General Information of Drug (ID: DMCMDVR)

Drug Name
Triptolide Drug Info
Synonyms
triptolide; 38748-32-2; Triptolid; PG490; UNII-19ALD1S53J; NSC 163062; CHEMBL463763; CHEBI:9747; 19ALD1S53J; C20H24O6; PG-490; CPD000466307; Triptolide, Tripterygium wilfordii; (-)-Triptolide; PG 490; Trisoxireno(4b,5:6,7:8a,9)phenanthro(1,2-c)furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-; SMR000466307; NSC163062; Triptolide, 1; Triptolide(PG490)/; AC1Q6AXN; BSPBio_001595; KBioGR_000315; KBioSS_000315
Indication
Disease Entry ICD 11 Status REF
Autoimmune diabetes 5A10 Phase 3 [1]
Cross-matching ID
PubChem CID
107985
ChEBI ID
CHEBI:9747
CAS Number
CAS 38748-32-2
TTD Drug ID
DMCMDVR
INTEDE Drug ID
DR1904

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [10]
Laquinimod DM3IWS8 Lupus 4A40 Phase 3 [11]
Edasalonexent DMYVBF6 Duchenne dystrophy 8C70 Phase 3 [12]
MD1003 DMVZ57G Multiple sclerosis 8A40 Phase 3 [12]
Vadimezan DMK7CYX Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
CAT 1004 DMQBP7R Duchenne dystrophy 8C70 Phase 2 [14]
Parthenolide DMCQBFT N. A. N. A. Phase 2 [15]
Recoflavone DMCSR8I Inflammatory bowel disease DD72 Phase 2 [16]
CZEN-002 DMUDMHA Fungal infection 1F29-1F2F Phase 2 [17]
XP-23829 DMELUYN Multiple sclerosis 8A40 Phase 2 [18]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [20]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
Leflunomide DMR8ONJ Arthritis FA20 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Ethanol DMDRQZU Chronic pain MG30 Approved [44]
Bortezomib DMNO38U Leukemia Approved [45]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [46]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [47]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [47]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [48]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [46]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [47]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [49]
Gefitinib DM15F0X Colon adenocarcinoma Approved [46]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [50]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [46]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [53]
Gefitinib DM15F0X Colon adenocarcinoma Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [56]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [57]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [64]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [67]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [71]
Epinephrine DM3KJBC Acute asthma CA23 Approved [72]
Quercetin DM3NC4M Obesity 5B81 Approved [73]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [74]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [78]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [78]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [81]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [84]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [85]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [86]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [88]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [56]
Etretinate DM2CZFA Keratosis ED56 Approved [90]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Gefitinib DM15F0X Colon adenocarcinoma Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [97]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [98]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [99]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [98]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [100]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [101]
Methotrexate DM2TEOL Anterior urethra cancer Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [103]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [104]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [105]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [106]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Verapamil DMA7PEW Angina pectoris BA40 Approved [107]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [108]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [109]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [110]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [88]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [56]
Etretinate DM2CZFA Keratosis ED56 Approved [90]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [99]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [112]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [113]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Selenium DM25CGV N. A. N. A. Approved [64]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [117]
Etretinate DM2CZFA Keratosis ED56 Approved [118]
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [120]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [121]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [122]
Quercetin DM3NC4M Obesity 5B81 Approved [123]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [79]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [124]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [125]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [79]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [79]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [126]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [126]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [128]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [129]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [110]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [130]
Gefitinib DM15F0X Colon adenocarcinoma Approved [131]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [64]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [88]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [135]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Selenium DM25CGV N. A. N. A. Approved [56]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [99]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [137]
Methotrexate DM2TEOL Anterior urethra cancer Approved [138]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [140]
Methotrexate DM2TEOL Anterior urethra cancer Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [142]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [143]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [144]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [145]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [146]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [111]
Gefitinib DM15F0X Colon adenocarcinoma Approved [147]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
Etretinate DM2CZFA Keratosis ED56 Approved [90]
Prednisone DM2HG4X Acute asthma CA23 Approved [149]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [99]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [153]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [154]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [155]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [156]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [157]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [158]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [159]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [161]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [162]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [163]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [164]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [165]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [144]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Propranolol DM79NTF Angina pectoris BA40 Approved [168]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [171]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [172]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [173]
Mebendazole DMO14SG Ascariasis 1F62 Approved [174]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [176]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [177]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [178]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [178]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [179]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [181]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [182]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [186]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [187]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
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Drug(s) Affected By Cyclin-A1 (CCNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [188]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [189]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [190]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Folic Acid DMEMBJC Colorectal carcinoma Approved [192]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [193]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [194]
Flucytosine DM13VTW Cryptococcal meningitis Approved [195]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [195]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [197]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [198]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [199]
Amifostine DM5FL14 Mucositis CA00 Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [201]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [160]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [97]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [202]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [203]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [205]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [206]
Selenium DM25CGV N. A. N. A. Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [207]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [208]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [209]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [209]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [209]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [212]
Selenium DM25CGV N. A. N. A. Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [213]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
Leflunomide DMR8ONJ Arthritis FA20 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Quercetin DM3NC4M Obesity 5B81 Approved [162]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [215]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [216]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [217]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [218]
Verapamil DMA7PEW Angina pectoris BA40 Approved [219]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [220]
Selenium DM25CGV N. A. N. A. Approved [64]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [221]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [222]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [224]
Sulfinpyrazone DMEV954 Gout FA25 Approved [225]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [226]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [228]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [229]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [230]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [231]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [233]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [234]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [235]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [33]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [236]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [237]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [238]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [239]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [240]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [241]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [242]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
Selenium DM25CGV N. A. N. A. Approved [64]
Etretinate DM2CZFA Keratosis ED56 Approved [243]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [244]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nuclear factor NF-kappa-B (NFKB) TTSXVID NFKB1_HUMAN; NFKB2_HUMAN; TF65_HUMAN; RELB_HUMAN; REL_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Gene/Protein Processing [4]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [5]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Gene/Protein Processing [6]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Gene/Protein Processing [6]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Gene/Protein Processing [7]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [7]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [8]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Gene/Protein Processing [9]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Gene/Protein Processing [9]

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114 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
115 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
116 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
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