Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2348V)

• Drug Name: PP-242 Drug Info
• Synonyms: PP242; TORKinib

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 135565635
  ChEBI ID: CHEBI:90679
  CAS Number: CAS 1092351-67-1
  TTD Drug ID: DM2348V

Molecule-Related Drug Atlas

Drug(s) Targeting Serine/threonine-protein kinase mTOR (mTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[3]
Temsirolimus	DMS104F	Renal cell carcinoma	2C90	Approved	[4]
PF-04449913	DMSB068	Chronic myelomonocytic leukaemia	2A40	Approved	[5]
Everolimus	DM8X2EH	Advanced cancer	2A00-2F9Z	Approved	[6]
Novolimus	DM6ZPLQ	Artery stenosis	BD52	Approved	[7]
Zotarolimus	DMRMCXW	Solid tumour/cancer	2A00-2F9Z	Approved	[8]
Ridaforolimus	DMLHEU7	Sarcoma	2A60-2C35	Phase 3	[9]
AZD2014	DMOEARH	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
MM-141	DM2RJ4D	Pancreatic cancer	2C10	Phase 2	[11]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[7]

Drug(s) Affected By Deoxyribonuclease-2-alpha (DNASE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]

Drug(s) Affected By Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[26]

Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]

Drug(s) Affected By Tripeptidyl-peptidase 1 (TPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[19]

Drug(s) Affected By Transcription elongation regulator 1 (TCERG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[45]

Drug(s) Affected By NPC intracellular cholesterol transporter 1 (NPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]

Drug(s) Affected By ATP-dependent RNA helicase DHX15 (DHX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[57]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[58]

Drug(s) Affected By U4/U6 small nuclear ribonucleoprotein Prp4 (PRPF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[60]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[62]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[59]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase H (PPIH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]

Drug(s) Affected By Cystinosin (CTNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[72]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Haloperidol	DM96SE0	Delirium		Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[79]
Bortezomib	DMNO38U	Leukemia		Approved	[80]

Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[81]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[93]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[95]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[104]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[105]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[96]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]

Drug(s) Affected By Tissue alpha-L-fucosidase (FUCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[115]

Drug(s) Affected By Glucose-6-phosphate isomerase (GPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[117]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[117]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]

Drug(s) Affected By Beta-hexosaminidase subunit alpha (HEXA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[81]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[121]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]

Drug(s) Affected By Prosaposin (PSAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[128]
Bortezomib	DMNO38U	Leukemia		Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[129]

Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[134]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[135]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[115]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[87]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]

Drug(s) Affected By Lysosomal alpha-glucosidase (GAA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[141]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[142]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[143]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[150]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[156]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[158]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[159]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]

Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[115]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[115]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[110]

Drug(s) Affected By Aldo-keto reductase family 1 member A1 (AKR1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[162]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[69]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[162]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]

Drug(s) Affected By N-acetylglucosamine-6-sulfatase (GNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[169]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[69]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[170]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[171]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[62]

Drug(s) Affected By Beta-galactosidase (GLB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[177]

Drug(s) Affected By Sphingomyelin phosphodiesterase (SMPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, liver type (PFKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Penfluridol	DMG1DTE	Schizophrenia	6A20	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[119]

Drug(s) Affected By Ganglioside GM2 activator (GM2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[32]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[184]

Drug(s) Affected By Phosphoglycerate mutase 1 (PGAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[185]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[186]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]

Drug(s) Affected By Hexokinase-1 (HK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[188]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[189]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]

Drug(s) Affected By Iduronate 2-sulfatase (IDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[115]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[115]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[115]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[192]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[109]

Drug(s) Affected By Cathepsin S (CTSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[193]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[196]

Drug(s) Affected By N-acetylgalactosamine-6-sulfatase (GALNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[62]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[199]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]

Drug(s) Affected By RNA-binding motif protein, X chromosome (RBMX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]

Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Haloperidol	DM96SE0	Delirium		Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[117]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[117]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]

Drug(s) Affected By Protein BUD31 homolog (BUD31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[62]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[81]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[115]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[115]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[158]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[206]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[158]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[158]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[207]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[158]

Drug(s) Affected By Natural resistance-associated macrophage protein 2 (SLC11A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[209]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[210]

Drug(s) Affected By Aldehyde dehydrogenase family 3 member A2 (ALDH3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]

Drug(s) Affected By Hexokinase-2 (HK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[213]

Drug(s) Affected By Alpha-N-acetylglucosaminidase (NAGLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]

Drug(s) Affected By NHP2-like protein 1 (SNU13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[209]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[215]

Drug(s) Affected By 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[216]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Triosephosphate isomerase (TPI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[217]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Protein mago nashi homolog (MAGOH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[129]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[219]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[220]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By V-type proton ATPase subunit d 1 (ATP6V0D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[69]

Drug(s) Affected By AP-1 complex subunit sigma-1A (AP1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[158]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[159]

Drug(s) Affected By Small nuclear ribonucleoprotein E (SNRPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[223]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[72]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[224]

Drug(s) Affected By Small nuclear ribonucleoprotein F (SNRPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[225]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm3 (LSM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[72]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[227]

Drug(s) Affected By Small nuclear ribonucleoprotein Sm D1 (SNRPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[219]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[62]

Drug(s) Affected By Small nuclear ribonucleoprotein Sm D3 (SNRPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[231]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[72]

Drug(s) Affected By Serine/arginine-rich splicing factor 3 (SRSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[129]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[109]

Drug(s) Affected By Clathrin heavy chain 1 (CLTC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[232]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[69]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein U (HNRNPU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[235]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[236]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[237]

Drug(s) Affected By Serine/arginine-rich splicing factor 2 (SRSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[239]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[240]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[129]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[242]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[242]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[242]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]

Drug(s) Affected By Nuclear cap-binding protein subunit 1 (NCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[117]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[117]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[243]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By Hyaluronidase-1 (HYAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[244]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[244]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]

Drug(s) Affected By Splicing factor 3A subunit 3 (SF3A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[129]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[69]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[245]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[238]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[246]

Drug(s) Affected By Battenin (CLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[158]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[247]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[158]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[207]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[250]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]

Drug(s) Affected By 116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[253]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[254]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[238]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[215]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[59]

Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[115]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[255]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[256]

Drug(s) Affected By 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]

Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[257]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]

Drug(s) Affected By Splicing factor 3A subunit 1 (SF3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[238]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[238]

Drug(s) Affected By Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]

Drug(s) Affected By Lanosterol 14-alpha demethylase (CYP51A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[259]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]

Drug(s) Affected By Hexokinase HKDC1 (HKDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[49]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]

Drug(s) Affected By Small integral membrane protein 29 (SMIM29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[262]

Drug(s) Affected By ATP-dependent RNA helicase DDX42 (DDX42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[80]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[94]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[219]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[238]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[205]

Drug(s) Affected By Proprotein convertase subtilisin/kexin type 9 (PCSK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[263]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[264]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[265]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]

Drug(s) Affected By U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[266]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[238]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[238]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[267]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Mestranol	DMG3F94	Contraception	QA21	Approved	[267]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[267]

Drug(s) Affected By V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[269]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[109]

Drug(s) Affected By Protein mago nashi homolog 2 (MAGOHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[219]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[270]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Galactose mutarotase (GALM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[271]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]

Drug(s) Affected By StAR-related lipid transfer protein 4 (STARD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]

Drug(s) Affected By Arylsulfatase G (ARSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[273]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]

Drug(s) Affected By Sialidase-1 (NEU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[243]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX23 (DDX23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[220]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[220]

Drug(s) Affected By AP-1 complex subunit mu-1 (AP1M1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[62]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[238]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[139]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[275]

Drug(s) Affected By Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[30]

Drug(s) Affected By Sialin (SLC17A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[59]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[69]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[219]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[277]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]

Drug(s) Affected By Cathepsin F (CTSF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[283]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[284]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By V-type proton ATPase subunit H (ATP6V1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[286]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[72]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[110]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm7 (LSM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[220]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[225]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[287]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[59]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[72]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase E (PPIE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[288]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[288]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[72]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[121]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[289]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[289]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[120]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[62]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[59]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[224]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm2 (LSM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[283]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[139]

Drug(s) Affected By RNA-binding protein 8A (RBM8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[219]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[251]

Drug(s) Affected By AP-1 complex subunit mu-2 (AP1M2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[69]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]

Drug(s) Affected By Protein arginine N-methyltransferase 5 (PRMT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[291]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[293]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[294]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[295]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[296]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[297]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]

Drug(s) Affected By CREB-regulated transcription coactivator 2 (CRTC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[299]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[299]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[300]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[301]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[16]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[302]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[302]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PAS domain-containing serine/threonine-protein kinase (PASK)	TTC0V1J	PASK_HUMAN	Inhibitor	[1]
Serine/threonine-protein kinase mTOR (mTOR)	TTCJG29	MTOR_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2)	OT3X7QG2	U5S1_HUMAN	Gene/Protein Processing	[2]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	OTSMGKXQ	EBP_HUMAN	Gene/Protein Processing	[2]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[2]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Gene/Protein Processing	[2]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[2]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)	OTB1FZJU	ACSA_HUMAN	Gene/Protein Processing	[2]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Gene/Protein Processing	[2]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Gene/Protein Processing	[2]
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2)	OT714BUO	AL3A2_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member A1 (AKR1A1)	OTZT9NOW	AK1A1_HUMAN	Gene/Protein Processing	[2]

References

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