(23):5915-5928. doi: 10.1158/1078-0432.CCR-15-1739. Epub 2016 Jun 15.
48 Expression and significance of Pim-3 kinase in adult T-cell leukemia.Eur J Haematol. 2017 Dec;99(6):495-504. doi: 10.1111/ejh.12940. Epub 2017 Sep 11.
49 Oncogenomic analysis identifies novel biomarkers for tumor stage mycosis fungoides.Medicine (Baltimore). 2018 May;97(21):e10871. doi: 10.1097/MD.0000000000010871.
50 Reduced expression of human mismatch repair genes in adult T-cell leukemia.Am J Hematol. 2005 Feb;78(2):100-7. doi: 10.1002/ajh.20259.
51 Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma.Fam Cancer. 2019 Jan;18(1):113-119. doi: 10.1007/s10689-018-0099-x.
52 Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2(low) ATL and various cancer cells.Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118615. doi: 10.1016/j.bbamcr.2019.118615. Epub 2019 Nov 22.
53 Aberrant expression of caspase cascade regulatory genes in adult T-cell leukaemia: survivin is an important determinant for prognosis.Br J Haematol. 2001 Jul;114(1):63-9. doi: 10.1046/j.1365-2141.2001.02902.x.
54 MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells.Biochem Biophys Res Commun. 2018 Jul 2;501(4):833-837. doi: 10.1016/j.bbrc.2018.04.159. Epub 2018 May 19.
55 Decreased RORC expression and downstream signaling in HTLV-1-associated adult T-cell lymphoma/leukemia uncovers an antiproliferative IL17 link: A potential target for immunotherapy?.Int J Cancer. 2019 Apr 1;144(7):1664-1675. doi: 10.1002/ijc.31922. Epub 2018 Dec 18.
56 Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: its implications in the immunodeficient state.Blood. 2001 May 15;97(10):3177-83. doi: 10.1182/blood.v97.10.3177.
57 Serological identification of adult T-cell leukaemia-associated antigens.Br J Haematol. 2005 Aug;130(3):382-90. doi: 10.1111/j.1365-2141.2005.05619.x.
58 HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia.Sci Rep. 2017 Oct 9;7(1):12849. doi: 10.1038/s41598-017-12924-0.
59 Telomere attrition and chromosome instability via downregulation of TRF2 contributes to arsenic trioxide-induced apoptosis of human T-Cell leukemia cell line molt-4 cells.Cancer Biol Ther. 2007 Aug;6(8):1186-92. doi: 10.4161/cbt.6.8.4381. Epub 2007 May 4.
60 Association of high levels of plasma OX40 with acute adult T-cell leukemia.Int J Hematol. 2019 Mar;109(3):319-327. doi: 10.1007/s12185-018-02580-z. Epub 2019 Jan 16.
61 Primary cutaneous T-cell lymphoma: experience from the Peruvian National Cancer Institute.An Bras Dermatol. 2017 Sep-Oct;92(5):649-654. doi: 10.1590/abd1806-4841.20176825.
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