General Information of Drug (ID: DMW2KI5)

Drug Name
24(S), 25-epoxycholesterol Drug Info
Synonyms 24,25-epoxy-cholesterol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3247059
ChEBI ID
CHEBI:41633
CAS Number
CAS 77058-74-3
TTD Drug ID
DMW2KI5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
VTB-38543 DMNY3J0 Atopic dermatitis EA80 Phase 2 [5]
2-Propanol, Isopropanol DML5O0H Discovery agent N.A. Investigative [6]
desmosterol DMV8SUM Discovery agent N.A. Investigative [7]
L-783483 DM6OTGE Discovery agent N.A. Investigative [8]
WAY-214950 DM8ODI7 Discovery agent N.A. Investigative [9]
27-hydroxycholesterol DM2L6OZ Discovery agent N.A. Investigative [10]
22R-hydroxycholesterol DME8273 Discovery agent N.A. Investigative [11]
GSK-9772 DM4WS3R Discovery agent N.A. Investigative [12]
Riccardin C DM6MYGX Discovery agent N.A. Investigative [13]
2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione DMH76SO Discovery agent N.A. Investigative [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
US9073931, E2 DMK9FJG N. A. N. A. Patented [15]
BDBM50177019 DMEL28G N. A. N. A. Patented [16]
US9006244, E2b DMP0TBO N. A. N. A. Patented [17]
US9073931, E1 DM2Z43I N. A. N. A. Patented [15]
US9006244, E1 DMBF1C0 N. A. N. A. Patented [17]
BDBM50177012 DM52IQF N. A. N. A. Patented [16]
US9006244, E2a DMPDF9B N. A. N. A. Patented [17]
67S DMJL1MB N. A. N. A. Patented [16]
US9073931, E3 DMCYM8P N. A. N. A. Patented [15]
desmosterol DMV8SUM Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [20]
Testosterone DM7HUNW Hot flushes GA30 Approved [21]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Clozapine DMFC71L Schizophrenia 6A20 Approved [23]
Menthol DMG2KW7 Back pain ME84.Z Approved [24]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [25]
Arsenic DMTL2Y1 N. A. N. A. Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Fluoxetine DM3PD2C Bipolar depression Approved [30]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [37]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [37]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [40]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [43]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [44]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [46]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [47]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [49]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [50]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [54]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [52]
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Drug(s) Affected By E-selectin (SELE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [58]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [61]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [62]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [63]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [71]
Fructose DM43AN2 Vomiting MD90 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [74]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [4]
Arsenic DMTL2Y1 N. A. N. A. Approved [75]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [77]
PMID27336223-Compound-5 DM6E50A N. A. N. A. Patented [74]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [81]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [82]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [84]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [90]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [91]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [92]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [4]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [93]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [4]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [94]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [97]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [98]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [102]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Oxysterols receptor LXR-alpha (NR1H3) TTECBXN NR1H3_HUMAN Agonist [2]
Oxysterols receptor LXR-beta (NR1H2) TTXA6PH NR1H2_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
E-selectin (SELE) OT33RZWY LYAM2_HUMAN Gene/Protein Processing [3]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Gene/Protein Processing [3]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [3]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Gene/Protein Processing [3]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Gene/Protein Processing [3]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Gene/Protein Processing [4]
T-cell surface glycoprotein CD1a (CD1A) OTKSSG6N CD1A_HUMAN Gene/Protein Processing [4]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Gene/Protein Processing [4]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Gene/Protein Processing [4]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15) OTNGA2BW TNF15_HUMAN Gene/Protein Processing [3]

References

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33 Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist. Biochem Pharmacol. 2010 May 1;79(9):1310-6. doi: 10.1016/j.bcp.2009.12.018. Epub 2010 Jan 8.
34 Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid. J Lipid Res. 2019 Apr;60(4):794-804. doi: 10.1194/jlr.M088880. Epub 2019 Feb 1.
35 Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071.
36 Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1228-36. doi: 10.1161/ATVBAHA.110.205500. Epub 2010 Mar 25.
37 Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells: a possible factor in the pathogenesis of infusion phlebitis. J Antimicrob Chemother. 2004 Feb;53(2):174-9. doi: 10.1093/jac/dkh056. Epub 2004 Jan 16.
38 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
39 Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
40 The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils. Allergy Asthma Proc. 2005 Jul-Aug;26(4):292-8.
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42 Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. J Dermatol Sci. 2001 Jun;26(2):85-93. doi: 10.1016/s0923-1811(00)00165-1.
43 Correlation of sICAM-1 and sVCAM-1 level with biochemical, histological and viral findings in chronic hepatitis C after interferon-alpha + ribavirin therapy. Rom J Gastroenterol. 2003 Jun;12(2):91-5.
44 Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J Toxicol Sci. 2019;44(3):213-224. doi: 10.2131/jts.44.213.
45 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
46 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
47 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
48 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
49 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
50 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
51 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
52 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
53 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
54 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
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56 Vitamin E inhibits lipid peroxidation-induced adhesion molecule expression in endothelial cells and decreases soluble cell adhesion molecules in healthy subjects. Cardiovasc Res. 2003 Feb;57(2):563-71. doi: 10.1016/s0008-6363(02)00699-5.
57 Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 2004 Oct;50(10):3286-95. doi: 10.1002/art.20518.
58 Effects of bezafibrate and simvastatin on endothelial activation and lipid peroxidation in hypercholesterolemia: evidence of different vascular protection by different lipid-lowering treatments. J Clin Endocrinol Metab. 2003 Nov;88(11):5341-7. doi: 10.1210/jc.2003-030724.
59 Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-kappaB, and p38. Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H741-7. doi: 10.1152/ajpheart.01182.2005. Epub 2006 Mar 31.
60 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
61 The in vitro effects of quinupristin/dalfopristin, erythromycin and levofloxacin at low concentrations on the expression of different cell adhesion molecules on the surface of endothelial cells (Eahy926). Toxicology. 2006 Jan 20;218(1):30-8. doi: 10.1016/j.tox.2005.09.014. Epub 2005 Nov 16.
62 Effects of hormone treatment on hemostasis variables. Climacteric. 2007 Oct;10 Suppl 2:32-7. doi: 10.1080/13697130701598548.
63 Markers of inflammation, thrombosis and endothelial activation correlate with carotid IMT regression in stable coronary disease after atorvastatin treatment. Nutr Metab Cardiovasc Dis. 2009 Sep;19(7):481-90. doi: 10.1016/j.numecd.2008.10.003. Epub 2009 Jan 26.
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65 Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244. doi: 10.1002/jat.3809. Epub 2019 May 7.
66 Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
67 Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity. DNA Cell Biol. 2009 Mar;28(3):119-29.
68 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
69 Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med. 2005 Oct 15;172(8):987-93. doi: 10.1164/rccm.200501-041OC. Epub 2005 Jul 7.
70 A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide. 2005 Mar;12(2):97-104.
71 The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. J Diabetes Complications. 2006 Sep-Oct;20(5):336-42.
72 Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol. 2008 Sep;19(9):1712-20.
73 Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway. Circulation. 2005 Aug 2;112(5):727-36. doi: 10.1161/CIRCULATIONAHA.104.500959. Epub 2005 Jul 25.
74 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
75 Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire. Reprod Toxicol. 2017 Oct;73:184-195. doi: 10.1016/j.reprotox.2017.07.023. Epub 2017 Aug 6.
76 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
77 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
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