Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6Q7U4)

Drug Name
Lenalidomide Drug Info
Synonyms
Revamid; Revimid; Revlimid; Celgene brand of lenalidomide; Lenalidomide [USAN]; CC 5013; CC5013; CDC 501; IMiD3; IMiD3cpd; ALBB-015321; CC-5013; CDC-501; CDC-5013; ENMD-0997; IMID-5013; Revlimid (Celgene); Revlimid (TN); Thalidomide analog CC-5013; Lenalidomide (USAN/INN); CC-5013, Revlimid, Lenalidomide; 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione; 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione; 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione; Lenalidomide (Immunomodulator)
Indication
Disease Entry ICD 11 Status REF
Adult T-cell leukemia/lymphoma Approved [1]
Advanced cancer 2A00-2F9Z Approved [1]
Complex regional pain syndrome type 1 Approved [1]
Hepatosplenic T-cell lymphoma Approved [1]
Large granular lymphocytic leukemia 2A90.1 Approved [1]
Leukemia Approved [1]
MALT lymphoma Approved [1]
Multiple myeloma 2A83 Approved [2]
Nodal marginal zone lymphoma 2A85.0 Approved [1]
Pain MG30-MG3Z Approved [1]
Plasma cell myeloma 2A83.1 Approved [1]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified Approved [1]
Prolymphocytic leukaemia 2A82.1 Approved [1]
Recurrent adult burkitt lymphoma 2A85.6 Approved [1]
Small intestine lymphoma Approved [1]
Splenic marginal zone lymphoma Approved [1]
Testicular lymphoma Approved [1]
Urinary bladder neoplasm Approved [1]
Waldenstrom macroglobulinemia 2A85.4 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Colon cancer 2B90.Z Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
216326
ChEBI ID
CHEBI:63791
CAS Number
CAS 191732-72-6
TTD Drug ID
DM6Q7U4
VARIDT Drug ID
DR00261
ACDINA Drug ID
D00353

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [11]
Nafamostat DMU1XOD Pancreatitis DC31-DC34 Approved [12]
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [13]
Enbrel DM7RNP3 Arthritis FA20 Approved [14]
Golimumab DMHZV7X Psoriatic arthritis FA21 Approved [15]
Certolizumab DM5CL9Z Rheumatoid arthritis FA20 Approved [16]
Etanercept DMCV109 Arthritis FA20 Approved [17]
Adalimumab DMQMV1B Crohn disease DD70 Approved [18]
Infliximab DMH7OIA Crohn disease DD70 Approved [19]
Golnerminogene pradenovac DMKWV4B Esophageal cancer 2B70 Phase 3 [20]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [21]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [24]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
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Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [30]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [8]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Folic Acid DMEMBJC Colorectal carcinoma Approved [36]
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Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [43]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [52]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [53]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [53]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Ethanol DMDRQZU Chronic pain MG30 Approved [57]
Menthol DMG2KW7 Back pain ME84.Z Approved [58]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [59]
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Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [8]
Testosterone DM7HUNW Hot flushes GA30 Approved [63]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Ethanol DMDRQZU Chronic pain MG30 Approved [65]
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Drug(s) Affected By Fibroblast growth factor receptor 3 (FGFR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [30]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [69]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [8]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [70]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
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Drug(s) Affected By Proteinase-activated receptor 1 (F2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Selenium DM25CGV N. A. N. A. Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [76]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [69]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
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Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Diazepam DM08E9O Alcohol withdrawal Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [55]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [79]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [81]
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Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [83]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Testosterone DM7HUNW Hot flushes GA30 Approved [63]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [63]
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Drug(s) Affected By Angiopoietin-1 receptor (TEK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Propranolol DM79NTF Angina pectoris BA40 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Capsaicin DMGMF6V Back pain ME84.Z Approved [85]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [86]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [87]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [88]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [89]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [90]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [91]
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Drug(s) Affected By DNA damage-binding protein 1 (DDB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [95]
Arsenic DMTL2Y1 N. A. N. A. Approved [96]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [97]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [88]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [98]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [99]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [100]
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Drug(s) Affected By Sal-like protein 4 (SALL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [10]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [101]
Pomalidomide DMTGBAX Plasma cell myeloma 2A83.1 Approved [10]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [87]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [102]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [103]
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Drug(s) Affected By Protein cereblon (CRBN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [74]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [104]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [105]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [106]
Pomalidomide DMTGBAX Plasma cell myeloma 2A83.1 Approved [9]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [107]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [108]
Milchsaure DM462BT Pruritus EC90 Investigative [109]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor necrosis factor (TNF) TTF8CQI TNFA_HUMAN Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiopoietin-1 receptor (TEK) OT78YN57 TIE2_HUMAN Gene/Protein Processing [6]
DNA damage-binding protein 1 (DDB1) OTTR2L3Z DDB1_HUMAN Protein Interaction/Cellular Processes [7]
Fibroblast growth factor receptor 1 (FGFR1) OT4GLCXW FGFR1_HUMAN Gene/Protein Processing [8]
Fibroblast growth factor receptor 2 (FGFR2) OTLOPACK FGFR2_HUMAN Gene/Protein Processing [8]
Fibroblast growth factor receptor 3 (FGFR3) OTSAXDIL FGFR3_HUMAN Gene/Protein Processing [8]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Gene/Protein Processing [6]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Gene/Protein Processing [6]
Protein cereblon (CRBN) OTXH9MDC CRBN_HUMAN Drug Response [9]
Proteinase-activated receptor 1 (F2R) OT4WVWBO PAR1_HUMAN Gene/Protein Processing [6]
Sal-like protein 4 (SALL4) OTC08PR5 SALL4_HUMAN Protein Interaction/Cellular Processes [10]

References

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3 Low-dose Lenalidomide for Non-severe COVID-19 Treatment Trial (GETAFE)
4 Thalidomide and thalidomide analogues for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007351.
5 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB00480)
6 Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
7 Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat Struct Mol Biol. 2014 Sep;21(9):803-9. doi: 10.1038/nsmb.2874. Epub 2014 Aug 10.
8 Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
9 A Dual Color Immunohistochemistry Assay for Measurement of Cereblon in Multiple Myeloma Patient Samples. Appl Immunohistochem Mol Morphol. 2016 Nov/Dec;24(10):695-702. doi: 10.1097/PAI.0000000000000246.
10 Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. Elife. 2018 Aug 1;7:e38430. doi: 10.7554/eLife.38430.
11 Efficacy of different thalidomide regimens for patients with multiple myeloma and its relationship with TNF-alpha level. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Dec;16(6):1312-5.
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17 The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72.
18 Adalimumab for psoriasis patients who are non-responders to etanercept: open-label prospective evaluation. J Eur Acad Dermatol Venereol. 2009 Dec;23(12):1394-7.
19 Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nat Clin Pract Rheumatol. 2008 Jun;4(6):300-9.
20 TNFerade, an adenovector carrying the transgene for human tumor necrosis factor alpha, for patients with advanced solid tumors: surgical experience... Ann Surg Oncol. 2005 Oct;12(10):825-30.
21 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
22 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
23 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
24 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
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27 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
28 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
29 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
30 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
31 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
32 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
33 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
34 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
35 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
36 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
37 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
38 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
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41 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
42 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
43 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
44 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
45 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
46 Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005 Jan 28;280(4):2912-23. doi: 10.1074/jbc.M409524200. Epub 2004 Nov 17.
47 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
48 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
49 Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Cancer Res. 2005 Sep 15;65(18):8193-9. doi: 10.1158/0008-5472.CAN-05-1177.
50 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
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