Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3JDRP)

Drug Name
Cladribine Drug Info
Synonyms
Chlorodeoxyadenosine; Cladarabine; Cladaribine; Cladribina; Cladribinum; CldAdo; Leustat; Leustatin; Litak; Movectro;Mylinax; CL9; RWJ 26251; Leustatin (TN); RWJ-26251; Cladribine [USAN:INN:BAN]; RWJ-26251-000; Cladribine (JAN/USAN/INN); Leustatin, 2-chlorodeoxyadenosine, Cladribine; Adenosine, 2-chloro-2'-deoxy; (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol; 2 Chlorodeoxyadenosine; 2'-Deoxy-2-chloroadenosine; 2-CdA; 2-Chloro-2'-deoxy-beta-adenosine; 2-Chloro-2'-deoxyadenosine; 2-Chloro-6-amino-9-(2-deoxy-beta-D-erythropentofuranosyl)purine; 2-Chlorodeoxyadenosine; 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine; 2-chloro-deoxyadenosine
Indication
Disease Entry ICD 11 Status REF
Hairy cell leukaemia 2A82.2 Approved [1]
Multiple sclerosis 8A40 Phase 3 [2]
Relapsing-remitting multiple sclerosis 8A40.0 Phase 3 [3]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
20279
ChEBI ID
CHEBI:567361
CAS Number
CAS 4291-63-8
TTD Drug ID
DM3JDRP
VARIDT Drug ID
DR00087
INTEDE Drug ID
DR1918
ACDINA Drug ID
D00951

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adenosine deaminase (ADA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Elapegademase DMS7OU8 Adenosine deaminase defciency 4A01.1 Approved [15]
Fludarabine DMVRLT7 Acute myelogenous leukaemia 2A41 Approved [16]
Pentostatin DM0HXDS Acute graft versus host disease 4B24.0 Approved [16]
GSK2696273 DMP5O1U Chronic pain MG30 Preregistration [17]
OTL-101 DMLMS6J Severe combined immunodeficiency 4A01.10 Phase 3 [18]
Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy DMIREUZ Immunodeficiency 4A00-4A85 Phase 1/2 [17]
EHNA DM014WS Discovery agent N.A. Investigative [19]
3-(6-Amino-purin-9-yl)-6-phenyl-hexan-2-ol DMZT8QX Discovery agent N.A. Investigative [20]
3-(6-Amino-purin-9-yl)-8-phenyl-octan-2-ol DMAIS1D Discovery agent N.A. Investigative [20]
1-Deaza-Adenosine DMG0VN6 Discovery agent N.A. Investigative [21]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [24]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
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Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [34]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [36]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [37]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [38]
Propranolol DM79NTF Angina pectoris BA40 Approved [39]
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Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Folic Acid DMEMBJC Colorectal carcinoma Approved [41]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [42]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [43]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [44]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [45]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [46]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [47]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [6]
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Drug(s) Transported By Equilibrative nucleoside transporter 3 (SLC29A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
tubercidin DMHICK8 Discovery agent N.A. Investigative [5]
cordycepin DM72Y01 Discovery agent N.A. Investigative [5]
Drug(s) Metabolized By Deoxycytidine kinase (DCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [48]
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [49]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [50]
Fructose DM43AN2 Vomiting MD90 Approved [51]
Ketoprofen DMRKXPT Bursitis Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [53]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [54]
Gefitinib DM15F0X Colon adenocarcinoma Approved [55]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [62]
Paclitaxel DMLB81S Breast carcinoma Approved [63]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [64]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [66]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
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Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [68]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [69]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [70]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [71]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [72]
Prednisone DM2HG4X Acute asthma CA23 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Gefitinib DM15F0X Colon adenocarcinoma Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [80]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [81]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [82]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [81]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [83]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [86]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [87]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [89]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [90]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [94]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [92]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [95]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [96]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [97]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [98]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Verapamil DMA7PEW Angina pectoris BA40 Approved [99]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [100]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [53]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [101]
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Drug(s) Affected By Lamin-B1 (LMNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [107]
Testosterone DM7HUNW Hot flushes GA30 Approved [108]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
Leflunomide DMR8ONJ Arthritis FA20 Approved [109]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [110]
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Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [113]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [116]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [118]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [119]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [120]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [121]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [122]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [123]
Gefitinib DM15F0X Colon adenocarcinoma Approved [124]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Prednisone DM2HG4X Acute asthma CA23 Approved [128]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [82]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [129]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [131]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [133]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [137]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [138]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [139]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [141]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [62]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [142]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [143]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [144]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [145]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [146]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [147]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [149]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [151]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [152]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [152]
Methotrexate DM2TEOL Anterior urethra cancer Approved [153]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [104]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [154]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [155]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [156]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [157]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [100]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [158]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [159]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [80]
Meloxicam DM2AR7L Arthritis FA20 Approved [160]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [161]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [162]
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Drug(s) Affected By Caspase-6 (CASP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [165]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [166]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [168]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [169]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [170]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [171]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [173]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [174]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [175]
Testosterone DM7HUNW Hot flushes GA30 Approved [176]
Leflunomide DMR8ONJ Arthritis FA20 Approved [109]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [177]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [178]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [179]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Gefitinib DM15F0X Colon adenocarcinoma Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [181]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [80]
Selenium DM25CGV N. A. N. A. Approved [182]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [161]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
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Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [184]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [120]
Testosterone enanthate DMB6871 N. A. N. A. Approved [185]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [186]
Ethanol DMDRQZU Chronic pain MG30 Approved [187]
Clozapine DMFC71L Schizophrenia 6A20 Approved [188]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [189]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [190]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [191]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenosine deaminase (ADA) TTLP57V ADA_HUMAN Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Equilibrative nucleoside transporter 3 (SLC29A3) DTZAWTH S29A3_HUMAN Substrate [5]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [6]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [6]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Deoxycytidine kinase (DCK) Main DME DE9FGNK DCK_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [9]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [10]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Gene/Protein Processing [10]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [11]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [10]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [10]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [12]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [13]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Gene/Protein Processing [13]
Histone-lysine N-methyltransferase 2A (KMT2A) OT9GLJI6 KMT2A_HUMAN Drug Response [14]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4799).
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Cladribine: from the bench to the bedside--focus on hairy cell leukemia. Expert Rev Anticancer Ther. 2004 Oct;4(5):745-57.
5 Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005 Apr 22;280(16):15880-7.
6 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
7 Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. Mol Cancer Ther. 2008 Sep;7(9):3092-102.
8 Potential mechanisms of action related to the efficacy and safety of cladribine. Mult Scler Relat Disord. 2019 May;30:176-186.
9 2-Chlorodeoxyadenosine alone and in combination with cyclophosphamide and mitoxantrone induce apoptosis in B chronic lymphocytic leukemia cells in vivo. Cancer Detect Prev. 2004;28(6):433-42. doi: 10.1016/j.cdp.2004.08.001.
10 Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria. Biochem J. 2001 Nov 1;359(Pt 3):537-46. doi: 10.1042/0264-6021:3590537.
11 Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. Biochem Pharmacol. 2003 Sep 1;66(5):711-24. doi: 10.1016/s0006-2952(03)00410-6.
12 Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation. Arch Toxicol. 2022 Jul;96(7):1975-1987. doi: 10.1007/s00204-022-03291-5. Epub 2022 Apr 18.
13 Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br J Nutr. 2012 Mar;107(6):781-90. doi: 10.1017/S0007114511003631. Epub 2011 Aug 1.
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