Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN4ZKC)

Drug Name
PARAOXON Drug Info
Synonyms
PARAOXON; Phosphacol; Diethyl paraoxon; 311-45-5; Ethyl paraoxon; Diethyl 4-nitrophenyl phosphate; Phosphachole; Mintacol; Paraoxone; Miotisal; Fosfakol; Phosphakol; Oxyparathion; Chinorto; Diethyl p-nitrophenyl phosphate; Paroxan; Mintaco; Chinorta; Eticol; Miotisal A; Diethylparaoxon; Soluglaucit; Soluglacit; Paraoxon-ethyl; Ethyl paraoxan; p-Nitrophenyl diethyl phosphate; Phosphoric acid, diethyl 4-nitrophenyl ester; Ester 25; Pestox 101; E 600 (pesticide); Diethyl-p-nitrophenyl phosphate; Phosphoric acid diethyl 4-nitrophenyl ester
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9395
ChEBI ID
CHEBI:27827
CAS Number
CAS 311-45-5
TTD Drug ID
DMN4ZKC
INTEDE Drug ID
DR1241

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Fatty acid amide hydrolase (FAAH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [14]
Thiopental DMGP8AX Anaesthesia 9A78.6 Approved [15]
JNJ-42165279 DM72GZO Anxiety disorder 6B00-6B0Z Phase 2 [16]
SSR411298 DMGTB2Q Major depressive disorder 6A70.3 Phase 2 [17]
IW-6118 DMP42W1 Inflammation 1A00-CA43.1 Phase 2 [18]
PF-04457845 DMPRYU1 Liver disease DB90-BD99 Phase 2 [19]
IPI-940 DMEIM5G Pain MG30-MG3Z Phase 1 [20]
PMID29053063-Compound-11d DMDRK68 N. A. N. A. Patented [21]
Piperazine carbamic compound 1 DMZSYU4 N. A. N. A. Patented [21]
Piperazine carbamic compound 2 DMMQ0ZO N. A. N. A. Patented [21]
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Drug(s) Targeting Carbonic anhydrase I (CA-I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [22]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [23]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [23]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [24]
Acetazolamide DM1AF5U Absence epilepsy Approved [23]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [25]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [26]
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [27]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [25]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [28]
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Drug(s) Targeting Carbonic anhydrase II (CA-II)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [22]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [29]
Dorzolamide DMA17D0 Ocular hypertension 9C61.01 Approved [30]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [31]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [32]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [32]
Cyclothiazide DMJ4AWC Congestive heart failure BD10 Approved [33]
Ethinamate DMK57GB Insomnia 7A00-7A0Z Approved [34]
Benzthiazide DMQWZ0H High blood pressure BA00 Approved [35]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [25]
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Drug(s) Targeting Acetylcholinesterase (AChE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [36]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [37]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [38]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [39]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [40]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [41]
YM443 DMNZCI1 Functional dyspepsia DD90.3 Approved [42]
Ambenonium DMOP0BL Myasthenia gravis 8C6Y Approved [43]
Demecarium bromide DMAYEU1 Open-angle glaucoma 9C61 Approved [44]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [45]
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Drug(s) Targeting Carbonic anhydrase (CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [46]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [47]
Quinethazone DMWCOSR Hypertension BA00-BA04 Approved [48]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [25]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [26]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [25]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [28]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [49]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [26]
PMID30074415-Compound-21 DM3NPOU N. A. N. A. Patented [50]
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Drug(s) Targeting Cannabinoid receptor 1 (CB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [51]
NABILONE DMVRYT2 Insomnia 7A00-7A0Z Approved [52]
Orlistat DMRJSP8 Obesity 5B81 Approved [53]
SR141716A DMCO5JZ Obesity 5B81 Approved [54]
Tebipenem DMVSX6O Urinary tract infection GC08 Phase 3 [55]
Conatumumab DM2UOSN Colorectal cancer 2B91.Z Phase 2 [56]
GW-42004 DMY3KSU Lipid metabolism disorder 5C52.Z Phase 2 [57]
SR-147778 DMNAECP Obesity 5B81 Phase 2 [58]
Nimacimab DM21Z68 Diabetic nephropathy GB61.Z Phase 2 [59]
AEF0117 DMQ1GH4 Marijuana use disorder 6C41 Phase 2 [60]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [61]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [62]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [63]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [64]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [65]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [66]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [67]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [68]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [62]
Verapamil DMA7PEW Angina pectoris BA40 Approved [69]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [70]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [71]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [72]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [73]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [74]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [75]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [67]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [76]
Verapamil DMA7PEW Angina pectoris BA40 Approved [77]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [78]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [79]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [80]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [81]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [82]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [83]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [84]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [85]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [86]
Verapamil DMA7PEW Angina pectoris BA40 Approved [87]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [82]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [88]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [89]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [90]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [91]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [92]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [76]
Verapamil DMA7PEW Angina pectoris BA40 Approved [93]
Estrone DM5T6US Acne vulgaris ED80 Approved [94]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [95]
Ethanol DMDRQZU Chronic pain MG30 Approved [96]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [70]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [97]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [97]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [93]
Verapamil DMA7PEW Angina pectoris BA40 Approved [98]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [99]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [100]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [97]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [101]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [102]
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Drug(s) Metabolized By Serum paraoxonase/arylesterase 1 (PON1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Loteprednol Etabonate DM8QTJI Eye inflammation 9A02 Approved [103]
Prulifloxacin DMOK965 Urinary tract infection GC08 Approved [7]
RTR-003632 DM45NHF N. A. N. A. Phase 2 [6]
gamma-butyrolactone DMDCZWY Discovery agent N.A. Investigative [6]
Coumaranone DM7TCPG N. A. N. A. Investigative [6]
Dihydrocoumarin DMGLX1R N. A. N. A. Investigative [6]
Gamma-thiobutyrolactone DM83HUI N. A. N. A. Investigative [6]
Homogentisic acid DMQD0YW N. A. N. A. Investigative [6]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [106]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [107]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [109]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [111]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [13]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [104]
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Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [112]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Testosterone DM7HUNW Hot flushes GA30 Approved [114]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [115]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [115]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [119]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
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Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [121]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [122]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [123]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [126]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [127]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Testosterone enanthate DMB6871 N. A. N. A. Approved [129]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [130]
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Drug(s) Affected By Liver carboxylesterase 1 (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [131]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [123]
Selenium DM25CGV N. A. N. A. Approved [112]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [135]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [121]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
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Drug(s) Affected By Carboxylesterase 3 (CES3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [138]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [140]
S 3025 DMZN0RW Discovery agent N.A. Investigative [141]
Nitrophenyl acetate DMHSD8A N. A. N. A. Investigative [142]
Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [145]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [146]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [148]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [151]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [13]
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Drug(s) Affected By Acetylcholinesterase (ACHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetylcholine DMDF79Z Cataract 9B10 Approved [152]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [153]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [154]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [155]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [154]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [156]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [157]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [158]
Testosterone DM7HUNW Hot flushes GA30 Approved [114]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Verapamil DMA7PEW Angina pectoris BA40 Approved [159]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [160]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [159]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [161]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Methotrexate DM2TEOL Anterior urethra cancer Approved [163]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [165]
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Drug(s) Affected By Muscarinic acetylcholine receptor M2 (CHRM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [166]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [166]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Acetylcholine DMDF79Z Cataract 9B10 Approved [167]
Omadacycline DMR2J95 Acute bacterial skin infection 1C41 Approved [168]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [169]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [170]
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [171]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
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Drug(s) Affected By Muscarinic acetylcholine receptor M1 (CHRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pirenzepine DMP6M1N Peptic ulcer DA61 Approved [172]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [173]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [174]
Acetylcholine DMDF79Z Cataract 9B10 Approved [175]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [176]
Clozapine DMFC71L Schizophrenia 6A20 Approved [177]
Olanzapine DMPFN6Y Bipolar depression Approved [178]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [179]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [175]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [170]
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Drug(s) Affected By Muscarinic acetylcholine receptor M3 (CHRM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [170]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [180]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Testosterone DM7HUNW Hot flushes GA30 Approved [182]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [182]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [183]
Acetylcholine DMDF79Z Cataract 9B10 Approved [176]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [176]
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Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [185]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Fluoxetine DM3PD2C Bipolar depression Approved [186]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [187]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [188]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [189]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [190]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [193]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [173]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [194]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [195]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [197]
Prednisone DM2HG4X Acute asthma CA23 Approved [198]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [199]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [200]
Methotrexate DM2TEOL Anterior urethra cancer Approved [201]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [202]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [203]
Fructose DM43AN2 Vomiting MD90 Approved [173]
Ketoprofen DMRKXPT Bursitis Approved [173]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [204]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [205]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [206]
Gefitinib DM15F0X Colon adenocarcinoma Approved [207]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [208]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [209]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [210]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [211]
Gefitinib DM15F0X Colon adenocarcinoma Approved [212]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [213]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [214]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [215]
Quercetin DM3NC4M Obesity 5B81 Approved [216]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [213]
Estrone DM5T6US Acne vulgaris ED80 Approved [218]
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Drug(s) Affected By Platelet-derived growth factor subunit A (PDGFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [219]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [220]
Methotrexate DM2TEOL Anterior urethra cancer Approved [221]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [222]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Estrone DM5T6US Acne vulgaris ED80 Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Leflunomide DMR8ONJ Arthritis FA20 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [225]
Selenium DM25CGV N. A. N. A. Approved [226]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [228]
Epinephrine DM3KJBC Acute asthma CA23 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [230]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [231]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [187]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [232]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
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Drug(s) Affected By Histone H2A type 1-B/E (H2AC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [235]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [237]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [238]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [119]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [240]
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Drug(s) Affected By Cholinesterase (BCHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [241]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [242]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [243]
Rivastigmine DMG629M Alzheimer disease 8A20 Approved [244]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [173]
Succinylcholine DM2ET1M Plasma cell myeloma 2A83.1 Approved [245]
Ethopropazine DM0N3L7 Parkinson disease 8A00.0 Approved [242]
Dimenhydrinate DM264B3 Meniere disease AB31.0 Approved [246]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [247]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [246]
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Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [248]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [219]
Etretinate DM2CZFA Keratosis ED56 Approved [249]
Quercetin DM3NC4M Obesity 5B81 Approved [250]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [252]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Ethanol DMDRQZU Chronic pain MG30 Approved [254]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [251]
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Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [255]
Etretinate DM2CZFA Keratosis ED56 Approved [249]
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Quercetin DM3NC4M Obesity 5B81 Approved [257]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [187]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [258]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [259]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [260]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [261]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [115]
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Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [262]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [263]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [143]
Gefitinib DM15F0X Colon adenocarcinoma Approved [264]
Selenium DM25CGV N. A. N. A. Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [265]
Quercetin DM3NC4M Obesity 5B81 Approved [266]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [267]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
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Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [268]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [258]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [269]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
Testosterone enanthate DMB6871 N. A. N. A. Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [271]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Folic Acid DMEMBJC Colorectal carcinoma Approved [272]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
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Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [273]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Selenium DM25CGV N. A. N. A. Approved [112]
Etretinate DM2CZFA Keratosis ED56 Approved [249]
Quercetin DM3NC4M Obesity 5B81 Approved [266]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [275]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [276]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [259]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Synaptophysin (SYP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [277]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Ethanol DMDRQZU Chronic pain MG30 Approved [278]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [277]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [279]
Methamphetamine DMPM4SK Anxiety Approved [280]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [282]
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Drug(s) Affected By Glutathione S-transferase theta-2 (GSTT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [283]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [284]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [285]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [286]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [287]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [288]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [289]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [290]
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Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [276]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [235]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [291]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [292]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [293]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [293]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [294]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurofilament heavy polypeptide (NEFH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [258]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [295]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [296]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [297]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [240]
Arsenic DMTL2Y1 N. A. N. A. Approved [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Synapsin-1 (SYN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [286]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [290]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
Drug(s) Affected By Neuromodulin (GAP43)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [299]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [300]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [299]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [301]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [302]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [303]
Megestrol DMDH9KX Breast cancer 2C60-2C65 Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histidine decarboxylase (HDC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [304]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [305]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [306]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [307]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [307]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [110]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [12]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [308]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aromatic-L-amino-acid decarboxylase (DDC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [309]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [235]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [310]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [311]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [312]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [313]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Testosterone DM7HUNW Hot flushes GA30 Approved [182]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [182]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [314]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [315]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [316]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
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Drug(s) Affected By Bone morphogenetic protein 8B (BMP8B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [303]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [317]
Urethane DM7NSI0 N. A. N. A. Phase 4 [318]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [317]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [319]
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Drug(s) Affected By Prohibitin 1 (PHB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [320]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [321]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [322]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [323]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [321]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [252]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Ethanol DMDRQZU Chronic pain MG30 Approved [254]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Haloperidol DM96SE0 Delirium Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [303]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Benzatropine DMF7EXL Parkinsonian disorder Approved [320]
Clozapine DMFC71L Schizophrenia 6A20 Approved [320]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [324]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [240]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [325]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [326]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [327]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [328]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [329]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [330]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [331]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [332]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [333]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [334]
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Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [335]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [336]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [337]
Testosterone DM7HUNW Hot flushes GA30 Approved [114]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [271]
Clozapine DMFC71L Schizophrenia 6A20 Approved [338]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [283]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [339]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [340]
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Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [341]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [342]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [343]
Quercetin DM3NC4M Obesity 5B81 Approved [344]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [235]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [259]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [345]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [346]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [347]
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Drug(s) Affected By Glutathione synthetase (GSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [349]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [237]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [350]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [351]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [281]
Arsenic DMTL2Y1 N. A. N. A. Approved [352]
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Drug(s) Affected By C-C chemokine receptor type 6 (CCR6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [353]
Leflunomide DMR8ONJ Arthritis FA20 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [354]
Arsenic DMTL2Y1 N. A. N. A. Approved [355]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [356]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [357]
Urethane DM7NSI0 N. A. N. A. Phase 4 [318]
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Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Selenium DM25CGV N. A. N. A. Approved [112]
Etretinate DM2CZFA Keratosis ED56 Approved [249]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Estrone DM5T6US Acne vulgaris ED80 Approved [358]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [359]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [323]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [271]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Ampicillin DMHWE7P Acute epiglottitis Approved [125]
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Drug(s) Affected By Pancreatic lipase-related protein 2 (PNLIPRP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [252]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Orlistat DMRJSP8 Obesity 5B81 Approved [360]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [317]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [361]
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Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Selenium DM25CGV N. A. N. A. Approved [112]
Etretinate DM2CZFA Keratosis ED56 Approved [249]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [362]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Leflunomide DMR8ONJ Arthritis FA20 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [125]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H4 (H4C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [363]
Selenium DM25CGV N. A. N. A. Approved [112]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [364]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [365]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Panobinostat DM58WKG Chronic graft versus host disease Approved [366]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [337]
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Drug(s) Affected By Tropomyosin alpha-4 chain (TPM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [319]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [367]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Leflunomide DMR8ONJ Arthritis FA20 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Ampicillin DMHWE7P Acute epiglottitis Approved [125]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [368]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein SET (SET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [369]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [370]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [370]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [271]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [371]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [372]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By A-kinase anchor protein 12 (AKAP12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [373]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [374]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [375]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [376]
Testosterone DM7HUNW Hot flushes GA30 Approved [182]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [301]
Leflunomide DMR8ONJ Arthritis FA20 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lamin-B2 (LMNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [377]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [378]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [379]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [380]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [381]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [382]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate decarboxylase 2 (GAD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [271]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [12]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [317]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [12]
Chlorphrifos oxon DMGBT68 Discovery agent N.A. Investigative [12]
CHLORPYRIFOS DMKPUI6 Discovery agent N.A. Investigative [12]
Hexadecanoic acid DMWUXDZ Discovery agent N.A. Investigative [383]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin enhancer-binding factor 2 (ILF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [219]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [384]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [385]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [384]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [386]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [387]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [388]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein-tyrosine kinase 2-beta (PTK2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [389]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [276]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [390]
Ethanol DMDRQZU Chronic pain MG30 Approved [391]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [285]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [392]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [356]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [169]
Urethane DM7NSI0 N. A. N. A. Phase 4 [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2B type 2-E (H2BC21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [365]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [235]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [393]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [238]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [339]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [285]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [119]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acyl-CoA-binding domain-containing protein 5 (ACBD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [219]
Leflunomide DMR8ONJ Arthritis FA20 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [394]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [169]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [395]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [395]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pecanex-like protein 4 (PCNX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [271]
Bortezomib DMNO38U Leukemia Approved [396]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [169]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [387]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [397]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Kin of IRRE-like protein 2 (KIRREL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [398]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [285]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
Urethane DM7NSI0 N. A. N. A. Phase 4 [318]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [361]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Stearoyl-CoA desaturase 5 (SCD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [258]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [237]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [238]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [339]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [281]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [386]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [399]
Ganoderic acid A DM42EVG Discovery agent N.A. Investigative [400]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Immunoglobulin-like domain-containing receptor 1 (ILDR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [301]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [238]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [402]
Drug(s) Affected By RING finger protein 113B (RNF113B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [399]
Drug(s) Affected By Tetratricopeptide repeat protein 16 (TTC16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Drug(s) Affected By Histone H2A type 1-H (H2AC12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [403]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [404]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Ethanol DMDRQZU Chronic pain MG30 Approved [405]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [240]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [406]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [378]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [407]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [258]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [408]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Leflunomide DMR8ONJ Arthritis FA20 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [236]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [409]
Clozapine DMFC71L Schizophrenia 6A20 Approved [410]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Linker for activation of T-cells family member 2 (LAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [411]
Testosterone DM7HUNW Hot flushes GA30 Approved [182]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [182]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [412]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [413]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [414]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coiled-coil domain-containing protein 177 (CCDC177)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [258]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [110]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [415]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [110]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP4 (PARP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [268]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [376]
Leflunomide DMR8ONJ Arthritis FA20 Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [253]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [394]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [416]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [169]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [417]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Axin-2 (AXIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [418]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [271]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [283]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [419]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [420]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [239]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [394]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [173]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [422]
Diazepam DM08E9O Alcohol withdrawal Approved [423]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [424]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [425]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [426]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [427]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Quercetin DM3NC4M Obesity 5B81 Approved [429]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [2]
Cannabinoid receptor 1 (CB1) TT6OEDT CNR1_HUMAN Inhibitor [1]
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [3]
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [3]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [3]
Fatty acid amide hydrolase (FAAH) TTDP1UC NOUNIPROTAC Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [5]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [4]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [4]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [4]
Serum paraoxonase/arylesterase 1 (PON1) DESDN74 PON1_HUMAN Substrate [6]
Serum paraoxonase/arylesterase 2 (PON2) DEHJU7E PON2_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Gene/Protein Processing [8]
Abscission/NoCut checkpoint regulator OT6V9IDI ANCHR_HUMAN Gene/Protein Processing [9]
Acetylcholinesterase (ACHE) OT2H8HG6 ACES_HUMAN Gene/Protein Processing [10]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Gene/Protein Processing [9]
Acyl-CoA-binding domain-containing protein 5 (ACBD5) OT7L16DY ACBD5_HUMAN Gene/Protein Processing [8]
Albumin (ALB) OTVMM513 ALBU_HUMAN Drug Response [11]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Gene/Protein Processing [9]
Aromatic-L-amino-acid decarboxylase (DDC) OT0TSW09 DDC_HUMAN Protein Interaction/Cellular Processes [12]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [13]
ATP synthase subunit beta, mitochondrial (ATP5F1B) OTLFZUQK ATPB_HUMAN Gene/Protein Processing [9]

References

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2 Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8.
3 Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12.
4 Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32.
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6 Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42.
7 Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
8 Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox. Int J Mol Sci. 2014 Jan 9;15(1):905-26. doi: 10.3390/ijms15010905.
9 Paraoxon-induced protein expression changes to SH-SY5Y cells. Chem Res Toxicol. 2010 Nov 15;23(11):1656-62. doi: 10.1021/tx100192f. Epub 2010 Oct 8.
10 Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators. Talanta. 2008 Oct 19;77(1):451-4.
11 Serum albumins and detoxication of anti-cholinesterase agents. Chem Biol Interact. 2010 Sep 6;187(1-3):325-9. doi: 10.1016/j.cbi.2010.03.001. Epub 2010 Mar 6.
12 Decarboxylases as hypothetical targets for actions of organophosphates: Molecular modeling for prediction of hidden and unexpected health threats. Food Chem Toxicol. 2022 Mar;161:112856. doi: 10.1016/j.fct.2022.112856. Epub 2022 Feb 11.
13 Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
14 Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
15 The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13.
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19 Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS Med Chem Lett. 2011 Feb 10;2(2):91-96.
20 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1400).
21 A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351.
22 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
23 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
24 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2597).
25 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
26 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
27 Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches. Protein Pept Lett. 2015;22(10):903-12.
28 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
29 Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
30 Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
31 Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
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