Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4N2O0)

Drug Name

Apilimod dimesylate Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Non-hodgkin lymphoma	2B33.5	Phase 2	[1]

Cross-matching ID

PubChem CID: 11527330
CAS Number: CAS 870087-36-8
TTD Drug ID: DM4N2O0

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

Approved Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Phosphatidylinositol-3-phosphate 5-kinase (PIP5K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LAM-002	DMR0N74	Chronic lymphocytic leukaemia	2A82.0	Phase 2	[1]
YM-201636	DMU86XT	Discovery agent	N.A.	Preclinical	[5]
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Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[6]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[7]
Fructose	DM43AN2	Vomiting	MD90	Approved	[8]
Ketoprofen	DMRKXPT	Bursitis		Approved	[8]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[9]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[10]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[11]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[12]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
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Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[15]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[16]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[17]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[24]
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Drug(s) Affected By Keratin, type I cytoskeletal 16 (KRT16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[29]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[35]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[36]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[38]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[39]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[43]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[41]
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Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[16]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[46]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[50]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[51]
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Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[52]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[55]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[56]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[57]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[58]
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Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[59]
Indomethacin	DMSC4A7	Bursitis		Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[67]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[68]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[73]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
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Drug(s) Affected By Next to BRCA1 gene 1 protein (NBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[85]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[86]
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Drug(s) Affected By Interleukin-17A (IL17A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[20]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[51]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[90]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[91]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[92]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[95]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[98]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[85]
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Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[20]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[100]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[101]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[100]
Bortezomib	DMNO38U	Leukemia		Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[85]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[100]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[100]
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Drug(s) Affected By Sorting nexin-10 (SNX10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[98]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[59]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[108]
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Drug(s) Affected By Transcription factor EB (TFEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[110]
Prochlorperazine	DM53SRA	Nausea	MD90	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]
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Drug(s) Affected By H(+)/Cl(-) exchange transporter 7 (CLCN7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[117]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[118]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[119]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]
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Drug(s) Affected By Osteopetrosis-associated transmembrane protein 1 (OSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[124]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[126]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphatidylinositol-3-phosphate 5-kinase (PIP5K3)	TTA4M1N	FYV1_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
H(+)/Cl(-) exchange transporter 7 (CLCN7)	OTJVSUK1	CLCN7_HUMAN	Drug Response	[2]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Gene/Protein Processing	[3]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Gene/Protein Processing	[3]
Interleukin-12 subunit beta (IL12B)	OT0JF8A3	IL12B_HUMAN	Gene/Protein Processing	[3]
Interleukin-17A (IL17A)	OTY72FT2	IL17_HUMAN	Gene/Protein Processing	[3]
Interleukin-23 subunit alpha (IL23A)	OTYO99HC	IL23A_HUMAN	Gene/Protein Processing	[3]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[3]
Keratin, type I cytoskeletal 16 (KRT16)	OTGA0EQN	K1C16_HUMAN	Gene/Protein Processing	[3]
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A)	OTPMGIU4	MLP3A_HUMAN	Gene/Protein Processing	[4]
Next to BRCA1 gene 1 protein (NBR1)	OTVRL7J9	NBR1_HUMAN	Gene/Protein Processing	[4]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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4	PIKfyve inhibition increases exosome release and induces secretory autophagy. Cell Mol Life Sci. 2016 Dec;73(24):4717-4737. doi: 10.1007/s00018-016-2309-8. Epub 2016 Jul 20.
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6	Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
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10	Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
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26	Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
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29	Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
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