Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI4EL5)

Drug Name
Ketorolac Drug Info
Synonyms
Ketoralac; Ketorolaco; Ketorolacum; Macril; Ketorolaco [Spanish]; Ketorolacum [Latin]; RS 37619; Acular (TN); Ketorolac (INN); Ketorolac [INN:BAN]; RS-37619; Toradol (TN); (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; (+-)-Ketorolac; (+-)-isomer; (+/-)-2,3-Dihydro-5-benzoyl-1H-pyrrolizine-1-carboxylic acid; 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro; 5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; 5-Benzoyl-1,2-dihydro-3H-pyrrolo(1,2a)pyrrole-1-carboxylic acid; 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Postoperative inflammation 1A00-CA43.1 Approved [1]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
3826
ChEBI ID
CHEBI:76223
CAS Number
CAS 74103-06-3
TTD Drug ID
DMI4EL5
INTEDE Drug ID
DR0908
ACDINA Drug ID
D00344

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase (COX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [7]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [8]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [9]
Dexibuprofen DMFYBD0 Ankylosing spondylitis FA92.0 Approved [10]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [11]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [12]
Aceclofenac DMZDF0B Inflammation 1A00-CA43.1 Approved [13]
Lornoxicam DMYZFXN Migraine 8A80 Approved [14]
Morniflumate DM9UTDE Otitis media AA80-AB0Z Approved [15]
Nepafenac DMYK490 Osteoarthritis FA00-FA05 Approved [16]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [19]
Verapamil DMA7PEW Angina pectoris BA40 Approved [20]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [21]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [22]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [18]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [23]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [24]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 2B7 (UGT2B7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [23]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [27]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [31]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [32]
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Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [39]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [38]
Panobinostat DM58WKG Chronic graft versus host disease Approved [40]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [41]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [42]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [34]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [45]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [47]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
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Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [50]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [51]
Allopurinol DMLPAOB Gout FA25 Approved [52]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [53]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [54]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [55]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [5]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [5]
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Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [5]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [5]
Selenium DM25CGV N. A. N. A. Approved [57]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [5]
Testosterone DM7HUNW Hot flushes GA30 Approved [61]
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Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain G (HLA-G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [57]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [5]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [59]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [5]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [5]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [5]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Prednisone DM2HG4X Acute asthma CA23 Approved [65]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [66]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Epinephrine DM3KJBC Acute asthma CA23 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Fluoxetine DM3PD2C Bipolar depression Approved [70]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [71]
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Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [73]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Panobinostat DM58WKG Chronic graft versus host disease Approved [40]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [4]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [78]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C8 (CYP2C8) Main DME DES5XRU CP2C8_HUMAN Substrate [3]
UDP-glucuronosyltransferase 2B7 (UGT2B7) Main DME DEB3CV1 UD2B7_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Gene/Protein Processing [4]
HLA class I histocompatibility antigen, A alpha chain (HLA-A) OTAH14LU HLAA_HUMAN Gene/Protein Processing [5]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Gene/Protein Processing [5]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Gene/Protein Processing [5]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Gene/Protein Processing [4]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Gene/Protein Processing [6]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Gene/Protein Processing [6]

References

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