Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJS4RP)

• Drug Name: PMID26882240-Compound-32 Drug Info
• Cross-matching ID:
  PubChem CID: 5288674
  ChEBI ID: CHEBI:65324
  CAS Number: CAS 467214-20-6
  TTD Drug ID: DMJS4RP

Molecule-Related Drug Atlas

Drug(s) Targeting Hypoxia-inducible factor 1 (HIF-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID26882240-Compound-1	DMPAE8N	N. A.	N. A.	Patented	[1]
2,2-dimethylbenzopyran derivative 2	DM9XUYM	N. A.	N. A.	Patented	[1]
Oligooxopiperazine derivative 1	DM74T5L	N. A.	N. A.	Patented	[1]
2,2-dimethylbenzopyran derivative 3	DMTCPSQ	N. A.	N. A.	Patented	[1]
Triptolidenol analog 1	DMZTPUA	N. A.	N. A.	Patented	[1]
Aromatic and heteroaryl compound 1	DMXW0PV	N. A.	N. A.	Patented	[1]
Steroid derivative 4	DMJPYVS	N. A.	N. A.	Patented	[1]
Imidazo [1,2-a]pyridine compound 1	DMWABOJ	N. A.	N. A.	Patented	[1]
PMID26882240-Compound-7	DMOX8E3	N. A.	N. A.	Patented	[1]
PMID26882240-Compound-4	DMS4RLZ	N. A.	N. A.	Patented	[1]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[10]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[11]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[16]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[21]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[22]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[26]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[33]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[18]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[45]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[53]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[59]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[62]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[68]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[70]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[71]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[74]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[65]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[75]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[76]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[68]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[82]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[83]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[56]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[84]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[85]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[86]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[88]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[89]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[90]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[6]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[6]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[97]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[98]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[6]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[6]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[6]

Drug(s) Affected By Echinoderm microtubule-associated protein-like 4 (EML4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[105]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By ALK tyrosine kinase receptor (ALK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[108]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[110]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[112]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[115]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[116]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[120]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[121]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[122]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[124]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[130]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[135]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hypoxia-inducible factor 1 (HIF-1)	TTUX68I	NOUNIPROTAC	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ALK tyrosine kinase receptor (ALK)	OTV3P4V8	ALK_HUMAN	Protein Interaction/Cellular Processes	[2]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[3]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Drug Response	[4]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Gene/Protein Processing	[3]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Gene/Protein Processing	[5]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[5]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Gene/Protein Processing	[5]
Echinoderm microtubule-associated protein-like 4 (EML4)	OTJC45TA	EMAL4_HUMAN	Protein Interaction/Cellular Processes	[2]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Gene/Protein Processing	[6]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[3]

References

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