Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGZQ5P)

• Drug Name: linalool Drug Info
• Synonyms: Linalool; 78-70-6; 3,7-Dimethylocta-1,6-dien-3-ol; Linalol; 3,7-Dimethyl-1,6-octadien-3-ol; beta-Linalool; allo-Ocimenol; LINALYL ALCOHOL; 1,6-Octadien-3-ol, 3,7-dimethyl-; p-Linalool; (+-)-Linalool; Linanool; 2,6-Dimethyl-2,7-octadien-6-ol; 2,6-Dimethylocta-2,7-dien-6-ol; .beta.-Linalool; Linalool (natural); 2,6-Dimethyl-2,7-octadiene-6-ol; Caswell No. 526A; Linolool; FEMA Number 2635; NSC 3789; FEMA No. 2635; CCRIS 3726; CCRIS 6557; HSDB 645; Linalool, 97%; EINECS 201-134-4; EINECS 245-083-6; 3,7-dimethyl-octa-1,6-dien-3-ol; EPA Pest

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6549
  ChEBI ID: CHEMBL17580
  CAS Number: CAS 78-70-6
  TTD Drug ID: DMGZQ5P
  INTEDE Drug ID: DR2327

Molecule-Related Drug Atlas

Drug(s) Targeting Long transient receptor potential channel 8 (TRPM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[10]
D-3263	DM7V2OM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
PF-05105679	DM4QPT0	Pain	MG30-MG3Z	Phase 1	[12]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[13]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[14]
5-METHOXYTRYPTAMINE	DMARCKD	Discovery agent	N.A.	Investigative	[15]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[16]
2-(5-fluoro-1H-indol-3-yl)ethanamine	DMHW5FT	Discovery agent	N.A.	Investigative	[15]
NADA	DM3ORGM	Discovery agent	N.A.	Investigative	[14]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine	DMD2QVO	Discovery agent	N.A.	Investigative	[15]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[17]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[17]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[31]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[32]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[35]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[38]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[39]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]

Drug(s) Affected By Cytoplasmic aconitate hydratase (ACO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[49]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[50]

Drug(s) Affected By Enoyl-CoA hydratase, mitochondrial (ECHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[6]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[61]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[32]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[32]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[32]

Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Haloperidol	DM96SE0	Delirium		Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[62]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[62]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[36]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[71]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[72]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[6]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[74]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[75]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[76]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[62]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[79]

Drug(s) Affected By Long-chain fatty acid transport protein 4 (SLC27A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[6]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[82]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By Methylmalonyl-CoA epimerase, mitochondrial (MCEE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[89]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[90]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[91]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[92]

Drug(s) Affected By Aconitate hydratase, mitochondrial (ACO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[6]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Very long chain fatty acid elongase 3 (ELOVL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[98]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[42]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[99]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[100]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[29]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]

Drug(s) Affected By Insulin-induced gene 2 protein (INSIG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[31]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[105]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]

Drug(s) Affected By PHD finger protein 1 (PHF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[31]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[108]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[98]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[99]

Drug(s) Affected By RuvB-like 2 (RUVBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[118]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[119]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[121]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[122]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[125]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[116]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[126]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[127]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[128]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[118]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[119]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 9 (PSMD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[131]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[132]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[138]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[139]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]

Drug(s) Affected By Pro-neuropeptide Y (NPY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[33]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Guanethidine	DM9NSWT	Moderate and severe hypertension	BA00.Z	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[143]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[144]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[145]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Fructose	DM43AN2	Vomiting	MD90	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[149]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]

Drug(s) Affected By Beta-casein (CSN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[154]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[98]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[163]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[164]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[167]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[170]
Bortezomib	DMNO38U	Leukemia		Approved	[108]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[171]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[172]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[177]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[184]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[185]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[191]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[193]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[195]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[196]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[197]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[198]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[196]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[205]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[206]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[31]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[31]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[31]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[215]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[219]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[220]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[227]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[227]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[158]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[227]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[231]
Selenium	DM25CGV	N. A.	N. A.	Approved	[34]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[232]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[233]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[235]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[190]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[236]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[237]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[233]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[240]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[236]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[237]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[241]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[240]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[244]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[245]

Drug(s) Affected By Heat shock protein beta-2 (HSPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[247]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[250]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[252]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[89]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[253]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[258]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[259]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[260]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[262]
Mestranol	DMG3F94	Contraception	QA21	Approved	[260]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[263]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[264]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[263]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[265]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[264]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Long transient receptor potential channel 8 (TRPM8)	TTXDKTO	TRPM8_HUMAN	Activator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 111A2 (cyp111) Main DME	DEQOJDP	A0A2S6X9I3_9ACTN	Substrate	[3] , [4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
26S proteasome non-ATPase regulatory subunit 9 (PSMD9)	OT6Y5CC3	PSMD9_HUMAN	Gene/Protein Processing	[5]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[6]
Aconitate hydratase, mitochondrial (ACO2)	OTF2UVNV	ACON_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[7]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Gene/Protein Processing	[8]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[8]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[9]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[9]
Beta-casein (CSN2)	OT22C0PD	CASB_HUMAN	Gene/Protein Processing	[8]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2469).
• [2] Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45.
• [3] Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7.
• [4] A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.
• [5] Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs. Int J Mol Sci. 2015 Nov 26;16(12):28169-79. doi: 10.3390/ijms161226089.
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