Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ3I1Q)

Drug Name

Niflumic Acid Drug Info

Synonyms

Actol; Donalgin; Flunir; Forenol; Landruma; NFL; Niflactol; Niflam; Niflugel; Niflumate; Nifluril; Acide niflumique; Acide niflumique [French]; Acido niflumico; Acido niflumico [Italian]; Acidum niflumicum; Nifluminic acid; UPSA Conseil Brand of Niflumic Acid; Upsamedica Brand of Niflumic Acid; N 0630; SC 1332; UP 83; UPSA Brand 1 of Niflumic Acid; UPSA Brand 2 of Niflumic Acid; Acid, Niflumic; Acide niflumique [INN-French]; Acido niflumico [INN-Spanish]; Acidum niflumicum [INN-Latin]; Niflugel (TN); Niflumic acid (INN); Niflumic acid [INN:DCF]; Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino; Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino [French]; 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid; 2-(3-(Trifluoromethyl)anilino)nicotinic acid; 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid; 2-(3-Trifluoromethylanilino)nicotinic Acid; 2-(3-[Trifluoromethyl]anilino)nicotinic acid; 2-(A,A,A-Trifluoro-m-toluidino)nicotinic acid; 2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid; 2-[(3-TRIFLUOROMETHYL)PHENYL]AMINO-3-PYRIDINE-CARBOXYLIC ACID; 2-[(3-Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid; 2-[(3-Trifluoromethylphenyl)amino]nicotinic Acid; 2-[3-(Trifluoromethyl)anilino]nicotinic acid; 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid; 2-[alpha,alpha,alpha-trifluoro-m-toluidino]-nicotinic acid; 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID; 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid; 39690A

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Approved	[1]

Therapeutic Class

Antiinflammatory Agents

Cross-matching ID

PubChem CID: 4488
ChEBI ID: CHEBI:34888
CAS Number: CAS 4394-00-7
TTD Drug ID: DMJ3I1Q
VARIDT Drug ID: DR01158
INTEDE Drug ID: DR1153

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[8]
Naproxen	DMZ5RGV	Bursitis		Approved	[9]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[10]
Indomethacin	DMSC4A7	Bursitis		Approved	[11]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[12]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[13]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[14]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[15]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[16]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[11]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[20]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[23]
Metronidazole	DMTIVEN	Abscess		Approved	[24]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[26]
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Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[32]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[29]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[38]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[39]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[40]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[39]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[41]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[44]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[45]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[48]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[53]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[54]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[56]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[59]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[67]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[70]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[71]
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Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[74]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[78]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
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Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
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Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[92]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[93]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[94]
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Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[101]
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Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivacaftor	DMZC1HS	Cystic fibrosis	CA25	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[104]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[105]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[106]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[103]
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[107]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)^{Main DME}	DEYGVN4	UD11_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[4]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[5]
Cystic fibrosis transmembrane conductance regulator (CFTR)	OT6B22QH	CFTR_HUMAN	Gene/Protein Processing	[6]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Gene/Protein Processing	[5]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Post-Translational Modifications	[5]
Eukaryotic translation initiation factor 2A (EIF2A)	OTWXELQP	EIF2A_HUMAN	Post-Translational Modifications	[5]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Gene/Protein Processing	[5]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[5]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Gene/Protein Processing	[5]
Prostaglandin reductase 1 (PTGR1)	OTMAR351	PTGR1_HUMAN	Gene/Protein Processing	[7]

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References

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