Details of Disease

General Information of Disease (ID: DISRCKR7)

Disease Name	Hypoglycemia
Synonyms	blood glucose, Low; low blood glucose; hypoglycaemia; glucose, Low blood
Disease Class	5A41: Hypo-glycaemia
Definition	Abnormally low level of glucose in the blood.
Disease Hierarchy	DIS5IK09: Glucose metabolism disease DISRCKR7: Hypoglycemia
ICD Code	ICD-11 ICD-11: 5A41 Expand ICD-11 '5A41 Expand ICD-10 'E15; 'E16.0; 'E16.2 Expand ICD-9 250.8,251.0,251.1,251.2,270.3,775.6,962.3
Disease Identifiers	MONDO ID MONDO_0004946 MESH ID D007003 UMLS CUI C0020615 MedGen ID 6979 HPO ID HP:0001943 SNOMED CT ID 237630007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Dasiglucagon	DM74SVE	Approved	Peptide	[1]
Glucagon recombinant	DMFLUTR	Approved	Small molecular drug	[2]
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This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Nasal glucagon	DMCRL9W	Phase 3	NA	[3]
Avexitide	DMQCXSG	Phase 2	Peptide	[4]
Glucagon injection	DMS98SB	Phase 2	NA	[5]
Glucagon	DMX7GAX	Phase 1	NA	[5]
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This Disease is Treated as An Indication in 4 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BPI-3006	DM70FX4	Investigative	NA	[6]
BPI-711001	DMOSG0Q	Investigative	NA	[7]
MAR-531	DMKT21X	Investigative	NA	[8]
XMetD	DMHWTCY	Investigative	Antibody	[9]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 52 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DBH	TTYIP79	Limited	Altered Expression	[10]
EIF2AK3	TT79U1M	Limited	Genetic Variation	[11]
GHR	TTHJWYD	Limited	Biomarker	[12]
INSR	TTCBFJO	Limited	Altered Expression	[13]
NR3C1	TTOZRK6	Limited	Genetic Variation	[14]
SETD2	TTPC3H4	Limited	Altered Expression	[15]
ABCC8	TTP835K	moderate	Genetic Variation	[16]
ADCY5	TTN64VU	moderate	Biomarker	[17]
AQP7	TTNGCRK	moderate	Biomarker	[18]
CHAT	TTKYFSB	moderate	Altered Expression	[19]
GCGR	TT9O6WS	moderate	Biomarker	[20]
GHRHR	TTG4R8V	moderate	Genetic Variation	[21]
GIPR	TTYMKBE	moderate	Genetic Variation	[17]
GRIN1	TTLD29N	moderate	Biomarker	[22]
HNF4A	TT2F3CD	moderate	Altered Expression	[23]
IGF2	TTE8WGO	moderate	Biomarker	[24]
IGFBP6	TTLAYV8	moderate	Biomarker	[25]
KHK	TTPAFR9	moderate	Biomarker	[26]
POR	TTOQ9GZ	moderate	Genetic Variation	[27]
PPY	TTIB95A	moderate	Biomarker	[28]
ROBO4	TT3S9TY	moderate	Biomarker	[29]
AKT2	TTH24WI	Strong	Genetic Variation	[30]
AKT3	TTO6SGY	Strong	Genetic Variation	[31]
ANTXR2	TTOD34I	Strong	Genetic Variation	[32]
CACNA1C	TTZIFHC	Strong	Biomarker	[33]
CRH	TTA7YIZ	Strong	Altered Expression	[34]
FFAR1	TTB8FUC	Strong	Biomarker	[35]
G6PC	TTBQMJ8	Strong	Biomarker	[36]
GCK	TTDLNGZ	Strong	Biomarker	[37]
GIP	TT40HS5	Strong	Altered Expression	[38]
GLA	TTIS03D	Strong	Genetic Variation	[39]
GPR119	TT7QNVC	Strong	Biomarker	[40]
GRIN2B	TTN9D8E	Strong	Biomarker	[41]
GSR	TTEP6RV	Strong	Biomarker	[42]
IAPP	TTHN8EM	Strong	Biomarker	[28]
IGF1	TTT6LOU	Strong	Biomarker	[43]
INS	TTZOPHG	Strong	Biomarker	[44]
KCNH2	TTQ6VDM	Strong	Genetic Variation	[45]
LIPE	TTLUQ8E	Strong	Biomarker	[46]
MGAM	TTXWASR	Strong	Biomarker	[47]
NFKB2	TTKLNRV	Strong	Genetic Variation	[48]
NPY	TT64REZ	Strong	Altered Expression	[49]
PNMT	TT0NZIC	Strong	Biomarker	[50]
PPARA	TTJ584C	Strong	Biomarker	[51]
RORC	TTGV6LY	Strong	Biomarker	[52]
SERPINA1	TTA7UJC	Strong	Biomarker	[53]
SLC2A4	TTP6MT5	Strong	Biomarker	[54]
SLC5A1	TT2UE56	Strong	Biomarker	[55]
TH	TTUHP71	Strong	Biomarker	[56]
TXNIP	TTTLDZK	Strong	Biomarker	[57]
UCP2	TTSC2YM	Strong	Genetic Variation	[58]
TMPRSS11D	TTWHYC8	Definitive	Genetic Variation	[59]
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⏷ Show the Full List of 52 DTT(s)

This Disease Is Related to 7 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC22A5	DT3HUVD	Limited	Genetic Variation	[60]
SLC2A3	DT9SQ3L	Limited	Biomarker	[61]
SLC16A7	DTLT3UG	moderate	Biomarker	[62]
SLC39A14	DTZ6IJW	moderate	Biomarker	[63]
SLC2A2	DTUJPOL	Strong	Altered Expression	[64]
SLC35A2	DT0567K	Strong	Genetic Variation	[65]
SLC52A3	DTBVQIO	Strong	Biomarker	[66]
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⏷ Show the Full List of 7 DTP(s)

This Disease Is Related to 7 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
NDUFS2	DEKX5CD	Limited	Biomarker	[67]
PCK1	DEPLH5Z	Limited	Genetic Variation	[68]
PGM1	DEA3VM1	Limited	Biomarker	[69]
CYP2C8	DES5XRU	moderate	Genetic Variation	[70]
HK1	DEDMAGE	Strong	Altered Expression	[64]
SI	DE5EO4Y	Strong	Biomarker	[47]
UGDH	DE48Q2Z	Strong	Genetic Variation	[71]
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⏷ Show the Full List of 7 DME(s)

This Disease Is Related to 61 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AGL	OTWBM7WY	Limited	Altered Expression	[72]
BNC2	OTU22H9Z	Limited	Biomarker	[73]
CKB	OTUCKOTT	Limited	Biomarker	[74]
DSC3	OTYG47F8	Limited	Genetic Variation	[75]
ETFDH	OTOSKSFH	Limited	Biomarker	[76]
FBP1	OTQBANEP	Limited	Biomarker	[77]
HMGCL	OTRO9RII	Limited	Biomarker	[78]
HNRNPC	OT47AK4C	Limited	Altered Expression	[79]
HNRNPDL	OTB3BFCV	Limited	Altered Expression	[79]
HNRNPL	OT0DJX74	Limited	Altered Expression	[79]
MEN1	OTN6U6V0	Limited	Genetic Variation	[80]
PC	OT6O0V51	Limited	Biomarker	[81]
SORCS1	OTP8PAKU	Limited	Genetic Variation	[73]
TANGO2	OTT9UI89	Limited	Biomarker	[82]
AAAS	OTJT9T23	moderate	Genetic Variation	[83]
ACADL	OTP7Y0UF	moderate	Biomarker	[84]
ACADM	OTA4P0FC	moderate	Genetic Variation	[85]
ARNT	OTMSIEZY	moderate	Biomarker	[86]
CALD1	OTNJKJ6Q	moderate	Biomarker	[84]
CDH15	OTJ1TO02	moderate	Genetic Variation	[87]
CNBP	OTTGM9NK	moderate	Altered Expression	[88]
CPT1C	OT8F1MBF	moderate	Biomarker	[89]
CRIP1	OT0EICG3	moderate	Biomarker	[90]
DCAF1	OT3ZDVOE	moderate	Biomarker	[91]
DEPP1	OTB36PHJ	moderate	Biomarker	[92]
ERO1A	OTVKOQWM	moderate	Biomarker	[15]
GLS2	OT08MSHL	moderate	Genetic Variation	[93]
GYS1	OTJZJRWK	moderate	Biomarker	[94]
HGH1	OTY4H7ZZ	moderate	Genetic Variation	[95]
LRBA	OTOUZN9G	moderate	Biomarker	[96]
PADI1	OT13WAQX	moderate	Biomarker	[97]
PDIA2	OTC2WMXS	moderate	Biomarker	[97]
PIAS1	OTZVAHZI	moderate	Biomarker	[98]
RAD21	OTQS84ZF	moderate	Biomarker	[99]
RPAIN	OTBMXAYK	moderate	Biomarker	[91]
SH3BP1	OTGED7Z2	moderate	Biomarker	[100]
SIAH2	OTKED2XN	moderate	Biomarker	[101]
SOCS7	OT503VJG	moderate	Altered Expression	[102]
TBPL2	OTDEC1KO	moderate	Biomarker	[103]
TFAM	OTXXV5V7	moderate	Genetic Variation	[104]
TIGAR	OTR7NMRJ	moderate	Biomarker	[105]
TMEM132A	OTNUI7O1	moderate	Biomarker	[98]
ACADVL	OT50L4XB	Strong	Genetic Variation	[106]
ARFIP2	OTK9JXIJ	Strong	Genetic Variation	[27]
ARID1B	OTILK3Q7	Strong	Genetic Variation	[107]
ARID3A	OTZZ4SFP	Strong	Genetic Variation	[107]
ATP5F1D	OTXTAG2V	Strong	CausalMutation	[108]
CCHCR1	OT22C116	Strong	Genetic Variation	[109]
CHPT1	OT4FJ0K3	Strong	Biomarker	[110]
CPT1A	OTI862QH	Strong	Genetic Variation	[111]
CPT2	OTIN6G20	Strong	Biomarker	[112]
CRYL1	OT0SJSJM	Strong	Genetic Variation	[71]
EIF2S3	OTARRES9	Strong	Genetic Variation	[113]
GLUD1	OTXKOCUH	Strong	Genetic Variation	[114]
H6PD	OTO7TNDD	Strong	Genetic Variation	[71]
HADH	OTJDOL20	Strong	Genetic Variation	[115]
HADHA	OTO557N2	Strong	Biomarker	[98]
MPI	OTBH6ZK1	Strong	Biomarker	[116]
RIT2	OTSNYG0D	Strong	Genetic Variation	[117]
SERAC1	OTWH1ULQ	Strong	Biomarker	[118]
KCNH6	OTQ52G7V	Definitive	Genetic Variation	[119]
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⏷ Show the Full List of 61 DOT(s)

References

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