Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTY9LU)

• Drug Name: Piperazine Drug Info
• Synonyms: Anthalazine; Antiren; Diethylenediamine; Diethyleneimine; Dispermine; Eraverm; Hexahydropyrazine; Lumbrical; PZE; Piperazidine; Piperazin; Pipersol; Upixon; Uvilon; Vermex; Vermizine; Wurmirazin; Piperazin [German]; Piperazin [Germany]; Piperazine Dihydrochloride Dihydrochloride Hydrate; Piperazine [USAN]; Piperazine anhydrous; Piperazinium oleate; Pyrazine hexahydride; LTBB000432; Piperazine [UN2579] [Corrosive]; Eraverm (VAN); PIPERAZINE (HEXAHYDRATE); Piperazine (USP); Piperazine Hexa-Hydrate; Piperazine, anhydrous; Pyrazine, hexahy; Vermizine (TN); Worm-away; Asca-Trol No. 3; Worm-A-Ton; Hexahydro-1,4-diazine; 1,4-Diazacyclohexane; 1,4-Diethylenediamine; 1,4-Piperazine

Indication

Disease Entry	ICD 11	Status	REF
Ascariasis	1F62	Approved	[1]
Enterobiasis	1F65	Approved	[1]

• Therapeutic Class: Antinematodal Agents
• Cross-matching ID:
  PubChem CID: 4837
  ChEBI ID: CHEBI:28568
  CAS Number: CAS 110-85-0
  TTD Drug ID: DMTY9LU
  INTEDE Drug ID: DR1297
  ACDINA Drug ID: D00535

Molecule-Related Drug Atlas

Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[6]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[7]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[8]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[9]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[10]
Moxidectin	DMYGHX5	Onchocerciasis	1F6A	Approved	[11]
DP-VPA	DMGOXPQ	Bipolar disorder	6A60	Approved	[12]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[7]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[13]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[8]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[14]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[15]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[19]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[20]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[21]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[22]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[23]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Haloperidol	DM96SE0	Delirium		Approved	[25]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[26]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Haloperidol	DM96SE0	Delirium		Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[37]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]

Drug(s) Affected By Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[48]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[49]
Methamphetamine	DMPM4SK	Anxiety		Approved	[50]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[51]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[52]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[55]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[57]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[58]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[59]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[60]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[63]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[64]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[65]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[70]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[25]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[71]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[72]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[52]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[70]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[57]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[26]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[80]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[83]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[84]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Antagonist	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[4]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[4]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Gene/Protein Processing	[5]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Gene/Protein Processing	[4]
Tyrosine 3-monooxygenase (TH)	OT6ZORKP	TY3H_HUMAN	Gene/Protein Processing	[4]

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