Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGZQ5P)

• Drug Name: linalool Drug Info
• Synonyms: Linalool; 78-70-6; 3,7-Dimethylocta-1,6-dien-3-ol; Linalol; 3,7-Dimethyl-1,6-octadien-3-ol; beta-Linalool; allo-Ocimenol; LINALYL ALCOHOL; 1,6-Octadien-3-ol, 3,7-dimethyl-; p-Linalool; (+-)-Linalool; Linanool; 2,6-Dimethyl-2,7-octadien-6-ol; 2,6-Dimethylocta-2,7-dien-6-ol; .beta.-Linalool; Linalool (natural); 2,6-Dimethyl-2,7-octadiene-6-ol; Caswell No. 526A; Linolool; FEMA Number 2635; NSC 3789; FEMA No. 2635; CCRIS 3726; CCRIS 6557; HSDB 645; Linalool, 97%; EINECS 201-134-4; EINECS 245-083-6; 3,7-dimethyl-octa-1,6-dien-3-ol; EPA Pest

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6549
  ChEBI ID: CHEBI:17580
  CAS Number: CAS 78-70-6
  TTD Drug ID: DMGZQ5P
  INTEDE Drug ID: DR2327

Molecule-Related Drug Atlas

Drug(s) Targeting Long transient receptor potential channel 8 (TRPM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[11]
D-3263	DM7V2OM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
PF-05105679	DM4QPT0	Pain	MG30-MG3Z	Phase 1	[13]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[14]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[15]
5-METHOXYTRYPTAMINE	DMARCKD	Discovery agent	N.A.	Investigative	[16]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[17]
2-(5-fluoro-1H-indol-3-yl)ethanamine	DMHW5FT	Discovery agent	N.A.	Investigative	[16]
NADA	DM3ORGM	Discovery agent	N.A.	Investigative	[15]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine	DMD2QVO	Discovery agent	N.A.	Investigative	[16]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[18]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[19]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[20]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[25]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[26]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[27]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[30]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[31]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[38]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[38]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[49]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[53]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[54]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[55]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[56]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[60]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[57]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[62]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[49]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[65]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[71]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[72]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[76]

Drug(s) Affected By Apolipoprotein C-III (APOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[7]

Drug(s) Affected By Lipoprotein lipase (LPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[57]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[86]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[89]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[92]

Drug(s) Affected By Cytoplasmic aconitate hydratase (ACO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[97]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[98]

Drug(s) Affected By Enoyl-CoA hydratase, mitochondrial (ECHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[7]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[104]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[106]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[107]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[53]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[53]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[53]

Drug(s) Affected By Phosphoglucomutase-1 (PGM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Haloperidol	DM96SE0	Delirium		Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[109]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[109]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[117]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[118]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[7]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[129]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[130]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[131]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[109]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]

Drug(s) Affected By Long-chain fatty acid transport protein 4 (SLC27A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[7]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[135]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[137]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[138]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[139]

Drug(s) Affected By Methylmalonyl-CoA epimerase, mitochondrial (MCEE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[141]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[142]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[143]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[144]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[145]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[146]

Drug(s) Affected By Aconitate hydratase, mitochondrial (ACO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[7]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[147]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[149]

Drug(s) Affected By Very long chain fatty acid elongase 3 (ELOVL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[150]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[141]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[93]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[153]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[154]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[157]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]

Drug(s) Affected By Insulin-induced gene 2 protein (INSIG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[53]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[103]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[159]

Drug(s) Affected By PHD finger protein 1 (PHF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Bortezomib	DMNO38U	Leukemia		Approved	[161]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[163]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[153]

Drug(s) Affected By RuvB-like 2 (RUVBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[109]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[147]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[166]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[167]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[168]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[168]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[170]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[173]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[174]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[175]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[176]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[178]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[179]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[181]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[175]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[184]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[186]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[187]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[191]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[192]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[193]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[196]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[198]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[199]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[202]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[193]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[203]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[204]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[192]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[196]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[208]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[209]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[209]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 9 (PSMD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[149]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[213]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[214]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[215]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[216]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[217]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[219]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Selenium	DM25CGV	N. A.	N. A.	Approved	[222]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[223]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Selenium	DM25CGV	N. A.	N. A.	Approved	[227]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[228]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[229]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]

Drug(s) Affected By Pro-neuropeptide Y (NPY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[57]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Guanethidine	DM9NSWT	Moderate and severe hypertension	BA00.Z	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[233]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[234]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[235]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[238]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[240]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[241]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[243]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[244]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[217]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[250]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[247]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[251]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[255]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[256]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[257]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[259]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[267]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[268]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[269]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[271]
Fructose	DM43AN2	Vomiting	MD90	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[273]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[277]

Drug(s) Affected By Beta-casein (CSN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[278]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[281]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[282]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[284]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[285]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[286]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[288]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[293]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[296]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[297]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[298]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[299]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[301]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[302]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[303]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[306]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[307]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[309]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Selenium	DM25CGV	N. A.	N. A.	Approved	[222]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[312]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[315]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[316]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[106]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[319]
Bortezomib	DMNO38U	Leukemia		Approved	[161]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[176]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[320]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[324]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[325]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[329]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[331]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[332]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[333]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[334]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[335]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[303]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[336]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[338]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[58]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[228]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[340]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[341]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[342]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[344]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[346]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[347]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[348]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[349]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[350]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[352]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[255]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[353]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[355]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[356]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[357]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[358]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[347]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[360]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[361]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[362]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[363]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[364]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[365]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[367]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[369]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[215]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[370]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[371]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[372]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[373]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[375]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[376]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[377]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[161]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[378]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[379]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[302]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[380]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[381]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[382]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[383]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[384]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[385]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[387]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[387]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[388]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[294]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[387]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[387]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[387]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[389]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[389]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[390]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[253]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[392]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[393]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[394]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[393]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[296]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[358]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[301]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[304]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[380]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[396]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[348]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[382]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[398]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[389]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[400]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[358]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[382]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[402]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[400]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[358]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[399]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[403]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[404]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[402]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[406]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[407]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[408]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[409]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[410]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[411]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[412]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[382]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]

Drug(s) Affected By Heat shock protein beta-2 (HSPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[413]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[414]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[415]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[416]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[417]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[418]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[419]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[143]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[421]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[422]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[423]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[424]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[425]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[426]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[427]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[428]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[427]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[429]
Mestranol	DMG3F94	Contraception	QA21	Approved	[427]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[430]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[431]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[432]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[431]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[433]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Long transient receptor potential channel 8 (TRPM8)	TTXDKTO	TRPM8_HUMAN	Activator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 111A2 (cyp111) Main DME	DEQOJDP	A0A2S6X9I3_9ACTN	Substrate	[3] , [4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
26S proteasome non-ATPase regulatory subunit 9 (PSMD9)	OT6Y5CC3	PSMD9_HUMAN	Gene/Protein Processing	[5]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[6]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[7]
Aconitate hydratase, mitochondrial (ACO2)	OTF2UVNV	ACON_HUMAN	Gene/Protein Processing	[7]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[8]
Apolipoprotein A-I (APOA1)	OT5THARI	APOA1_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein C-III (APOC3)	OTW3520C	APOC3_HUMAN	Gene/Protein Processing	[7]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[9]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Gene/Protein Processing	[10]

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