Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKWFBT)

Drug Name
Melatonin Drug Info
Synonyms
73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; 5-Methoxy-N-acetyltryptamine; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melatol; Melovine; Melatonex; N-[2-(5-methoxyindol-3-yl)ethyl]acetamide; Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-; UNII-JL5DK93RCL; N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide; N-acetyl-5-methoxy-tryptamine; NSC 113928; CCRIS 3472; CHEMBL45; EINECS 200-797-7; JL5DK93RCL; Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)-; BRN 0205542; Circadin; Melapure; Melatonina; Posidorm; Vivitas; Night Rest; Pineal Hormone; Revital Melatonin; Rx Balance; Sleep Right; IN1244; M 5250; M1105; ML1; MT6; TNP00300; M-1200; M-1250; Mela-T; Melatonex, Melatonin; Melatonina (TN); NMR/14327425; Nature'S Harmony; PREVENTION 2 (MELATONIN); PREVENTION 3 (MELATONIN); PREVENTION 4 (MELATONIN); PREVENTION 5 (MELATONIN); PREVENTION 1 (MELATONIN) (PREVENTION 1); Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}; Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]-(6CI,8CI); N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide; Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-(9CI); Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}; Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-(9CI); 4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID; [3H]melatonin; N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Insomnia 7A00-7A0Z Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2/3 [3]
Sleep disorder, initiating and maintaining sleep Investigative [4]
Therapeutic Class
Central Nervous System Stimulants
Cross-matching ID
PubChem CID
896
ChEBI ID
CHEBI:16796
CAS Number
CAS 73-31-4
TTD Drug ID
DMKWFBT
INTEDE Drug ID
DR1018

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Quinone reductase 2 (NQO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NSC-645809 DMPJQZG Breast cancer 2C60-2C65 Phase 2 [18]
Prolarix DMZIQ8G Solid tumour/cancer 2A00-2F9Z Phase 2 [19]
CB1954 DMVP4YK Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [20]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [20]
2-iodo-melatonin DMSEIUP Discovery agent N.A. Investigative [21]
3,4,5-Trimethoxy-4'-amino-trans-stilbene DMDBOJ5 Discovery agent N.A. Investigative [22]
NSC-645808 DMMBAR3 Discovery agent N.A. Investigative [18]
decynium 22 DMWCTZ7 Discovery agent N.A. Investigative [23]
NSC-106080 DMR6P9S Discovery agent N.A. Investigative [23]
NSC-99528 DMXZAIG Discovery agent N.A. Investigative [23]
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Drug(s) Targeting Melatonin receptor type 1A (MTNR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [24]
Tasimelteon DMLOQ1V Insomnia 7A00-7A0Z Approved [25]
Neu-P11 DMIQDFW Alzheimer disease 8A20 Phase 2 [26]
LY-156735 DM5IX9M Anxiety disorder 6B00-6B0Z Phase 2 [27]
Agomelatine DMXYA5K Major depressive disorder 6A70.3 Withdrawn from market [28]
Luzindole DMXRJQV Sleep-wake disorder 7A00-7B2Z Terminated [29]
S-20928 DMQDWMJ Sleep-wake disorder 7A00-7B2Z Terminated [30]
GR-133347 DMNRJA0 Anxiety disorder 6B00-6B0Z Terminated [31]
GR-131663 DMKAGLV Anxiety disorder 6B00-6B0Z Terminated [32]
SL-18.1616 DMI1WNF Insomnia 7A00-7A0Z Terminated [33]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [34]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [35]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [37]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [38]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [39]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [40]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [41]
Verapamil DMA7PEW Angina pectoris BA40 Approved [42]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [43]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [99]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [99]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [99]
Capsaicin DMGMF6V Back pain ME84.Z Approved [95]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [100]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [97]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [101]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [102]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [103]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [98]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [44]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [45]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [41]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [48]
Estrone DM5T6US Acne vulgaris ED80 Approved [49]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [50]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [51]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [52]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [73]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [74]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [75]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [76]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [77]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Ethacrynic acid DM60QMR Edema MG29 Approved [79]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [80]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [81]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [82]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [53]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [54]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [55]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [57]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [7]
Estrone DM5T6US Acne vulgaris ED80 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [61]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [53]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [62]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [63]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [64]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [65]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [66]
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Drug(s) Metabolized By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [67]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [46]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [41]
Estrone DM5T6US Acne vulgaris ED80 Approved [49]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [50]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [68]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [69]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [70]
Theophylline DMRJFN9 Bronchitis CA20 Approved [70]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [71]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [84]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [85]
Estrone DM5T6US Acne vulgaris ED80 Approved [86]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [69]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [87]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [88]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [90]
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Drug(s) Metabolized By Indoleamine 2,3-dioxygenase 1 (IDO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [72]
Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [92]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [93]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [94]
Capsaicin DMGMF6V Back pain ME84.Z Approved [95]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [96]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [97]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [96]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [92]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [98]
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Drug(s) Affected By Alternative prion protein (PRNP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [110]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [111]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [15]
Bortezomib DMNO38U Leukemia Approved [112]
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Drug(s) Affected By Histone deacetylase 3 (HDAC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [114]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [116]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [117]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [118]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [119]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [120]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [121]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [122]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [123]
Gefitinib DM15F0X Colon adenocarcinoma Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [125]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [126]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [128]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [129]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [130]
Quercetin DM3NC4M Obesity 5B81 Approved [131]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [132]
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Drug(s) Affected By Prominin-1 (PROM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [133]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [136]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [139]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [140]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [141]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [117]
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Drug(s) Affected By Mitofusin-2 (MFN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [138]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [144]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [116]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [145]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [146]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [119]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [147]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [148]
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Drug(s) Affected By Pro-opiomelanocortin (POMC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [149]
Prednisone DM2HG4X Acute asthma CA23 Approved [150]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [151]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [152]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [153]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [154]
Triamcinolone DM98IXF Acute adrenal insufficiency Approved [155]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [156]
Ethanol DMDRQZU Chronic pain MG30 Approved [157]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [158]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [159]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [160]
Fructose DM43AN2 Vomiting MD90 Approved [98]
Ketoprofen DMRKXPT Bursitis Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [161]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [162]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [163]
Gefitinib DM15F0X Colon adenocarcinoma Approved [164]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [165]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [166]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [167]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [168]
Gefitinib DM15F0X Colon adenocarcinoma Approved [169]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [170]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [171]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [170]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [172]
Selenium DM25CGV N. A. N. A. Approved [173]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [174]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [175]
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Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [176]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [177]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [178]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [179]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [180]
Pamidronate DMB4AVP Bone Paget disease Approved [181]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [182]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [183]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [139]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [184]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [185]
Gefitinib DM15F0X Colon adenocarcinoma Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [188]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [189]
Quercetin DM3NC4M Obesity 5B81 Approved [190]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [187]
Estrone DM5T6US Acne vulgaris ED80 Approved [192]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [193]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [194]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [195]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [196]
Paclitaxel DMLB81S Breast carcinoma Approved [197]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [198]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [199]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [200]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [201]
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Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [98]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [145]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [178]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [203]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [204]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [187]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [180]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [182]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [205]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [206]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [207]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [208]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [89]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [209]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [168]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [166]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [172]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [210]
Methotrexate DM2TEOL Anterior urethra cancer Approved [206]
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Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [211]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [212]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [123]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [213]
Selenium DM25CGV N. A. N. A. Approved [214]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [215]
Methotrexate DM2TEOL Anterior urethra cancer Approved [216]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [217]
Quercetin DM3NC4M Obesity 5B81 Approved [218]
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Drug(s) Affected By Lipoprotein lipase (LPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [98]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [166]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [220]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [204]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [223]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [224]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [225]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [226]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [107]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [227]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [141]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [117]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [228]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [230]
Selenium DM25CGV N. A. N. A. Approved [231]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [232]
Quercetin DM3NC4M Obesity 5B81 Approved [233]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [234]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [235]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [226]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [236]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [237]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [239]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [240]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [241]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [242]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [208]
Verapamil DMA7PEW Angina pectoris BA40 Approved [243]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [244]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [162]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [245]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [246]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [247]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [248]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [248]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [249]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [251]
Fluoxetine DM3PD2C Bipolar depression Approved [248]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [252]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [253]
Selenium DM25CGV N. A. N. A. Approved [214]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Methotrexate DM2TEOL Anterior urethra cancer Approved [216]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [255]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [256]
Quercetin DM3NC4M Obesity 5B81 Approved [218]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [257]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [208]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [258]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [259]
Selenium DM25CGV N. A. N. A. Approved [214]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [260]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [261]
Meloxicam DM2AR7L Arthritis FA20 Approved [262]
Methotrexate DM2TEOL Anterior urethra cancer Approved [216]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [217]
Epinephrine DM3KJBC Acute asthma CA23 Approved [263]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [211]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [212]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [264]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [213]
Selenium DM25CGV N. A. N. A. Approved [214]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [265]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [266]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [128]
Methotrexate DM2TEOL Anterior urethra cancer Approved [267]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [268]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Gefitinib DM15F0X Colon adenocarcinoma Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [166]
Selenium DM25CGV N. A. N. A. Approved [231]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [269]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [270]
Methotrexate DM2TEOL Anterior urethra cancer Approved [271]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [272]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [274]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [275]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [276]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [277]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [274]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [278]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [279]
Capsaicin DMGMF6V Back pain ME84.Z Approved [280]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribosyldihydronicotinamide dehydrogenase (NQO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [226]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [281]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [282]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [283]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [116]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [284]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aggrecan core protein (ACAN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [285]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [286]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [287]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [288]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [289]
Berberine DMC5Q8X N. A. N. A. Phase 4 [290]
Diacerein DMN2Q5I N. A. N. A. Phase 4 [291]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [106]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [293]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [294]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [245]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [185]
Gefitinib DM15F0X Colon adenocarcinoma Approved [295]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [296]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [297]
Selenium DM25CGV N. A. N. A. Approved [225]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [298]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [300]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [301]
Epinephrine DM3KJBC Acute asthma CA23 Approved [302]
Quercetin DM3NC4M Obesity 5B81 Approved [303]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [304]
Fructose DM43AN2 Vomiting MD90 Approved [305]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [300]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [307]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [308]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [199]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [245]
Gefitinib DM15F0X Colon adenocarcinoma Approved [309]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [311]
Selenium DM25CGV N. A. N. A. Approved [225]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [260]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polycomb complex protein BMI-1 (BMI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [204]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [312]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [313]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [314]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [315]
Arsenic DMTL2Y1 N. A. N. A. Approved [316]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [145]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [317]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [319]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [320]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [275]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [204]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [321]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [322]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [304]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [323]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [324]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [325]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [326]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [264]
Gefitinib DM15F0X Colon adenocarcinoma Approved [124]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [296]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Prednisone DM2HG4X Acute asthma CA23 Approved [327]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [265]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leptin (LEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [209]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [166]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [329]
Quercetin DM3NC4M Obesity 5B81 Approved [330]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [331]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [209]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [209]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [223]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [332]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [333]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [334]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [335]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [336]
Gefitinib DM15F0X Colon adenocarcinoma Approved [337]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [338]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [298]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [339]
Quercetin DM3NC4M Obesity 5B81 Approved [340]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [341]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [342]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [343]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [344]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [345]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [196]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [346]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [347]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [348]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [349]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [350]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [351]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [352]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [353]
Gefitinib DM15F0X Colon adenocarcinoma Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [354]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [355]
Quercetin DM3NC4M Obesity 5B81 Approved [356]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [357]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [358]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [355]
Ethacrynic acid DM60QMR Edema MG29 Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [353]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [355]
Methotrexate DM2TEOL Anterior urethra cancer Approved [360]
Quercetin DM3NC4M Obesity 5B81 Approved [361]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [362]
Sorbitol DMAN0DE Constipation DD91.1 Approved [363]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [364]
Methotrexate DM2TEOL Anterior urethra cancer Approved [267]
Quercetin DM3NC4M Obesity 5B81 Approved [365]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [257]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [366]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [367]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [368]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [370]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [371]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nestin (NES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [326]
Quercetin DM3NC4M Obesity 5B81 Approved [372]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [283]
Testosterone enanthate DMB6871 N. A. N. A. Approved [375]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [116]
Clozapine DMFC71L Schizophrenia 6A20 Approved [376]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [314]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melatonin receptor type 1B (MTNR1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [377]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Testosterone DM7HUNW Hot flushes GA30 Approved [378]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [379]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [292]
Agomelatine DMXYA5K Major depressive disorder 6A70.3 Withdrawn from market [380]
CHRYSOERIOL DM96ECL Discovery agent N.A. Investigative [379]
4P-PDOT DMEMN0W Discovery agent N.A. Investigative [381]
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Drug(s) Affected By Mitogen-activated protein kinase 10 (MAPK10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [204]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Sorbitol DMAN0DE Constipation DD91.1 Approved [382]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [144]
Ethanol DMDRQZU Chronic pain MG30 Approved [383]
Dicumarol DMFQCB1 Bleeding disorder GA20-GA21 Approved [382]
Menthol DMG2KW7 Back pain ME84.Z Approved [384]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [140]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [382]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [385]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [386]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [387]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [208]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [244]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [388]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [389]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [126]
Meloxicam DM2AR7L Arthritis FA20 Approved [390]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [391]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [392]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [167]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [126]
Selenium DM25CGV N. A. N. A. Approved [393]
Quercetin DM3NC4M Obesity 5B81 Approved [356]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [394]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [395]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [396]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [397]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [398]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [98]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [399]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [400]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [401]
Methotrexate DM2TEOL Anterior urethra cancer Approved [402]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [403]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [404]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [405]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [406]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [407]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [408]
Quercetin DM3NC4M Obesity 5B81 Approved [409]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [410]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [412]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [413]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [414]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [415]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [416]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [213]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [372]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [417]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [418]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [419]
Testosterone DM7HUNW Hot flushes GA30 Approved [420]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [421]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [422]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [239]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [351]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [208]
Verapamil DMA7PEW Angina pectoris BA40 Approved [243]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [300]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [388]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [296]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Meloxicam DM2AR7L Arthritis FA20 Approved [262]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [265]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [217]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [423]
Quinolones DM5GVHU Bacterial infection 1A00-1C4Z Approved [424]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [425]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [426]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [427]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [428]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [429]
Quercetin DM3NC4M Obesity 5B81 Approved [430]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [180]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [431]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [432]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [427]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [433]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [208]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [338]
Methotrexate DM2TEOL Anterior urethra cancer Approved [216]
Quercetin DM3NC4M Obesity 5B81 Approved [434]
Fluoxetine DM3PD2C Bipolar depression Approved [435]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [436]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [437]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [438]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [439]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [440]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [441]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [442]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [167]
Gefitinib DM15F0X Colon adenocarcinoma Approved [443]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [444]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [126]
Selenium DM25CGV N. A. N. A. Approved [225]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [391]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [209]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [209]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [445]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [446]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [209]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [447]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [448]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [209]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [223]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [450]
Verapamil DMA7PEW Angina pectoris BA40 Approved [451]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [452]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [171]
Selenium DM25CGV N. A. N. A. Approved [225]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [453]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [454]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [455]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [456]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitofusin-1 (MFN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [457]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Leflunomide DMR8ONJ Arthritis FA20 Approved [458]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [413]
Ethanol DMDRQZU Chronic pain MG30 Approved [459]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [460]
Bortezomib DMNO38U Leukemia Approved [112]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [117]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [461]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [351]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [167]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [462]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [463]
Quercetin DM3NC4M Obesity 5B81 Approved [464]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [394]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [465]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [466]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [467]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [468]
Selenium DM25CGV N. A. N. A. Approved [225]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [469]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [470]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [471]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [472]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [473]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [474]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [475]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [369]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [476]
Ethanol DMDRQZU Chronic pain MG30 Approved [477]
Capsaicin DMGMF6V Back pain ME84.Z Approved [478]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [479]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [314]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [480]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [450]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [259]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [126]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [481]
Quercetin DM3NC4M Obesity 5B81 Approved [303]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [482]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [397]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [371]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [413]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [116]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [410]
Fructose DM43AN2 Vomiting MD90 Approved [483]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [484]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [470]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [431]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [485]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [486]
Leflunomide DMR8ONJ Arthritis FA20 Approved [458]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [486]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Melatonin receptor type 1A (MTNR1A) TT0WAIE MTR1A_HUMAN Binder [5]
Quinone reductase 2 (NQO2) TTJLP0R NQO2_HUMAN Inhibitor [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [7]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [8]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [9]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [10]
Cytochrome P450 1B1 (CYP1B1) DE9QHP6 CP1B1_HUMAN Substrate [8]
Indoleamine 2,3-dioxygenase 1 (IDO1) DE43MW5 I23O1_HUMAN Substrate [11]
Hydroxyindole O-methyltransferase (ASMT) DEHGR57 ASMT_HUMAN Substrate [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [13]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Gene/Protein Processing [14]
Aggrecan core protein (ACAN) OTUOCW8K PGCA_HUMAN Gene/Protein Processing [14]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Gene/Protein Processing [14]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Gene/Protein Processing [15]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [13]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [13]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [16]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [13]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Post-Translational Modifications [17]

References

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4 Melatonin in sleep disorders. Neurologia (Engl Ed). 2022 Sep;37(7):575-585.
5 The human MT1 melatonin receptor stimulates cAMP production in the human neuroblastoma cell line SH-SY5Y cells via a calcium-calmodulin signal transduction pathway. J Neuroendocrinol. 2005 Mar;17(3):170-8.
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36 Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
37 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
38 PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
39 The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184.
40 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
41 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
42 Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7.
43 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
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45 Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74.
46 Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism. 2007 Jul;56(7):887-94.
47 Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. J Med Chem. 1994 Mar 18;37(6):860-7.
48 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
49 A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clin Chem Lab Med. 2005;43(7):702-6.
50 Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):157-72.
51 Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J. 1998 Apr 1;331 ( Pt 1):273-81.
52 Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Curr Drug Metab. 2007 Aug;8(6):554-62.
53 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
54 Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
55 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
56 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
57 Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076.
58 Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
59 A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7.
60 A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63.
61 High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.
62 Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006 Mar 13;25(11):1679-91.
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