Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG5OZP)

Drug Name

Fascaplysin Drug Info

Synonyms

Pyrido[1,2-a:3,4-b']diindol-5-ium,12,13-dihydro-13-oxo-, chloride; GNF-PF-1458; ACMC-20bu3v; AC1L2JLY; AC1Q6JA3; SCHEMBL1728912; CHEMBL602937; GTPL5969; BDBM59087; CTK4A8872; CHEBI:93765; ZINC1616841; pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-; HSCI1_000331; NCGC00346951-01; CJ-26101; BRD-K13287209-003-03-2; BRD-K13287209-311-02-1; BRD-K13287209-311-01-3; BRD-K13287209-003-02-4; BRD-K13287209-003-01-6

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 73292
CAS Number: CAS 114719-57-2
TTD Drug ID: DMG5OZP

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[4]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[5]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[6]
Ribociclib Succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[7]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[8]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[9]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[11]
P-276	DMMJUHD	Breast cancer	2C60-2C65	Phase 2	[12]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[13]
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Drug(s) Targeting Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[4]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[5]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[6]
Ribociclib Succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[7]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[8]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[9]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[13]
GLR2007	DM7DWLY	Glioblastoma of brain	2A00.00	Phase 1/2	[14]
FCN-437	DMQ8VUW	Breast cancer	2C60-2C65	Phase 1/2	[15]
NUV-422	DMQJQNT	Malignant glioma	2A00.0	Phase 1/2	[16]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[24]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[34]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[38]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[39]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[40]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[39]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[41]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[45]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[48]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
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Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Haloperidol	DM96SE0	Delirium		Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[61]
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Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[62]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[63]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
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Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Fructose	DM43AN2	Vomiting	MD90	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[90]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[93]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[96]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[97]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[98]
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Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Haloperidol	DM96SE0	Delirium		Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[58]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[105]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[106]
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Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[112]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[113]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[115]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[63]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[98]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[121]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[124]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[125]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[126]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[127]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[128]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[129]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[130]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[131]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[134]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[134]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[135]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[139]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[68]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cyclin-dependent kinase 4 (CDK4)	TT0PG8F	CDK4_HUMAN	Inhibitor	[2]
Cyclin-dependent kinase 6 (CDK6)	TTO0FDJ	CDK6_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[3]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[3]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Gene/Protein Processing	[3]
Eukaryotic translation initiation factor 4E (EIF4E)	OTDAWNLA	IF4E_HUMAN	Post-Translational Modifications	[3]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Gene/Protein Processing	[3]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Gene/Protein Processing	[3]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Gene/Protein Processing	[3]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)	OTTOMI8J	PK3CA_HUMAN	Gene/Protein Processing	[3]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[3]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Gene/Protein Processing	[3]

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