Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXLBCQ)

• Drug Name: Sodium phenylbutyrate Drug Info
• Synonyms: Ammonaps; Buphenyl; EL-532; Sodium 4-phenylbutyrate; Sodium phenylbutyrate, Elan; Sodium phenylbutyrate, Medicis; Sodium phenylbutyrate, Ucyclyd; VP-101; Sodium 4-phenylbutyrate, Elan; Sodium 4-phenylbutyrate, Ucyclyd; Sodium phenylbutyrate (cancer), MacroChem/Access; Sodium phenylbutyrate (cancer), Virium/ Somanta; Sodium phenylbutyrate (cancer), Virium/Access Pharmaceuticals; Sodium 4-phenyibutyrate (cancer), MacroChem/Access; Sodium 4-phenylbutyrate (cancer), Virium/ Somanta; Sodium 4-phenylbutyrate (cancer), Virium/Access Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Spinal muscular atrophy	8B61	Approved	[1]
Spinal muscular atrophy, type II		Approved	[2]
Urea cycle disorder	5C50.A	Approved	[2]
Citrullinemia		Investigative	[2]

• Cross-matching ID:
  PubChem CID: 5258
  ChEBI ID: CHEBI:75316
  CAS Number: CAS 1716-12-7
  TTD Drug ID: DMXLBCQ
  ACDINA Drug ID: D00633

Molecule-Related Drug Atlas

Drug(s) Targeting Protein kinase C alpha (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[7]
PMID28460551-Compound-3	DMA1FRM	N. A.	N. A.	Patented	[8]
ISIS 3521	DMZFS69	N. A.	N. A.	Discontinued in Phase 2	[9]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[10]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[11]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[12]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[13]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[14]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[15]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting Histone deacetylase (HDAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
HBI-8000	DMDWYUN	Non-small-cell lung cancer	2C25.Y	Registered	[18]
ITF2357	DMFZBNE	Duchenne dystrophy	8C70	Phase 3	[19]
Pracinostat	DMTD7AB	Acute myeloid leukaemia	2A60	Phase 3	[20]
NVP-LAQ824	DM8JWNA	Mood disorder	6A60-6E23	Phase 3	[21]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[18]
CMS-024-02	DMC4X7L	Solid tumour/cancer	2A00-2F9Z	Phase 3	[22]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[23]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[24]
MGCD-0103	DM726HX	Non-small-cell lung cancer	2C25.Y	Phase 2	[18]

Drug(s) Affected By Fatty-acid amide hydrolase 1 (FAAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[32]
ASP-8477	DMBZQS7	Neuropathic pain	8E43.0	Phase 2	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[34]

Drug(s) Affected By Tax1-binding protein 3 (TAX1BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[37]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[39]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Glutathione S-transferase A4 (GSTA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[49]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[42]

Drug(s) Affected By Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[51]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[55]

Drug(s) Affected By Serine/arginine-rich splicing factor 10 (SRSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[51]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[50]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[58]

Drug(s) Affected By Cold shock domain-containing protein E1 (CSDE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[63]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[64]

Drug(s) Affected By Chondroitin sulfate proteoglycan 5 (CSPG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[63]

Drug(s) Affected By Pre-mRNA-splicing factor SLU7 (SLU7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[73]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[74]

Drug(s) Affected By Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Celastrol	DMWQIJX	Motor neurone disease	8B60	Preclinical	[76]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[77]

Drug(s) Affected By Heat shock 70 kDa protein 4L (HSPA4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[79]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[81]

Drug(s) Affected By Claudin-1 (CLDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[73]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[93]

Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[101]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[102]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[103]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[105]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[106]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[107]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[115]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[115]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]

Drug(s) Affected By High mobility group protein HMG-I/HMG-Y (HMGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Methamphetamine	DMPM4SK	Anxiety		Approved	[122]

Drug(s) Affected By Collagen alpha-1(V) chain (COL5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[123]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[124]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[126]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[69]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[130]

Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]

Drug(s) Affected By Fibulin-1 (FBLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By DNA-directed RNA polymerase II subunit RPB1 (POLR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Deferasirox	DM6ETS0	Beta thalassemia	3A50.2	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-2 (MAT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[149]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[148]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[150]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[155]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By B-cell lymphoma 6 protein (BCL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[156]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[157]
Bortezomib	DMNO38U	Leukemia		Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Alanine--tRNA ligase, cytoplasmic (AARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[161]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[147]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[161]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[42]

Drug(s) Affected By Cysteine--tRNA ligase, cytoplasmic (CARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[161]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]

Drug(s) Affected By Tuberin (TSC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[166]
Methamphetamine	DMPM4SK	Anxiety		Approved	[167]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[169]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[171]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By Large ribosomal subunit protein eL8 (RPL7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[147]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[173]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[174]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[175]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[176]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[177]

Drug(s) Affected By Small ribosomal subunit protein mS22 (MRPS22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[77]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[74]

Drug(s) Affected By SAP domain-containing ribonucleoprotein (SARNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[181]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[182]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[58]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[176]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[183]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[184]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[185]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[185]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[185]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[189]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[187]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[185]

Drug(s) Affected By Transcription factor SOX-4 (SOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[97]

Drug(s) Affected By Growth factor receptor-bound protein 10 (GRB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[154]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Transformer-2 protein homolog alpha (TRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By Growth arrest-specific protein 6 (GAS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[195]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[194]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[198]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[199]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[194]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[200]

Drug(s) Affected By Nucleolar and coiled-body phosphoprotein 1 (NOLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[59]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[52]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 2 (NR1D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[193]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[79]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[201]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]

Drug(s) Affected By 116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[202]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[60]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[204]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[77]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[205]

Drug(s) Affected By Pre-rRNA-processing protein TSR1 homolog (TSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[209]

Drug(s) Affected By Histone-lysine N-methyltransferase KMT5B (KMT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[210]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[211]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[55]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[213]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]

Drug(s) Affected By Nucleolar MIF4G domain-containing protein 1 (NOM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[214]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[215]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[60]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By E3 ubiquitin-protein ligase synoviolin (SYVN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[216]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[217]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[218]

Drug(s) Affected By Tax1-binding protein 1 (TAX1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[219]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[63]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[220]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[209]

Drug(s) Affected By ATP-dependent RNA helicase DDX55 (DDX55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[208]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[162]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[60]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[156]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[222]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By Solute carrier family 22 member 18 (SLC22A18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[225]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By LIM domain-containing protein ajuba (AJUBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[198]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[162]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]

Drug(s) Affected By PRKC apoptosis WT1 regulator protein (PAWR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[228]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[230]

Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]

Drug(s) Affected By Protein CMSS1 (CMSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[232]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]

Drug(s) Affected By Programmed cell death protein 2-like (PDCD2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[208]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[198]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]

Drug(s) Affected By MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Haloperidol	DM96SE0	Delirium		Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]

Drug(s) Affected By Neurolysin, mitochondrial (NLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[66]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[234]

Drug(s) Affected By Mitochondrial dynamics protein MIEF1 (MIEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[215]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[77]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[235]

Drug(s) Affected By DNA polymerase epsilon subunit 4 (POLE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[236]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[55]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[60]

Drug(s) Affected By Phenylalanine--tRNA ligase beta subunit (FARSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[147]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[237]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[59]

Drug(s) Affected By Nuclear distribution protein nudE homolog 1 (NDE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]

Drug(s) Affected By EH domain-containing protein 3 (EHD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[238]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[176]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[239]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[164]

Drug(s) Affected By CCR4-NOT transcription complex subunit 2 (CNOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[205]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[60]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[240]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[241]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[164]

Drug(s) Affected By Protein cornichon homolog 4 (CNIH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By DNA-directed RNA polymerase I subunit RPA12 (POLR1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[155]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[198]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]

Drug(s) Affected By Importin-11 (IPO11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[208]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[238]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[244]

Drug(s) Affected By Transmembrane emp24 domain-containing protein 5 (TMED5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[55]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[246]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By Small ribosomal subunit protein bS18m (MRPS18C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[246]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[239]

Drug(s) Affected By RNA-binding protein 8A (RBM8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[55]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[58]

Drug(s) Affected By Sorting nexin-5 (SNX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[52]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[248]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[244]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[241]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[164]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[252]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[253]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[254]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[255]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[257]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[258]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[259]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[260]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[267]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[268]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[269]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[266]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[270]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[271]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[151]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[273]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[277]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[275]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[266]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[112]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[280]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[281]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[282]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[284]

Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivacaftor	DMZC1HS	Cystic fibrosis	CA25	Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[287]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[288]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[289]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[286]
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[290]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[145]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[268]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[269]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[292]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[268]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[296]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[292]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[298]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[299]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[300]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[301]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[302]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[303]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[304]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[305]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[306]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[307]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[308]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[309]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[300]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[310]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[311]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[312]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[299]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[313]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[302]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[303]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[315]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[256]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[259]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[318]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[319]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[320]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[321]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[323]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[324]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[326]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[328]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[329]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[298]

Drug(s) Affected By High mobility group protein HMGI-C (HMGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[330]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[331]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[232]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[332]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[335]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[155]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[323]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[336]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[338]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]

Drug(s) Affected By Parkinson disease protein 7 (PARK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[342]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[343]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[344]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[182]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[346]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[347]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[348]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[349]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[350]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[292]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[352]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[353]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[298]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[266]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[354]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[268]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[269]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[293]

Drug(s) Affected By Epidermal growth factor-like protein 7 (EGFL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[211]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[355]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[60]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By Sodium-dependent multivitamin transporter (SLC5A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[215]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[356]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[215]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[246]

Drug(s) Affected By Cysteine protease ATG4B (ATG4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[71]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[357]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone deacetylase (HDAC)	TTBH0VX	NOUNIPROTAC	Inhibitor	[3]
Protein kinase C alpha (PRKCA)	TTFJ8Q1	KPCA_HUMAN	Modulator	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2)	OT3X7QG2	U5S1_HUMAN	Gene/Protein Processing	[5]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[6]
Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1)	OTC7AFHT	AHSA1_HUMAN	Gene/Protein Processing	[5]
Alanine--tRNA ligase, cytoplasmic (AARS1)	OTW8D813	SYAC_HUMAN	Gene/Protein Processing	[5]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[5]
ATP-dependent RNA helicase DDX55 (DDX55)	OTH8ZBPA	DDX55_HUMAN	Gene/Protein Processing	[5]
B-cell lymphoma 6 protein (BCL6)	OTQAWWO1	BCL6_HUMAN	Gene/Protein Processing	[5]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[6]
Cbp/p300-interacting transactivator 2 (CITED2)	OT812TV7	CITE2_HUMAN	Gene/Protein Processing	[5]
CCR4-NOT transcription complex subunit 2 (CNOT2)	OT98OJ42	CNOT2_HUMAN	Gene/Protein Processing	[5]

References

• [1] ClinicalTrials.gov (NCT00533559) Mechanism of Fatty Acid-induced Impairment of Glucose-simulated Insulin Secretion - Effect of Buphenyl. U.S. National Institutes of Health.
• [2] Sodium phenylbutyrate FDA Label
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