Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNLQHK)

• Drug Name: Tanespimycin Drug Info
• Synonyms: CNF-101; [(3S,5S,6R,7S,8E,10R,11S,12E,14E)-6-Hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; 17AAG, Tanespimycin, Geldanamycin, NSC330507, 17-(Allylamino)-17-demethoxygeldanamycin, CP 127374

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 2	[1]
Multiple myeloma	2A83	Discontinued in Phase 3	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 6505803
  ChEBI ID: CHEMBL64153
  CAS Number: CAS 75747-14-7
  TTD Drug ID: DMNLQHK

Molecule-Related Drug Atlas

Drug(s) Targeting Heat shock protein 90 alpha (HSP90A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cromoglicate	DM74LZK	Asthma	CA23	Approved	[9]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[9]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[10]
BIIB-021	DMPAJ41	Breast cancer	2C60-2C65	Phase 2	[11]
KW-2478	DMJGL72	Solid tumour/cancer	2A00-2F9Z	Phase 2	[12]
VER 50589	DMFLZPC	Breast cancer	2C60-2C65	Phase 2	[10]
Efungumab	DMBHP56	Breast cancer	2C60-2C65	Phase 2	[13]
SNX-5422	DMIU0VP	Haematological malignancy	2B33.Y	Phase 1/2	[14]
PU3	DMJO0BP	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
Debio 0932	DMWP3G1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[15]

Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[16]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[17]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Venetoclax	DM8I94Y	Chronic lymphocytic leukaemia	2A82.0	Approved	[22]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[23]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[24]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[25]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[31]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By Protein MTSS 1 (MTSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[45]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[48]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[49]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[53]

Drug(s) Affected By Anterior gradient protein 2 homolog (AGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[31]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[68]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[74]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[76]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[85]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[46]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]

Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[95]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[93]

Drug(s) Affected By Alpha-enolase (ENO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[100]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[103]

Drug(s) Affected By L-lactate dehydrogenase B chain (LDHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[39]

Drug(s) Affected By Profilin-1 (PFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[111]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[112]
Haloperidol	DM96SE0	Delirium		Approved	[113]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[107]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[119]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[49]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[120]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[120]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[121]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[126]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[127]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[128]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[127]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[129]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]

Drug(s) Affected By Elongation factor 2 (EEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[141]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[142]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[144]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]

Drug(s) Affected By Plastin-2 (LCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[147]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[148]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]

Drug(s) Affected By Intron Large complex component GCFC2 (GCFC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[149]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[151]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[148]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]

Drug(s) Affected By Moesin (MSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]

Drug(s) Affected By Elongation factor 1-gamma (EEF1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[158]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[159]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[160]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[161]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[162]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[163]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[164]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[168]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[171]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[162]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[172]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[173]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[161]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[164]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[165]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]

Drug(s) Affected By Serine hydroxymethyltransferase, mitochondrial (SHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Radixin (RDX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Haloperidol	DM96SE0	Delirium		Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[188]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[189]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Serpin B5 (SERPINB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[195]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[197]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[103]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[199]

Drug(s) Affected By Transcription initiation factor IIA subunit 2 (GTF2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[201]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[202]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[203]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[207]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[209]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[214]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[214]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[215]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[185]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[214]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]

Drug(s) Affected By Echinoderm microtubule-associated protein-like 5 (EML5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[217]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[5]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[219]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[201]

Drug(s) Affected By Protein CBFA2T1 (RUNX1T1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[220]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[151]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[221]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[50]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[50]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[223]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[225]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[229]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[230]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit I (EIF3I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[5]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[231]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[103]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By La-related protein 7 (LARP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[233]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[151]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[234]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (TPTE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[235]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[236]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[18]

Drug(s) Affected By Potassium voltage-gated channel subfamily V member 2 (KCNV2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]

Drug(s) Affected By SRC kinase signaling inhibitor 1 (SRCIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[219]

Drug(s) Affected By Pinin (PNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[193]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[237]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[55]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[238]

Drug(s) Affected By PRKR-interacting protein 1 (PRKRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[180]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[202]

Drug(s) Affected By Transcription factor COE2 (EBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[151]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[18]

Drug(s) Affected By Phenylalanine--tRNA ligase beta subunit (FARSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[113]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[240]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[241]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[55]

Drug(s) Affected By Poly polymerase 2 (PARP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[229]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[244]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By Proliferation-associated protein 2G4 (PA2G4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[248]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[250]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[35]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
Selenium	DM25CGV	N. A.	N. A.	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[253]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[70]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[99]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[75]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[258]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[259]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[260]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[261]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[262]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heat shock protein 90 alpha (HSP90A)	TT78R5H	HS90A_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Gene/Protein Processing	[3]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Drug Response	[4]
Alpha-enolase (ENO1)	OTB1KWJS	ENOA_HUMAN	Gene/Protein Processing	[5]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Gene/Protein Processing	[5]
Anterior gradient protein 2 homolog (AGR2)	OTRRZT7W	AGR2_HUMAN	Gene/Protein Processing	[5]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Gene/Protein Processing	[6]
ATP synthase subunit beta, mitochondrial (ATP5F1B)	OTLFZUQK	ATPB_HUMAN	Gene/Protein Processing	[5]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[7]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[8]
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)	OTFHWIY8	DHRS2_HUMAN	Gene/Protein Processing	[5]

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