Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1Z74X)

Drug Name
Tacedinaline Drug Info
Synonyms
Acetyldinaline; Tacedinalina; Goe 5549; PD 123654; Ci-994; Goe-5549; PD-123654; Tacedinalina [INN-Spanish]; Tacedinaline [USAN:INN]; C.I. 994; Tacedinaline (USAN/INN); 4-(Acetylamino)-N-(2-aminophenyl)benzamide; 4-acetamido-N-(2-aminophenyl)benzamide; 4-acetamido-n-(2-aminophenyl)benzamid; 4-acetylamino-N-(2'-aminophenyl)benzamide
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
2746
ChEBI ID
CHEBI:90195
CAS Number
CAS 112522-64-2
TTD Drug ID
DM1Z74X

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histone deacetylase 1 (HDAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [4]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [5]
Panobinostat DM58WKG Chronic graft versus host disease Approved [4]
HBI-8000 DMDWYUN Non-small-cell lung cancer 2C25.Y Registered [6]
ITF2357 DMFZBNE Duchenne dystrophy 8C70 Phase 3 [7]
NVP-LAQ824 DM8JWNA Mood disorder 6A60-6E23 Phase 3 [8]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [9]
Phenylbutyrate DMBHPDW Urea cycle disorder 5C50.A Phase 2 [10]
MGCD-0103 DM726HX Non-small-cell lung cancer 2C25.Y Phase 2 [4]
Resminostat DMNE1FR Hepatocellular carcinoma 2C12.02 Phase 2 [11]
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Drug(s) Affected By Putative POTE ankyrin domain family member M (POTEM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Testosterone DM7HUNW Hot flushes GA30 Approved [13]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [13]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [3]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [3]
Nabiximols DMHKJ5I Cancer related pain MG30 Phase 3 [15]
MGCD-0103 DM726HX Non-small-cell lung cancer 2C25.Y Phase 2 [3]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [16]
Scriptaid DM9JZ21 Solid tumour/cancer 2A00-2F9Z Preclinical [3]
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Drug(s) Affected By Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Testosterone DM7HUNW Hot flushes GA30 Approved [13]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [13]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [22]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [23]
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Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [25]
Gefitinib DM15F0X Colon adenocarcinoma Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Selenium DM25CGV N. A. N. A. Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [29]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [32]
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Drug(s) Affected By Glycine dehydrogenase (GLDC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [34]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [38]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [40]
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Drug(s) Affected By Interleukin-3 receptor subunit alpha (IL3RA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [3]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [42]
Urethane DM7NSI0 N. A. N. A. Phase 4 [43]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [42]
Drug(s) Affected By G-protein coupled receptor 183 (GPR183)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Panobinostat DM58WKG Chronic graft versus host disease Approved [3]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [3]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [45]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [48]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [3]
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Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Fluoxetine DM3PD2C Bipolar depression Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [53]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [34]
Leflunomide DMR8ONJ Arthritis FA20 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
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Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [57]
Leflunomide DMR8ONJ Arthritis FA20 Approved [54]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [57]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [57]
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Drug(s) Affected By Transcriptional protein SWT1 (SWT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [58]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [58]
Arsenic DMTL2Y1 N. A. N. A. Approved [59]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [48]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [60]
Urethane DM7NSI0 N. A. N. A. Phase 4 [43]
PEITC DMOMN31 Prostate cancer 2C82.0 Phase 2 [61]
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Drug(s) Affected By Centrosomal protein of 68 kDa (CEP68)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Leflunomide DMR8ONJ Arthritis FA20 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [62]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [63]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [64]
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Drug(s) Affected By Sialidase-1 (NEU1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Fluoxetine DM3PD2C Bipolar depression Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Panobinostat DM58WKG Chronic graft versus host disease Approved [3]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [66]
Arsenic DMTL2Y1 N. A. N. A. Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [67]
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Drug(s) Affected By PH and SEC7 domain-containing protein 3 (PSD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [71]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [22]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
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Drug(s) Affected By Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Panobinostat DM58WKG Chronic graft versus host disease Approved [3]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [71]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [77]
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Drug(s) Affected By ERBB receptor feedback inhibitor 1 (ERRFI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [13]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [13]
Leflunomide DMR8ONJ Arthritis FA20 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [3]
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Drug(s) Affected By Transmembrane and coiled-coil domain protein 3 (TMCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [13]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [13]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [60]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [3]
Bleomycin DMNER5S Cervical cancer 2C77.0 Approved [3]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [82]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [83]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [60]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [83]
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Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [85]
Leflunomide DMR8ONJ Arthritis FA20 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [38]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [86]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone deacetylase 1 (HDAC1) TT6R7JZ HDAC1_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Centrosomal protein of 68 kDa (CEP68) OTZDM4J1 CEP68_HUMAN Gene/Protein Processing [3]
Ceramide glucosyltransferase OTRT5P5I CEGT_HUMAN Gene/Protein Processing [3]
Enhancer of filamentation 1 (NEDD9) OTGCFN4M CASL_HUMAN Gene/Protein Processing [3]
ERBB receptor feedback inhibitor 1 (ERRFI1) OT7VZ2IZ ERRFI_HUMAN Gene/Protein Processing [3]
G-protein coupled receptor 183 (GPR183) OTRILX7G GP183_HUMAN Gene/Protein Processing [3]
Glycine dehydrogenase (GLDC) OTVVDNW0 GCSP_HUMAN Gene/Protein Processing [3]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Gene/Protein Processing [3]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Gene/Protein Processing [3]
Interleukin-3 receptor subunit alpha (IL3RA) OTDC3Y8O IL3RA_HUMAN Gene/Protein Processing [3]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Gene/Protein Processing [3]

References

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45 Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
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