Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRMS0L)

• Drug Name: Morphine Drug Info
• Synonyms: Avinza; Kadian; Morphine Sulfate; Depodur; Astramorph Pf; Duramorph Pf; Infumorph; Ms Contin; Oramorph Sr

Indication

Disease Entry	ICD 11	Status	REF
Advanced cancer	2A00-2F9Z	Approved	[1]
Chronic pain	MG30	Approved	[2]
Pain	MG30-MG3Z	Approved	[1]
Diarrhea	ME05.1	Investigative	[1]

• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 5288826
  ChEBI ID: CHEBI:17303
  CAS Number: CAS 57-27-2
  TTD Drug ID: DMRMS0L
  VARIDT Drug ID: DR00467
  INTEDE Drug ID: DR1112
  ACDINA Drug ID: D00447

Molecule-Related Drug Atlas

Drug(s) Targeting Opioid receptor mu (MOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[21]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[22]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[23]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[24]
Alfentanil	DMVO0UB	Anaesthesia	9A78.6	Approved	[25]
Naloxegol	DML0B41	Opioid-induced constipation	DB32.1	Approved	[26]
Eluxadoline	DMYZ0P1	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[27]
Nalfurafine hcl	DMA9DHW	Uremic pruritus	EC90.10	Approved	[28]
Oxycodone	DMXLKHV	Osteoarthritis	FA00-FA05	Approved	[29]
Methylnaltrexone bromide	DMZTGN2	Opioid-induced constipation	DB32.1	Approved	[23]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[33]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[34]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[36]

Drug(s) Transported By Multidrug resistance-associated protein 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[38]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[39]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[41]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[42]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[43]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[45]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[46]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[47]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[48]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[53]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[54]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[48]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[55]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[56]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[59]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[62]
Metronidazole	DMTIVEN	Abscess		Approved	[63]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[64]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[65]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[66]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[67]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[69]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[70]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[71]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[72]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[94]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[97]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[98]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[99]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[100]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[101]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[102]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[77]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[78]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[79]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[75]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[80]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[81]

Drug(s) Metabolized By UDP-glucuronosyltransferase 2B7 (UGT2B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[82]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[80]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[55]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[86]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[87]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[88]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A3 (UGT1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[55]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[90]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[91]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[86]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[92]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[88]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[55]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[103]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[104]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[105]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[106]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[107]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[108]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[109]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[110]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[111]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[109]

Drug(s) Affected By Mu-type opioid receptor (OPRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alvimopan	DMHR8KW	Gastrointestinal disease	DE2Z	Approved	[112]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[116]
Oliceridine	DM6MDCF	Acute pain	MG31	Approved	[113]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[119]
Tianeptine	DMYN8MA	Major depressive disorder	6A70.3	Approved	[116]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[127]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[128]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[132]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[133]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[137]

Drug(s) Affected By LIM homeobox transcription factor 1-beta (LMX1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[139]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[140]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By Krueppel-like factor 7 (KLF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[148]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[149]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[150]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[153]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[154]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[153]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[160]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[161]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[164]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[165]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[166]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[167]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[137]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[169]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[169]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[173]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[169]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[174]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Selenium	DM25CGV	N. A.	N. A.	Approved	[176]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[178]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[181]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[187]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[188]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[189]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[191]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[192]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[193]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[194]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[195]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[196]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[197]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[198]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[200]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[201]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[177]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[202]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[204]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[205]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[208]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]

Drug(s) Affected By Coagulation factor VII (F7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Mestranol	DMG3F94	Contraception	QA21	Approved	[211]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[212]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[213]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[214]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[215]
Cenestin	DMXQS7K	Menopause symptom	GA30.0	Approved	[216]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[218]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[219]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[220]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[223]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[224]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[225]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[226]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[227]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[228]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[160]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[229]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[230]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[231]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[232]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[236]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[239]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[240]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[241]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[160]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[242]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[244]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[245]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[246]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[248]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[249]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[250]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[231]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[251]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[252]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[253]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[254]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[257]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[249]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[258]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[259]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[260]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[248]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[160]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[231]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[251]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[261]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[262]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[232]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[263]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[265]
Selenium	DM25CGV	N. A.	N. A.	Approved	[266]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[267]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[268]

Drug(s) Affected By Kappa-type opioid receptor (OPRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[269]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[270]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[134]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[271]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[160]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[272]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[273]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[275]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[187]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[276]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[277]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[279]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[280]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[242]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[281]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[282]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[230]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[285]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[286]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[287]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[288]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[160]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[194]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[196]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[289]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[290]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[293]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[295]

Drug(s) Affected By Eukaryotic translation initiation factor 5A-1 (EIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[298]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[299]
Bortezomib	DMNO38U	Leukemia		Approved	[145]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[298]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[300]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[301]

Drug(s) Affected By C-C motif chemokine 8 (CCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[303]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[304]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Bortezomib	DMNO38U	Leukemia		Approved	[306]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[307]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[308]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[310]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[311]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[313]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[314]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[232]
Selenium	DM25CGV	N. A.	N. A.	Approved	[266]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[315]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[316]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[317]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[318]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[225]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[242]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[229]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[319]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[283]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[320]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[321]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[322]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[323]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[326]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[329]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[330]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[331]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[332]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[333]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[334]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[285]
Selenium	DM25CGV	N. A.	N. A.	Approved	[266]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[287]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[337]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[338]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[340]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[341]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[342]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[343]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[344]

Drug(s) Affected By DNA damage-binding protein 2 (DDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[303]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[143]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[127]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[172]

Drug(s) Affected By Ninjurin-1 (NINJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[346]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[347]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[137]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[346]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[348]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[127]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[285]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[349]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[350]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[351]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[352]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[353]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[354]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[356]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[357]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[358]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[359]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[358]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[360]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[361]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[362]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[137]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[364]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[365]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[366]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[367]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[210]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[370]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[299]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[371]

Drug(s) Affected By Beta-arrestin-2 (ARRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[340]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[137]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[372]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[299]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[373]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[374]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[375]
Methamphetamine	DMPM4SK	Anxiety		Approved	[376]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[377]

Drug(s) Affected By Cocaine esterase (CES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[378]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[379]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[381]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[382]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[383]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[384]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[385]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[386]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[299]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[387]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[388]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[389]
Fructose	DM43AN2	Vomiting	MD90	Approved	[160]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[390]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[391]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[392]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[393]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[394]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[395]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[390]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[396]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[393]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[397]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[398]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[399]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[393]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[400]

Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[402]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[403]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[404]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[404]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[406]

Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[407]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[408]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[409]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[410]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[160]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[411]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[408]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[412]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[413]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[412]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor mu (MOP)	TTKWM86	OPRM_HUMAN	Modulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 3 (ABCC3)	DTQ3ZHF	MRP3_HUMAN	Substrate	[4]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[6]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[7]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[8]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[9]
UDP-glucuronosyltransferase 2B7 (UGT2B7) Main DME	DEB3CV1	UD2B7_HUMAN	Substrate	[10]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Substrate	[11]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Biotransformations	[12]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Gene/Protein Processing	[13]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[14]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[14]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Drug Response	[15]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[16]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[17]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[18]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Gene/Protein Processing	[19]
Beta-arrestin-2 (ARRB2)	OTAEJZCI	ARRB2_HUMAN	Drug Response	[20]

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