Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2348V)

• Drug Name: PP-242 Drug Info
• Synonyms: PP242; TORKinib

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 135565635
  ChEBI ID: CHEMBL1241674
  CAS Number: CAS 1092351-67-1
  TTD Drug ID: DM2348V

Molecule-Related Drug Atlas

Drug(s) Targeting Serine/threonine-protein kinase mTOR (mTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[3]
Temsirolimus	DMS104F	Renal cell carcinoma	2C90	Approved	[4]
PF-04449913	DMSB068	Chronic myelomonocytic leukaemia	2A40	Approved	[5]
Everolimus	DM8X2EH	Advanced cancer	2A00-2F9Z	Approved	[6]
Novolimus	DM6ZPLQ	Artery stenosis	BD52	Approved	[7]
Zotarolimus	DMRMCXW	Solid tumour/cancer	2A00-2F9Z	Approved	[8]
Ridaforolimus	DMLHEU7	Sarcoma	2A60-2C35	Phase 3	[9]
AZD2014	DMOEARH	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
MM-141	DM2RJ4D	Pancreatic cancer	2C10	Phase 2	[11]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[7]

Drug(s) Affected By Deoxyribonuclease-2-alpha (DNASE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]

Drug(s) Affected By Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[26]

Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]

Drug(s) Affected By Transcription elongation regulator 1 (TCERG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[41]

Drug(s) Affected By NPC intracellular cholesterol transporter 1 (NPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]

Drug(s) Affected By ATP-dependent RNA helicase DHX15 (DHX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[53]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[54]

Drug(s) Affected By U4/U6 small nuclear ribonucleoprotein Prp4 (PRPF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[56]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[57]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[58]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[55]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[59]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase H (PPIH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Haloperidol	DM96SE0	Delirium		Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Tissue alpha-L-fucosidase (FUCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[78]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[79]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[82]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[83]

Drug(s) Affected By Prosaposin (PSAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[85]
Bortezomib	DMNO38U	Leukemia		Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[87]

Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[91]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[93]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[94]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[95]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[83]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[97]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[64]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[73]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[109]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[111]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[112]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[115]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[118]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]

Drug(s) Affected By Aldo-keto reductase family 1 member A1 (AKR1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[79]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[121]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[120]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]

Drug(s) Affected By N-acetylglucosamine-6-sulfatase (GNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[126]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[121]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[127]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[128]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[58]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, liver type (PFKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Penfluridol	DMG1DTE	Schizophrenia	6A20	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[130]

Drug(s) Affected By Phosphoglycerate mutase 1 (PGAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[132]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[133]

Drug(s) Affected By Hexokinase-1 (HK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[134]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[75]

Drug(s) Affected By RNA-binding motif protein, X chromosome (RBMX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[141]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]

Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Haloperidol	DM96SE0	Delirium		Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[98]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[98]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]

Drug(s) Affected By Protein BUD31 homolog (BUD31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[58]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[146]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[97]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[64]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[83]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[83]

Drug(s) Affected By Aldehyde dehydrogenase family 3 member A2 (ALDH3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[79]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]

Drug(s) Affected By NHP2-like protein 1 (SNU13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[150]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[151]

Drug(s) Affected By 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[152]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Triosephosphate isomerase (TPI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[153]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Protein mago nashi homolog (MAGOH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[87]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By V-type proton ATPase subunit d 1 (ATP6V0D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[121]

Drug(s) Affected By AP-1 complex subunit sigma-1A (AP1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[118]

Drug(s) Affected By Small nuclear ribonucleoprotein E (SNRPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[161]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[157]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[162]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[163]

Drug(s) Affected By Small nuclear ribonucleoprotein F (SNRPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[164]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm3 (LSM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[157]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[162]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Small nuclear ribonucleoprotein Sm D1 (SNRPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[167]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[168]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[58]

Drug(s) Affected By Small nuclear ribonucleoprotein Sm D3 (SNRPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[170]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[157]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[162]

Drug(s) Affected By Serine/arginine-rich splicing factor 3 (SRSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[75]

Drug(s) Affected By Clathrin heavy chain 1 (CLTC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[171]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[121]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein U (HNRNPU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[174]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[175]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]

Drug(s) Affected By Serine/arginine-rich splicing factor 2 (SRSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[178]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[180]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[87]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[182]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[182]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]

Drug(s) Affected By Nuclear cap-binding protein subunit 1 (NCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[98]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[98]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[184]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Hyaluronidase-1 (HYAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[186]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]

Drug(s) Affected By Splicing factor 3A subunit 3 (SF3A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[121]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[187]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[188]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[189]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[159]

Drug(s) Affected By 116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[191]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[193]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[151]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[55]

Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[83]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[195]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]

Drug(s) Affected By 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[79]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]

Drug(s) Affected By Splicing factor 3A subunit 1 (SF3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[177]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[79]

Drug(s) Affected By Hexokinase HKDC1 (HKDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]

Drug(s) Affected By Small integral membrane protein 29 (SMIM29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]

Drug(s) Affected By ATP-dependent RNA helicase DDX42 (DDX42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[86]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[177]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[148]

Drug(s) Affected By U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[201]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[177]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[202]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Mestranol	DMG3F94	Contraception	QA21	Approved	[202]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[202]

Drug(s) Affected By V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[205]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[75]

Drug(s) Affected By Protein mago nashi homolog 2 (MAGOHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[58]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By StAR-related lipid transfer protein 4 (STARD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]

Drug(s) Affected By Arylsulfatase G (ARSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By Sialidase-1 (NEU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[184]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX23 (DDX23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[156]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[156]

Drug(s) Affected By AP-1 complex subunit mu-1 (AP1M1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[58]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[210]

Drug(s) Affected By Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[30]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[204]

Drug(s) Affected By V-type proton ATPase subunit H (ATP6V1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[162]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[77]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm7 (LSM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[156]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[164]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[222]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[55]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[162]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase E (PPIE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[162]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[224]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[225]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[58]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[55]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[163]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm2 (LSM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]

Drug(s) Affected By RNA-binding protein 8A (RBM8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[191]

Drug(s) Affected By AP-1 complex subunit mu-2 (AP1M2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[144]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[121]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[227]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[146]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[231]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[232]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[233]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[234]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[235]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[16]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[237]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[237]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PAS domain-containing serine/threonine-protein kinase (PASK)	TTC0V1J	PASK_HUMAN	Inhibitor	[1]
Serine/threonine-protein kinase mTOR (mTOR)	TTCJG29	MTOR_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2)	OT3X7QG2	U5S1_HUMAN	Gene/Protein Processing	[2]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	OTSMGKXQ	EBP_HUMAN	Gene/Protein Processing	[2]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Gene/Protein Processing	[2]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[2]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)	OTB1FZJU	ACSA_HUMAN	Gene/Protein Processing	[2]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Gene/Protein Processing	[2]
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2)	OT714BUO	AL3A2_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member A1 (AKR1A1)	OTZT9NOW	AK1A1_HUMAN	Gene/Protein Processing	[2]
AP-1 complex subunit mu-1 (AP1M1)	OT1IR6CD	AP1M1_HUMAN	Gene/Protein Processing	[2]
AP-1 complex subunit mu-2 (AP1M2)	OTUE5YLC	AP1M2_HUMAN	Gene/Protein Processing	[2]

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