Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTQBANEP)

DOT Name	Fructose-1,6-bisphosphatase 1 (FBP1)
Synonyms	FBPase 1; EC 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase
Gene Name	FBP1
Related Disease	Fructose-1,6-bisphosphatase deficiency ( ) Acute liver failure ( ) Adult glioblastoma ( ) Advanced cancer ( ) B-cell lymphoma ( ) B-cell neoplasm ( ) Bone osteosarcoma ( ) Carcinoma ( ) Carcinoma of liver and intrahepatic biliary tract ( ) Cervical cancer ( ) Cervical carcinoma ( ) Cholangiocarcinoma ( ) Colon cancer ( ) Colonic neoplasm ( ) Colorectal carcinoma ( ) Cryohydrocytosis ( ) Cryptococcosis ( ) Disorder of glycogen metabolism ( ) Epithelial ovarian cancer ( ) Follicular lymphoma ( ) Gastric neoplasm ( ) Glioblastoma multiforme ( ) Glioma ( ) Hepatitis C virus infection ( ) Hepatocellular carcinoma ( ) Hereditary diffuse gastric adenocarcinoma ( ) Liver cancer ( ) Matthew-Wood syndrome ( ) Myocardial infarction ( ) Non-insulin dependent diabetes ( ) Osteosarcoma ( ) Ovarian cancer ( ) Ovarian neoplasm ( ) Pancreatic cancer ( ) Prostate cancer ( ) Prostate carcinoma ( ) Schizophrenia ( ) Squamous cell carcinoma ( ) Breast cancer ( ) Breast carcinoma ( ) Clear cell renal carcinoma ( ) Metastatic malignant neoplasm ( ) Parkinson disease ( ) Colon carcinoma ( ) Congenital contractural arachnodactyly ( ) Hypoglycemia ( ) Pancreatic ductal carcinoma ( ) Rett syndrome ( )
UniProt ID	F16P1_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
PDB ID	1FTA ; 2FHY ; 2FIE ; 2FIX ; 2JJK ; 2VT5 ; 2WBB ; 2WBD ; 2Y5K ; 2Y5L ; 3A29 ; 3KBZ ; 3KC0 ; 3KC1 ; 4MJO ; 5LDZ ; 5PZQ ; 5PZR ; 5PZS ; 5PZT ; 5PZU ; 5PZV ; 5PZW ; 5PZX ; 5PZY ; 5PZZ ; 5Q00 ; 5Q01 ; 5Q02 ; 5Q03 ; 5Q04 ; 5Q05 ; 5Q06 ; 5Q07 ; 5Q08 ; 5Q09 ; 5Q0A ; 5Q0B ; 6LS5 ; 6LW2 ; 7C9Q ; 7CVH ; 7CVN ; 7CWE ; 7EZF ; 7EZP ; 7EZR ; 7WJV ; 7WVB
EC Number	3.1.3.11
Pfam ID	PF00316 ; PF18913
Sequence	MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
Function	Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Tissue Specificity	Expressed in pancreatic islets.
KEGG Pathway	Glycolysis / Gluconeogenesis (hsa00010 ) Pentose phosphate pathway (hsa00030 ) Fructose and mannose metabolism (hsa00051 ) Metabolic pathways (hsa01100 ) Carbon metabolism (hsa01200 ) AMPK sig.ling pathway (hsa04152 ) Insulin sig.ling pathway (hsa04910 ) Glucagon sig.ling pathway (hsa04922 )
Reactome Pathway	Gluconeogenesis (R-HSA-70263 )
BioCyc Pathway	MetaCyc:HS09189-MONOMER

Molecular Interaction Atlas (MIA) of This DOT

48 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance
Fructose-1,6-bisphosphatase deficiency	DISUR1NO	Definitive	Autosomal recessive	[1]
Acute liver failure	DIS5EZKX	Strong	Altered Expression	[2]
Adult glioblastoma	DISVP4LU	Strong	Altered Expression	[3]
Advanced cancer	DISAT1Z9	Strong	Biomarker	[4]
B-cell lymphoma	DISIH1YQ	Strong	Altered Expression	[5]
B-cell neoplasm	DISVY326	Strong	Altered Expression	[5]
Bone osteosarcoma	DIST1004	Strong	Biomarker	[6]
Carcinoma	DISH9F1N	Strong	Altered Expression	[7]
Carcinoma of liver and intrahepatic biliary tract	DIS8WA0W	Strong	Altered Expression	[8]
Cervical cancer	DISFSHPF	Strong	Altered Expression	[9]
Cervical carcinoma	DIST4S00	Strong	Altered Expression	[9]
Cholangiocarcinoma	DIS71F6X	Strong	Biomarker	[10]
Colon cancer	DISVC52G	Strong	Biomarker	[11]
Colonic neoplasm	DISSZ04P	Strong	Biomarker	[11]
Colorectal carcinoma	DIS5PYL0	Strong	Biomarker	[12]
Cryohydrocytosis	DISMQHL3	Strong	Altered Expression	[13]
Cryptococcosis	DISDYDTK	Strong	Biomarker	[14]
Disorder of glycogen metabolism	DISYGNOB	Strong	Biomarker	[15]
Epithelial ovarian cancer	DIS56MH2	Strong	Altered Expression	[16]
Follicular lymphoma	DISVEUR6	Strong	Altered Expression	[5]
Gastric neoplasm	DISOKN4Y	Strong	Biomarker	[11]
Glioblastoma multiforme	DISK8246	Strong	Biomarker	[3]
Glioma	DIS5RPEH	Strong	Altered Expression	[17]
Hepatitis C virus infection	DISQ0M8R	Strong	Biomarker	[13]
Hepatocellular carcinoma	DIS0J828	Strong	Biomarker	[18]
Hereditary diffuse gastric adenocarcinoma	DISUIBYS	Strong	Biomarker	[11]
Liver cancer	DISDE4BI	Strong	Altered Expression	[8]
Matthew-Wood syndrome	DISA7HR7	Strong	Biomarker	[19]
Myocardial infarction	DIS655KI	Strong	Genetic Variation	[20]
Non-insulin dependent diabetes	DISK1O5Z	Strong	Biomarker	[21]
Osteosarcoma	DISLQ7E2	Strong	Biomarker	[6]
Ovarian cancer	DISZJHAP	Strong	Altered Expression	[16]
Ovarian neoplasm	DISEAFTY	Strong	Altered Expression	[16]
Pancreatic cancer	DISJC981	Strong	Altered Expression	[19]
Prostate cancer	DISF190Y	Strong	Biomarker	[22]
Prostate carcinoma	DISMJPLE	Strong	Biomarker	[22]
Schizophrenia	DISSRV2N	Strong	Genetic Variation	[23]
Squamous cell carcinoma	DISQVIFL	Strong	Altered Expression	[9]
Breast cancer	DIS7DPX1	moderate	Altered Expression	[24]
Breast carcinoma	DIS2UE88	moderate	Altered Expression	[24]
Clear cell renal carcinoma	DISBXRFJ	moderate	Altered Expression	[25]
Metastatic malignant neoplasm	DIS86UK6	moderate	Altered Expression	[26]
Parkinson disease	DISQVHKL	moderate	Biomarker	[27]
Colon carcinoma	DISJYKUO	Limited	Altered Expression	[11]
Congenital contractural arachnodactyly	DISOM1K7	Limited	Altered Expression	[28]
Hypoglycemia	DISRCKR7	Limited	Biomarker	[29]
Pancreatic ductal carcinoma	DIS26F9Q	Limited	Altered Expression	[30]
Rett syndrome	DISGG5UV	Limited	Biomarker	[31]
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⏷ Show the Full List of 48 Disease(s)

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DOT

3 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the methylation of Fructose-1,6-bisphosphatase 1 (FBP1).	[32]
Decitabine	DMQL8XJ	Approved	Decitabine decreases the methylation of Fructose-1,6-bisphosphatase 1 (FBP1).	[11]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Fructose-1,6-bisphosphatase 1 (FBP1).	[45]
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20 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Tretinoin	DM49DUI	Approved	Tretinoin decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[33]
Cupric Sulfate	DMP0NFQ	Approved	Cupric Sulfate decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[34]
Estradiol	DMUNTE3	Approved	Estradiol decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[35]
Quercetin	DM3NC4M	Approved	Quercetin decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[36]
Arsenic trioxide	DM61TA4	Approved	Arsenic trioxide decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[37]
Calcitriol	DM8ZVJ7	Approved	Calcitriol increases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[38]
Vorinostat	DMWMPD4	Approved	Vorinostat increases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[39]
Isotretinoin	DM4QTBN	Approved	Isotretinoin decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[41]
Obeticholic acid	DM3Q1SM	Approved	Obeticholic acid decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[42]
Tamibarotene	DM3G74J	Phase 3	Tamibarotene increases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[43]
Seocalcitol	DMKL9QO	Phase 3	Seocalcitol increases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[44]
(+)-JQ1	DM1CZSJ	Phase 1	(+)-JQ1 decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[46]
Flavonoid derivative 1	DMCQP0B	Patented	Flavonoid derivative 1 decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[36]
THAPSIGARGIN	DMDMQIE	Preclinical	THAPSIGARGIN decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[48]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[49]
Milchsaure	DM462BT	Investigative	Milchsaure decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[50]
Chrysin	DM7V2LG	Investigative	Chrysin decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[36]
Kaempferol	DMHEMUB	Investigative	Kaempferol decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[36]
Apigenin	DMI3491	Investigative	Apigenin decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[36]
Myricetin	DMTV4L0	Investigative	Myricetin decreases the expression of Fructose-1,6-bisphosphatase 1 (FBP1).	[36]
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⏷ Show the Full List of 20 Drug(s)

1 Drug(s) Affected the Protein Interaction/Cellular Processes of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
T83193	DMHO29Y	Patented	T83193 affects the binding of Fructose-1,6-bisphosphatase 1 (FBP1).	[47]
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References

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26	Downregulation of FBP1 Promotes Tumor Metastasis and Indicates Poor Prognosis in Gastric Cancer via Regulating Epithelial-Mesenchymal Transition.PLoS One. 2016 Dec 15;11(12):e0167857. doi: 10.1371/journal.pone.0167857. eCollection 2016.
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