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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8308).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8182).
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Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats. Pharmacol Biochem Behav. 2013 Apr;105:41-50.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030225)
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Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001264)
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6452).
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ClinicalTrials.gov (NCT01246908) Efficacy, Safety and Tolerability of CX157 in Treatment Resistant Depression. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015473)
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Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study. Aliment Pharmacol Ther.2012 Feb;35(3):360-7.
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3219).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 568).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 199).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 108).
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009248)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014469)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001441)
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Dopaminergic mechanisms of reinstatement of MDMA-seeking behaviour in rats. Br J Pharmacol. 2011 Apr;162(8):1770-80.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034342)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010517)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025127)
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Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001731)
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Direct Involvement of Androgen Receptor in Oxytocin Gene Expression: Possible Relevance for Mood Disorders.Neuropsychopharmacology. 2017 Sep;42(10):2064-2071. doi: 10.1038/npp.2017.76. Epub 2017 Apr 27.
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CRY2 genetic variants associate with dysthymia.PLoS One. 2013 Aug 8;8(8):e71450. doi: 10.1371/journal.pone.0071450. eCollection 2013.
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Analysis of Lithuanian CYP2D6 polymorphism and its relevance to psychiatric care of the local population.Nord J Psychiatry. 2019 Jan;73(1):31-35. doi: 10.1080/08039488.2018.1548648. Epub 2019 Jan 19.
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Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain.Mol Psychiatry. 2014 Dec;19(12):1258-66. doi: 10.1038/mp.2013.165. Epub 2013 Dec 10.
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Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders.J Psychiatry Neurosci. 2011 May;36(3):195-203. doi: 10.1503/jpn.100048.
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GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders.PLoS One. 2016 Feb 5;11(2):e0148558. doi: 10.1371/journal.pone.0148558. eCollection 2016.
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Genetic Studies on the Tripartite Glutamate Synapse in the Pathophysiology and Therapeutics of Mood Disorders.Neuropsychopharmacology. 2017 Mar;42(4):787-800. doi: 10.1038/npp.2016.149. Epub 2016 Aug 11.
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Genetic association, mutation screening, and functional analysis of a Kozak sequence variant in the metabotropic glutamate receptor 3 gene in bipolar disorder.JAMA Psychiatry. 2013 Jun;70(6):591-8. doi: 10.1001/jamapsychiatry.2013.38.
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Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour.Neuropharmacology. 2019 Sep 15;156:107527. doi: 10.1016/j.neuropharm.2019.02.009. Epub 2019 Feb 10.
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Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood.Depress Anxiety. 2010 Aug;27(8):752-9. doi: 10.1002/da.20726.
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Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis.Neurosci Res. 2010 Jul;67(3):250-5. doi: 10.1016/j.neures.2010.04.003. Epub 2010 Apr 13.
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Whole Exome Sequencing Identifies a Novel Predisposing Gene, MAPKAP1, for Familial Mixed Mood Disorder.Front Genet. 2019 Feb 15;10:74. doi: 10.3389/fgene.2019.00074. eCollection 2019.
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Neurotrophin 3 genotype and emotional adverse effects of osmotic-release oral system methylphenidate (OROS-MPH) in children with attention-deficit/hyperactivity disorder.J Psychopharmacol. 2014 Mar;28(3):220-6. doi: 10.1177/0269881113480989. Epub 2013 Mar 7.
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Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.Nat Genet. 2010 Feb;42(2):128-31. doi: 10.1038/ng.523. Epub 2010 Jan 17.
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Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.Mol Psychiatry. 2020 Oct;25(10):2410-2421. doi: 10.1038/s41380-018-0218-y. Epub 2018 Aug 16.
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Targeting Hormones for Improving Cognition in Major Mood Disorders and Schizophrenia: Thyroid Hormones and Prolactin.Clin Drug Investig. 2020 Jan;40(1):1-14. doi: 10.1007/s40261-019-00854-w.
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The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder.Mol Neurobiol. 2018 Dec;55(12):8885-8903. doi: 10.1007/s12035-018-1016-x. Epub 2018 Apr 2.
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Maternal depression and anxiety are associated with altered gene expression in the human placenta without modification by antidepressant use: implications for fetal programming.Dev Psychobiol. 2011 Nov;53(7):711-23. doi: 10.1002/dev.20549. Epub 2011 May 5.
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Association study of adenosine A2a receptor (1976C>T) genetic polymorphism and mood disorders and age of onset.Psychiatr Genet. 2006 Oct;16(5):185. doi: 10.1097/01.ypg.0000218627.26622.eb.
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Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families.Am J Med Genet B Neuropsychiatr Genet. 2006 Apr 5;141B(3):227-33. doi: 10.1002/ajmg.b.30292.
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Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses.Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R209-22. doi: 10.1152/ajpregu.00099.2006. Epub 2007 Mar 15.
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CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype.Int J Neuropsychopharmacol. 2010 May;13(4):499-513. doi: 10.1017/S1461145709990368. Epub 2009 Aug 11.
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CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study.Hum Mol Genet. 2005 Aug 15;14(16):2421-34. doi: 10.1093/hmg/ddi244. Epub 2005 Jul 6.
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(2A)-Adrenergic Receptor Activation Decreases Parabrachial Nucleus Excitatory Drive onto BNST CRF Neurons and Reduces Their Activity In Vivo.J Neurosci. 2019 Jan 16;39(3):472-484. doi: 10.1523/JNEUROSCI.1035-18.2018. Epub 2018 Nov 26.
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A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders.J Neural Transm (Vienna). 2009 Feb;116(2):121-30. doi: 10.1007/s00702-008-0138-0. Epub 2008 Nov 4.
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Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females.Brain Sci. 2018 Dec 7;8(12):219. doi: 10.3390/brainsci8120219.
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Childhood trauma in mood disorders: Neurobiological mechanisms and implications for treatment.Pharmacol Rep. 2019 Feb;71(1):112-120. doi: 10.1016/j.pharep.2018.10.004. Epub 2018 Oct 11.
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Depressive disorder moderates the effect of the FTO gene on body mass index.Mol Psychiatry. 2012 Jun;17(6):604-11. doi: 10.1038/mp.2011.45. Epub 2011 Apr 19.
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Gene expression of GABA and glutamate pathway markers in the prefrontal cortex of non-suicidal elderly depressed patients.J Affect Disord. 2012 May;138(3):494-502. doi: 10.1016/j.jad.2012.01.013. Epub 2012 Feb 21.
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Association of the GABRD gene and childhood-onset mood disorders.Genes Brain Behav. 2010 Aug;9(6):668-72. doi: 10.1111/j.1601-183X.2010.00598.x. Epub 2010 Jun 18.
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Early parental deprivation in the marmoset monkey produces long-term changes in hippocampal expression of genes involved in synaptic plasticity and implicated in mood disorder.Neuropsychopharmacology. 2009 May;34(6):1381-94. doi: 10.1038/npp.2008.106. Epub 2008 Jul 9.
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Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depression.Eur J Neurosci. 2008 Apr;27(8):2156-64. doi: 10.1111/j.1460-9568.2008.06155.x. Epub 2008 Mar 25.
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A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.PLoS One. 2013 Aug 14;8(8):e71323. doi: 10.1371/journal.pone.0071323. eCollection 2013.
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Altered gene expression of histone deacetylases in mood disorder patients.J Psychiatr Res. 2010 Apr;44(5):263-70. doi: 10.1016/j.jpsychires.2009.08.015. Epub 2009 Sep 19.
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Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders.Neurosci Lett. 2015 Jan 12;585:132-7. doi: 10.1016/j.neulet.2014.11.002. Epub 2014 Nov 6.
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Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens.Sci Transl Med. 2010 Oct 20;2(54):54ra76. doi: 10.1126/scitranslmed.3001079.
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5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor.Neuropharmacology. 2009 Feb;56(2):448-54. doi: 10.1016/j.neuropharm.2008.09.014. Epub 2008 Oct 7.
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Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse.PLoS One. 2013 Sep 3;8(9):e73902. doi: 10.1371/journal.pone.0073902. eCollection 2013.
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Alteration of working memory but not in anxiety or stress response in p300/CBP associated factor (PCAF) histone acetylase knockout mice bred on a C57BL/6 background.Neurosci Lett. 2010 May 21;475(3):179-83. doi: 10.1016/j.neulet.2010.03.077. Epub 2010 Apr 4.
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TASK-3 as a potential antidepressant target.Brain Res. 2011 Oct 6;1416:69-79. doi: 10.1016/j.brainres.2011.08.021. Epub 2011 Aug 16.
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Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.Nat Genet. 2018 Jul;50(7):920-927. doi: 10.1038/s41588-018-0151-7. Epub 2018 Jun 25.
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Regrowing the adult brain: NF-B controls functional circuit formation and tissue homeostasis in the dentate gyrus.PLoS One. 2012;7(2):e30838. doi: 10.1371/journal.pone.0030838. Epub 2012 Feb 1.
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Association of the neurotrophic tyrosine kinase receptor 3 (NTRK3) gene and childhood-onset mood disorders.Am J Psychiatry. 2008 May;165(5):610-6. doi: 10.1176/appi.ajp.2007.07050805. Epub 2008 Mar 17.
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Altered sleep and affect in the neurotensin receptor 1 knockout mouse.Sleep. 2012 Jul 1;35(7):949-56. doi: 10.5665/sleep.1958.
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Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140).J Med Chem. 2019 Feb 28;62(4):1761-1780. doi: 10.1021/acs.jmedchem.8b01679. Epub 2019 Feb 13.
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Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPAR.Hum Mol Genet. 2014 Aug 1;23(15):4094-102. doi: 10.1093/hmg/ddu126. Epub 2014 Mar 20.
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The involvement of retinoic acid receptor-alpha in corticotropin-releasing hormone gene expression and affective disorders.Biol Psychiatry. 2009 Nov 1;66(9):832-9. doi: 10.1016/j.biopsych.2009.05.031. Epub 2009 Jul 12.
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Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.FASEB J. 2014 Apr;28(4):1735-44. doi: 10.1096/fj.13-235648. Epub 2014 Jan 13.
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Altered sirtuin deacetylase gene expression in patients with a mood disorder.J Psychiatr Res. 2011 Aug;45(8):1106-12. doi: 10.1016/j.jpsychires.2011.01.016. Epub 2011 Feb 23.
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Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders.J Neurosci. 2012 Apr 11;32(15):5216-22. doi: 10.1523/JNEUROSCI.4626-11.2012.
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Monitoring cholinergic activity during attentional performance in mice heterozygous for the choline transporter: a model of cholinergic capacity limits.Neuropharmacology. 2013 Dec;75:274-85. doi: 10.1016/j.neuropharm.2013.07.032. Epub 2013 Aug 16.
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Dopamine transporter (DAT) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice.Behav Brain Res. 2019 Feb 1;359:104-115. doi: 10.1016/j.bbr.2018.10.028. Epub 2018 Oct 24.
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Somatostatin, neuronal vulnerability and behavioral emotionality.Mol Psychiatry. 2015 Mar;20(3):377-87. doi: 10.1038/mp.2014.184. Epub 2015 Jan 20.
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Long-term alterations to the brain transcriptome in a maternal voluntary consumption model of fetal alcohol spectrum disorders.Brain Res. 2012 Jun 6;1458:18-33. doi: 10.1016/j.brainres.2012.04.016. Epub 2012 Apr 17.
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Reduced adult neurogenesis and altered emotional behaviors in autoimmune-prone B-cell activating factor transgenic mice.Biol Psychiatry. 2010 Mar 15;67(6):558-66. doi: 10.1016/j.biopsych.2009.12.008.
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Variants within the GABA transaminase (ABAT) gene region are associated with somatosensory evoked EEG potentials in families at high risk for affective disorders.Psychol Med. 2013 Jun;43(6):1207-17. doi: 10.1017/S0033291711002923. Epub 2012 Jan 9.
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Genetic markers of comorbid depression and alcoholism in women.Alcohol Clin Exp Res. 2013 Jun;37(6):896-904. doi: 10.1111/acer.12060. Epub 2012 Dec 27.
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An association of AKT1 gene polymorphism with antidepressant treatment response.World J Biol Psychiatry. 2016 Apr;17(3):239-42. doi: 10.3109/15622975.2015.1112921. Epub 2015 Dec 16.
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Amelioration of apelin-13 in chronic normobaric hypoxia-induced anxiety-like behavior is associated with an inhibition of NF-B in the hippocampus.Brain Res Bull. 2017 Apr;130:67-74. doi: 10.1016/j.brainresbull.2017.01.005. Epub 2017 Jan 5.
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Metallomics-based platforms for comparing the human blood serum profiles between bipolar disorder and schizophrenia patients.Rapid Commun Mass Spectrom. 2020 Sep;34 Suppl 3:e8698. doi: 10.1002/rcm.8698. Epub 2020 Feb 18.
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CACNA1C risk variant affects microstructural connectivity of the amygdala.Neuroimage Clin. 2019;22:101774. doi: 10.1016/j.nicl.2019.101774. Epub 2019 Mar 12.
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The unappreciated roles of the cholecystokinin receptor CCK(1) in brain functioning.Rev Neurosci. 2017 Jul 26;28(6):573-585. doi: 10.1515/revneuro-2016-0088.
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Characterization and gonadal hormone regulation of a sexually dimorphic corticotropin-releasing factor receptor 1 cell group.J Comp Neurol. 2019 Apr 15;527(6):1056-1069. doi: 10.1002/cne.24588. Epub 2018 Dec 24.
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Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression.Transl Psychiatry. 2017 Dec 8;7(12):1269. doi: 10.1038/s41398-017-0023-4.
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Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.Neuropsychopharmacology. 2010 May;35(6):1279-89. doi: 10.1038/npp.2009.230. Epub 2010 Jan 13.
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Significant role of gene-gene interactions of clock genes in mood disorder.J Affect Disord. 2019 Oct 1;257:510-517. doi: 10.1016/j.jad.2019.06.056. Epub 2019 Jul 2.
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State-dependent changes in the expression of DNA methyltransferases in mood disorder patients.J Psychiatr Res. 2011 Oct;45(10):1295-300. doi: 10.1016/j.jpsychires.2011.04.008. Epub 2011 May 17.
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Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans.PLoS Med. 2014 Nov 11;11(11):e1001755. doi: 10.1371/journal.pmed.1001755. eCollection 2014 Nov.
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Impact of adolescent GluA1 AMPA receptor ablation in forebrain excitatory neurons on behavioural correlates of mood disorders.Eur Arch Psychiatry Clin Neurosci. 2014 Oct;264(7):625-9. doi: 10.1007/s00406-014-0509-5. Epub 2014 Jun 4.
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A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort.World J Biol Psychiatry. 2019 Jun;20(5):393-401. doi: 10.1080/15622975.2017.1417637. Epub 2018 Jan 11.
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A systematic review of the antidepressant effects of glucagon-like peptide 1 (GLP-1) functional agonists: Further link between metabolism and psychopathology: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.J Affect Disord. 2019 Oct 1;257:S0165-0327(19)30593-2. doi: 10.1016/j.jad.2019.05.044. Epub 2019 May 28.
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