General Information of Drug (ID: DM7P3IZ)

Drug Name
3-aminobenzamide Drug Info
Synonyms
3-Aminobenzamide; 3544-24-9; m-Aminobenzamide; Benzamide, 3-amino-; 3-Amino-benzamide; Benzamide, m-amino-; meta-aminobenzamide; 3-ABA; 3-Aminobenzimide; 3-amino benzamide; aniline-3-carboxamide; 3-aminobenzoic acid amide; UNII-8J365YF1YH; CCRIS 3925; EINECS 222-586-9; NSC 36962; BRN 2802373; PARP Inhibitor I, 3-ABA; 3-H2NC6H4CONH2; CHEMBL81977; 3-AB; 8J365YF1YH; CHEBI:64042; GSCPDZHWVNUUFI-UHFFFAOYSA-N; MFCD00007989; 3-Aminobenzamide, 98%; SR-01000075657; HSDB 7581; 3-azanylbenzamide; m-amino benzamide; 4pml; 3-Aminobenzaminde
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1645
ChEBI ID
CHEBI:64042
CAS Number
CAS 3544-24-9
TTD Drug ID
DM7P3IZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotinamide DMUPE07 Acne vulgaris ED80 Approved [6]
KU-0058948 DMSA4HZ Ovarian cancer 2C73 Approved [7]
Niraparib Tosylate DMLPSWQ Fallopian tube cancer 2C74 Approved [8]
CC-486 DMTNQB0 Acute myeloid leukaemia 2A60 Phase 3 [9]
Nicaraven DMFBNA3 Cerebrovascular disease 8B2Z Phase 3 [10]
PMID27841036-Compound-37 DM0OVZ2 Ovarian cancer 2C73 Phase 2 [11]
Stenoparib DMKVBL8 Ovarian cancer 2C73 Phase 2 [12]
AG140699 DMA9FKY Melanoma 2C30 Phase 2 [13]
AZD5305 DMW9R1C Prostate cancer 2C82.0 Phase 2 [14]
AMXI 5001 DMR9H6B Solid tumour/cancer 2A00-2F9Z Phase 1/2 [15]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [17]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [18]
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Selenium DM25CGV N. A. N. A. Approved [21]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [22]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [23]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
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Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Aripiprazole DM3NUMH Bipolar I disorder Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [31]
Ethacrynic acid DM60QMR Edema MG29 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [34]
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Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [35]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [40]
Pamidronate DMB4AVP Bone Paget disease Approved [41]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [42]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [45]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [46]
Fructose DM43AN2 Vomiting MD90 Approved [47]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [49]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [17]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [57]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [58]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [60]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [61]
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Drug(s) Affected By Osteopontin (SPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [56]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [70]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [71]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [73]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Gefitinib DM15F0X Colon adenocarcinoma Approved [75]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Selenium DM25CGV N. A. N. A. Approved [54]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [22]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [78]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [83]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Testosterone DM7HUNW Hot flushes GA30 Approved [85]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [86]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [87]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Gefitinib DM15F0X Colon adenocarcinoma Approved [89]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Etretinate DM2CZFA Keratosis ED56 Approved [91]
Prednisone DM2HG4X Acute asthma CA23 Approved [92]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [93]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [54]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [99]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [20]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [96]
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Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [101]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [101]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [103]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [101]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [101]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [106]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [107]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [108]
Testosterone DM7HUNW Hot flushes GA30 Approved [109]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [110]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Arsenic DMTL2Y1 N. A. N. A. Approved [113]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [114]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [115]
Bortezomib DMNO38U Leukemia Approved [116]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [5]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [118]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [60]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [119]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [119]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [123]
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Drug(s) Affected By Poly polymerase 2 (PARP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Testosterone DM7HUNW Hot flushes GA30 Approved [127]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [127]
Leflunomide DMR8ONJ Arthritis FA20 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [118]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [130]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Poly [ADP-ribose] polymerase 1 (PARP1) TTVDSZ0 PARP1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Gene/Protein Processing [2]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [3]
Chimeric ERCC6-PGBD3 protein (ERCC6) OT2QZKSF ERPG3_HUMAN Drug Response [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Gene/Protein Processing [5]
DNA repair endonuclease XPF (ERCC4) OTFIOPG1 XPF_HUMAN Gene/Protein Processing [5]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Gene/Protein Processing [3]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Gene/Protein Processing [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [3]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [3]

References

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15 AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020 Aug 1;10(8):2649-2676.
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17 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
18 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
19 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
20 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
21 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
22 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
23 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
24 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
25 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
26 Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway. Free Radic Biol Med. 2006 May 1;40(9):1664-74. doi: 10.1016/j.freeradbiomed.2006.01.003. Epub 2006 Jan 26.
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29 Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
30 Retinoic acid remodels extracellular matrix (ECM) of cultured human fetal palate mesenchymal cells (hFPMCs) through down-regulation of TGF-/Smad signaling. Toxicol Lett. 2014 Mar 3;225(2):208-15. doi: 10.1016/j.toxlet.2013.12.013. Epub 2013 Dec 24.
31 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
32 Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14;4(12):e8294. doi: 10.1371/journal.pone.0008294.
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34 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
35 20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines. Anticancer Res. 1999 May-Jun;19(3A):1689-97.
36 Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
37 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
38 The effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cells. J Korean Med Sci. 2005 Jun;20(3):438-44. doi: 10.3346/jkms.2005.20.3.438.
39 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
40 Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor. J Cell Physiol. 2010 Oct;225(1):140-51.
41 Pamidronate increases markers of bone formation in patients with multiple myeloma in plateau phase under interferon-alpha treatment. Calcif Tissue Int. 2001 May;68(5):285-90.
42 A highly potent 26,27-Hexafluoro-1a,25-dihydroxyvitamin D3 on calcification in SV40-transformed human fetal osteoblastic cells. Calcif Tissue Int. 2002 Jun;70(6):488-95.
43 Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures. J Cell Biochem. 2007 Aug 15;101(6):1430-8. doi: 10.1002/jcb.21259.
44 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
45 High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
46 Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
47 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
48 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
49 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
50 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
51 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
52 Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
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54 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
55 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
56 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
57 Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions. World J Hepatol. 2014 Apr 27;6(4):230-42. doi: 10.4254/wjh.v6.i4.230.
58 Pemetrexed downregulates ERCC1 expression and enhances cytotoxicity effected by resveratrol in human nonsmall cell lung cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1047-59. doi: 10.1007/s00210-013-0905-9. Epub 2013 Aug 3.
59 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
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