Details of Disease

General Information of Disease (ID: DISVPNPB)

• Disease Name: Retinoblastoma
• Synonyms: eye cancer, retinoblastoma; Rb; RB1; retinoblastoma; RB; retinoblastoma, malignant; RB - retinoblastoma
• Disease Class: 2D02: Retina cancer
• Definition: A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma.
• Disease Hierarchy:
  DISY94YF: Retinal cell cancer
  DISVPNPB: Retinoblastoma
• ICD Code:
  ICD-11: ICD-11: 2D02.2
  ICD-10: ICD-10: C69.2
  Expand ICD-11: '2D02
  Expand ICD-10: 'C69.2
• Disease Identifiers:
  MONDO ID: MONDO_0008380
  MESH ID: D012175
  UMLS CUI: C0035335
  OMIM ID: 180200
  MedGen ID: 20552
  HPO ID: HP:0009919
  Orphanet ID: 790
  SNOMED CT ID: 19906005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Busulfan	DMXYJ9C	Approved	Small molecular drug	[1]
Cyclophosphamide	DM4O2Z7	Approved	Small molecular drug	[2]
Ifosfamide	DMCT3I8	Approved	Small molecular drug	[3]
Melphalan	DMOLNHF	Approved	Small molecular drug	[4]

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PD-0183812	DMWYP86	Terminated	Small molecular drug	[5]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 97 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CCNE1	TTCEJ4F	Limited	Biomarker	[6]
CDH11	TTRGWZC	Limited	Biomarker	[7]
CDKN2C	TTBRUGA	Limited	Biomarker	[8]
CHEK1	TTTU902	Limited	Biomarker	[9]
DEK	TT1NMGV	Limited	Genetic Variation	[10]
DHFR	TTYZVDJ	Limited	Genetic Variation	[11]
EPCAM	TTZ8WH4	Limited	Biomarker	[12]
FOXM1	TTD3KOX	Limited	Altered Expression	[6]
HMGA1	TTBA219	Limited	Biomarker	[13]
HMGB2	TTA78JQ	Limited	Biomarker	[14]
LMO2	TTFX379	Limited	Biomarker	[15]
MDM2	TT9TE0O	Limited	Genetic Variation	[16]
NEK7	TTJ5SWP	Limited	Biomarker	[17]
OAT	TTTSCQ2	Limited	Biomarker	[18]
PCNA	TTLG1PD	Limited	Biomarker	[19]
S100A4	TTPR5SX	Limited	Altered Expression	[20]
SP1	TTZEP6S	Limited	Biomarker	[21]
SUV39H1	TTUWQTK	Limited	Biomarker	[22]
CDK6	TTO0FDJ	Disputed	Biomarker	[23]
SYK	TT2HUPM	Disputed	Biomarker	[24]
TFF1	TTNOJIZ	Disputed	Altered Expression	[25]
KDM5A	TTIG67W	moderate	Genetic Variation	[15]
NEK2	TT3VZ24	moderate	Biomarker	[26]
ODC1	TTUMGNO	moderate	Altered Expression	[27]
ADCYAP1	TTW4LYC	Strong	Biomarker	[28]
ADCYAP1R1	TT5OREU	Strong	Biomarker	[28]
ADRB3	TTMXGCW	Strong	Biomarker	[29]
APC2	TTSMK36	Strong	Altered Expression	[30]
ATAD2	TT9A0HI	Strong	Altered Expression	[31]
ATF3	TTCE793	Strong	Altered Expression	[32]
ATRAID	TTFLIKM	Strong	Biomarker	[8]
BGN	TT0JPVF	Strong	Altered Expression	[33]
CASP5	TTWR48J	Strong	Biomarker	[34]
CCNB1	TT9P6OW	Strong	Altered Expression	[35]
CDC25A	TTLZS4Q	Strong	Biomarker	[36]
CDC25B	TTR0SWN	Strong	Altered Expression	[36]
CDC25C	TTESBNC	Strong	Biomarker	[36]
CDC37	TT5SOEU	Strong	Biomarker	[37]
CDK1	TTH6V3D	Strong	Biomarker	[38]
CDK5	TTL4Q97	Strong	Altered Expression	[39]
CDKN1C	TTBSUAR	Strong	Altered Expression	[40]
CEACAM3	TTPX7I5	Strong	Biomarker	[41]
CHEK2	TT9ABMF	Strong	Altered Expression	[42]
CHRM5	TTH18TF	Strong	Biomarker	[43]
CRHR1	TT7EFHR	Strong	Biomarker	[44]
CRHR2	TTIY658	Strong	Altered Expression	[45]
DDX5	TTZKPVC	Strong	Biomarker	[46]
E2F2	TT5FYX0	Strong	Biomarker	[47]
E2F3	TTWIJYH	Strong	Biomarker	[48]
FAP	TTGPQ0F	Strong	Biomarker	[49]
FOLH1	TT9G4N0	Strong	Altered Expression	[50]
GHRHR	TTG4R8V	Strong	Biomarker	[51]
GJA3	TTFZRG0	Strong	Biomarker	[52]
GRK3	TT5A4DX	Strong	Biomarker	[28]
HDAC1	TT6R7JZ	Strong	Biomarker	[53]
HDGF	TTKGV26	Strong	Altered Expression	[54]
ID2	TTW8A5N	Strong	Altered Expression	[55]
IL2RB	TT9721Y	Strong	Altered Expression	[56]
IL31	TT1RJXK	Strong	Altered Expression	[57]
ILK	TT7ALZG	Strong	Altered Expression	[58]
KDM4A	TTZHPB8	Strong	Altered Expression	[59]
LASP1	TTZJA87	Strong	Biomarker	[60]
LIPG	TTHSZXO	Strong	Biomarker	[61]
LY9	TTZCL1U	Strong	Altered Expression	[62]
LYVE1	TTG8DNU	Strong	Altered Expression	[63]
MAP2K7	TT6QY3J	Strong	Altered Expression	[64]
MCM6	TTQGKSD	Strong	Posttranslational Modification	[65]
MDM4	TT9OUDQ	Strong	Genetic Variation	[66]
MELK	TTBZOTY	Strong	Biomarker	[67]
MMP15	TTNSTO3	Strong	Altered Expression	[68]
MTDH	TTH6SA5	Strong	Biomarker	[69]
MTR	TTUTO39	Strong	Genetic Variation	[70]
NEK6	TT8I2M7	Strong	Biomarker	[71]
NME1	TTDY8JH	Strong	Biomarker	[72]
PDE3B	TTN34SQ	Strong	Altered Expression	[73]
PDK1	TTCZOF2	Strong	Biomarker	[74]
PLK1	TTH4IP0	Strong	Biomarker	[75]
PPM1D	TTENJAB	Strong	Altered Expression	[76]
PPP1CA	TTFLH0E	Strong	Biomarker	[77]
PSIP1	TTH9LDP	Strong	Altered Expression	[56]
PTPN14	TTNIR6C	Strong	Biomarker	[78]
RBBP9	TTUA38Z	Strong	Genetic Variation	[79]
RCVRN	TTDQTEY	Strong	Altered Expression	[80]
REL	TT1ZCTH	Strong	Genetic Variation	[81]
RHO	TTH0KSX	Strong	Altered Expression	[82]
SERPINF1	TTR59S1	Strong	Biomarker	[83]
SKP2	TT5B2EO	Strong	Altered Expression	[27]
SLC19A1	TT09I7D	Strong	Genetic Variation	[84]
SLC26A4	TT7X02I	Strong	Biomarker	[85]
SLC5A6	TT61XTV	Strong	Altered Expression	[86]
SNCG	TT5TQNZ	Strong	Biomarker	[87]
STC2	TT4EFTR	Strong	Altered Expression	[88]
TCF3	TTULOD8	Strong	Altered Expression	[56]
TRIM27	TTTO3QN	Strong	Biomarker	[89]
TRIM59	TT613U4	Strong	Biomarker	[90]
TRPA1	TTELV3W	Strong	Altered Expression	[91]
UBC	TTBP3XA	Strong	Genetic Variation	[92]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A23	DTLQ0EZ	Strong	Altered Expression	[30]

This Disease Is Related to 4 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ASMT	DEHGR57	Strong	Biomarker	[93]
CBR3	DEIVKZ8	Strong	Altered Expression	[94]
NT5C2	DE1DOKJ	Strong	Biomarker	[73]
PGPEP1	DEVDR46	Strong	Biomarker	[95]

This Disease Is Related to 218 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACY1	OT9WU7X3	Limited	Biomarker	[96]
ARR3	OTRZ00CH	Limited	Altered Expression	[97]
CAPN5	OTQ8QM7K	Limited	Altered Expression	[98]
CDKN2B	OTAG24N1	Limited	Altered Expression	[99]
COIL	OTP4I4DL	Limited	Biomarker	[100]
CYFIP2	OTCAY35T	Limited	Biomarker	[79]
E2F4	OTB3JFH4	Limited	Biomarker	[101]
FOXL2	OTFRQUYL	Limited	Altered Expression	[102]
GRB10	OTCKXGRC	Limited	Altered Expression	[103]
H2AX	OT18UX57	Limited	Biomarker	[38]
INTS6	OT6GDV46	Limited	Altered Expression	[104]
KLF6	OTQY9S7F	Limited	Altered Expression	[105]
MRPL28	OT4LUTZU	Limited	Altered Expression	[106]
NXT1	OT0VO6AY	Limited	Altered Expression	[106]
OTUD4	OT7U62SW	Limited	Posttranslational Modification	[107]
OTX2	OTTV05B1	Limited	Biomarker	[108]
PRDM2	OT8L7CGX	Limited	Biomarker	[109]
RB1CC1	OTZK8PFX	Limited	Altered Expression	[100]
RBBP6	OTTVG4HU	Limited	Biomarker	[110]
RBBP7	OTLB56HX	Limited	Biomarker	[111]
RBM45	OTWTHD77	Limited	Posttranslational Modification	[22]
RGCC	OTYJMLWM	Limited	Biomarker	[112]
RNF40	OTC8SDA3	Limited	Biomarker	[113]
SCGB3A1	OTIR98RB	Limited	Posttranslational Modification	[107]
SMAD2	OTC6VB4K	Limited	Biomarker	[114]
SUB1	OTK71JYU	Limited	Altered Expression	[106]
PAX6	OTOC9876	Disputed	Biomarker	[115]
CKS1B	OTNUPLUJ	moderate	Altered Expression	[116]
INSM1	OTG8RV8E	moderate	Biomarker	[117]
PIK3R3	OTXGJ8N1	moderate	Biomarker	[118]
RPL34	OT0U9VMQ	moderate	Biomarker	[15]
THOC1	OTVABJ4Z	moderate	Biomarker	[119]
A2ML1	OTWNUXIS	Strong	Altered Expression	[120]
AANAT	OTUBJ7SX	Strong	Biomarker	[93]
ABCE1	OTH19LOA	Strong	Biomarker	[121]
ACVR1C	OTOTYERF	Strong	Altered Expression	[114]
ADAM19	OTH88TXU	Strong	Biomarker	[122]
AGFG2	OTXQZHCR	Strong	Altered Expression	[123]
AHSA1	OTC7AFHT	Strong	Altered Expression	[124]
AIPL1	OT4VBD78	Strong	Biomarker	[125]
AKAP12	OTCVRDDX	Strong	Biomarker	[126]
AKAP8	OTK3EQAI	Strong	Altered Expression	[127]
ANAPC2	OTAGLIAO	Strong	Altered Expression	[30]
ANOS1	OTZJT4KN	Strong	Altered Expression	[128]
APOC2	OTLINYIQ	Strong	Altered Expression	[30]
ARHGEF1	OTXU4HBW	Strong	Biomarker	[129]
ARID3B	OTUP9MS4	Strong	Biomarker	[130]
ARID4B	OTYLPILE	Strong	Biomarker	[131]
AZIN2	OT8OB7CG	Strong	Biomarker	[132]
BCOR	OTG013AX	Strong	Genetic Variation	[133]
BCORL1	OTPTFQN5	Strong	Genetic Variation	[133]
C1QL1	OTNQ0G3E	Strong	Biomarker	[134]
CADM2	OT45PVKC	Strong	Altered Expression	[135]
CADM3	OTSGOMWB	Strong	Altered Expression	[136]
CBX1	OT2L4XZX	Strong	Biomarker	[137]
CCNA1	OTX4HD45	Strong	Altered Expression	[64]
CCNDBP1	OTBWG1M0	Strong	Altered Expression	[138]
CCNG1	OT17IA9L	Strong	Altered Expression	[139]
CDC73	OT6JASZ1	Strong	Biomarker	[140]
CDCA7	OT12HDZY	Strong	Altered Expression	[141]
CDH17	OT9EV2XK	Strong	Biomarker	[142]
CDKN2D	OT2TTZPZ	Strong	Genetic Variation	[143]
CDKN3	OTBE3H07	Strong	Biomarker	[144]
CDT1	OTVY53VG	Strong	Biomarker	[145]
CDX1	OTOHTMJE	Strong	Altered Expression	[146]
CEACAM7	OTKFDTZY	Strong	Biomarker	[41]
CEMIP	OTK80FYN	Strong	Biomarker	[147]
CEP57	OTPOHLIX	Strong	Altered Expression	[148]
CETN2	OTJTTGS0	Strong	Altered Expression	[149]
CFL1	OTT6D5MH	Strong	Biomarker	[8]
CINP	OTZ31XOT	Strong	Altered Expression	[150]
CLDN8	OT7IIWXG	Strong	Biomarker	[151]
CRB1	OTXYUNG0	Strong	Biomarker	[152]
CUL2	OTPF83PG	Strong	Biomarker	[153]
CUX1	OTU1LCNJ	Strong	Altered Expression	[56]
DAB1	OTPL9MA3	Strong	Posttranslational Modification	[154]
DAXX	OTX6O7PL	Strong	Genetic Variation	[155]
DCT	OTYVNTBG	Strong	Altered Expression	[156]
DDX1	OT3U8FD0	Strong	Altered Expression	[157]
DDX3X	OTDO4TRX	Strong	Biomarker	[46]
DDX53	OTHK3EGZ	Strong	Altered Expression	[158]
DIXDC1	OT87DXEG	Strong	Altered Expression	[159]
DRAM2	OTBOCZH8	Strong	Biomarker	[160]
DUSP2	OTH54FMR	Strong	Biomarker	[28]
E2F5	OT1XWING	Strong	Biomarker	[161]
E2F8	OTQKZGFP	Strong	Biomarker	[101]
EAF1	OTN27MJW	Strong	Biomarker	[162]
EAF2	OTSOET5L	Strong	Biomarker	[162]
EEF1E1	OTRA6XOB	Strong	Biomarker	[8]
EFNA2	OTEAUKRX	Strong	Biomarker	[163]
EI24	OTD4NOYS	Strong	Altered Expression	[148]
ELF1	OTV5LKIA	Strong	Biomarker	[163]
ELF4	OT167PR5	Strong	Biomarker	[164]
ELL2	OTZJRTFM	Strong	Biomarker	[162]
ELOF1	OT8BXS5U	Strong	Biomarker	[163]
ENDOG	OT5IM7B3	Strong	Genetic Variation	[165]
EP400	OTVQ75NX	Strong	Biomarker	[166]
EVPL	OTZIAFEK	Strong	Biomarker	[167]
EXO1	OTI87RS5	Strong	Genetic Variation	[168]
FANCB	OTMZTXB5	Strong	Altered Expression	[169]
FBXW11	OT2A6RLR	Strong	Biomarker	[170]
FUT7	OTJF6BSN	Strong	Altered Expression	[171]
GADL1	OTJM4A0R	Strong	Biomarker	[132]
GDF10	OTEVXGJ7	Strong	Biomarker	[172]
GDF3	OTD3KGJK	Strong	Altered Expression	[114]
GPC6	OTNJBESF	Strong	Genetic Variation	[173]
GTF2H5	OTRL219S	Strong	Biomarker	[174]
HCLS1	OTX7WGYN	Strong	Altered Expression	[56]
HELLS	OTVVV668	Strong	Biomarker	[175]
HLF	OTTRK9XN	Strong	Biomarker	[176]
HOXB5	OTU74TB8	Strong	Biomarker	[177]
KCNIP3	OTCQPEM4	Strong	Biomarker	[178]
KHSRP	OTDHZARB	Strong	Altered Expression	[56]
KIF13A	OTSSZGBQ	Strong	Biomarker	[179]
KIF14	OTXHT4JM	Strong	Biomarker	[180]
KIF4A	OT3UWL7D	Strong	Biomarker	[181]
KPNA2	OTU7FOE6	Strong	Genetic Variation	[182]
LAMTOR1	OTIBJBW9	Strong	Biomarker	[8]
LCP1	OTK61F2A	Strong	Biomarker	[183]
LIN9	OTLHW00C	Strong	Biomarker	[184]
LMNB1	OT100T3P	Strong	Altered Expression	[185]
LMO7	OTDLY6TC	Strong	Altered Expression	[186]
LRG1	OTLD0KWA	Strong	Altered Expression	[187]
MAD2L1	OTXNGZCG	Strong	Altered Expression	[188]
MAFK	OTZJUE4P	Strong	Biomarker	[8]
MCM2	OTGGORIQ	Strong	Biomarker	[189]
MED23	OTKZQT0R	Strong	Biomarker	[190]
MED4	OTALFN4S	Strong	Biomarker	[191]
MIB1	OT5C404P	Strong	Biomarker	[192]
MKKS	OTLF5T11	Strong	Altered Expression	[128]
MMUT	OTBBBV70	Strong	Biomarker	[145]
MPG	OTAHW80B	Strong	Biomarker	[193]
MPZL2	OTKFNDUI	Strong	Biomarker	[85]
MSN	OTZJ4J6G	Strong	Altered Expression	[12]
MXI1	OTUQ9E0D	Strong	Altered Expression	[188]
MYBL2	OTZ3JX8Q	Strong	Altered Expression	[194]
MYCL	OT1MFQ5U	Strong	Biomarker	[195]
MYOD1	OTV2S79X	Strong	Genetic Variation	[196]
MZB1	OT071TET	Strong	Biomarker	[28]
NAPG	OTY4WS64	Strong	Biomarker	[197]
NEUROG1	OTMJZP9G	Strong	Biomarker	[198]
NFE2L1	OT1QHOS2	Strong	Biomarker	[199]
NKTR	OTIADJNW	Strong	Biomarker	[200]
NOL7	OTIJ1KQI	Strong	Altered Expression	[201]
NOVA2	OTQ2X3Q4	Strong	Altered Expression	[154]
NRF1	OTOXWNV8	Strong	Biomarker	[199]
NUP153	OTCAS0AR	Strong	Altered Expression	[202]
NUP205	OTJKHCY6	Strong	Biomarker	[152]
PFDN4	OT5NRHER	Strong	Altered Expression	[203]
PHF20L1	OTCLYOCL	Strong	Posttranslational Modification	[204]
PI3	OT47MTC3	Strong	Biomarker	[205]
PIAS4	OTB7SVMZ	Strong	Biomarker	[206]
PIGF	OTJKE6VW	Strong	Altered Expression	[207]
PIWIL1	OT7CRGZ3	Strong	Biomarker	[108]
PIWIL4	OTDA9MY0	Strong	Biomarker	[108]
PLAGL1	OTZAO900	Strong	Biomarker	[92]
PLK3	OT19CT2Z	Strong	Altered Expression	[208]
POLD1	OTWO4UCJ	Strong	Altered Expression	[165]
POLDIP2	OT8SZSJ6	Strong	Altered Expression	[124]
PPM1K	OTNZ4N4E	Strong	Biomarker	[130]
PRAP1	OT48QD82	Strong	Genetic Variation	[209]
PRB1	OTV0SYMD	Strong	Biomarker	[210]
PRB2	OTAD4JZ0	Strong	Altered Expression	[211]
PRC1	OTHD0XS0	Strong	Altered Expression	[212]
PRDM1	OTQLSVBS	Strong	Biomarker	[213]
PRDM16	OT0BGA27	Strong	Biomarker	[213]
PSG2	OT2EIXAI	Strong	Biomarker	[41]
PSMG1	OTZ5I6UM	Strong	Biomarker	[28]
PTGES3	OTPPQWI0	Strong	Biomarker	[214]
PTPN12	OT5WA666	Strong	Altered Expression	[215]
RALGAPB	OTY8CGA3	Strong	Altered Expression	[120]
RASSF6	OT25GVWY	Strong	Biomarker	[216]
RBBP4	OTG3BT3M	Strong	Genetic Variation	[217]
RBBP8	OTRHJ3GI	Strong	Biomarker	[34]
RBL1	OTDEBFYC	Strong	Biomarker	[218]
RBMY1A1	OTM2F25H	Strong	Biomarker	[219]
RBP1	OTRP1MFC	Strong	Biomarker	[130]
RBP2	OTR8QG5V	Strong	Biomarker	[130]
RBP3	OTIWM4GT	Strong	Altered Expression	[220]
RECQL4	OT59LSW7	Strong	Biomarker	[221]
RFC1	OT3L5PK3	Strong	Genetic Variation	[84]
RGPD2	OTMUZ0HX	Strong	Altered Expression	[123]
RPE	OT0XT3JU	Strong	Biomarker	[222]
RPS27A	OTIIGGZ2	Strong	Genetic Variation	[92]
RRAS	OTBBF28C	Strong	Biomarker	[214]
SAG	OTDNS3ZQ	Strong	Biomarker	[223]
SEMA6A	OTDQ7QAW	Strong	Biomarker	[224]
SH2B1	OTJZO2CI	Strong	Altered Expression	[50]
SH3BP4	OTVIRKW7	Strong	Altered Expression	[225]
SIGLEC7	OTNDLURR	Strong	Altered Expression	[56]
SIN3A	OTM8OZWV	Strong	Biomarker	[226]
SMARCA1	OT0Y6PTU	Strong	Biomarker	[227]
SMURF2	OT3TRVL7	Strong	Altered Expression	[228]
SOX17	OT9H4WWE	Strong	Biomarker	[8]
SRCAP	OT82P6CN	Strong	Biomarker	[162]
SRGAP2	OTUWFMCQ	Strong	Altered Expression	[229]
SRSF3	OTOFT707	Strong	Biomarker	[7]
STX17	OT8TUN64	Strong	Biomarker	[197]
SUCLA2	OTMZD4PW	Strong	Genetic Variation	[230]
TBCEL	OT2PZLLL	Strong	Biomarker	[154]
TBPL2	OTDEC1KO	Strong	Altered Expression	[231]
TBX5	OT70PISV	Strong	Biomarker	[170]
TCF19	OT7NKLF9	Strong	Altered Expression	[40]
TFAP2B	OTR1T8E9	Strong	Posttranslational Modification	[232]
TFDP1	OT6RZ7VT	Strong	Altered Expression	[233]
TFF2	OTRXB19X	Strong	Altered Expression	[234]
TFF3	OTJJDRTU	Strong	Biomarker	[235]
TIGAR	OTR7NMRJ	Strong	Biomarker	[236]
TMED10	OTUXSHH7	Strong	Biomarker	[214]
TOPBP1	OT6UPZPD	Strong	Genetic Variation	[237]
TPPP2	OTI3WA6X	Strong	Biomarker	[8]
TRIP11	OT4FJEAR	Strong	Biomarker	[238]
CASK	OT8EF7ZF	Definitive	Biomarker	[239]
CEBPD	OTNBIPMY	Definitive	Altered Expression	[240]
NOLC1	OTKDZU0D	Definitive	Altered Expression	[241]
RAB3GAP1	OT4DQ8F2	Definitive	Altered Expression	[241]
RB1	OTQJUJMZ	Definitive	Autosomal dominant	[242]
RBL2	OTBQSOE6	Definitive	Altered Expression	[241]

References

• [1] Busulfan FDA Label
• [2] Cyclophosphamide FDA Label
• [3] Ifosfamide FDA Label
• [4] Melphalan FDA Label
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014130)
• [6] Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer.Cancers (Basel). 2019 Feb 21;11(2):251. doi: 10.3390/cancers11020251.
• [7] Genomic landscape of retinoblastoma in Rb(-/-) p130(-/-) mice resembles human retinoblastoma.Genes Chromosomes Cancer. 2017 Mar;56(3):231-242. doi: 10.1002/gcc.22429. Epub 2016 Nov 21.
• [8] The effect of miR-340 over-expression on cell-cycle-related genes in triple-negative breast cancer cells.Eur J Cancer Care (Engl). 2017 Nov;26(6). doi: 10.1111/ecc.12496. Epub 2016 May 27.
• [9] Dnmt1-dependent Chk1 pathway suppression is protective against neuron division.Development. 2017 Sep 15;144(18):3303-3314. doi: 10.1242/dev.154013.
• [10] Profiling genomic copy number changes in retinoblastoma beyond loss of RB1.Genes Chromosomes Cancer. 2007 Feb;46(2):118-29. doi: 10.1002/gcc.20383.
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