Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEHRAJ)

• Drug Name: Rutin Drug Info
• Synonyms: RUTIN; 153-18-4; rutoside; Phytomelin; Quercetin 3-rutinoside; Birutan; Eldrin; Rutin trihydrate; Myrticolorin; Venoruton; Bioflavonoid; Paliuroside; Tanrutin; Osyritrin; Rutine; Rutozyd; 3-Rutinosyl quercetin; 3-Rhamnoglucosylquercetin; Quercetin 3-O-rutinoside; Rutosido; Rutosidum; Rutinum; Globularicitrin; Quercetin-3-rutinoside; Rutabion; Violaquercitrin; Globulariacitrin; Melin; Rutinic acid; Birutan Forte; Birutin; Quercetin rhamnoglucosine; Quercetin-3beta-rutinoside; UNII-5G06TVY3R7; Oxyritin; Rutosid; Ilixanthin; Rutinion acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5280805
  ChEBI ID: CHEMBL226335
  CAS Number: CAS 153-18-4
  TTD Drug ID: DMEHRAJ
  VARIDT Drug ID: DR01181
  INTEDE Drug ID: DR2149

Molecule-Related Drug Atlas

Drug(s) Targeting Dihydrodiol dehydrogenase type I (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[8]
ASP-9521	DM8V0UL	Prostate cancer	2C82.0	Phase 1/2	[9]
N-(benzimidazole/indole) benzoic acid derivative 2	DMOPUFM	N. A.	N. A.	Patented	[10]
N-(phenylamino)-benzoate derivative 1	DMNIWVG	N. A.	N. A.	Patented	[10]
Indomethacin analog 3	DM53JXE	N. A.	N. A.	Patented	[10]
Indomethacin analog 2	DMKFPJ7	N. A.	N. A.	Patented	[10]
Beta-naphthylacetic acids derivative 1	DM5KTDY	N. A.	N. A.	Patented	[10]
Indomethacin analog 1	DM3E5V6	N. A.	N. A.	Patented	[10]
N-(naphthylamino)-benzoate derivative 1	DM310ES	N. A.	N. A.	Patented	[10]
N-(benzimidazolylcarbonyl)-piperidine derivative 1	DM541QW	N. A.	N. A.	Patented	[10]

Drug(s) Metabolized By Alpha-L-rhamnosidase (lrA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HY-N2258	DML4IAX	N. A.	N. A.	Preclinical	[3]
Ginsenoside Re	DM46FVD	N. A.	N. A.	Investigative	[3]
naringin	DM4DG1Y	Discovery agent	N.A.	Investigative	[3]
PNA-l-rhamnopyranoside	DMZF7RQ	N. A.	N. A.	Investigative	[3]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[12]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[13]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[17]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[20]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[29]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[30]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[33]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]

Drug(s) Affected By Integrin alpha-IIb (ITGA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[39]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[39]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[42]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[44]
Abciximab	DMJO6GV	Acute disease		Approved	[45]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[45]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[49]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[50]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[51]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[50]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[61]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]

Drug(s) Affected By B-cell antigen receptor complex-associated protein alpha chain (CD79A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Bortezomib	DMNO38U	Leukemia		Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[66]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[67]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Interferon regulatory factor 2 (IRF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[72]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[77]

Drug(s) Affected By POU domain, class 3, transcription factor 2 (POU3F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[79]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[80]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[83]

Drug(s) Affected By Homeobox protein Hox-D3 (HOXD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[85]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[86]
Indomethacin	DMSC4A7	Bursitis		Approved	[87]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[90]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By Cytokine receptor common subunit beta (CSF2RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[95]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Nuclear pore complex protein Nup214 (NUP214)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[100]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[101]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[96]

Drug(s) Affected By Transcription factor 7 (TCF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[104]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[105]
Bortezomib	DMNO38U	Leukemia		Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[80]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 2 (PBX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[104]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[66]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[90]

Drug(s) Affected By Lys-63-specific deubiquitinase BRCC36 (BRCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[99]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[105]
Bortezomib	DMNO38U	Leukemia		Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[80]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[111]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[112]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By Protein PRRC2A (PRRC2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[115]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[116]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[112]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[117]

Drug(s) Affected By Fms-related tyrosine kinase 3 ligand (FLT3LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[120]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[4]

Drug(s) Affected By Host cell factor 1 (HCFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[99]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[123]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]

Drug(s) Affected By CCAAT/enhancer-binding protein gamma (CEBPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[97]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[128]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[114]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[111]

Drug(s) Affected By CD81 antigen (CD81)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]

Drug(s) Affected By Rho GTPase-activating protein 4 (ARHGAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[99]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[126]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[119]

Drug(s) Affected By Large ribosomal subunit protein eL6 (RPL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[135]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[136]

Drug(s) Affected By Activated CDC42 kinase 1 (TNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[99]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[118]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[112]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[138]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[96]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[113]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[78]
Bortezomib	DMNO38U	Leukemia		Approved	[141]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[143]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[144]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By Myeloid leukemia factor 2 (MLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[109]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[77]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[96]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Sodium-dependent phosphate transporter 1 (SLC20A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[79]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[154]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[155]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[157]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[158]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[162]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[160]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[163]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[164]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[167]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[168]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[6]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[172]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[174]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[176]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[177]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[178]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]

Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator (ARNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[183]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[184]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[185]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[187]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[172]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[188]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[189]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[190]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[45]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[174]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[175]

Drug(s) Affected By Group 10 secretory phospholipase A2 (PLA2G10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[71]

Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[151]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[196]

Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[198]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[99]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[202]
Fructose	DM43AN2	Vomiting	MD90	Approved	[45]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[158]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[204]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[207]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]

Drug(s) Affected By Laminin subunit beta-2 (LAMB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[79]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[211]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[125]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[47]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[216]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[217]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[216]
Fructose	DM43AN2	Vomiting	MD90	Approved	[225]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[226]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[229]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[230]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[230]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dihydrodiol dehydrogenase type I (AKR1C3)	TT5ZWB6	AK1C3_HUMAN	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Alpha-L-rhamnosidase (lrA)	DEC389G	A0A385NJR4_9BACI	Substrate	[2]
Alpha-L-rhamnosidase (lrA)	DEBI82Z	A0A1V8Q7P3_9BIF	Substrate	[3]
Alpha-L-rhamnosidase (lrA)	DE7BILX	A0A1H8EBM0_9BACE	Substrate	[2]
Alpha-L-rhamnosidase (lrA)	DE13AYF	A0A179YH30_LACRH	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[4]
Activated CDC42 kinase 1 (TNK2)	OTRGG0T8	ACK1_HUMAN	Gene/Protein Processing	[4]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Gene/Protein Processing	[5]
Aryl hydrocarbon receptor nuclear translocator (ARNT)	OTMSIEZY	ARNT_HUMAN	Protein Interaction/Cellular Processes	[6]
B-cell antigen receptor complex-associated protein alpha chain (CD79A)	OTOJC8DV	CD79A_HUMAN	Gene/Protein Processing	[4]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[7]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[6]
CCAAT/enhancer-binding protein gamma (CEBPG)	OTGNAX3H	CEBPG_HUMAN	Gene/Protein Processing	[4]
CD81 antigen (CD81)	OTQFXNAZ	CD81_HUMAN	Gene/Protein Processing	[4]
Chemokine XC receptor 1	OTECP9O1	XCR1_HUMAN	Gene/Protein Processing	[4]

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