Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFZXI2)

Drug Name
NVP-TAE684 Drug Info
Synonyms
761439-42-3; NVP-TAE684; NVP-TAE 684; TAE684; TAE-684; 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine; TAE684 (NVP-TAE684); TAE 684; UNII-EH1713MN4K; CHEMBL509032; EH1713MN4K; 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine; C30H40ClN7O3S
Indication
Disease Entry ICD 11 Status REF
Lymphoma 2A80-2A86 Investigative [1]
Cross-matching ID
PubChem CID
16038120
ChEBI ID
CHEBI:91338
CAS Number
CAS 761439-42-3
TTD Drug ID
DMFZXI2

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Insulin receptor (INSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meglitinides DM1OFHN Type-2 diabetes 5A11 Approved [6]
Human neutral insulin DMA5OBU Diabetic complication 5A2Y Approved [7]
Insulin Lyspro recombinant DM5XHVR Diabetic complication 5A2Y Approved [7]
Insulin, porcine DMO95XI Diabetic complication 5A2Y Approved [8]
Insulin recombinant DMYVP5G Diabetic complication 5A2Y Approved [7]
Metformin arginine-hemisuccinimide DMTPAM3 Type-2 diabetes 5A11 Approved [9]
Insulin-lispro DM4O90W Diabetic complication 5A2Y Approved [10]
Insulin-glulisine DMQI0FU Diabetic complication 5A2Y Approved [11]
Ryzodeq DMOFP18 Type-2 diabetes 5A11 Approved [12]
NN5401 DM0QV27 Diabetic complication 5A2Y Phase 3 [12]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [13]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [14]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [15]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [16]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [17]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [18]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [19]
Gefitinib DM15F0X Colon adenocarcinoma Approved [20]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [21]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [14]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [24]
Paclitaxel DMLB81S Breast carcinoma Approved [25]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [26]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [13]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [16]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [17]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [29]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [30]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [32]
Gefitinib DM15F0X Colon adenocarcinoma Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [35]
Selenium DM25CGV N. A. N. A. Approved [36]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [37]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [38]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [41]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
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Drug(s) Affected By GRB2-associated-binding protein 1 (GAB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Folic Acid DMEMBJC Colorectal carcinoma Approved [51]
Menthol DMG2KW7 Back pain ME84.Z Approved [52]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [53]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [54]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [55]
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Drug(s) Affected By Pro-epidermal growth factor (EGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Panobinostat DM58WKG Chronic graft versus host disease Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [62]
Testosterone DM7HUNW Hot flushes GA30 Approved [63]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [64]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [67]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [68]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [69]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [70]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [74]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [75]
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Drug(s) Affected By Hepatocyte growth factor (HGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [80]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [81]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
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Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [90]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [91]
Testosterone DM7HUNW Hot flushes GA30 Approved [64]
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Drug(s) Affected By Protransforming growth factor alpha (TGFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [92]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Leflunomide DMR8ONJ Arthritis FA20 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [97]
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Drug(s) Affected By ALK tyrosine kinase receptor (ALK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ceritinib DMB920Z Non-small-cell lung cancer 2C25.Y Approved [98]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [100]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [102]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [103]
Arsenic DMTL2Y1 N. A. N. A. Approved [104]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [106]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Insulin receptor (INSR) TTCBFJO INSR_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ALK tyrosine kinase receptor (ALK) OTV3P4V8 ALK_HUMAN Drug Response [3]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Drug Response [3]
GRB2-associated-binding protein 1 (GAB1) OTQKE6V4 GAB1_HUMAN Post-Translational Modifications [4]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Drug Response [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Drug Response [4]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Drug Response [4]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Drug Response [4]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [4]

References

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29 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
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33 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
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37 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
38 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
39 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
40 Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L422-9. doi: 10.1152/ajplung.00204.2006. Epub 2006 Oct 6.
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43 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
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45 Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer. 2011 Jun 16;11:255. doi: 10.1186/1471-2407-11-255.
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47 Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion. Mol Cancer. 2015 May 14;14:103. doi: 10.1186/s12943-015-0367-4.
48 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
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50 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
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52 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
53 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
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55 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
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59 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
60 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
61 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
62 Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo. Prostate. 2009 May 15;69(7):744-54. doi: 10.1002/pros.20923.
63 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
64 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
65 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
66 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
67 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
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