Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUOQZD)

• Drug Name: Arachidonic Acid Drug Info
• Synonyms: arachidonic acid; 506-32-1; arachidonate; (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid; Immunocytophyte; (all-Z)-5,8,11,14-Eicosatetraenoic acid; cis-5,8,11,14-Eicosatetraenoic acid; 5,8,11,14-Eicosatetraenoic acid, (all-Z)-; 5Z,8Z,11Z,14Z-eicosatetraenoic acid; UNII-27YG812J1I; all-cis-5,8,11,14-eicosatetraenoic acid; Arachidonic Acid, 99%; CHEMBL15594; CHEBI:15843; YZXBAPSDXZZRGB-DOFZRALJSA-N; 27YG812J1I; cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid; (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 444899
  ChEBI ID: CHEBI:15843
  CAS Number: CAS 506-32-1
  TTD Drug ID: DMUOQZD
  INTEDE Drug ID: DR0129

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[15]
Naproxen	DMZ5RGV	Bursitis		Approved	[16]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[17]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[18]
Bromfenac	DMKB79O	Pain	MG30-MG3Z	Approved	[19]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[20]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[21]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[20]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[22]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[38]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[38]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[38]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[38]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[38]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[38]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[38]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[24]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[3]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[55]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[56]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[57]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[58]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[55]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[59]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[56]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[55]

Drug(s) Metabolized By Cytochrome P450 4F2 (CYP4F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[32]
Fingolimod	DM5JVAN	Multiple sclerosis	8A40	Approved	[33]
Ebastine	DMH21D9	N. A.	N. A.	Phase 4	[34]
Pafuramidine	DMFKOR9	Malaria	1F40-1F45	Phase 3	[35]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[36]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[37]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[74]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[75]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]

Drug(s) Metabolized By Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[39]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[38]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[40]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[41]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[40]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[40]
Omega-6-FA	DMBWY8V	N. A.	N. A.	Phase 3	[42]
alpha-linolenic acid	DMY64HE	Discovery agent	N.A.	Investigative	[40]
Eicosadienoic acid	DMVJK9W	N. A.	N. A.	Investigative	[40]
Icosapentum	DMF1CM7	N. A.	N. A.	Investigative	[40]

Drug(s) Metabolized By Arachidonate 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[43]
Omega-6-FA	DMBWY8V	N. A.	N. A.	Phase 3	[42]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[60]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[61]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[62]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[46]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[64]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[65]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[81]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[84]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[85]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[90]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[84]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[102]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[103]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[106]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[107]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[100]

Drug(s) Affected By Cytosolic phospholipase A2 (PLA2G4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[112]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[113]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By 2-hydroxyacyl-CoA lyase 2 (ILVBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[119]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[119]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[121]

Drug(s) Affected By CTD small phosphatase-like protein (CTDSPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[125]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[127]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[128]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[129]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]

Drug(s) Affected By U4/U6 small nuclear ribonucleoprotein Prp4 (PRPF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[131]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[132]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[133]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[134]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[135]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[119]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[141]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[146]

Drug(s) Affected By Stanniocalcin-2 (STC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[153]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[155]

Drug(s) Affected By Luc7-like protein 3 (LUC7L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[131]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[156]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[158]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[159]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[160]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[164]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[166]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[167]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Fructose	DM43AN2	Vomiting	MD90	Approved	[161]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]

Drug(s) Affected By SPARC (SPARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[176]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[178]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[179]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[180]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[182]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Selenium	DM25CGV	N. A.	N. A.	Approved	[186]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[187]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]

Drug(s) Affected By COUP transcription factor 1 (NR2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[192]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[193]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[172]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[200]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[212]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[214]

Drug(s) Affected By Fibroblast growth factor receptor 3 (FGFR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[215]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[216]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[216]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]

Drug(s) Affected By Integrin alpha-6 (ITGA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[222]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[223]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]

Drug(s) Affected By ATP-binding cassette sub-family D member 3 (ABCD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By Collagen alpha-1(XVIII) chain (COL18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[228]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[229]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[232]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[233]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[234]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[238]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[239]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[244]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[245]

Drug(s) Affected By Glucosamine-6-phosphate isomerase 1 (GNPDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[247]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[134]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[249]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[250]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[252]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[253]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[254]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[253]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[253]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[255]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[253]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[256]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[254]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[257]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[258]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[259]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[260]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[214]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[264]

Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[267]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[268]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[150]

Drug(s) Affected By Insulin gene enhancer protein ISL-1 (ISL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[271]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[125]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[52]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]

Drug(s) Affected By Double-stranded RNA-specific editase 1 (ADARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[146]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[129]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[273]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[156]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[274]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[276]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[277]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[279]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[283]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[285]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[288]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[289]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[291]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[214]

Drug(s) Affected By Krueppel-like factor 5 (KLF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[294]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[164]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[295]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]

Drug(s) Affected By 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[229]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]

Drug(s) Affected By Insulin-like growth factor-binding protein 7 (IGFBP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[269]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[296]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[297]

Drug(s) Affected By Myomegalin (PDE4DIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[298]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[299]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[298]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[300]

Drug(s) Affected By Tensin-3 (TNS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]

Drug(s) Affected By Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[303]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[131]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]

Drug(s) Affected By All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[131]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[128]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[157]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[150]

Drug(s) Affected By Protein tyrosine phosphatase type IVA 1 (PTP4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[277]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[308]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[74]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[309]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[310]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[277]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[311]

Drug(s) Affected By Neurturin (NRTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[312]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[314]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[315]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[316]

Drug(s) Affected By ATP-dependent RNA helicase DDX24 (DDX24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[317]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[317]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[156]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[133]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[301]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[301]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[319]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[277]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[153]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[323]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[164]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[324]

Drug(s) Affected By Spastin (SPAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[131]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[134]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[301]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[121]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[326]

Drug(s) Affected By Ergosterol biosynthetic protein 28 homolog (ERG28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[327]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[296]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[328]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[200]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[67]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[279]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[295]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]

Drug(s) Affected By Rap guanine nucleotide exchange factor 2 (RAPGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[296]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[301]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[152]

Drug(s) Affected By Intraflagellar transport protein 25 homolog (IFT25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[330]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[331]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[332]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[317]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[333]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[333]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[333]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[57]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[334]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[335]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[336]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[337]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[338]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[161]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[339]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[340]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[161]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[341]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[247]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[161]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[344]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[345]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[53]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[56]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[347]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[348]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[349]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[350]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[53]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[344]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[56]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[351]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[57]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[55]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[335]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[55]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[344]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[161]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[352]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[353]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Tyrosine-protein kinase CSK (CSK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[355]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[356]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[131]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[161]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[357]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[250]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[358]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[359]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[360]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[361]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]

Drug(s) Affected By Transient receptor potential cation channel subfamily V member 4 (TRPV4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[146]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[364]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[254]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[365]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[365]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[366]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[365]
Fructose	DM43AN2	Vomiting	MD90	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[365]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[369]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[229]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[370]
Bortezomib	DMNO38U	Leukemia		Approved	[371]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[372]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[373]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[374]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[182]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[170]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[375]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[376]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[67]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[377]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[378]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[164]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[379]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[382]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[250]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[384]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[384]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[386]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[387]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[388]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[389]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[390]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[391]
Fructose	DM43AN2	Vomiting	MD90	Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[393]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[394]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[395]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[396]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[397]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[398]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[399]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[400]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[107]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[401]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[402]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[403]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Selenium	DM25CGV	N. A.	N. A.	Approved	[404]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[279]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[405]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[366]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[332]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[409]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[410]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[411]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[412]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[413]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[414]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[247]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[416]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[161]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[331]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[161]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[417]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[418]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[419]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[420]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[421]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[422]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[279]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[182]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[424]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[426]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[279]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[427]
Selenium	DM25CGV	N. A.	N. A.	Approved	[428]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[429]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[430]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[433]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[434]

Drug(s) Affected By Integrin alpha-IIb (ITGA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[435]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[435]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[414]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[436]
Abciximab	DMJO6GV	Acute disease		Approved	[161]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[161]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[437]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[438]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[288]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[439]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[440]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[439]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[441]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[442]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[444]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[445]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[446]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[447]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[161]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[448]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[449]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[450]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[451]

Drug(s) Affected By Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[452]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[453]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[454]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[455]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[324]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[157]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[456]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[457]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[458]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[459]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[460]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[461]
Fructose	DM43AN2	Vomiting	MD90	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[463]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[457]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[176]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[464]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[465]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[466]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[467]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[331]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[468]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[469]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[470]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[471]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Selenium	DM25CGV	N. A.	N. A.	Approved	[428]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[472]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[441]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[306]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[473]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[474]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[476]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[477]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[478]
Bortezomib	DMNO38U	Leukemia		Approved	[371]

Drug(s) Affected By P-selectin (SELP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[480]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[481]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[482]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[435]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[483]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[484]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[485]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[486]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[487]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[488]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[489]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[490]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[491]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[317]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[492]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[493]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[288]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[494]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[495]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[496]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Fructose	DM43AN2	Vomiting	MD90	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[295]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[497]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[498]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[497]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[212]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[11]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[499]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[498]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[500]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[501]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[378]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[502]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[317]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[317]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[295]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[504]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[495]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[505]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Fructose	DM43AN2	Vomiting	MD90	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[506]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[507]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[508]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[509]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[510]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[511]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[512]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[513]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[514]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[449]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[515]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[516]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[288]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[517]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[518]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[519]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[319]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[288]
Selenium	DM25CGV	N. A.	N. A.	Approved	[520]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[521]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[522]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[523]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[476]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[319]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[524]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[437]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[515]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[525]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[526]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[527]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[528]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[444]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[239]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[448]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[493]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[515]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[529]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[530]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[440]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[531]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[532]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[288]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[533]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[534]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[535]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[521]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[536]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[537]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[538]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[319]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[539]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[288]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[518]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[540]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[541]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[542]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[200]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[540]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[541]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[543]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[544]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[277]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]

Drug(s) Affected By Resistin (RETN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[545]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[546]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[547]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[548]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[549]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[550]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[551]
isobutylmethylxanthine	DM46F5X	Discovery agent	N.A.	Investigative	[552]
Icosapentum	DMF1CM7	N. A.	N. A.	Investigative	[553]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[554]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[555]
Fructose	DM43AN2	Vomiting	MD90	Approved	[161]
Ketoprofen	DMRKXPT	Bursitis		Approved	[161]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[556]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[450]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[557]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[471]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[558]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[559]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[560]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[561]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[562]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[563]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[564]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[565]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[566]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[567]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[379]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[567]
Bortezomib	DMNO38U	Leukemia		Approved	[568]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[567]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[567]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[569]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[570]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[571]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[570]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[571]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[572]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[570]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[570]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[570]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[573]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[574]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[575]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[576]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[577]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[578]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[351]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[579]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[502]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[580]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[581]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[582]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[583]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[584]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[585]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[586]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[587]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[588]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[588]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[588]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[588]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[588]

Drug(s) Affected By Cytochrome P450 4F3 (CYP4F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[545]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[589]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[560]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[356]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[591]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[592]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[593]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[594]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[595]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[182]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[596]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[597]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[598]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[599]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[600]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[601]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[57]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[55]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[602]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[603]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[3]
Prostaglandin G/H synthase 2 (COX-2)	DE492CE	PGH2_HUMAN	Substrate	[4]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Substrate	[5]
Arachidonate 5-lipoxygenase (ALOX5)	DE87OZS	LOX5_HUMAN	Substrate	[6]
Arachidonate 12-lipoxygenase (ALOX12B)	DEISPU8	LX12B_HUMAN	Substrate	[7]
Arachidonate 15-lipoxygenase (ALOX15)	DEH0J8X	LOX15_HUMAN	Substrate	[8]
Cytochrome P450 4F2 (CYP4F2)	DE3GT9C	CP4F2_HUMAN	Substrate	[9]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein zeta/delta	OT2TKG9P	1433Z_HUMAN	Gene/Protein Processing	[10]
2-hydroxyacyl-CoA lyase 2 (ILVBL)	OTNRRCGY	HACL2_HUMAN	Gene/Protein Processing	[10]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	OTSMGKXQ	EBP_HUMAN	Gene/Protein Processing	[10]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[10]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[10]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[11]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Gene/Protein Processing	[12]
All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2)	OTEOQBMX	DLP1_HUMAN	Gene/Protein Processing	[10]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Regulation of Drug Effects	[13]
Apolipoprotein A-I (APOA1)	OT5THARI	APOA1_HUMAN	Gene/Protein Processing	[14]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2391).
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
• [4] PharmGKB summary: very important pharmacogene information for PTGS2. Pharmacogenet Genomics. 2011 Sep;21(9):607-13.
• [5] Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenet Genomics. 2007 Feb;17(2):145-60.
• [6] A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors. Eur J Pharmacol. 2008 Apr 14;584(1):166-74.
• [7] Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. Nat Commun. 2018 Sep 26;9(1):3931.
• [8] Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts. Prostaglandins Other Lipid Mediat. 2013 Oct;106:8-15.
• [9] Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. Biochim Biophys Acta. 2011 Jan;1814(1):210-22.
• [10] Arachidonic acid-induced gene expression in colon cancer cells. Carcinogenesis. 2006 Oct;27(10):1950-60.
• [11] Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. J Invest Dermatol. 2005 Oct;125(4):673-84. doi: 10.1111/j.0022-202X.2005.23848.x.
• [12] Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis. Br J Dermatol. 2011 Aug;165(2):269-76.
• [13] Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. NPJ Aging Mech Dis. 2016 Jun 23;2:16012. doi: 10.1038/npjamd.2016.12. eCollection 2016.
• [14] Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element. J Biol Chem. 1994 Dec 9;269(49):31012-8.
• [15] The C50T polymorphism of the cyclooxygenase-1 gene and the risk of thrombotic events during low-dose therapy with acetyl salicylic acid. Thromb Haemost. 2008 Jul;100(1):70-5.
• [16] Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. J Clin Pharmacol. 2000 Oct;40(10):1109-20.
• [17] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [18] Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun;64(6):745-9.
• [19] Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40.
• [20] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [21] Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51.
• [22] Differential binding mode of diverse cyclooxygenase inhibitors. J Mol Graph Model. 2002 Mar;20(5):359-71.
• [23] Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J. 2002 Jul 15;365(Pt 2):489-96.
• [24] Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
• [25] Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
• [26] Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
• [27] Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
• [28] Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076.
• [29] Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
• [30] A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7.
• [31] A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63.
• [32] Cloning and characterization of CYP4F21: a prostaglandin E2 20-hydroxylase of ram seminal vesicles. Arch Biochem Biophys. 2001 May 1;389(1):123-9.
• [33] CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. Drug Metab Dispos. 2011 Feb;39(2):191-8.
• [34] cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine. Biochem Biophys Res Commun. 2001 Feb 2;280(4):1135-41.
• [35] Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. Drug Metab Dispos. 2007 Nov;35(11):2067-75.
• [36] Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism. Ann N Y Acad Sci. 2004 Dec;1031:13-21.
• [37] Product information - Gilenya.
• [38] Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
• [39] Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20.
• [40] Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108.
• [41] Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16;285(29):22152-63.
• [42] Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426.
• [43] Omega-3 fatty acids and inflammatory processes. Nutrients. 2010 Mar;2(3):355-74.
• [44] Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. Pain. 2007 Jun;129(3):279-86.
• [45] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [46] Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
• [47] Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
• [48] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [49] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [50] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [51] The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. Anesth Analg. 2008 Jan;106(1):321-7, table of contents.
• [52] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [53] Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
• [54] Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46.
• [55] Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
• [56] The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
• [57] Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
• [58] Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. Xenobiotica. 2004 May;34(5):429-38.
• [59] The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. Life Sci. 2006 Nov 25;79(26):2432-40.
• [60] Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
• [61] Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
• [62] Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
• [63] COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
• [64] Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
• [65] Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
• [66] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [67] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [68] A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
• [69] CYP4F2 genetic variant alters required warfarin dose. Blood. 2008 Apr 15;111(8):4106-12. doi: 10.1182/blood-2007-11-122010. Epub 2008 Feb 4.
• [70] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [71] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [72] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [73] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [74] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [75] CYP4F2 repression and a modified alpha-tocopherol (vitamin E) metabolism are two independent consequences of ethanol toxicity in human hepatocytes. Toxicol In Vitro. 2017 Apr;40:124-133.
• [76] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [77] Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
• [78] The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-). Food Funct. 2015 Apr;6(4):1098-107. doi: 10.1039/c5fo00076a.
• [79] Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3951-6. doi: 10.1073/pnas.96.7.3951.
• [80] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [81] Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1. J Rheumatol. 2012 Mar;39(3):635-44. doi: 10.3899/jrheum.110621. Epub 2011 Nov 15.
• [82] Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes. Toxicol Appl Pharmacol. 2013 Dec 15;273(3):435-41. doi: 10.1016/j.taap.2013.10.005. Epub 2013 Oct 12.
• [83] Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
• [84] Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomed Pharmacother. 2010 Feb;64(2):118-23. doi: 10.1016/j.biopha.2009.04.033. Epub 2009 Oct 17.
• [85] Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Antivir Ther. 2003 Aug;8(4):323-31.
• [86] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [87] Functional characterization of peroxisome proliferator-activated receptor-/ expression in colon cancer. Mol Carcinog. 2011 Nov;50(11):884-900. doi: 10.1002/mc.20757. Epub 2011 Mar 11.
• [88] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [89] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [90] Aspirin-induced apoptosis in jurkat cells is not mediated by peroxisome proliferator-activated receptor delta. Mol Cell Biochem. 2004 Nov;266(1-2):57-63. doi: 10.1023/b:mcbi.0000049138.67699.7b.
• [91] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [92] (9)-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR induction: A possible evidence for the cancellation of PPAR/-mediated inhibition of PPAR in MDA-MB-231?cells. Arch Biochem Biophys. 2019 Feb 15;662:219-225. doi: 10.1016/j.abb.2018.12.011. Epub 2018 Dec 13.
• [93] Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. Anticancer Res. 2009 Sep;29(9):3647-58.
• [94] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [95] The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism. 2001 Jan;50(1):3-11.
• [96] Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai). 2011 Mar;43(3):204-9. doi: 10.1093/abbs/gmq130. Epub 2011 Jan 21.
• [97] Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators. Mol Pharmacol. 2008 Mar;73(3):968-76. doi: 10.1124/mol.107.036780. Epub 2007 Dec 13.
• [98] (9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARalpha in MDA-MB-231 breast cancer cells. Toxicology. 2014 Dec 4;326:18-24.
• [99] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [100] Antiepileptic drugs: impacts on human serum paraoxonase-1. J Biochem Mol Toxicol. 2017 Jun;31(6).
• [101] Beneficial effect of oleoylated lipids on paraoxonase 1: protection against oxidative inactivation and stabilization. Biochem J. 2003 Oct 15;375(Pt 2):275-85.
• [102] Serum paraoxonase activity before and after treatment of thyrotoxicosis. Clin Endocrinol (Oxf). 2004 Jan;60(1):75-80.
• [103] Effects of some antibiotics on paraoxonase from human serum in vitro and from mouse serum and liver in vivo. Biol Pharm Bull. 2006 Aug;29(8):1559-63.
• [104] Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2. Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2083-9. doi: 10.1161/01.ATV.0000096207.01487.36. Epub 2003 Sep 18.
• [105] Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Mol Cell Biol. 2004 Jun;24(12):5209-22.
• [106] Transcriptional regulation of human paraoxonase 1 by PXR and GR in human hepatoma cells. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):348-54.
• [107] Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
• [108] Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages. J Nutr Biochem. 2008 Sep;19(9):594-603. doi: 10.1016/j.jnutbio.2007.08.003. Epub 2007 Dec 21.
• [109] TCDD and omeprazole prime platelets through the aryl hydrocarbon receptor (AhR) non-genomic pathway. Toxicol Lett. 2015 May 19;235(1):28-36. doi: 10.1016/j.toxlet.2015.03.005. Epub 2015 Mar 19.
• [110] Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 in human bronchial epithelial cells. Am J Physiol. 1998 Jun;274(6):L1030-9.
• [111] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [112] Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G233-40. doi: 10.1152/ajpgi.00409.2009. Epub 2009 Dec 3.
• [113] Comparison of in vitro-activity of commonly used topical glucocorticoids on cytokine- and phospholipase inhibition. Eur J Med Res. 2004 Aug 31;9(8):383-90.
• [114] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [115] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [116] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [117] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [118] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [119] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [120] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [121] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [122] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [123] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [124] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [125] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [126] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [127] Progestins regulate genes that can elicit both proliferative and antiproliferative effects in breast cancer cells. Oncol Rep. 2008 Jun;19(6):1627-34.
• [128] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [129] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [130] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [131] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [132] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [133] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [134] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [135] Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. Sci Rep. 2019 Jan 24;9(1):675.
• [136] Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
• [137] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [138] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [139] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [140] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [141] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [142] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [143] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [144] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [145] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [146] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [147] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [148] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [149] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [150] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [151] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [152] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [153] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [154] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [155] Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study. J Nutrigenet Nutrigenomics. 2008;1(1-2):30-48. doi: 10.1159/000109873. Epub 2007 Oct 16.
• [156] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [157] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [158] Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. Biochem J. 2009 May 13;420(2):305-15.
• [159] Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin. J Lipid Res. 1999 Jun;40(6):1078-89.
• [160] Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation. 2008 Jul 22;118(4):355-62. doi: 10.1161/CIRCULATIONAHA.108.773267. Epub 2008 Jun 16.
• [161] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [162] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [163] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [164] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [165] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [166] PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages. FEBS Lett. 2002 Jun 5;520(1-3):177-81.
• [167] High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
• [168] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [169] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [170] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [171] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [172] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [173] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [174] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [175] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [176] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [177] Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
• [178] Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett. 2005 Jul 4;579(17):3651-9. doi: 10.1016/j.febslet.2005.05.056.
• [179] Folic acid modulates cancer-associated micro RNAs and inflammatory mediators in neoplastic and non-neoplastic colonic cells in a different way. Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700260. Epub 2017 Nov 9.
• [180] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [181] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [182] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [183] Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
• [184] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [185] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [186] High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage. Clin Chim Acta. 2010 Sep 6;411(17-18):1312-8.
• [187] Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
• [188] Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases. Oncol Rep. 2008 Aug;20(2):379-84.
• [189] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [190] Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation. 2012 Nov;84(4):330-43. doi: 10.1016/j.diff.2012.07.006. Epub 2012 Aug 18.
• [191] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [192] Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
• [193] Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines. Jpn J Cancer Res. 2001 Oct;92(10):1133-7. doi: 10.1111/j.1349-7006.2001.tb01069.x.
• [194] HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase II and . Chem Res Toxicol. 2018 Feb 19;31(2):137-144. doi: 10.1021/acs.chemrestox.7b00302. Epub 2018 Jan 8.
• [195] Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry. 2011 Apr 19;50(15):3240-9. doi: 10.1021/bi200094z. Epub 2011 Mar 28.
• [196] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [197] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [198] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [199] Arsenic trioxide exposure to ovarian carcinoma cells leads to decreased level of topoisomerase II and cytotoxicity. Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1552-6. doi: 10.1111/j.1525-1438.2006.00626.x.
• [200] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [201] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [202] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [203] Antitumor effect of aspirin in glioblastoma cells by modulation of -catenin/T-cell factor-mediated transcriptional activity. J Neurosurg. 2011 Oct;115(4):780-8. doi: 10.3171/2011.5.JNS113. Epub 2011 Jul 1.
• [204] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [205] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [206] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [207] The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
• [208] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [209] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [210] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [211] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [212] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [213] Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
• [214] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [215] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [216] Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
• [217] Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia. Leukemia. 2003 Dec;17(12):2418-25. doi: 10.1038/sj.leu.2403152.
• [218] Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
• [219] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [220] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [221] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [222] Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
• [223] The differential effects of neuroleptic drugs and PACAP on the expression of BDNF mRNA and protein in a human glioblastoma cell line. Acta Neurobiol Exp (Wars). 2017;77(3):205-213.
• [224] Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017 Dec;110:189-199. doi: 10.1016/j.fct.2017.10.031. Epub 2017 Oct 20.
• [225] LncRNA SNHG12 ameliorates bupivacaine-induced neurotoxicity by sponging miR-497-5p to upregulate NLRX1. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089001. doi: 10.1177/09603271221089001.
• [226] Mechanism of arsenic trioxide inhibiting angiogenesis in multiple myeloma. J Huazhong Univ Sci Technolog Med Sci. 2006;26(1):43-6. doi: 10.1007/BF02828035.
• [227] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [228] Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis. 2011 May;32(5):686-94. doi: 10.1093/carcin/bgr025. Epub 2011 Feb 10.
• [229] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [230] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [231] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [232] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [233] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [234] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [235] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [236] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [237] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [238] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [239] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [240] Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 2009 Oct;46(16):3345-57. doi: 10.1016/j.molimm.2009.07.019. Epub 2009 Sep 3.
• [241] Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
• [242] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [243] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [244] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [245] Identification of cornifelin and early growth response-1 gene as novel biomarkers for in vitro eye irritation using a 3D reconstructed human cornea model MCTT HCE?. Arch Toxicol. 2015 Sep;89(9):1589-98. doi: 10.1007/s00204-014-1390-8. Epub 2014 Nov 7.
• [246] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [247] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [248] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [249] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [250] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [251] The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism. Biochimie. 2006 Mar-Apr;88(3-4):387-97. doi: 10.1016/j.biochi.2005.11.007. Epub 2005 Dec 7.
• [252] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [253] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [254] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [255] Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
• [256] Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
• [257] Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
• [258] Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med. 2002 Mar 1;32(5):386-93. doi: 10.1016/s0891-5849(01)00812-7.
• [259] Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study. Food Chem Toxicol. 2022 Aug;166:113251. doi: 10.1016/j.fct.2022.113251. Epub 2022 Jun 21.
• [260] Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
• [261] Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun. 2009 Sep 11;387(1):109-14. doi: 10.1016/j.bbrc.2009.06.136. Epub 2009 Jul 1.
• [262] Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
• [263] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [264] An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. Toxicol In Vitro. 2017 Apr;40:11-25. doi: 10.1016/j.tiv.2016.12.005. Epub 2016 Dec 10.
• [265] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [266] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [267] Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
• [268] [Differential proteomic expression in human liver cells stimulated by hydroquinone]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Nov;24(11):658-61.
• [269] Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
• [270] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [271] Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
• [272] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [273] A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
• [274] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [275] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [276] Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
• [277] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [278] Expression of the helix-loop-helix protein inhibitor of DNA binding-1 (ID-1) is activated by all-trans retinoic acid in normal human keratinocytes. Toxicol Appl Pharmacol. 2006 Aug 1;214(3):219-29. doi: 10.1016/j.taap.2005.12.015. Epub 2006 Feb 21.
• [279] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [280] Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells. Hepatology. 2003 May;37(5):1086-96. doi: 10.1053/jhep.2003.50186.
• [281] E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Nov;45(5):2033-43. doi: 10.3892/ijo.2014.2609. Epub 2014 Aug 19.
• [282] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [283] Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
• [284] Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
• [285] Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
• [286] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [287] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [288] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [289] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [290] Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
• [291] Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
• [292] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [293] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [294] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [295] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [296] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [297] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [298] Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
• [299] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [300] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [301] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [302] The RET oncogene is a critical component of transcriptional programs associated with retinoic acid-induced differentiation in neuroblastoma. Mol Cancer Ther. 2007 Apr;6(4):1300-9.
• [303] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [304] Effect of mitochondrial dysfunction and oxidative stress on endogenous levels of coenzyme Q(10) in human cells. J Biochem Mol Toxicol. 2011 Sep-Oct;25(5):280-9. doi: 10.1002/jbt.20387. Epub 2011 Feb 9.
• [305] Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems. Toxicol Lett. 2016 Jan 5;240(1):50-9.
• [306] Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
• [307] In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53. doi: 10.1021/tx200491f. Epub 2012 Jan 26.
• [308] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [309] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [310] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [311] Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
• [312] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [313] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [314] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [315] Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
• [316] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [317] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [318] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [319] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [320] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [321] Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
• [322] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [323] Hydroxychloroquine decreases human MSC-derived osteoblast differentiation and mineralization in vitro. J Cell Mol Med. 2018 Feb;22(2):873-882. doi: 10.1111/jcmm.13373. Epub 2017 Oct 3.
• [324] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [325] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [326] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [327] Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
• [328] A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
• [329] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [330] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [331] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [332] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [333] In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):157-65.
• [334] Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
• [335] Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
• [336] Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
• [337] Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2003 Nov;31(11):1352-60.
• [338] Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
• [339] Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity. Eur J Drug Metab Pharmacokinet. 2011 Mar;36(1):1-16.
• [340] Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93.
• [341] Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
• [342] An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells. Toxicol Sci. 2013 Mar;132(1):131-41.
• [343] Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
• [344] Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
• [345] The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
• [346] Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
• [347] Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
• [348] Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
• [349] Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
• [350] Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
• [351] Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
• [352] [Effects of As2O3 on tissue factor, plasminogen activator inhibitor-1 and -2 expression in NB4, HL-60 and THP-1 cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Oct;34(4):645-9.
• [353] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [354] A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol. 2010 Jun;24(6):1151-64.
• [355] The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
• [356] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [357] Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes. Int J Cancer. 2004 Sep 10;111(4):617-26. doi: 10.1002/ijc.20289.
• [358] Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1. J Pharmacol Exp Ther. 1999 Jul;290(1):314-8.
• [359] Human carboxylesterase 1: from drug metabolism to drug discovery. Biochem Soc Trans. 2003 Jun;31(Pt 3):620-4. doi: 10.1042/bst0310620.
• [360] Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chem Biol. 2003 Apr;10(4):341-9. doi: 10.1016/s1074-5521(03)00071-1.
• [361] Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000 Feb;28(2):186-91.
• [362] Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
• [363] Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. Autophagy. 2021 Nov;17(11):3592-3606. doi: 10.1080/15548627.2021.1885203. Epub 2021 Feb 25.
• [364] A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14034-9. doi: 10.1073/pnas.0904084106. Epub 2009 Aug 4.
• [365] Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
• [366] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [367] Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
• [368] Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures. Diabetes. 2002 Apr;51(4):1060-5. doi: 10.2337/diabetes.51.4.1060.
• [369] Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
• [370] Phospholipidosis induced by PPARgama signaling in human bronchial epithelial (BEAS-2B) cells exposed to amiodarone. Toxicol Sci. 2011 Mar;120(1):98-108.
• [371] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [372] Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
• [373] Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
• [374] Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
• [375] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [376] Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
• [377] Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages. Arthritis Rheum. 2008 Dec;58(12):3675-83.
• [378] Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples. Clin Cancer Res. 2009 May 1;15(9):3076-83. doi: 10.1158/1078-0432.CCR-08-3004. Epub 2009 Apr 21.
• [379] Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages. Metabolism. 2003 May;52(5):652-7. doi: 10.1053/meta.2003.50100.
• [380] Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist. Biochem Pharmacol. 2010 May 1;79(9):1310-6. doi: 10.1016/j.bcp.2009.12.018. Epub 2010 Jan 8.
• [381] Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid. J Lipid Res. 2019 Apr;60(4):794-804. doi: 10.1194/jlr.M088880. Epub 2019 Feb 1.
• [382] Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071.
• [383] Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1228-36. doi: 10.1161/ATVBAHA.110.205500. Epub 2010 Mar 25.
• [384] Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
• [385] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [386] Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
• [387] Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
• [388] The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
• [389] Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM. Diabetes. 1997 Mar;46(3):508-12. doi: 10.2337/diab.46.3.508.
• [390] A receptor mechanism for the inhibition of insulin release by epinephrine in man. J Clin Invest. 1967 Jan;46(1):86-94. doi: 10.1172/JCI105514.
• [391] Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus. Hypertension. 1999 Jul;34(1):83-8. doi: 10.1161/01.hyp.34.1.83.
• [392] Quinapril treatment restores the vasodilator action of insulin in fructose-hypertensive rats. Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):381-5. doi: 10.1046/j.1440-1681.2002.03668.x.
• [393] Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model. J Clin Pathol. 2006 Jun;59(6):603-10. doi: 10.1136/jcp.2005.032003. Epub 2006 Feb 10.
• [394] Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets. J Diabetes Complications. 2005 Jan-Feb;19(1):60-4. doi: 10.1016/j.jdiacomp.2004.05.001.
• [395] Clonidine effect on insulin secretion and lipolysis in man. Acta Diabetol Lat. 1978 May-Aug;15(3-4):192-7. doi: 10.1007/BF02581064.
• [396] Beta-adrenergic contribution to glucagon-induced glucose production and insulin secretion in uremia. Am J Physiol. 1986 Sep;251(3 Pt 1):E322-7. doi: 10.1152/ajpendo.1986.251.3.E322.
• [397] Effect of testosterone replacement on whole body glucose utilisation and other cardiovascular risk factors in males with idiopathic hypogonadotrophic hypogonadism. Horm Metab Res. 1998 Oct;30(10):642-5. doi: 10.1055/s-2007-978950.
• [398] Simvastatin, an HMG-CoA reductase inhibitor, induces the synthesis and secretion of apolipoprotein AI in HepG2 cells and primary hamster hepatocytes. Atherosclerosis. 2002 Jul;163(1):59-68. doi: 10.1016/s0021-9150(01)00754-7.
• [399] Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBP. PLoS One. 2015 Apr 15;10(4):e0121784. doi: 10.1371/journal.pone.0121784. eCollection 2015.
• [400] Effect of glucosamine on apolipoprotein AI mRNA stabilization and expression in HepG2 cells. Metabolism. 2004 Jun;53(6):766-71. doi: 10.1016/j.metabol.2003.11.027.
• [401] Nevirapine increases high-density lipoprotein cholesterol concentration by stimulation of apolipoprotein A-I production. Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1336-41. doi: 10.1161/ATVBAHA.109.192088. Epub 2009 Aug 10.
• [402] The effects of clonidine hydrochloride versus atenolol monotherapy on serum lipids, lipid subfractions, and apolipoproteins in mild hypertension. Am Heart J. 1990 Jul;120(1):172-9. doi: 10.1016/0002-8703(90)90175-w.
• [403] Hepatic apolipoprotein A-I gene expression in patients with cholesterol gallstones treated with ursodeoxycholic acid. Ann Hepatol. 2002 Apr-Jun;1(2):85-9.
• [404] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [405] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [406] Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
• [407] Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
• [408] Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
• [409] Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T(GP Ia/IIa) and C-5T Kozak (GP Ibalpha) polymorphisms. J Am Coll Cardiol. 2003 Sep 17;42(6):1115-9. doi: 10.1016/s0735-1097(03)00921-5.
• [410] Pro-apoptotic role of integrin 3 in glioma cells. J Neurochem. 2011 May;117(3):494-503. doi: 10.1111/j.1471-4159.2011.07219.x. Epub 2011 Mar 15.
• [411] In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation. Blood Cells Mol Dis. 2006 Jan-Feb;36(1):59-76. doi: 10.1016/j.bcmd.2005.10.005. Epub 2005 Dec 15.
• [412] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [413] Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
• [414] Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
• [415] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [416] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [417] An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivity. Toxicol Lett. 2017 Oct 5;280:48-56.
• [418] Differentiation between stoichiometric and anticatalytic antioxidant properties of benzoic acid analogues: a structure/redox potential relationship study. Chem Biol Interact. 2013 Nov 25;206(2):194-203.
• [419] Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
• [420] Effect of anti-rheumatic drugs on the release of lysosomal enzymes from human leukocytes. Z Rheumatol. 1984 Jan-Feb;43(1):23-6.
• [421] Benzodithiophenes induce differentiation and apoptosis in human leukemia cells. Cancer Res. 2005 Sep 1;65(17):7847-55. doi: 10.1158/0008-5472.CAN-05-1053.
• [422] Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis. Clin Immunol. 2007 Feb;122(2):187-93. doi: 10.1016/j.clim.2006.09.011. Epub 2006 Oct 27.
• [423] Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
• [424] Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
• [425] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [426] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [427] Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
• [428] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [429] Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression. Hum Reprod. 2007 Apr;22(4):1161-7. doi: 10.1093/humrep/del464. Epub 2006 Dec 11.
• [430] Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway. Pharmacogn Mag. 2016 May;12(Suppl 2):S237-44. doi: 10.4103/0973-1296.182154. Epub 2016 May 11.
• [431] Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
• [432] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [433] Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
• [434] Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4098-112. doi: 10.1167/iovs.05-1230.
• [435] Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
• [436] Cholinergic drugs inhibit in?vitro megakaryopoiesis via the alpha7-nicotinic acetylcholine receptor. Platelets. 2011;22(5):390-5. doi: 10.3109/09537104.2010.551304. Epub 2011 Mar 9.
• [437] Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
• [438] Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
• [439] The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
• [440] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [441] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [442] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [443] Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
• [444] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [445] Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
• [446] Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
• [447] Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
• [448] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [449] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [450] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [451] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [452] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
• [453] The estrogen receptor influences microtubule-associated protein tau (MAPT) expression and the selective estrogen receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast cancer cells. Breast Cancer Res. 2010;12(3):R43. doi: 10.1186/bcr2598. Epub 2010 Jun 28.
• [454] Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol Neurodegener. 2006 Jul 26;1:6. doi: 10.1186/1750-1326-1-6.
• [455] Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102. doi: 10.1194/jlr.M900236-JLR200. Epub 2009 May 21.
• [456] Inhibition of interleukin-1-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. Oncotarget. 2016 Sep 20;7(38):61438-61457. doi: 10.18632/oncotarget.11367.
• [457] Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects. Int J Mol Sci. 2015 Jan 5;16(1):1008-29. doi: 10.3390/ijms16011008.
• [458] The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces. Br J Haematol. 2003 Jan;120(2):315-24. doi: 10.1046/j.1365-2141.2003.03971.x.
• [459] Mechanisms of tissue factor induction by the uremic toxin indole-3 acetic acid through aryl hydrocarbon receptor/nuclear factor-kappa B signaling pathway in human endothelial cells. Arch Toxicol. 2019 Jan;93(1):121-136.
• [460] Simvastatin attenuates vascular hypercoagulability in cardiac transplant recipients. Transplantation. 2000 May 15;69(9):1830-6. doi: 10.1097/00007890-200005150-00017.
• [461] Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells. J Thromb Haemost. 2003 May;1(5):1089-95. doi: 10.1046/j.1538-7836.2003.00217.x.
• [462] Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
• [463] Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents. Leukemia. 1999 Jul;13(7):1062-70. doi: 10.1038/sj.leu.2401448.
• [464] Effects of red grape juice polyphenols in NADPH oxidase subunit expression in human neutrophils and mononuclear blood cells. Br J Nutr. 2009 Oct;102(8):1125-35. doi: 10.1017/S0007114509382148. Epub 2009 May 19.
• [465] Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
• [466] Organochlorine pesticide-mediated induction of NADPH oxidase and nitric-oxide synthase in endothelial cell. J Clin Diagn Res. 2017 Jan;11(1):BC09-BC12.
• [467] Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells. Toxicology. 2015 Aug 6;334:104-10. doi: 10.1016/j.tox.2015.06.006. Epub 2015 Jun 12.
• [468] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [469] Nicotine stimulates CYP1A1 expression in human hepatocellular carcinoma cells via AP-1, NF-B, and AhR. Toxicol Lett. 2021 Oct 1;349:155-164. doi: 10.1016/j.toxlet.2021.06.013. Epub 2021 Jun 24.
• [470] Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
• [471] Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
• [472] Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
• [473] Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PLoS One. 2014 Jun 23;9(6):e99993. doi: 10.1371/journal.pone.0099993. eCollection 2014.
• [474] Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci. 2004 Apr;94(4):403-9. doi: 10.1254/jphs.94.403.
• [475] Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
• [476] p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
• [477] Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg. 2008 Apr;106(4):1150-60, table of contents. doi: 10.1213/ane.0b013e3181683d37.
• [478] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [479] Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy. Circulation. 2003 Aug 26;108(8):939-44. doi: 10.1161/01.CIR.0000085163.21752.0A. Epub 2003 Aug 11.
• [480] Hemostatic abnormalities associated with acute promyelocytic leukemia and corrective effects of all-trans-retinoic acid or arsenic trioxide treatment. Chin Med J (Engl). 2000 Mar;113(3):236-40.
• [481] Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
• [482] Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy. Ann Med. 2004;36(7):552-7. doi: 10.1080/07853890410017386.
• [483] Effects of histamine 2 receptor antagonists on endothelial-neutrophil adhesion and surface expression of endothelial adhesion molecules induced by high glucose levels. J Diabetes Complications. 2007 Jan-Feb;21(1):50-5. doi: 10.1016/j.jdiacomp.2006.02.002.
• [484] Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules. Atherosclerosis. 2008 Jul;199(1):55-64. doi: 10.1016/j.atherosclerosis.2007.10.038. Epub 2008 Feb 21.
• [485] Cocaine activates platelets and increases the formation of circulating platelet containing microaggregates in humans. Heart. 2000 Jun;83(6):688-95. doi: 10.1136/heart.83.6.688.
• [486] Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor , , subtypes: an in silico approach. J Appl Toxicol. 2014 Jul;34(7):754-65. doi: 10.1002/jat.2902. Epub 2013 Jul 11.
• [487] Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium. BMC Genomics. 2004 Aug 20;5(1):58. doi: 10.1186/1471-2164-5-58.
• [488] Identification and characterization of the human retinoid X receptor alpha gene promoter. Gene. 2006 May 10;372:118-27. doi: 10.1016/j.gene.2005.12.027. Epub 2006 Mar 6.
• [489] Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environ Health Perspect. 2011 Aug;119(8):1142-8. doi: 10.1289/ehp.1002952. Epub 2011 May 4.
• [490] Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
• [491] Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library. Environ Health Perspect. 2019 Sep;127(9):97009. doi: 10.1289/EHP5314. Epub 2019 Sep 30.
• [492] The functional consequences of cross-talk between the vitamin D receptor and ERK signaling pathways are cell-specific. J Biol Chem. 2004 Nov 5;279(45):47298-310. doi: 10.1074/jbc.M404101200. Epub 2004 Aug 25.
• [493] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [494] Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
• [495] Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
• [496] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [497] Contrasting effects of fluoroquinolone antibiotics on the expression of the collagenases, matrix metalloproteinases (MMP)-1 and -13, in human tendon-derived cells. Rheumatology (Oxford). 2005 Dec;44(12):1514-7. doi: 10.1093/rheumatology/kei087. Epub 2005 Sep 7.
• [498] Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 2010 Jul;116(1):140-50. doi: 10.1093/toxsci/kfq085. Epub 2010 Mar 25.
• [499] Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation. Osteoarthritis Cartilage. 2007 Jun;15(6):646-55. doi: 10.1016/j.joca.2007.01.014. Epub 2007 Mar 6.
• [500] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [501] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [502] Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
• [503] The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
• [504] NF-B potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15;6(2):e16815. doi: 10.1371/journal.pone.0016815.
• [505] Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep. 2011 Feb;25(2):583-91. doi: 10.3892/or.2010.1097. Epub 2010 Dec 10.
• [506] Influence of antitumor drugs on the expression of Fas system in SW480 colon cancer cells. Eur J Gastroenterol Hepatol. 2006 Oct;18(10):1071-7. doi: 10.1097/01.meg.0000231750.68513.6c.
• [507] Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26.
• [508] Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
• [509] Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine. Eur J Nutr. 2006 Mar;45(3):159-64. doi: 10.1007/s00394-005-0576-5. Epub 2005 Dec 20.
• [510] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [511] Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. J Toxicol Sci. 2015 Feb;40(1):127-36. doi: 10.2131/jts.40.127.
• [512] Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. J Biol Chem. 2013 Jan 11;288(2):807-18. doi: 10.1074/jbc.M112.437970. Epub 2012 Dec 3.
• [513] Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
• [514] Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
• [515] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [516] The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
• [517] Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
• [518] Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
• [519] Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
• [520] Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
• [521] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [522] Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. Cell Biol Int. 2011 Aug;35(8):803-10. doi: 10.1042/CBI20100739.
• [523] Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G731-8. doi: 10.1152/ajpgi.00150.2005. Epub 2005 Jun 23.
• [524] Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
• [525] K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
• [526] Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
• [527] Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
• [528] Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. J Photochem Photobiol B. 2018 Jan;178:593-605. doi: 10.1016/j.jphotobiol.2017.12.014. Epub 2017 Dec 15.
• [529] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [530] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [531] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [532] Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
• [533] Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
• [534] Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
• [535] Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
• [536] Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis. 2005 May;26(5):883-91. doi: 10.1093/carcin/bgi036. Epub 2005 Feb 10.
• [537] Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis. Br J Cancer. 2011 Apr 12;104(8):1278-87. doi: 10.1038/bjc.2011.84.
• [538] Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer. 2011 Jul 31;10:95. doi: 10.1186/1476-4598-10-95.
• [539] Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem. 2011 Jul;353(1-2):167-76. doi: 10.1007/s11010-011-0783-8. Epub 2011 Mar 23.
• [540] Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
• [541] Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
• [542] The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1400-9. doi: 10.1152/ajpregu.00781.2006. Epub 2007 Jun 13.
• [543] Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity. Biochem Pharmacol. 2012 Jun 15;83(12):1674-81. doi: 10.1016/j.bcp.2012.02.027. Epub 2012 Mar 7.
• [544] Oxidative stress modulates KLF6Full and its splice variants. Alcohol Clin Exp Res. 2012 Nov;36(11):1851-62. doi: 10.1111/j.1530-0277.2012.01798.x. Epub 2012 Apr 6.
• [545] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [546] PML-RAR interaction with TRIB3 impedes PPAR/RXR function and triggers dyslipidemia in acute promyelocytic leukemia. Theranostics. 2020 Aug 15;10(22):10326-10340. doi: 10.7150/thno.45924. eCollection 2020.
• [547] Amlodipine improves endothelial function and metabolic parameters in patients with hypertension. Int J Cardiol. 2009 Mar 20;133(1):23-31. doi: 10.1016/j.ijcard.2007.11.058. Epub 2008 Jan 15.
• [548] Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes. J Clin Endocrinol Metab. 2007 Feb;92(2):720-4.
• [549] Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis. J Biochem Mol Toxicol. 2015 Mar;29(3):99-108. doi: 10.1002/jbt.21672. Epub 2014 Oct 26.
• [550] Adipokines and treatment with niacin. Metabolism. 2006 Oct;55(10):1283-5. doi: 10.1016/j.metabol.2006.07.002.
• [551] Bisphenol A is associated with insulin resistance and modulates adiponectin and resistin gene expression in obese children. Pediatr Obes. 2017 Oct;12(5):380-387. doi: 10.1111/ijpo.12154. Epub 2016 May 17.
• [552] Aloe-emodin inhibits adipocyte differentiation and maturation during in vitro human mesenchymal stem cell adipogenesis. J Biochem Mol Toxicol. 2012 Aug;26(8):291-300. doi: 10.1002/jbt.21415. Epub 2012 May 29.
• [553] Fatty acids and expression of adipokines. Biochim Biophys Acta. 2005 May 30;1740(2):287-92. doi: 10.1016/j.bbadis.2004.11.019. Epub 2004 Dec 8.
• [554] Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
• [555] A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
• [556] CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
• [557] Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
• [558] Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
• [559] Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
• [560] Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
• [561] Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
• [562] Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
• [563] Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
• [564] Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
• [565] The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
• [566] Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
• [567] Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme. Food Chem Toxicol. 2007 Mar;45(3):508-14. doi: 10.1016/j.fct.2006.08.013. Epub 2006 Aug 30.
• [568] Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. doi: 10.1016/S1470-2045(10)70206-0. Epub 2010 Sep 21.
• [569] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [570] Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
• [571] Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. Pharmacogenetics. 1997 Jun;7(3):211-21.
• [572] Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. Arch Biochem Biophys. 2003 Jan 1;409(1):32-44.
• [573] Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. Chem Biol Interact. 2021 Apr 1;338:109401. doi: 10.1016/j.cbi.2021.109401. Epub 2021 Feb 5.
• [574] Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy. Toxicol Appl Pharmacol. 2022 Jan 1;434:115797. doi: 10.1016/j.taap.2021.115797. Epub 2021 Nov 13.
• [575] Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. J Neurochem. 2007 Apr;101(1):77-86. doi: 10.1111/j.1471-4159.2006.04375.x. Epub 2007 Jan 4.
• [576] Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. J Struct Biol. 2000 Jun;130(2-3):209-16. doi: 10.1006/jsbi.2000.4285.
• [577] Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cells. J Neurochem. 2005 Nov;95(4):1059-68. doi: 10.1111/j.1471-4159.2005.03440.x. Epub 2005 Sep 7.
• [578] Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis. 2005 Nov;8(2):117-27; discussion 209-15. doi: 10.3233/jad-2005-8204.
• [579] Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31-44.
• [580] Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chem Res Toxicol. 2014 Feb 17;27(2):304-308.
• [581] Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem. 2004 Jul 9;279(28):29295-301. doi: 10.1074/jbc.M400580200. Epub 2004 Apr 28.
• [582] Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3. Arch Toxicol. 2019 Aug;93(8):2247-2264. doi: 10.1007/s00204-019-02495-6. Epub 2019 Jul 16.
• [583] Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol. 2005 Jun;67(6):1954-65.
• [584] Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
• [585] Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Arch Biochem Biophys. 2005 Feb 1;434(1):75-85.
• [586] Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36.
• [587] Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine. Toxicol In Vitro. 2009 Oct;23(7):1259-67.
• [588] Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25.
• [589] Human drug metabolism genes in parathion-and estrogen-treated breast cells. Int J Mol Med. 2007 Dec;20(6):875-81.
• [590] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [591] In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
• [592] Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
• [593] Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
• [594] Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
• [595] Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
• [596] Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions. Toxicol Sci. 2014 Oct;141(2):344-52. doi: 10.1093/toxsci/kfu133. Epub 2014 Jul 24.
• [597] Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone. Psychopharmacology (Berl). 1999 Dec;147(3):300-5. doi: 10.1007/s002130051171.
• [598] Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450. J Toxicol Sci. 2016 Feb;41(1):143-6.
• [599] Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos. 2011 Nov;39(11):2049-56. doi: 10.1124/dmd.111.041384. Epub 2011 Aug 5.
• [600] Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. Biol Pharm Bull. 2005 Feb;28(2):328-34.
• [601] Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl. Eur J Clin Pharmacol. 2007 Feb;63(2):159-63.
• [602] Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test. Clin Pharmacol Ther. 2001 Oct;70(4):327-35.
• [603] Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro. Drug Metab Dispos. 2003 Jun;31(6):768-72.