General Information of Disease (ID: DISDE4BI)

Disease Name Liver cancer
Synonyms
primary tumour of the liver; primary tumor of the liver; primary cancer of liver; resectable malignant neoplasm of the liver; primary malignant neoplasm of liver; primary malignant liver neoplasm; primary liver cancer; non-resectable primary hepatic malignant neoplasm; malignant tumour of liver; malignant tumor of liver; malignant neoplasm of liver, primary; malignant neoplasm of liver, not specified as primary or secondary; malignant neoplasm of liver; malignant liver neoplasm; malignant hepato-biliary neoplasm; liver cancer; hepatic neoplasm; hepatic cancer; cancer of liver; ca liver - primary; Resectable malignant neoplasm of liver; Ca liver - primary
Disease Class 2C12: Liver cancer
Definition An epithelial or non-epithelial malignant neoplasm that arises from the liver. Representative examples include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, and sarcoma.
Disease Hierarchy
DIS3AOQ7: Aerodigestive tract cancer
DISAT1Z9: Advanced cancer
DISKTBM1: Malignant endocrine neoplasm
DISRQ76N: Liver and intrahepatic bile duct neoplasm
DISDE4BI: Liver cancer
ICD Code
ICD-11
ICD-11: 2C12
ICD-10
ICD-10: C22
Expand ICD-11
'2C12
Expand ICD-10
'C22
Expand ICD-9
140,141,142,143,144,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000.00
Disease Identifiers
MONDO ID
MONDO_0002691
MESH ID
D008113
UMLS CUI
C0345904
MedGen ID
87520
SNOMED CT ID
93870000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 5 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
90Y-loaded resin microspheres DMVEJVI Approved Radiopharmaceutical therapy agent [1]
DTI-015 DMXZRW0 Approved Small molecular drug [2]
Ferumoxides DMIWY08 Approved Small molecular drug [3]
Floxuridine DM04LR2 Approved Small molecular drug [4]
Thymalfasin DMADCYE Approved Small molecular drug [5]
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This Disease is Treated as An Indication in 29 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ABH001 DM847EM Phase 3 NA [6]
Brivanib DM942HP Phase 3 Small molecular drug [7]
JX-594 DM5WCV4 Phase 3 NA [8]
Nofazinlimab DMST5HF Phase 3 Antibody [9]
MTC-DOX DMKMZW2 Phase 2/3 NA [10]
32-P BioSilicon DM91TAS Phase 2 NA [11]
Cixutumumab DMNRYPF Phase 2 Monoclonal antibody [12]
CMC-001 DM1Y3KY Phase 2 NA [13]
Darinaparsin DMB4OFL Phase 2 Small molecular drug [14]
Doxorubicin-eluting beads DM8VWPH Phase 2 NA [15]
KD018 DMPIQAF Phase 2 NA [16]
Tigatuzumab DMKYJJC Phase 2 Monoclonal antibody [17]
[131I]-Metuximab DM4VWXI Phase 2 Antibody [18]
DCVax-Liver DMS79P2 Phase 1/2 NA [19]
INCB62079 DMQO5UF Phase 1/2 NA [20]
MBO7133 DMS19IH Phase 1/2 NA [21]
NV-1020 DMCWT17 Phase 1/2 NA [22]
OBP-301 DM9MF08 Phase 1/2 NA [23]
ADP-A2AFP DM7SOT3 Phase 1 CAR-T cell therapy [24]
ALN-VSP DM89DHO Phase 1 RNAi therapeutics [25]
Anti-CD133-CAR vector-transduced T cells DMGUM90 Phase 1 CAR T Cell Therapy [26]
Autologous ET1402L1-CART cells DMJW4TP Phase 1 CAR T Cell Therapy [27]
CRS-100 DM3HSYC Phase 1 NA [28]
ET140202 DM87XVD Phase 1 CAR-T cell therapy [29]
MRX34 DMWKDOQ Phase 1 NA [30]
PI-166 DMEHQVE Phase 1 NA [31]
SM04755 DM491NI Phase 1 NA [32]
SRF388 DMQMO4N Phase 1 Antibody [33]
EPCAM-targeted CAR-T cells DMV6RMB Clinical trial CAR T Cell Therapy [34]
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⏷ Show the Full List of 29 Drug(s)
This Disease is Treated as An Indication in 5 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ADI DM3WT21 Discontinued in Phase 3 NA [35]
AFP-Scan DMJ8MEJ Discontinued in Phase 2 NA [36]
GN-1140 DMT65E6 Discontinued in Phase 2 NA [37]
OGT-719 DMR9V9N Discontinued in Phase 2 NA [38]
HRC-201 DM5A3GX Terminated NA [41]
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This Disease is Treated as An Indication in 2 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Occlusin DMFADMV Preclinical NA [39]
SR1078 DM7MDZE Preclinical Small molecular drug [40]
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This Disease is Treated as An Indication in 7 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
1,2,3,4,5,6-hexabromocyclohexane DMVD702 Investigative Small molecular drug [42]
AMB-8LK DMW2IHU Investigative NA [43]
GR-DD1 DMX2LKZ Investigative NA [43]
MiR-34a mimics DMA3WEG Investigative NA [43]
OP-05 DMST3A1 Investigative NA [43]
P53 fusion protein DMKQ9CE Investigative NA [43]
STP-322 DM76ZBG Investigative NA [43]
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⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 354 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ADAM17 TT6AZXG Limited Biomarker [44]
AHR TT037IE Limited Altered Expression [45]
ALDH2 TTFLN4T Limited Altered Expression [46]
BCAT1 TTES57P Limited Biomarker [47]
BMI1 TTIPNSR Limited Biomarker [48]
CASP3 TTPF2QI Limited Altered Expression [49]
CASP4 TT6KIOT Limited Biomarker [50]
CD160 TTOFEAS Limited Altered Expression [51]
CEACAM1 TTA9CK4 Limited Biomarker [52]
CFD TT8D13I Limited Altered Expression [53]
CSE1L TTTRULD Limited Biomarker [54]
CYP2C9 TTR40YJ Limited Biomarker [55]
DKK2 TTST5KX Limited Genetic Variation [56]
DTL TT8396I Limited Biomarker [57]
E2F1 TTASI04 Limited Altered Expression [58]
EHMT2 TTS6RZT Limited Posttranslational Modification [59]
EPCAM TTZ8WH4 Limited Altered Expression [60]
GDF2 TTAP4T1 Limited Biomarker [61]
GJC1 TTEP7OC Limited Altered Expression [62]
GRIK2 TT0K5RG Limited Biomarker [63]
GSTA3 TT29VDX Limited Biomarker [64]
HOXA13 TTN26OM Limited Altered Expression [65]
HOXA7 TTMRE4Q Limited Altered Expression [66]
HSPA5 TTW26OG Limited Biomarker [67]
ID1 TTBXVDE Limited Biomarker [68]
IDUA TT0IUKX Limited Biomarker [69]
ISG15 TTVOH3T Limited Biomarker [70]
JUN TTS7IR5 Limited Biomarker [71]
KDM4A TTZHPB8 Limited Biomarker [72]
KIF20B TTQECT2 Limited Biomarker [73]
KISS1R TT3KBZY Limited Biomarker [74]
KLRK1 TTLRN4A Limited Biomarker [75]
KMO TTIY56R Limited Biomarker [76]
MAPKAPK2 TTMUG9D Limited Biomarker [77]
MPL TTIHYA4 Limited Biomarker [78]
NDUFA13 TTRU1NG Limited Altered Expression [79]
NEDD4 TT1QU6G Limited Biomarker [80]
NEDD9 TT1UREA Limited Biomarker [81]
NEK2 TT3VZ24 Limited Biomarker [82]
NR1H3 TTECBXN Limited Altered Expression [83]
NUAK2 TTHVOTQ Limited Biomarker [84]
PARG TT39J16 Limited Altered Expression [85]
PIK3CB TT9H4P3 Limited Biomarker [86]
PKD2L1 TTAHD89 Limited Biomarker [87]
PKM TT4LOT8 Limited Biomarker [88]
PRDX5 TTLPJWH Limited Biomarker [89]
PTP4A3 TT7YM8D Limited Biomarker [90]
RAB22A TTAJ746 Limited Altered Expression [91]
RTN4R TTVRZUO Limited Biomarker [92]
SIRT5 TTH0IOD Limited Altered Expression [93]
SLC10A1 TTWZRY5 Limited Genetic Variation [94]
SLC13A5 TTFIMH7 Limited Biomarker [95]
SLC3A2 TT5CZSM Limited Biomarker [96]
SPHK1 TTOHFIY Limited Biomarker [97]
SPHK2 TTCN0M9 Limited Biomarker [98]
SULF2 TTLQTHB Limited Biomarker [99]
TBL1X TTAL6S1 Limited Altered Expression [100]
TERF2 TT5XSLT Limited Altered Expression [101]
TLN1 TTQSMFG Limited Altered Expression [102]
TRPV2 TTBECWA Limited Biomarker [103]
USP30 TTQ9EDI Limited Biomarker [104]
VDAC1 TTAMKGB Limited Biomarker [105]
YAP1 TT8UN2D Limited Altered Expression [106]
CD44 TTWFBT7 Disputed Genetic Variation [107]
CHUK TT1F8OQ Disputed Biomarker [108]
HRAS TT28ZON Disputed Biomarker [109]
NCR1 TTQNRJM Disputed Altered Expression [110]
PBK TTMY6BZ Disputed Biomarker [111]
SLC7A11 TTBZMIO Disputed Biomarker [112]
SORD TTLSRBZ Disputed Genetic Variation [113]
ZWINT TTWY768 Disputed Altered Expression [114]
ABCB1 TT3OT40 moderate Altered Expression [115]
ANO1 TTOJI4S moderate Genetic Variation [116]
APOBEC3G TTP96KH moderate Genetic Variation [117]
BAP1 TT47RXJ moderate Biomarker [118]
BLVRA TTJBPN3 moderate Altered Expression [119]
CCNA2 TTAMQ62 moderate Biomarker [120]
CPS1 TT42M75 moderate Altered Expression [121]
DLK1 TTF4AVB moderate Altered Expression [122]
ENSA TTQD0YT moderate Biomarker [123]
FER TTRA9G0 moderate Altered Expression [124]
FOXM1 TTD3KOX moderate Altered Expression [46]
GPC3 TTJTSX4 moderate Biomarker [125]
HIF1A TTSN6QU moderate Biomarker [126]
LYVE1 TTG8DNU moderate Altered Expression [127]
MAD1L1 TTNE9U7 moderate Biomarker [128]
MAGEA1 TT63M7Q moderate Altered Expression [129]
MAN2A1 TT34DCN moderate Altered Expression [124]
MSI2 TTTXQF6 moderate Biomarker [130]
NCK1 TTMA3VF moderate Biomarker [131]
PEMT TT735V2 moderate Biomarker [132]
PINX1 TT4FJ3A moderate Genetic Variation [133]
SRC TT6PKBN moderate Altered Expression [134]
SRD5A2 TTT02K8 moderate Genetic Variation [135]
TAGLN2 TTP6BIJ moderate Biomarker [136]
TNFRSF25 TTDV6BQ moderate Biomarker [137]
TOP2A TTCGY2K moderate Biomarker [138]
TRIM24 TT9Q7AE moderate Biomarker [139]
TSG101 TTHU7JA moderate Biomarker [140]
TXNRD1 TTR7UJ3 moderate Altered Expression [141]
XRCC5 TTCB9KW moderate Genetic Variation [142]
ABCA1 TTJW1GN Strong Biomarker [143]
ABCB4 TTJUXV6 Strong Biomarker [144]
ABCC3 TTVLG21 Strong Biomarker [145]
ABL1 TT6B75U Strong Biomarker [146]
ACAT1 TTK3C21 Strong Genetic Variation [147]
ACHE TT1RS9F Strong Biomarker [148]
ADAM9 TTTYQNS Strong Altered Expression [149]
AKR1C3 TT5ZWB6 Strong Altered Expression [150]
AKT2 TTH24WI Strong Biomarker [151]
ALCAM TT2AFT6 Strong Biomarker [152]
ANXA2 TT4YANI Strong Biomarker [153]
APCS TTB7VAT Strong Biomarker [154]
AQP9 TTQEI32 Strong Altered Expression [155]
ASAP3 TTB4ZEN Strong Altered Expression [156]
ASPH TT2KHP7 Strong Altered Expression [157]
ATAD2 TT9A0HI Strong Genetic Variation [158]
ATF3 TTCE793 Strong Altered Expression [159]
BMPR2 TTGKF90 Strong Biomarker [160]
BTG1 TTL7N2W Strong Biomarker [161]
C3 TTJGY7A Strong Biomarker [162]
CAD TT2YT1K Strong Biomarker [163]
CAMKK2 TTV298Y Strong Biomarker [164]
CARM1 TTIZQFJ Strong Biomarker [165]
CASP8 TT6SZNG Strong Therapeutic [166]
CASP9 TTB6T7O Strong Altered Expression [167]
CCNB1 TT9P6OW Strong Altered Expression [168]
CCND1 TTFCJ7S Strong Biomarker [169]
CCR2 TTFZYTO Strong Altered Expression [170]
CCR4 TT7HQD0 Strong Biomarker [146]
CD96 TT83C4X Strong Biomarker [171]
CDH1 TTLAWO6 Strong Biomarker [172]
CDK1 TTH6V3D Strong Biomarker [173]
CDK2 TT7HF4W Strong Biomarker [174]
CDKN1A TT9GUW0 Strong Biomarker [174]
CDKN1B TTLGFVW Strong Biomarker [175]
CDKN2A TTFTWQ8 Strong Posttranslational Modification [176]
CEACAM3 TTPX7I5 Strong Altered Expression [177]
CEBPA TT5LWG1 Strong Altered Expression [178]
CHN2 TT39YVO Strong Biomarker [146]
COL18A1 TT63DI9 Strong Biomarker [179]
CPT1B TTDL0NY Strong Biomarker [180]
CSF2 TTNYZG2 Strong Therapeutic [181]
CSF3 TT5TQ2W Strong Therapeutic [182]
CSK TTX6F0Q Strong Biomarker [183]
CTDSP1 TTHZAF0 Strong Biomarker [184]
CTNNB1 TTRPKQG Strong Biomarker [185]
CTSB TTF2LRI Strong Altered Expression [186]
CTSL TT36ETB Strong Biomarker [187]
CUL3 TTPCU0Q Strong Altered Expression [188]
CXCL11 TTWG0RE Strong Altered Expression [189]
CXCL9 TTWE5PB Strong Biomarker [190]
CYP2E1 TTWVHQ5 Strong Genetic Variation [191]
DCN TTB3XAN Strong Biomarker [192]
DEK TT1NMGV Strong Biomarker [193]
DEPDC1 TT8S9CM Strong Biomarker [194]
DICER1 TTTEOPU Strong Biomarker [195]
DKK1 TTE3RAC Strong Biomarker [196]
DNAJB1 TTPXAWS Strong Biomarker [197]
DNMT1 TT6S2FE Strong Altered Expression [198]
DNMT3A TTJUALD Strong Biomarker [199]
DNMT3B TT6VZ78 Strong Biomarker [200]
DPP10 TTOVUPC Strong Biomarker [146]
DPYD TTZPS91 Strong Biomarker [201]
DYRK2 TT84OS6 Strong Altered Expression [202]
E2F2 TT5FYX0 Strong Altered Expression [203]
EED TTFNJ4R Strong Biomarker [204]
ENG TTB30LE Strong Biomarker [205]
ENPP2 TTSCIM2 Strong Biomarker [206]
EP300 TTGH73N Strong Biomarker [207]
EPHA3 TTHS2LR Strong Biomarker [208]
EPHB2 TTKPV6O Strong Altered Expression [209]
EPHB6 TTZEMUY Strong Genetic Variation [210]
ESR1 TTZAYWL Strong Altered Expression [211]
ESRRG TT9ZRHB Strong Altered Expression [212]
FAS TT7LTUJ Strong Biomarker [213]
FGF19 TTGCH11 Strong Biomarker [214]
FGFR4 TT1KX2S Strong Biomarker [214]
FGR TTPOGS1 Strong Biomarker [215]
FHIT TTMS54D Strong Genetic Variation [216]
FHL1 TTI7ENL Strong Altered Expression [217]
FLT4 TTDCBX5 Strong Biomarker [87]
FOXP1 TT0MUCI Strong Therapeutic [218]
FST TTDNM9W Strong Biomarker [219]
FTH1 TT975ZT Strong Biomarker [220]
G6PD TTKN8W0 Strong Altered Expression [221]
GADD45B TTMDW9L Strong Altered Expression [222]
GCK TTDLNGZ Strong Altered Expression [223]
GGT1 TTZVT7O Strong Altered Expression [224]
GJB1 TTSJIRP Strong Biomarker [225]
GJB2 TTRGZX3 Strong Biomarker [172]
GMPS TTCFP0V Strong Biomarker [226]
GP1BA TTVB0Q9 Strong Biomarker [227]
GRK2 TTAZ3MN Strong Altered Expression [228]
GRN TT0LWE3 Strong Altered Expression [229]
HAMP TTRV5YJ Strong Biomarker [230]
HDAC11 TT8K17W Strong Biomarker [231]
HDAC3 TT4YWTO Strong Biomarker [232]
HGF TT4V2JM Strong Biomarker [233]
HGFAC TTD96RW Strong Biomarker [234]
HK2 TTK02H8 Strong Biomarker [235]
HMBS TTT0HW3 Strong Altered Expression [236]
HMGA1 TTBA219 Strong Biomarker [237]
HMGCS2 TTS0EZJ Strong Biomarker [238]
HMOX1 TTI6V2A Strong Therapeutic [239]
HNF1A TT01M3K Strong Biomarker [240]
HNRNPA1 TTPJ9XK Strong Altered Expression [241]
HNRNPA2B1 TT8UPW6 Strong Biomarker [242]
HPD TT8DSFC Strong Biomarker [243]
HSD17B4 TTL1WGS Strong Biomarker [244]
HSP90B1 TTFPKXQ Strong Altered Expression [245]
HSPA9 TTMTPG3 Strong Altered Expression [246]
HSPB3 TTLH8WG Strong Biomarker [247]
IFNL3 TTRF4Q2 Strong Genetic Variation [248]
IGF2 TTE8WGO Strong Biomarker [249]
IL12A TTRTK6Y Strong Therapeutic [181]
IL12B TTGW72V Strong Therapeutic [181]
IL2 TTF89GD Strong Biomarker [250]
INSR TTCBFJO Strong Biomarker [251]
IRS2 TTF95B8 Strong Biomarker [252]
KAT2B TTVK7SB Strong Biomarker [86]
KDM1A TTNR0UQ Strong Biomarker [253]
KDM5A TTIG67W Strong Altered Expression [254]
KISS1 TTU2O6T Strong Biomarker [74]
KITLG TTDJ51N Strong Biomarker [255]
KLRC1 TTC4IMS Strong Altered Expression [256]
KRAS TTM8FR7 Strong Biomarker [86]
LAPTM4B TTEJQT0 Strong Biomarker [257]
LATS2 TTML7FG Strong Biomarker [258]
LDHA TTW76JE Strong Biomarker [259]
LGR5 TTTSGRH Strong Biomarker [260]
LPAR1 TTQ6S1K Strong Biomarker [261]
LTF TTSZDQU Strong Therapeutic [262]
MAGEC2 TTKGUEB Strong Altered Expression [263]
MANF TT56RYE Strong Biomarker [264]
MAP3K10 TT9FN4J Strong Biomarker [265]
MAP3K2 TTIX0ZU Strong Altered Expression [266]
MAPK14 TTQBR95 Strong Altered Expression [267]
MARCKS TTHRM39 Strong Biomarker [268]
MAT2A TTSMPXQ Strong Biomarker [269]
MCM7 TT1RM3F Strong Biomarker [270]
MECP2 TTTAU9R Strong Biomarker [200]
MME TT5TKPM Strong Biomarker [271]
MSLN TT4RXME Strong Biomarker [272]
MTDH TTH6SA5 Strong Biomarker [273]
MUTYH TTNB0ZK Strong Genetic Variation [274]
MYC TTNQ5ZP Strong Biomarker [275]
MYCN TT9JBY5 Strong Biomarker [276]
NFE2L2 TTA6ZN2 Strong Altered Expression [277]
NR0B2 TT25A9Q Strong Biomarker [278]
NR1H4 TTS4UGC Strong Biomarker [279]
NR1I3 TTRANFM Strong Biomarker [280]
NUAK1 TT65FL0 Strong Biomarker [281]
OAT TTTSCQ2 Strong Genetic Variation [282]
OGFR TT6IEYX Strong Biomarker [283]
PCNA TTLG1PD Strong Biomarker [101]
PCSK7 TTD30LY Strong Biomarker [284]
PCYT1B TTUAIKM Strong Biomarker [285]
PDCD1 TTNBFWK Strong Altered Expression [286]
PDCD2 TTYOVWN Strong Biomarker [287]
PHB TT6U071 Strong Altered Expression [288]
PHGDH TT8DRCK Strong Biomarker [289]
PLAU TTGY7WI Strong Biomarker [290]
PLK1 TTH4IP0 Strong Altered Expression [291]
PLK2 TT976FS Strong Biomarker [292]
PLK4 TTGPNZQ Strong Genetic Variation [293]
PLXDC1 TTPSK7A Strong Biomarker [294]
PPARA TTJ584C Strong Altered Expression [295]
PPARG TTT2SVW Strong Biomarker [296]
PPAT TTZFTY4 Strong Biomarker [297]
PPOX TTNFMS9 Strong Altered Expression [236]
PRKCE TT57MT2 Strong Biomarker [146]
PSMD10 TT2H4LN Strong Biomarker [298]
PTBP1 TTWMX0U Strong Altered Expression [299]
PTGER3 TTPNGDE Strong Biomarker [300]
PTK2 TTON5IT Strong Biomarker [301]
RACK1 TTJ10AL Strong Altered Expression [302]
REG3A TTL4H8N Strong Biomarker [303]
RHO TTH0KSX Strong Altered Expression [304]
RIPK1 TTVJHX8 Strong Biomarker [305]
ROS1 TTSZ6Y3 Strong Altered Expression [306]
RUNX3 TTKCVO7 Strong Altered Expression [110]
SATB1 TTLFRIC Strong Biomarker [267]
SEPTIN6 TTAGE7U Strong Biomarker [307]
SERPINB3 TT6QLPX Strong Biomarker [308]
SERPINC1 TT4QPUL Strong Biomarker [309]
SERPINE1 TTTO43N Strong Biomarker [310]
SIRT6 TTUXYWF Strong Biomarker [311]
SKP2 TT5B2EO Strong Genetic Variation [312]
SLC11A2 TT2IS7P Strong Biomarker [146]
SLC22A1 TTM5Q4V Strong Biomarker [313]
SLC2A1 TT79TKF Strong Biomarker [314]
SLC2A4 TTP6MT5 Strong Altered Expression [315]
SLC40A1 TT6Y1PG Strong Biomarker [316]
SLC5A2 TTF8JAT Strong Biomarker [317]
SLC5A5 TTW7HI9 Strong Biomarker [318]
SLC7A5 TTPH2JB Strong Biomarker [319]
SLCO1B1 TTFGXEB Strong Altered Expression [320]
SLCO2B1 TTDL3UZ Strong Altered Expression [320]
SMAD1 TT9GR53 Strong Biomarker [205]
SNCG TT5TQNZ Strong Altered Expression [321]
SQSTM1 TTOT2RY Strong Altered Expression [322]
SRMS TT7YMXZ Strong Biomarker [146]
STAT3 TTHJT3X Strong Altered Expression [244]
STRAP TT165DP Strong Biomarker [323]
TAGLN TTDRZ9H Strong Biomarker [324]
TEK TT9VGXW Strong Biomarker [325]
TERT TTQY2EJ Strong Biomarker [326]
TFRC TT8MG4S Strong Biomarker [327]
TGFA TTTLQFR Strong Biomarker [328]
TGFBR2 TTZE3P7 Strong Biomarker [329]
TLR1 TTW14D0 Strong Altered Expression [330]
TMSB4X TTMVAIU Strong Altered Expression [331]
TNF TTF8CQI Strong Altered Expression [332]
TNFRSF10A TT5WLRX Strong Biomarker [333]
TNFRSF10B TTW20TU Strong Altered Expression [334]
TNFSF10 TTA5MS9 Strong Biomarker [335]
TNK2 TTIET93 Strong Biomarker [146]
TNKS TTVUSO7 Strong Biomarker [336]
TOP1 TTGTQHC Strong Biomarker [138]
TPX2 TT0PHL4 Strong Altered Expression [337]
TREM1 TTHZQP0 Strong Biomarker [338]
TRIP10 TTKHTGE Strong Posttranslational Modification [339]
TTK TTP7EGM Strong Biomarker [69]
TXNIP TTTLDZK Strong Biomarker [340]
UCP1 TTI12YJ Strong Altered Expression [341]
VSIR TT51SK8 Strong Biomarker [342]
WWP2 TT6TU05 Strong Biomarker [343]
XDH TT7RJY8 Strong Biomarker [344]
XPA TTGT87E Strong Biomarker [345]
XPO1 TTCJUR4 Strong Biomarker [346]
YOD1 TTFSH0K Strong Biomarker [347]
YY1AP1 TTYED1Q Strong Biomarker [348]
ZNF224 TT1CDXL Strong Altered Expression [194]
ADORA2B TTNE7KG Definitive Biomarker [349]
ANPEP TTPHMWB Definitive Altered Expression [350]
ANXA10 TT0NL6U Definitive Altered Expression [153]
ATP7B TTOPO51 Definitive Biomarker [351]
BRAF TT0EOB8 Definitive Genetic Variation [352]
CEACAM5 TTY6DTE Definitive Altered Expression [177]
CLIC1 TT8KZG6 Definitive Biomarker [353]
FOLR2 TTT54CI Definitive Altered Expression [354]
HDAC2 TTSHTOI Definitive Biomarker [355]
JAK1 TT6DM01 Definitive Genetic Variation [356]
KRT6A TT2FX8W Definitive Genetic Variation [113]
LILRB2 TTHC6XU Definitive Altered Expression [357]
MAP4K3 TTI0AHJ Definitive Altered Expression [223]
PRKCI TTWJTHX Definitive Biomarker [358]
PROM1 TTXMZ81 Definitive Biomarker [350]
RAF1 TTAN5W2 Definitive Biomarker [359]
SCAP TTL6U2P Definitive Biomarker [360]
SCD TT6RIOV Definitive Biomarker [361]
TM6SF2 TTE1OHM Definitive Genetic Variation [362]
TMBIM6 TT7QSMG Definitive Biomarker [363]
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⏷ Show the Full List of 354 DTT(s)
This Disease Is Related to 6 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC25A11 DT0YAUQ Limited Biomarker [364]
SLCO5A1 DTYVQ5M moderate Biomarker [365]
ABCB5 DTKVEXO Strong Altered Expression [366]
SLC38A9 DTF7MYK Strong Biomarker [146]
SLC39A4 DTEZCUM Strong Biomarker [367]
SLC25A21 DT2UQYR Definitive Altered Expression [269]
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⏷ Show the Full List of 6 DTP(s)
This Disease Is Related to 32 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
MMEL1 DEYCUQ2 Limited Biomarker [368]
NDUFS7 DEIW03B Limited Biomarker [369]
PCK1 DEPLH5Z Limited Altered Expression [370]
UGP2 DE4U39Y Limited Biomarker [371]
AKR7A2 DE4G629 moderate Biomarker [372]
CPA4 DEXKD7J moderate Altered Expression [373]
SULT1A3 DEP7E8X moderate Altered Expression [374]
UBASH3B DE10BJ5 moderate Biomarker [375]
ACSS2 DEE76VW Strong Biomarker [376]
ADH1C DEM1HNL Strong Genetic Variation [377]
AKR1B10 DEP6GT1 Strong Biomarker [378]
AKR1C2 DEOY5ZM Strong Altered Expression [150]
APRT DE2MV1R Strong Altered Expression [379]
ASNS DEXISVQ Strong Posttranslational Modification [380]
DIO3 DET89OV Strong Biomarker [381]
EGLN3 DEMQTKH Strong Biomarker [289]
GPT DER5HFI Strong Biomarker [382]
GSTM1 DEYZEJA Strong Biomarker [383]
HPRT1 DEVXTP5 Strong Biomarker [297]
MAT1A DEQ6NC9 Strong Genetic Variation [147]
NAT2 DER7TA0 Strong Biomarker [384]
P4HA2 DE5EGK0 Strong Altered Expression [385]
PFAS DE5LFD8 Strong Biomarker [386]
UGDH DE48Q2Z Strong Biomarker [387]
UGT1A7 DEZO4N3 Strong Genetic Variation [388]
UGT1A9 DE85D2P Strong Genetic Variation [388]
UGT2B7 DEB3CV1 Strong Genetic Variation [389]
AKR1C1 DE7P2FB Definitive Altered Expression [150]
AKR1C4 DEAJN47 Definitive Biomarker [150]
HK1 DEDMAGE Definitive Altered Expression [390]
MAT2B DEKF1OH Definitive Biomarker [391]
NAT10 DEZV4AP Definitive Biomarker [392]
------------------------------------------------------------------------------------
⏷ Show the Full List of 32 DME(s)
This Disease Is Related to 572 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACADL OTP7Y0UF Limited Altered Expression [393]
ACOT7 OT7C68YV Limited Biomarker [394]
ACOX1 OTM0A0DY Limited Altered Expression [93]
ACRBP OT0MK3L1 Limited Biomarker [395]
ACSL1 OTB06ESI Limited Biomarker [396]
ACSM3 OT0AE1IV Limited Altered Expression [397]
ACTBL2 OTD6B81U Limited Biomarker [394]
ACTG2 OTRDWUO0 Limited Biomarker [394]
ACTR3 OT05LJSH Limited Altered Expression [398]
AFAP1L2 OTJBI0VN Limited Altered Expression [399]
AGFG1 OTI8ZKC4 Limited Biomarker [400]
AHNAK OT6KH1WG Limited Posttranslational Modification [401]
AKAP12 OTCVRDDX Limited Biomarker [402]
AKAP17A OT2CEJW4 Limited Biomarker [403]
ALDH7A1 OTV57BZD Limited Altered Expression [404]
ANXA7 OTLMD0TK Limited Biomarker [180]
ARSF OTC0L12N Limited Biomarker [405]
BTRC OT2EZDGR Limited Biomarker [406]
CALML3 OTM8DNQU Limited Biomarker [407]
CAND1 OTGB6NU0 Limited Biomarker [408]
CAPN6 OT8K5PR5 Limited Altered Expression [409]
CCNH OTKDU3SR Limited Biomarker [63]
CDCA3 OTUI8QK3 Limited Biomarker [395]
CEBPD OTNBIPMY Limited Biomarker [410]
CERS4 OTV5ENAX Limited Biomarker [411]
CHAF1A OTXSSY4H Limited Biomarker [412]
CHCHD2 OTL5PA3Y Limited Biomarker [413]
CISD2 OTVS7S2H Limited Altered Expression [414]
CLDN3 OT71MN9S Limited Biomarker [415]
CLEC7A OTRTBH27 Limited Altered Expression [416]
CLIC4 OT6KTPKD Limited Biomarker [417]
DCAF1 OT3ZDVOE Limited Biomarker [400]
DCTN4 OTM7C943 Limited Altered Expression [322]
DCTN6 OTI8PIN9 Limited Altered Expression [418]
DDX3X OTDO4TRX Limited Altered Expression [419]
DEFB1 OT5SV0E4 Limited Biomarker [420]
DEPDC7 OT62C942 Limited Altered Expression [421]
DGKQ OT8OEPYT Limited Biomarker [422]
DKK4 OTWCCVF6 Limited Biomarker [423]
DLC1 OTP8LMCR Limited Genetic Variation [424]
DLEC1 OTMKKBUW Limited Genetic Variation [424]
DPYS OTLTUIVL Limited Biomarker [201]
DYNLL1 OTR69LHT Limited Genetic Variation [424]
E2F7 OTWW358N Limited Biomarker [425]
ECHS1 OTS0593S Limited Biomarker [426]
EIF2B5 OTV3R4RB Limited Altered Expression [427]
FBXL2 OT5EZ7PD Limited Biomarker [428]
FGA OTMIHY80 Limited Biomarker [429]
FHL5 OT6C00Z1 Limited Biomarker [394]
FNDC3B OTBILGDR Limited Biomarker [430]
FSTL5 OT18C29S Limited Biomarker [431]
GALNT14 OT9BSDDQ Limited Genetic Variation [432]
GATAD1 OT0UZ3EP Limited Altered Expression [90]
GNPAT OTF6LWPO Limited Biomarker [104]
GPR107 OTX5VURU Limited Altered Expression [433]
GRIP1 OT958HK1 Limited Biomarker [434]
GTF2H1 OTCRXC6B Limited Altered Expression [322]
H2AZ1 OT3KJJNQ Limited Biomarker [435]
HHLA2 OTYBTVQS Limited Biomarker [436]
HLF OTTRK9XN Limited Biomarker [437]
HMBOX1 OTPKTBVI Limited Biomarker [438]
HMGB3 OTCJ2EZY Limited Biomarker [439]
HNRNPC OT47AK4C Limited Altered Expression [241]
HNRNPDL OTB3BFCV Limited Altered Expression [241]
HOXA10 OTB6GQ09 Limited Altered Expression [440]
HPR OTXSC9UB Limited Biomarker [441]
IER3 OTZJI5FZ Limited Biomarker [442]
IER5 OTJPTXMD Limited Posttranslational Modification [443]
IFNA1 OTPMKY0L Limited Biomarker [444]
IGF2BP1 OT9G360P Limited Biomarker [445]
JCAD OT7G1WJW Limited Biomarker [446]
KLF17 OT5NWVP7 Limited Biomarker [447]
KLHDC2 OTBHH882 Limited Biomarker [448]
LAT OTZC1XZ1 Limited Biomarker [319]
LATS1 OTOOCG4R Limited Altered Expression [449]
LGALS9 OT7MF91K Limited Biomarker [450]
MACIR OTPSW8Y8 Limited Biomarker [63]
MAFG OTBQFUZH Limited Biomarker [451]
MAPK6 OTDDNF3Q Limited Altered Expression [452]
MAVS OTTQ0J64 Limited Biomarker [453]
MBD3 OTRL76H5 Limited Biomarker [71]
MED15 OT0D0JVD Limited Altered Expression [454]
MPEG1 OT7DAO0F Limited Biomarker [69]
NANOG OTUEY1FM Limited Biomarker [395]
NASP OTNE4THC Limited Altered Expression [455]
NCOA1 OTLIUJQD Limited Biomarker [456]
NCR3LG1 OT15YWU7 Limited Biomarker [436]
NCS1 OT6JHAWM Limited Altered Expression [457]
NECTIN2 OTIE0W6O Limited Biomarker [458]
NKD1 OTY3MO97 Limited Altered Expression [459]
NOLC1 OTKDZU0D Limited Biomarker [460]
NR2E3 OTO3GBHQ Limited Biomarker [434]
NUMB OTMB586Q Limited Posttranslational Modification [461]
NUP62 OTMN63DH Limited Altered Expression [322]
ORM1 OTZKSBRE Limited Altered Expression [462]
OSCP1 OTZ4IFGJ Limited Biomarker [463]
PBX3 OT8WMVM4 Limited Altered Expression [266]
PCK2 OTJ8LX4N Limited Altered Expression [370]
PGK1 OT6V1ICH Limited Biomarker [464]
PIWIL1 OT7CRGZ3 Limited Biomarker [465]
PLEC OTU4XDEG Limited Biomarker [466]
POLE OTFM3MMU Limited Genetic Variation [467]
POTEM OT7L2HGH Limited Biomarker [394]
POU2F1 OTK7ELJ0 Limited Altered Expression [409]
PRC1 OTHD0XS0 Limited Biomarker [468]
PRDX1 OTZ3BEC4 Limited Altered Expression [469]
PREX2 OTYT1J6J Limited Altered Expression [470]
PRRX1 OTTZK5G8 Limited Altered Expression [471]
PSMD14 OTJWHMZ5 Limited Biomarker [472]
PSMD4 OTH1VZTM Limited Biomarker [405]
PSMD9 OT6Y5CC3 Limited Altered Expression [418]
RABGEF1 OTWC3Z3R Limited Biomarker [473]
RAD54B OTMWB2P2 Limited Altered Expression [474]
RAMP3 OTX6XLLM Limited Biomarker [475]
RAP1A OT5RH6TI Limited Biomarker [473]
RASA2 OTL06RG2 Limited Biomarker [476]
RBM38 OTPO8EXU Limited Altered Expression [477]
RBX1 OTYA1UIO Limited Altered Expression [478]
RECQL4 OT59LSW7 Limited Altered Expression [479]
RPA1 OT76POLP Limited Biomarker [480]
RPAIN OTBMXAYK Limited Biomarker [400]
RPS27 OTFXKY7P Limited Biomarker [69]
RSPO2 OT3HHXU0 Limited Biomarker [481]
RTP3 OTZUDJ6Q Limited Biomarker [482]
SAMHD1 OTBCIBC7 Limited Genetic Variation [483]
SARS1 OTFKXQ1O Limited Biomarker [484]
SARS2 OTU4T99W Limited Biomarker [484]
SASH1 OTQA8BD4 Limited Altered Expression [485]
SELENOP OT02B8IR Limited Biomarker [368]
SETD3 OTO5RAU2 Limited Altered Expression [486]
SF3B4 OTGB9OR9 Limited Biomarker [487]
SIRT4 OT5S0J23 Limited Biomarker [488]
SND1 OTT734JN Limited Altered Expression [489]
SOCS2 OTBPNKJQ Limited Biomarker [490]
SOX1 OTVI1RAR Limited Posttranslational Modification [491]
SPOP OTP0107S Limited Biomarker [492]
SPRTN OT01D5CE Limited Biomarker [493]
SRCIN1 OTQZNQQ5 Limited Biomarker [494]
SUMO1 OTJFD4P5 Limited Altered Expression [495]
SUZ12 OT655XF8 Limited Altered Expression [496]
TBC1D9 OTSSCTB5 Limited Altered Expression [497]
TCIM OTARUXQF Limited Biomarker [498]
TERF2IP OT3M5P3G Limited Biomarker [473]
TEX10 OTNTU9CB Limited Altered Expression [499]
TFDP1 OT6RZ7VT Limited Biomarker [500]
TICAM2 OTK7GIJ5 Limited Altered Expression [418]
TLN2 OT10QQBC Limited Altered Expression [102]
TM4SF5 OTPAV531 Limited Altered Expression [501]
TMED7 OTONO8E6 Limited Altered Expression [418]
TP53INP1 OT2363Z9 Limited Biomarker [502]
TRAF2 OT1MEZZN Limited Biomarker [305]
TRAP1 OTNG0L8J Limited Altered Expression [503]
TRIB2 OTHSX3MX Limited Biomarker [504]
TRMT11 OTRK0IOR Limited Biomarker [63]
CD5L OTPY4WQR Disputed Altered Expression [67]
CMTM7 OTI7Q2JW Disputed Biomarker [505]
DACT2 OTNLCC0K Disputed Biomarker [180]
DVL1 OTD67RF1 Disputed Biomarker [506]
ELOVL6 OTB26UJJ Disputed Altered Expression [507]
FHL2 OT0OAYWT Disputed Altered Expression [508]
FOSB OTW6C05J Disputed Biomarker [509]
FZD6 OTBCPII8 Disputed Biomarker [510]
GDF11 OTOSNMND Disputed Biomarker [511]
GOLPH3 OTDLGYM3 Disputed Biomarker [512]
GTSF1 OTV7PQJF Disputed Altered Expression [513]
KIF18A OTSMBJ24 Disputed Altered Expression [514]
MORC2 OT52A8BJ Disputed Altered Expression [515]
MRPL38 OTCE2I7M Disputed Genetic Variation [113]
RHEB OTFLTSEC Disputed Altered Expression [516]
RIT1 OTVNOGOH Disputed Biomarker [517]
SFMBT2 OTZQT61Q Disputed Altered Expression [518]
SVEP1 OTOBICRD Disputed Genetic Variation [113]
TCF4 OTB9ASTK Disputed Biomarker [146]
THY1 OTVONVTB Disputed Altered Expression [60]
ADAR OTQNOHR8 moderate Altered Expression [519]
ANAPC11 OTK2SJXR moderate Biomarker [520]
ANXA6 OT9KIQ0Y moderate Biomarker [375]
ARNT OTMSIEZY moderate Biomarker [521]
ASL OTI2NGQR moderate Biomarker [522]
CLIP1 OTTGAEJE moderate Biomarker [523]
CLIP2 OTSCIQIY moderate Biomarker [523]
CPEB4 OTW1SCZW moderate Altered Expression [524]
CRYL1 OT0SJSJM moderate Altered Expression [525]
CSMD1 OTIVDSC4 moderate Biomarker [526]
DIRAS3 OT3XHLQA moderate Altered Expression [527]
DRAM1 OTIJTXEN moderate Altered Expression [528]
EIF2S1 OTM0GDTP moderate Biomarker [529]
EIF2S2 OTXF0B09 moderate Biomarker [529]
EIF2S3 OTARRES9 moderate Biomarker [529]
ELK1 OTH9MXD6 moderate Biomarker [530]
FADD OTV7GFHH moderate Genetic Variation [116]
FOXK1 OTLZGS7J moderate Biomarker [531]
FUBP1 OT77SC9N moderate Biomarker [532]
KCNH4 OTHJ8WTU moderate Biomarker [530]
KCNH8 OT3I5FLB moderate Biomarker [530]
LDB2 OT6Y8IEK moderate Biomarker [533]
LMNB1 OT100T3P moderate Biomarker [534]
LTO1 OTQ17ZDT moderate Genetic Variation [116]
MAGED4B OTO37U7W moderate Altered Expression [129]
MAML1 OTQA4DDN moderate Altered Expression [535]
MAP1S OT5WUD4C moderate Biomarker [536]
MASTL OTQ7YKK5 moderate Altered Expression [123]
MLXIPL OTR9MLLW moderate Biomarker [537]
MNT OTPC4ANL moderate Biomarker [131]
MPP1 OTA2ENZQ moderate Altered Expression [538]
MRGPRF OT74OZ2Z moderate Biomarker [539]
NLK OT2LETFS moderate Biomarker [540]
NLRP2 OTJA81JU moderate Genetic Variation [541]
OSGIN1 OT9KIVZW moderate Biomarker [542]
PCDH20 OTFSNRXK moderate Altered Expression [543]
PEA15 OTKCKTSX moderate Biomarker [544]
PIK3R3 OTXGJ8N1 moderate Altered Expression [538]
POLG2 OTDBMZJB moderate Altered Expression [538]
PPFIA1 OTYYFA9C moderate Genetic Variation [116]
PRICKLE1 OT9HHEM9 moderate Biomarker [545]
PSMD12 OTWICA51 moderate Altered Expression [538]
PTMA OT2W4T1M moderate Altered Expression [546]
RAE1 OT54OKC3 moderate Biomarker [547]
RBFOX2 OTXY1WVH moderate Biomarker [539]
RNASE7 OTIXO0Z4 moderate Biomarker [547]
RPIA OT805SMH moderate Altered Expression [548]
SCARA5 OTOVA96E moderate Posttranslational Modification [549]
SFPQ OTLCIAPJ moderate Biomarker [550]
SH3BP4 OTVIRKW7 moderate Posttranslational Modification [551]
SHMT2 OT5NCAZN moderate Biomarker [552]
TIGAR OTR7NMRJ moderate Posttranslational Modification [553]
TNFAIP8L2 OTII0RM0 moderate Altered Expression [554]
TRIM3 OT704FQ0 moderate Altered Expression [555]
TSPY1 OTPY57X4 moderate Altered Expression [556]
TSPY3 OTQK3AKI moderate Altered Expression [556]
A2M OTFTX90K Strong Biomarker [557]
ACOT1 OTXFL7WM Strong Biomarker [180]
ACOT12 OTN4RQK8 Strong Biomarker [558]
ACYP2 OTRB4S6X Strong Genetic Variation [559]
ADAM12 OTZKOTDB Strong Altered Expression [560]
ADAMTS17 OTCFITM9 Strong Biomarker [146]
ADARB1 OTGKSZEV Strong Biomarker [561]
ALDOC OTEC13I5 Strong Biomarker [562]
ALX4 OTNS9A29 Strong Biomarker [563]
AMOTL2 OTRCTKV9 Strong Altered Expression [564]
ANXA3 OTDD8OI7 Strong Biomarker [565]
ANXA4 OTUCRYXL Strong Biomarker [146]
APC OTKV0TIK Strong Altered Expression [566]
APOBEC3A OTYO6F5P Strong Altered Expression [398]
APOBEC3B OTHLNI51 Strong Genetic Variation [567]
AQP5 OT77GBY8 Strong Altered Expression [568]
ARHGAP1 OT0H2ZBZ Strong Biomarker [569]
ARHGAP9 OTJNHX96 Strong Altered Expression [570]
ARID2 OTIRJXWM Strong Genetic Variation [571]
ARL4C OTQ3QNNU Strong Biomarker [572]
ARR3 OTRZ00CH Strong Biomarker [280]
ASH1L OTUT5NLJ Strong Biomarker [573]
ASPG OT5E2EKR Strong Biomarker [380]
ATF7 OTM8T3OD Strong Altered Expression [574]
AXIN1 OTRGZGZ5 Strong Genetic Variation [575]
AXIN2 OTRMGQNU Strong Biomarker [576]
B3GAT3 OTDSN5XF Strong Biomarker [577]
BIN1 OTK8O0X8 Strong Biomarker [550]
BIRC6 OTCQJAB0 Strong Biomarker [578]
BRI3BP OTWCFPRM Strong Biomarker [579]
BTBD7 OTNUV6MQ Strong Genetic Variation [580]
CADM1 OTRWG9QS Strong Posttranslational Modification [581]
CALD1 OTNJKJ6Q Strong Biomarker [582]
CAMK4 OT47RDGV Strong Biomarker [164]
CAPN3 OTCHG3YK Strong Biomarker [583]
CARD8 OTXXZYWU Strong Biomarker [584]
CBLL2 OTB4AD3V Strong Biomarker [585]
CBX5 OT8VYY84 Strong Genetic Variation [586]
CCDC134 OT70OQQV Strong Biomarker [146]
CCL28 OTY6XNQ7 Strong Biomarker [587]
CCN6 OTRFHQ2Z Strong Biomarker [588]
CD151 OTF3UZS7 Strong Altered Expression [589]
CD82 OTH8MC64 Strong Altered Expression [590]
CDCA5 OTZLCQ5U Strong Biomarker [591]
CDH17 OT9EV2XK Strong Altered Expression [592]
CDHR2 OTTHEUPO Strong Biomarker [593]
CEACAM7 OTKFDTZY Strong Altered Expression [177]
CELF1 OT6JQ5RS Strong Genetic Variation [594]
CGREF1 OTBZQX97 Strong Biomarker [289]
CHD1L OT7CZK7C Strong Biomarker [595]
CHD4 OTBDEHDP Strong Biomarker [596]
CIAPIN1 OTWS90F9 Strong Altered Expression [597]
CIDEA OTDUTSOV Strong Biomarker [289]
CIRBP OTXWTPBL Strong Biomarker [598]
CKS1B OTNUPLUJ Strong Biomarker [599]
CLEC2B OT0W0M0L Strong Altered Expression [600]
CLSTN2 OT2PJYHX Strong Biomarker [146]
COX1 OTG3O9BN Strong Biomarker [601]
CPQ OTTNZNLD Strong Altered Expression [602]
CPSF7 OT4WE5J7 Strong Biomarker [603]
CPT1A OTI862QH Strong Altered Expression [315]
CRABP1 OTISDG5X Strong Biomarker [146]
CTBS OT135K92 Strong Biomarker [285]
CTTN OTJRG4ES Strong Genetic Variation [116]
CUL4A OTTBV70J Strong Biomarker [604]
CUL5 OTMTZD47 Strong Altered Expression [585]
CXADR OT9ZP02A Strong Biomarker [280]
CYGB OTX153DQ Strong Biomarker [605]
DCD OTV5PBGJ Strong Biomarker [154]
DDX54 OTVOJU6G Strong Biomarker [146]
DERL2 OTI3TUUZ Strong Altered Expression [606]
DEUP1 OTXLM86J Strong Posttranslational Modification [607]
DHX9 OT5AAOQI Strong Biomarker [550]
DUOX1 OTQ2AEW0 Strong Altered Expression [608]
DUSP16 OTK7S078 Strong Altered Expression [609]
EFNB2 OT0DCUOM Strong Biomarker [146]
EIF3I OTE07WND Strong Biomarker [610]
ENC1 OTJEUB6U Strong Biomarker [611]
ESM1 OT331Y8V Strong Biomarker [289]
ETNPPL OTSXO9P6 Strong Altered Expression [612]
EXO1 OTI87RS5 Strong Altered Expression [613]
EXOSC2 OTN6NVKL Strong Biomarker [146]
FAH OTGZA1YR Strong Genetic Variation [614]
FAM83H OTN0SF11 Strong Biomarker [615]
FBP1 OTQBANEP Strong Altered Expression [616]
FHL3 OTMPRLZ5 Strong Biomarker [617]
FLCN OTVM78XM Strong Biomarker [146]
FOXA1 OTEBY0TD Strong Altered Expression [211]
FOXA2 OTJOCVOY Strong Biomarker [618]
FOXL2 OTFRQUYL Strong Altered Expression [312]
FOXO4 OT90X9LN Strong Biomarker [619]
FSD1 OT8P6PT3 Strong Biomarker [620]
FSD1L OTBQ48RF Strong Biomarker [620]
FUNDC1 OTA6IVKQ Strong Biomarker [621]
FXYD5 OT81DIOD Strong Biomarker [622]
GADL1 OTJM4A0R Strong Biomarker [146]
GC OTWS63BY Strong Biomarker [623]
GEMIN4 OTX7402E Strong Biomarker [624]
GGPS1 OTVEHG28 Strong Altered Expression [625]
GGTLC1 OTWJKUHQ Strong Biomarker [626]
GNMT OT0O2OQO Strong Altered Expression [627]
GOLM1 OTOZSV6O Strong Biomarker [628]
GPC2 OT3WSQE1 Strong Altered Expression [629]
GPX2 OTXI2NTI Strong Biomarker [289]
GPX3 OT6PK94R Strong Biomarker [154]
GSC OT4DH7PR Strong Biomarker [630]
H3C1 OTGBGOZW Strong Altered Expression [312]
HACE1 OTEZULKD Strong Biomarker [631]
HCFC1 OT0UCK62 Strong Biomarker [632]
HEBP2 OTVDIMLM Strong Biomarker [180]
HERC3 OTWMKYD9 Strong Biomarker [146]
HFE OTDD93KB Strong Biomarker [633]
HGS OTCYYCAC Strong Biomarker [634]
HHIP OT77RQYS Strong Altered Expression [635]
HIGD2A OTX1K4IH Strong Biomarker [146]
HLA-DRB4 OTNXIHQU Strong Genetic Variation [636]
HNRNPD OT5UO1FA Strong Biomarker [637]
HNRNPK OTNPRM8U Strong Altered Expression [638]
HSDL2 OT4IN0MV Strong Biomarker [180]
HSPB2 OTS01646 Strong Biomarker [247]
IFI27 OTI2XGIT Strong Altered Expression [418]
IL6ST OT1N9C70 Strong Biomarker [639]
ILF2 OTWWVM9X Strong Biomarker [640]
ING3 OTDIJXFP Strong Therapeutic [218]
IQGAP1 OTZRWTGA Strong Biomarker [641]
IQGAP2 OTX2UA7P Strong Biomarker [642]
ITGA7 OTTBTAYW Strong Altered Expression [643]
ITIH1 OTSXJGQF Strong Biomarker [387]
JAG1 OT3LGT6K Strong Genetic Variation [644]
JUNB OTG2JXV5 Strong Altered Expression [645]
KAT5 OTL7257A Strong Biomarker [646]
KCNK17 OTG2NEZM Strong Altered Expression [647]
KLF11 OTKVQDJD Strong Biomarker [648]
KRT10 OTSVRD3Q Strong Biomarker [649]
KRT18 OTVLQFIP Strong Biomarker [650]
KRT23 OTQW6UAG Strong Biomarker [295]
KRT8 OTTM4X11 Strong Biomarker [650]
LAMTOR5 OTER0U8L Strong Altered Expression [314]
LARGE1 OTUH7H9F Strong Biomarker [146]
LDLRAD4 OTQUX50Z Strong Biomarker [651]
LETMD1 OTZTZ4RD Strong Biomarker [579]
LGALS3BP OT9AGQKH Strong Biomarker [652]
LIN28B OTVWP0FN Strong Biomarker [653]
LINGO2 OT3N88Q1 Strong Biomarker [146]
LOXL4 OT6XY2JL Strong Altered Expression [654]
LRATD1 OT65IL83 Strong Biomarker [655]
MACROD2 OTNQCHC6 Strong Biomarker [573]
MAK16 OTD546E5 Strong Altered Expression [299]
MAP2K3 OTI2OREX Strong Biomarker [656]
MARCHF1 OTI2EYO6 Strong Biomarker [657]
MARVELD1 OT5CPOJE Strong Altered Expression [658]
MBD2 OTUQPP0R Strong Biomarker [72]
MCM9 OTALGFW8 Strong Biomarker [659]
MEF2D OT7CEIG0 Strong Biomarker [660]
METTL3 OTSXP1M3 Strong Altered Expression [661]
MFN2 OTPYN8A3 Strong Biomarker [662]
MICA OTPEIEAR Strong Altered Expression [663]
MIEF1 OTFSP3FS Strong Biomarker [664]
MOB2 OTMBE0NS Strong Biomarker [348]
MPST OTCDPH5D Strong Biomarker [265]
MRPS5 OTZZR208 Strong Biomarker [665]
MSTO1 OT37XCNP Strong Biomarker [265]
MT1H OT0MVBM6 Strong Altered Expression [666]
MTG1 OTC9U1LI Strong Altered Expression [156]
MTHFD2 OT1LQSGX Strong Biomarker [667]
MUL1 OT2JC9YR Strong Biomarker [585]
MXD1 OTS5CTHX Strong Biomarker [131]
MYO5B OTCKL3W3 Strong Biomarker [180]
NCAPG OT1AI9EO Strong Biomarker [668]
NCOA2 OTMQFPBB Strong Biomarker [215]
NCOR1 OT04XNOU Strong Biomarker [573]
ND5 OT45LW1K Strong Biomarker [669]
NDC80 OTS7D306 Strong Biomarker [670]
NDRG1 OTVO66BO Strong Altered Expression [671]
NDRG2 OT5L6KD7 Strong Biomarker [672]
NONO OTN36Q6U Strong Biomarker [550]
NOP16 OT2829ZC Strong Biomarker [146]
NPC2 OTE9UEJC Strong Biomarker [673]
NSD3 OT3677ZG Strong Altered Expression [674]
NUDCD3 OT2WYBNC Strong Biomarker [146]
NUDT6 OTCS3NYZ Strong Biomarker [675]
NUDT7 OTCPOQ6W Strong Biomarker [180]
NUP98 OTNT12G2 Strong Biomarker [561]
NUPR1 OT4FU8C0 Strong Biomarker [676]
NUSAP1 OT85HIJ5 Strong Altered Expression [677]
OGT OT1Z1ZXE Strong Altered Expression [678]
OIP5 OTI5C2DE Strong Altered Expression [160]
PADI2 OTT40K94 Strong Altered Expression [679]
PAEP OTQA0NV4 Strong Biomarker [582]
PCLAF OTMVIOUU Strong Genetic Variation [680]
PDE6D OTIFVXWD Strong Altered Expression [209]
PDK4 OTCMHMBZ Strong Biomarker [681]
PDRG1 OT8ZMFZE Strong Biomarker [146]
PDZD7 OTX3VAOB Strong Altered Expression [682]
PES1 OTMZK7XE Strong Biomarker [683]
PFKM OT1QY9JM Strong Biomarker [684]
PHF19 OTF6RUCR Strong Genetic Variation [685]
PLAAT4 OTI66SAJ Strong Biomarker [59]
PLS1 OTWURB8U Strong Biomarker [387]
PNO1 OT010GIS Strong Altered Expression [299]
POLG OTDUCT04 Strong SusceptibilityMutation [686]
POLR2E OTH5IL2A Strong Genetic Variation [687]
PPIL3 OT0GPU73 Strong Biomarker [688]
PPP1R9A OTJL2TOC Strong ModifyingMutation [689]
PPP2R3A OTSK5GFC Strong Altered Expression [690]
PRICKLE2 OTWBA48T Strong Biomarker [146]
PRKAA1 OT7TNF0L Strong Biomarker [662]
PRKAA2 OTU1KZPV Strong Biomarker [662]
PRKAB1 OT1OG4QZ Strong Biomarker [662]
PRPF31 OTSJ0Z1Y Strong Altered Expression [691]
PSG2 OT2EIXAI Strong Altered Expression [177]
PSMA4 OTAD2XXI Strong Biomarker [154]
PSMG2 OTEMF20S Strong Genetic Variation [692]
PTER OTBYJHDG Strong Biomarker [180]
PTPRO OTFLKWOY Strong Biomarker [693]
PYCR1 OTQHB52T Strong Biomarker [694]
PYGO2 OTZHB2OI Strong Altered Expression [695]
RASAL1 OTAHUNN7 Strong Biomarker [696]
RBMS3 OTFSC9MR Strong Altered Expression [299]
RDX OTNSYUN6 Strong Altered Expression [697]
RECQL OTPCH3JH Strong Biomarker [698]
RFC1 OT3L5PK3 Strong Genetic Variation [699]
RGN OTD04KB1 Strong Altered Expression [700]
RGS5 OTUY0Q2I Strong Altered Expression [701]
RIN2 OTCY73U9 Strong Biomarker [702]
RIOX2 OT2YFPI2 Strong Biomarker [703]
RNF17 OTKOEPRW Strong Biomarker [704]
RNF187 OTXTN1HP Strong Altered Expression [705]
RNGTT OT59E0KX Strong Biomarker [624]
RPE OT0XT3JU Strong Biomarker [706]
RPL29 OTUFIBJL Strong Altered Expression [635]
RPRD1B OTB41D5K Strong Biomarker [707]
RTN3 OTGZ51QF Strong Biomarker [523]
RUVBL1 OTWV19L7 Strong Biomarker [708]
SAFB OTGRV2LW Strong Biomarker [523]
SALL4 OTC08PR5 Strong Altered Expression [709]
SAV1 OTSAEV92 Strong Altered Expression [252]
SCPEP1 OT43LYEZ Strong Biomarker [184]
SCTR OTC80IMR Strong Altered Expression [710]
SEPTIN2 OT3G33TM Strong Biomarker [307]
SERPINA11 OTXM6IJM Strong Altered Expression [711]
SERPINB4 OT88LHZ8 Strong Biomarker [712]
SHARPIN OTU1J2KH Strong Altered Expression [713]
SHC1 OT1J5IRN Strong Biomarker [714]
SIRT7 OT5M4OT4 Strong Biomarker [715]
SIX3 OTP5E3VU Strong Biomarker [146]
SLC66A3 OT8IEN62 Strong Biomarker [180]
SMAD2 OTC6VB4K Strong Biomarker [511]
SMAD4 OTWQWCKG Strong Biomarker [716]
SMC4 OTEJE6AG Strong Altered Expression [717]
SMURF1 OT5UIZR8 Strong Biomarker [406]
SNX10 OT05B7BT Strong Altered Expression [718]
SOCS5 OTN1ABYR Strong Biomarker [719]
SPAG9 OT45AHMB Strong Altered Expression [656]
SPATA21 OTGTXLP9 Strong Biomarker [146]
SPIN1 OT69VAOX Strong Biomarker [720]
SPRY2 OTH0CRCZ Strong Posttranslational Modification [721]
SPZ1 OTQH8HJ5 Strong Biomarker [646]
SRA1 OTYOGMTG Strong Altered Expression [456]
SRF OTW18FQN Strong Biomarker [722]
SRRM2 OTSIMMC9 Strong Altered Expression [299]
SRSF1 OTF61HOV Strong Biomarker [405]
ST13 OTNML6UP Strong Altered Expression [635]
ST6GAL1 OT7US3NO Strong Altered Expression [723]
STAC3 OTPY3BGK Strong Biomarker [289]
STARD13 OTB4U1HY Strong Biomarker [569]
SULF1 OTJCNCO0 Strong Biomarker [272]
SUV39H2 OTU0F4LL Strong Altered Expression [724]
SYCP1 OTWFV4KA Strong Biomarker [184]
TARBP1 OT14Z6RJ Strong Altered Expression [725]
TAT OT2CJ91O Strong Biomarker [726]
TET1 OTZDHT1D Strong Altered Expression [727]
TEX11 OTJDBGSS Strong Biomarker [367]
THEM4 OTSIZU8Y Strong Biomarker [728]
TIAM2 OTPYIPT6 Strong Biomarker [729]
TIGD1 OTEQ4UT0 Strong Biomarker [730]
TIPRL OTS2FZ8O Strong Biomarker [731]
TJP1 OTBDCUPK Strong Altered Expression [732]
TM4SF4 OTRI8EHN Strong Biomarker [733]
TMEM132D OTV6I4Z0 Strong Biomarker [146]
TMEM176A OTOZDWXX Strong Biomarker [734]
TMEM176B OTEGF2BV Strong Genetic Variation [734]
TMEM74 OT3IZBM0 Strong Biomarker [735]
TMEM82 OTURDYCZ Strong Altered Expression [711]
TMEM9 OTXC0JXR Strong Altered Expression [736]
TMOD3 OTQPNSTH Strong Altered Expression [737]
TNFRSF6B OTKAN9G7 Strong Altered Expression [738]
TOP1MT OT2H77ID Strong Biomarker [739]
TOX3 OTC9NR4W Strong Biomarker [289]
TRADD OTBOSJHO Strong Altered Expression [740]
TRAF3 OT5TQBGV Strong Biomarker [741]
TRIM13 OTQIUACB Strong Biomarker [280]
TRIO OT71X1AK Strong Biomarker [146]
TRO OTRZQMU8 Strong Biomarker [742]
TROAP OTC8CE0R Strong Biomarker [743]
TRRAP OT68OI2Y Strong Biomarker [744]
TTC39A OT80PQWX Strong Biomarker [387]
TTLL9 OT1M1SZH Strong Biomarker [146]
AP1M1 OT1IR6CD Definitive Biomarker [745]
APOBEC2 OT4CCS0Q Definitive Altered Expression [746]
ARF6 OTVV7KJO Definitive Altered Expression [747]
ATP8B1 OTALGS63 Definitive Genetic Variation [748]
ATRNL1 OTY5JUX2 Definitive Biomarker [392]
BCAP31 OTKSACR4 Definitive Biomarker [582]
BMPR1A OTQOA4ZH Definitive Altered Expression [749]
CBX3 OTOP9RLD Definitive Biomarker [750]
CDKN3 OTBE3H07 Definitive Altered Expression [751]
CENPM OTYK9KOX Definitive Biomarker [752]
CITED2 OT812TV7 Definitive Altered Expression [753]
CLDN7 OTNE0XHQ Definitive Biomarker [754]
DIS3L2 OTWABM04 Definitive Biomarker [755]
EPS8 OTZ6ES6V Definitive Biomarker [756]
EPS8L3 OT7XYA2T Definitive Biomarker [756]
GADD45G OT8V1J4M Definitive Biomarker [757]
HNRNPU OTLQN1E2 Definitive Biomarker [755]
IFT88 OTDR3VBD Definitive Biomarker [758]
IKBKG OTNWJWSD Definitive Altered Expression [759]
IRF2BP2 OTSSRRCA Definitive Biomarker [760]
KPNA2 OTU7FOE6 Definitive Biomarker [58]
LARP4B OT2HI0QE Definitive Biomarker [761]
MTMR14 OTUUEY6Q Definitive Biomarker [762]
NR2F2 OTJFS67N Definitive Biomarker [763]
NUP155 OTIIAH4E Definitive Biomarker [764]
OGDHL OT1AZK6R Definitive Altered Expression [765]
OTUD1 OTE6O5XB Definitive Biomarker [766]
PDLIM3 OTVXQC81 Definitive Biomarker [392]
PGM5 OTEAS7OC Definitive Biomarker [767]
PHKB OTKXZZIU Definitive Biomarker [768]
PLXNA3 OTMZIBVG Definitive Genetic Variation [769]
PPP1R11 OTSHYPPW Definitive Biomarker [770]
RALA OT734R7X Definitive Altered Expression [134]
RAN OT2TER5M Definitive Altered Expression [771]
RRBP1 OT4ZTPTM Definitive Biomarker [582]
SIVA1 OTDT0XZK Definitive Altered Expression [772]
SUMO2 OT1Y5IKN Definitive Biomarker [773]
SUMO3 OTTUJQJ1 Definitive Biomarker [773]
SYTL2 OTUIOWKL Definitive Biomarker [774]
TBCA OTCCWMGK Definitive Biomarker [775]
TBX3 OTM64N7K Definitive Altered Expression [776]
TCF7L1 OTTUTF0O Definitive Biomarker [777]
TFCP2 OTA246TE Definitive Biomarker [778]
TRIM29 OT2DNESG Definitive Biomarker [779]
------------------------------------------------------------------------------------
⏷ Show the Full List of 572 DOT(s)

References

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33 ClinicalTrials.gov (NCT04374877) Study of SRF388 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
34 ClinicalTrials.gov (NCT02729493) Study Evaluating the Efficacy and Safety With CAR-T for Liver Cancer
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40 Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
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42 Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J Nutr. 2007 Nov;137(11):2366-70.
43 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
44 Treatment choice for early-stage hepatocellular carcinoma in real-world practice: impact of treatment stage migration to transarterial chemoembolization and treatment response on survival.Scand J Gastroenterol. 2018 Oct-Nov;53(10-11):1368-1375. doi: 10.1080/00365521.2018.1517277. Epub 2018 Nov 5.
45 Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b.Toxicol Sci. 2019 Feb 1;167(2):581-592. doi: 10.1093/toxsci/kfy263.
46 Silencing transcription factor FOXM1 represses proliferation, migration, and invasion while inducing apoptosis of liver cancer stem cells by regulating the expression of ALDH2.IUBMB Life. 2020 Feb;72(2):285-295. doi: 10.1002/iub.2166. Epub 2019 Oct 3.
47 Circulating Tumor Cells Undergoing EMT Provide a Metric for Diagnosis and Prognosis of Patients with Hepatocellular Carcinoma.Cancer Res. 2018 Aug 15;78(16):4731-4744. doi: 10.1158/0008-5472.CAN-17-2459. Epub 2018 Jun 18.
48 Biocompatible co-loading vehicles for delivering both nanoplatin cores and siRNA to treat hepatocellular carcinoma.Int J Pharm. 2019 Dec 15;572:118769. doi: 10.1016/j.ijpharm.2019.118769. Epub 2019 Oct 26.
49 MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-B/MMP-9/VEGF pathways.Oncol Rep. 2018 May;39(5):2288-2296. doi: 10.3892/or.2018.6289. Epub 2018 Mar 1.
50 Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells.Oncol Rep. 2018 Mar;39(3):1475-1484. doi: 10.3892/or.2018.6200. Epub 2018 Jan 8.
51 Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC.Cancer Res. 2018 Dec 1;78(23):6581-6593. doi: 10.1158/0008-5472.CAN-18-1049. Epub 2018 Sep 19.
52 Levels of HBx, VEGF, and CEACAM1 in HBV-related hepatocellular carcinoma and their correlation with cancer prognosis.Eur Rev Med Pharmacol Sci. 2017 Oct;21(17):3827-3833.
53 In vivo inhibitory activity of andrographolide derivative ADN-9 against liver cancer and its mechanisms involved in inhibition of tumor angiogenesis.Toxicol Appl Pharmacol. 2017 Jul 15;327:1-12. doi: 10.1016/j.taap.2017.04.022. Epub 2017 Apr 22.
54 Prosurvival function of the cellular apoptosis susceptibility/importin-1 transport cycle is repressed by p53 in liver cancer.Hepatology. 2014 Sep;60(3):884-95. doi: 10.1002/hep.27207. Epub 2014 Jul 17.
55 Bioinformatic analysis reveals CYP2C9 as a potential prognostic marker for HCC and liver cancer cell lines suitable for its mechanism study.Cell Mol Biol (Noisy-le-grand). 2018 May 30;64(7):70-74.
56 Increased liver carcinogenesis and enrichment of stem cell properties in livers of Dickkopf 2 (Dkk2) deleted mice.Oncotarget. 2016 May 17;7(20):28903-13. doi: 10.18632/oncotarget.3293.
57 Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells.Onco Targets Ther. 2018 Mar 21;11:1601-1616. doi: 10.2147/OTT.S147453. eCollection 2018.
58 Karyopherin 2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.Cell Commun Signal. 2019 Nov 29;17(1):159. doi: 10.1186/s12964-019-0456-x.
59 Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3.J Hepatol. 2017 Oct;67(4):758-769. doi: 10.1016/j.jhep.2017.05.015. Epub 2017 May 19.
60 TGF-1 accelerates the hepatitis B virus X-induced malignant transformation of hepatic progenitor cells by upregulating miR-199a-3p.Oncogene. 2020 Feb;39(8):1807-1820. doi: 10.1038/s41388-019-1107-9. Epub 2019 Nov 18.
61 Bone morphogenetic protein-9 is a potent growth inhibitor of hepatocellular carcinoma and reduces the liver cancer stem cells population.Oncotarget. 2016 Nov 8;7(45):73754-73768. doi: 10.18632/oncotarget.12062.
62 High glucose stimulates proliferative capacity of liver cancer cells possibly via O-GlcNAcylation-dependent transcriptional regulation of GJC1.J Cell Physiol. 2018 Jan;234(1):606-618. doi: 10.1002/jcp.26803. Epub 2018 Aug 5.
63 Identification of recurrent fusion genes across multiple cancer types.Sci Rep. 2019 Jan 31;9(1):1074. doi: 10.1038/s41598-019-38550-6.
64 Participation of liver stem cells in cholangiocarcinogenesis after aflatoxin B(1) exposure of glutathione S-transferase A3 knockout mice.Tumour Biol. 2018 May;40(5):1010428318777344. doi: 10.1177/1010428318777344.
65 High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models.Lab Invest. 2018 Jan;98(1):95-105. doi: 10.1038/labinvest.2017.107. Epub 2017 Oct 16.
66 HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail.Mol Cancer. 2016 Sep 6;15(1):57. doi: 10.1186/s12943-016-0540-4.
67 CD5L is upregulated in hepatocellular carcinoma and promotes liver cancer cell proliferation and antiapoptotic responses by binding to HSPA5 (GRP78).FASEB J. 2018 Jul;32(7):3878-3891. doi: 10.1096/fj.201700941RR. Epub 2018 Feb 20.
68 Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells.FASEB J. 2016 Jan;30(1):262-75. doi: 10.1096/fj.15-277749. Epub 2015 Sep 1.
69 TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.Br J Pharmacol. 2017 Jun;174(12):1810-1825. doi: 10.1111/bph.13782. Epub 2017 Apr 22.
70 ISG15 inhibits IFN--resistant liver cancer cell growth.Biomed Res Int. 2013;2013:570909. doi: 10.1155/2013/570909. Epub 2013 Aug 20.
71 MBD3 inhibits formation of liver cancer stem cells.Oncotarget. 2017 Jan 24;8(4):6067-6078. doi: 10.18632/oncotarget.13496.
72 HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.Oncotarget. 2017 Jul 25;8(30):49093-49109. doi: 10.18632/oncotarget.17095.
73 Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.Mol Carcinog. 2018 Jul;57(7):911-925. doi: 10.1002/mc.22812. Epub 2018 Apr 10.
74 KISS1/KISS1R in Cancer: Friend or Foe?.Front Endocrinol (Lausanne). 2018 Aug 3;9:437. doi: 10.3389/fendo.2018.00437. eCollection 2018.
75 The Paradoxical Role of NKG2D in Cancer Immunity.Front Immunol. 2018 Aug 13;9:1808. doi: 10.3389/fimmu.2018.01808. eCollection 2018.
76 Identifying Key Genes of Liver Cancer by Networking of Multiple Data Sets.IEEE/ACM Trans Comput Biol Bioinform. 2018 Oct 5. doi: 10.1109/TCBB.2018.2874238. Online ahead of print.
77 Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells.Free Radic Biol Med. 2015 Dec;89:34-46. doi: 10.1016/j.freeradbiomed.2015.07.011. Epub 2015 Jul 11.
78 Biological Response Modifier in Cancer Immunotherapy.Adv Exp Med Biol. 2016;909:69-138. doi: 10.1007/978-94-017-7555-7_2.
79 Taurolidine promotes cell apoptosis by enhancing GRIM?9 expression in liver cancer.Oncol Rep. 2018 Dec;40(6):3743-3751. doi: 10.3892/or.2018.6711. Epub 2018 Sep 18.
80 NEDD4 promotes cell growth and motility in hepatocellular carcinoma.Cell Cycle. 2018;17(6):728-738. doi: 10.1080/15384101.2018.1440879. Epub 2018 Apr 10.
81 Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration.Nat Commun. 2017 Oct 30;8(1):1185. doi: 10.1038/s41467-017-01107-0.
82 Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression.Int J Cancer. 2017 Apr 1;140(7):1581-1596. doi: 10.1002/ijc.30559. Epub 2017 Jan 19.
83 TO901317 inhibits the development of hepatocellular carcinoma by LXR/Glut1 decreasing glycometabolism.Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G598-G607. doi: 10.1152/ajpgi.00061.2018. Epub 2019 Feb 28.
84 NUAK2 is a critical YAP target in liver cancer.Nat Commun. 2018 Nov 16;9(1):4834. doi: 10.1038/s41467-018-07394-5.
85 PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models.BMC Cancer. 2014 Aug 20;14:603. doi: 10.1186/1471-2407-14-603.
86 K-Ras-PI3K regulates H3K56ac through PCAF to elevate the occurrence and growth of liver cancer.J Cell Physiol. 2020 Apr;235(4):3905-3915. doi: 10.1002/jcp.29284. Epub 2019 Oct 22.
87 Therapeutic Effect of Sorafenib-Loaded TPGS-b-PCL Nanoparticles on Liver Cancer.J Biomed Nanotechnol. 2018 Feb 1;14(2):396-403. doi: 10.1166/jbn.2018.2529.
88 Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting -catenin by activating PKM2 and inactivating PTEN.Cell Death Dis. 2018 Feb 15;9(3):253. doi: 10.1038/s41419-018-0305-7.
89 Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity.Oncol Rep. 2018 Dec;40(6):3447-3457. doi: 10.3892/or.2018.6740. Epub 2018 Sep 27.
90 Increased expression of GATA zinc finger domain containing 1 through gene amplification promotes liver cancer by directly inducing phosphatase of regenerating liver 3.Hepatology. 2018 Jun;67(6):2302-2319. doi: 10.1002/hep.29750. Epub 2018 Mar 23.
91 Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion.Exp Cell Res. 2017 Aug 1;357(1):9-16. doi: 10.1016/j.yexcr.2017.04.020. Epub 2017 Apr 19.
92 A CD13-targeting peptide integrated protein inhibits human liver cancer growth by killing cancer stem cells and suppressing angiogenesis.Mol Carcinog. 2017 May;56(5):1395-1404. doi: 10.1002/mc.22600. Epub 2017 Jan 4.
93 SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.EMBO Rep. 2018 May;19(5):e45124. doi: 10.15252/embr.201745124. Epub 2018 Feb 28.
94 The Loss-of-Function S267F Variant in HBV Receptor NTCP Reduces Human Risk for HBV Infection and Disease Progression.J Infect Dis. 2018 Sep 22;218(9):1404-1410. doi: 10.1093/infdis/jiy355.
95 Flipping a citrate switch on liver cancer cells.J Biol Chem. 2017 Aug 18;292(33):13902-13903. doi: 10.1074/jbc.H117.783860.
96 Basigin-mediated redistribution of CD98 promotes cell spreading and tumorigenicity in hepatocellular carcinoma.J Exp Clin Cancer Res. 2015 Oct 6;34:110. doi: 10.1186/s13046-015-0226-6.
97 Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.Oncotarget. 2018 Feb 26;9(21):15635-15649. doi: 10.18632/oncotarget.24583. eCollection 2018 Mar 20.
98 MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2.Oncol Res. 2018 Sep 14;26(8):1183-1189. doi: 10.3727/096504018X15151495109394. Epub 2018 Jan 10.
99 Recapitulation of pharmacogenomic data reveals that invalidation of SULF2 enhance sorafenib susceptibility in liver cancer.Oncogene. 2018 Aug;37(32):4443-4454. doi: 10.1038/s41388-018-0291-3. Epub 2018 May 3.
100 Identification of copy number variation-driven genes for liver cancer via bioinformatics analysis.Oncol Rep. 2014 Nov;32(5):1845-52. doi: 10.3892/or.2014.3425. Epub 2014 Aug 20.
101 HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2.Sci Rep. 2016 Oct 26;6:36045. doi: 10.1038/srep36045.
102 Talin-1 correlates with reduced invasion and migration in human hepatocellular carcinoma cells.Asian Pac J Cancer Prev. 2014;15(6):2655-61. doi: 10.7314/apjcp.2014.15.6.2655.
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362 Association of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis.BMC Cancer. 2019 Nov 21;19(1):1128. doi: 10.1186/s12885-019-6173-4.
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373 Carboxypeptidase A4 promotes proliferation and stem cell characteristics of hepatocellular carcinoma.Int J Exp Pathol. 2019 Apr;100(2):133-138. doi: 10.1111/iep.12315. Epub 2019 May 6.
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382 25-OH-vitamin D deficiency identifies poor tumor response in hepatocellular carcinoma treated with transarterial chemoembolization.Clin Transl Oncol. 2020 Jan;22(1):70-80. doi: 10.1007/s12094-019-02146-3. Epub 2019 Jun 10.
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384 Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.Drug Metab Dispos. 2009 Nov;37(11):2123-6. doi: 10.1124/dmd.109.029512. Epub 2009 Aug 10.
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391 MAT2B mediates invasion and metastasis by regulating EGFR signaling pathway in hepatocellular carcinoma.Clin Exp Med. 2019 Nov;19(4):535-546. doi: 10.1007/s10238-019-00579-2. Epub 2019 Sep 6.
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394 Alpha1-ACT Functions as a Tumour Suppressor in Hepatocellular Carcinoma by Inhibiting the PI3K/AKT/mTOR Signalling Pathway via Activation of PTEN.Cell Physiol Biochem. 2017;41(6):2289-2306. doi: 10.1159/000475648. Epub 2017 Apr 26.
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396 MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA.Biochem Biophys Res Commun. 2014 Feb 7;444(2):270-5. doi: 10.1016/j.bbrc.2014.01.051. Epub 2014 Jan 22.
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399 XB130 Knockdown Inhibits the Proliferation, Invasiveness, and Metastasis of Hepatocellular Carcinoma Cells and Sensitizes them to TRAIL-Induced Apoptosis.Chin Med J (Engl). 2018 Oct 5;131(19):2320-2331. doi: 10.4103/0366-6999.241800.
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401 Distinctive pattern of AHNAK methylation level in peripheral blood mononuclear cells and the association with HBV-related liver diseases.Cancer Med. 2018 Oct;7(10):5178-5186. doi: 10.1002/cam4.1778. Epub 2018 Sep 27.
402 A-kinase anchoring protein 12 is downregulated in human hepatocellular carcinoma and its deficiency in mice aggravates thioacetamide-induced liver injury.Oncol Lett. 2018 Nov;16(5):5907-5915. doi: 10.3892/ol.2018.9396. Epub 2018 Sep 4.
403 Design Graph Theoretical Analysis and In Silico Modeling of Dunaliella Bardawil Biomass Encapsulated N-Succinyl Chitosan Nanoparticles for Enhanced Anticancer Activity.Anticancer Agents Med Chem. 2018;18(13):1900-1918. doi: 10.2174/1871520618666180628155223.
404 Metabolic control of PPAR activity by aldehyde dehydrogenase regulates invasive cell behavior and predicts survival in hepatocellular and renal clear cell carcinoma.BMC Cancer. 2018 Nov 28;18(1):1180. doi: 10.1186/s12885-018-5061-7.
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407 Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma.Nat Commun. 2018 Feb 14;9(1):678. doi: 10.1038/s41467-018-03024-2.
408 Targeting CAND1 promotes caspase-8/RIP1-dependent apoptosis in liver cancer cells.Am J Transl Res. 2018 May 15;10(5):1357-1372. eCollection 2018.
409 miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.Oncotarget. 2016 Mar 22;7(12):13491-501. doi: 10.18632/oncotarget.4821.
410 HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver Cancer Cells.Mol Cancer Ther. 2015 Nov;14(11):2623-33. doi: 10.1158/1535-7163.MCT-15-0025. Epub 2015 Sep 10.
411 Ceramide synthase-4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through the nuclear factor-B signaling pathway.Oncol Lett. 2017 Aug;14(2):1477-1483. doi: 10.3892/ol.2017.6365. Epub 2017 Jun 9.
412 Inducible factors for cancer-associated fibroblasts in liver cancer versus myofibroblasts in inflammatory liver disease.Histol Histopathol. 2016 Feb;31(2):141-8. doi: 10.14670/HH-11-668. Epub 2015 Sep 23.
413 Cyclic adenosine monophosphate response element-binding protein transcriptionally regulates CHCHD2 associated with the molecular pathogenesis of hepatocellular carcinoma.Mol Med Rep. 2015 Jun;11(6):4053-62. doi: 10.3892/mmr.2015.3256. Epub 2015 Jan 26.
414 CISD2 associated with proliferation indicates negative prognosis in patients with hepatocellular carcinoma.Int J Clin Exp Pathol. 2015 Oct 1;8(10):13725-38. eCollection 2015.
415 CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma.Oncotarget. 2014 Sep 15;5(17):7663-76. doi: 10.18632/oncotarget.2288.
416 Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways.Cell Rep. 2015 Dec 1;13(9):1909-1921. doi: 10.1016/j.celrep.2015.10.058. Epub 2015 Nov 19.
417 SiRNA-Mediated Down-Regulation of CLIC4 Gene Inhibits Cell Proliferation and Accelerates Cell Apoptosis of Mouse Liver Cancer Hca-F and Hca-P Cells.J Cell Biochem. 2018 Jan;119(1):659-668. doi: 10.1002/jcb.26229. Epub 2017 Jul 31.
418 High GSTP1 inhibits cell proliferation by reducing Akt phosphorylation and is associated with a better prognosis in hepatocellular carcinoma.Oncotarget. 2017 Dec 19;9(10):8957-8971. doi: 10.18632/oncotarget.23420. eCollection 2018 Feb 6.
419 DDX3, a potential target for cancer treatment.Mol Cancer. 2015 Nov 5;14:188. doi: 10.1186/s12943-015-0461-7.
420 -defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development.Sci Rep. 2017 Oct 17;7(1):13404. doi: 10.1038/s41598-017-13332-0.
421 DEPDC7 inhibits cell proliferation, migration and invasion in hepatoma cells.Oncol Lett. 2017 Dec;14(6):7332-7338. doi: 10.3892/ol.2017.7128. Epub 2017 Oct 3.
422 Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGK gene knockout.Mol Med Rep. 2018 Feb;17(2):2169-2176. doi: 10.3892/mmr.2017.8140. Epub 2017 Nov 22.
423 Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis.Oncotarget. 2016 Nov 29;7(48):79774-79786. doi: 10.18632/oncotarget.12967.
424 Hepatitis B core protein promotes liver cancer metastasis through miR-382-5p/DLC-1 axis.Biochim Biophys Acta Mol Cell Res. 2018 Jan;1865(1):1-11. doi: 10.1016/j.bbamcr.2017.09.020. Epub 2017 Oct 3.
425 MicroRNA-302a/d inhibits the self-renewal capability and cell cycle entry of liver cancer stem cells by targeting the E2F7/AKT axis.J Exp Clin Cancer Res. 2018 Oct 16;37(1):252. doi: 10.1186/s13046-018-0927-8.
426 Attenuation of enoyl coenzyme A hydratase 1 expression in colorectal cancer cells using small interfering RNA inhibits cell proliferation and migration.Mol Med Rep. 2015 Jul;12(1):470-4. doi: 10.3892/mmr.2015.3418. Epub 2015 Mar 4.
427 High EIF2B5 mRNA expression and its prognostic significance in liver cancer: a study based on the TCGA and GEO database.Cancer Manag Res. 2018 Nov 20;10:6003-6014. doi: 10.2147/CMAR.S185459. eCollection 2018.
428 miRNA-346 promotes proliferation, migration and invasion in liver cancer.Oncol Lett. 2017 Sep;14(3):3255-3260. doi: 10.3892/ol.2017.6561. Epub 2017 Jul 8.
429 Genetic risk analysis for an individual according to the theory of programmed onset, illustrated by lung and liver cancers.Gene. 2018 Oct 5;673:107-111. doi: 10.1016/j.gene.2018.06.044. Epub 2018 Jun 15.
430 NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis.Cancer Sci. 2017 Jan;108(1):12-22. doi: 10.1111/cas.13117.
431 Follistatin-like protein 5 inhibits hepatocellular carcinoma progression by inducing caspase-dependent apoptosis and regulating Bcl-2 family proteins.J Cell Mol Med. 2018 Dec;22(12):6190-6201. doi: 10.1111/jcmm.13906. Epub 2018 Sep 25.
432 GALNT14 genotype effectively predicts the therapeutic response in unresectable hepatocellular carcinoma treated with transcatheter arterial chemoembolization.Pharmacogenomics. 2016 Mar;17(4):353-66. doi: 10.2217/pgs.15.179. Epub 2016 Feb 12.
433 LncGPR107 drives the self-renewal of liver tumor initiating cells and liver tumorigenesis through GPR107-dependent manner.J Exp Clin Cancer Res. 2018 Jun 20;37(1):121. doi: 10.1186/s13046-018-0794-3.
434 Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer.Sci Rep. 2017 Sep 6;7(1):10662. doi: 10.1038/s41598-017-11106-2.
435 H2A.Z regulates tumorigenesis, metastasis and sensitivity to cisplatin in intrahepatic cholangiocarcinoma.Int J Oncol. 2018 Apr;52(4):1235-1245. doi: 10.3892/ijo.2018.4292. Epub 2018 Feb 28.
436 Comprehensive molecular profiling of the B7 family in gastrointestinal cancer.Cell Prolif. 2018 Oct;51(5):e12468. doi: 10.1111/cpr.12468. Epub 2018 Jul 12.
437 Suppression of Lefty expression in induced pluripotent cancer cells.FASEB J. 2013 Jun;27(6):2165-74. doi: 10.1096/fj.12-221432. Epub 2013 Feb 13.
438 Homeobox containing1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.Oncol Rep. 2018 Sep;40(3):1657-1665. doi: 10.3892/or.2018.6551. Epub 2018 Jul 10.
439 Abnormal expression of HMGB-3 is significantly associated with malignant transformation of hepatocytes.World J Gastroenterol. 2018 Aug 28;24(32):3650-3662. doi: 10.3748/wjg.v24.i32.3650.
440 LncHOXA10 drives liver TICs self-renewal and tumorigenesis via HOXA10 transcription activation.Mol Cancer. 2018 Dec 13;17(1):173. doi: 10.1186/s12943-018-0921-y.
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447 Suppressed Krppellike factor 17 expression induces tumor proliferation, metastasis and a poor prognosis in papillary thyroid carcinoma.Mol Med Rep. 2014 Oct;10(4):2087-92. doi: 10.3892/mmr.2014.2429. Epub 2014 Jul 29.
448 Galactose Derivative-Modified Nanoparticles for Efficient siRNA Delivery to Hepatocellular Carcinoma.Biomacromolecules. 2018 Jun 11;19(6):2330-2339. doi: 10.1021/acs.biomac.8b00358. Epub 2018 May 29.
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450 microRNA-22 downregulation of galectin-9 influences lymphocyte apoptosis and tumor cell proliferation in liver cancer.Oncol Rep. 2015 Oct;34(4):1771-8. doi: 10.3892/or.2015.4167. Epub 2015 Jul 31.
451 Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.Gastroenterology. 2018 Aug;155(2):557-571.e14. doi: 10.1053/j.gastro.2018.04.032. Epub 2018 May 5.
452 LncMAPK6 drives MAPK6 expression and liver TIC self-renewal.J Exp Clin Cancer Res. 2018 May 15;37(1):105. doi: 10.1186/s13046-018-0770-y.
453 Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma.Oncotarget. 2015 Sep 15;6(27):23807-19. doi: 10.18632/oncotarget.4278.
454 Increased mediator complex subunit 15 expression is associated with poor prognosis in hepatocellular carcinoma.Oncol Lett. 2018 Apr;15(4):4303-4313. doi: 10.3892/ol.2018.7820. Epub 2018 Jan 18.
455 NASP antagonize chromatin accessibility through maintaining histone H3K9me1 in hepatocellular carcinoma.Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3438-3448. doi: 10.1016/j.bbadis.2018.07.033. Epub 2018 Aug 1.
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487 SF3B4 as an early-stage diagnostic marker and driver of hepatocellular carcinoma.BMB Rep. 2018 Feb;51(2):57-58. doi: 10.5483/bmbrep.2018.51.2.021.
488 Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway.Eur Rev Med Pharmacol Sci. 2017 Mar;21(6):1248-1253.
489 SND1 acts as an anti-apoptotic factor via regulating the expression of lncRNA UCA1 in hepatocellular carcinoma.RNA Biol. 2018;15(10):1364-1375. doi: 10.1080/15476286.2018.1534525. Epub 2018 Oct 25.
490 RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.Hepatology. 2018 Jun;67(6):2254-2270. doi: 10.1002/hep.29683. Epub 2018 Apr 19.
491 Cisplatin-induced downregulation of SOX1 increases drug resistance by activating autophagy in non-small cell lung cancer cell.Biochem Biophys Res Commun. 2013 Sep 20;439(2):187-90. doi: 10.1016/j.bbrc.2013.08.065. Epub 2013 Aug 29.
492 Speckle-type POZ protein is negatively associated with malignancies and inhibits cell proliferation and migration in liver cancer.Tumour Biol. 2015 Dec;36(12):9753-61. doi: 10.1007/s13277-015-3753-z. Epub 2015 Jul 10.
493 SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.Nat Commun. 2019 Jul 17;10(1):3142. doi: 10.1038/s41467-019-11095-y.
494 [ARTICLE WITHDRAWN] Downregulation of SRC Kinase Signaling Inhibitor 1 (SRCIN1) Expression by MicroRNA-32 Promotes Proliferation and Epithelial-Mesenchymal Transition in Human Liver Cancer Cells.Oncol Res. 2018 May 7;26(4):573-579. doi: 10.3727/096504017X14954923820137. Epub 2017 May 22.
495 Connexin 43 SUMOylation improves gap junction functions between liver cancer stem cells and enhances their sensitivity to HSVtk/GCV.Int J Oncol. 2018 Mar;52(3):872-880. doi: 10.3892/ijo.2018.4263. Epub 2018 Feb 1.
496 The Down-Regulation of SUZ12 Accelerates the Migration and Invasion of Liver Cancer Cells via Activating ERK1/2 Pathway.J Cancer. 2019 Feb 23;10(6):1375-1384. doi: 10.7150/jca.29932. eCollection 2019.
497 Knockdown of TWIST enhances the cytotoxicity of chemotherapeutic drugs in doxorubicin-resistant HepG2 cells by suppressing MDR1 and EMT.Int J Oncol. 2018 Oct;53(4):1763-1773. doi: 10.3892/ijo.2018.4495. Epub 2018 Jul 20.
498 C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling.Nat Commun. 2015 May 19;6:7122. doi: 10.1038/ncomms8122.
499 Tex10 is upregulated and promotes cancer stem cell properties and chemoresistance in hepatocellular carcinoma.Cell Cycle. 2018;17(11):1310-1318. doi: 10.1080/15384101.2018.1480208. Epub 2018 Jul 25.
500 LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6.Biosci Rep. 2019 May 2;39(5):BSR20182374. doi: 10.1042/BSR20182374. Print 2019 May 31.
501 CD133-induced TM4SF5 expression promotes sphere growth via recruitment and blocking of protein tyrosine phosphatase receptor type F (PTPRF).Cancer Lett. 2018 Dec 1;438:219-231. doi: 10.1016/j.canlet.2018.09.009. Epub 2018 Sep 11.
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503 Effect on the liver cancer cell invasion ability by studying the associations between autophagy and TRAP1 expression.Oncol Lett. 2018 Jul;16(1):991-997. doi: 10.3892/ol.2018.8774. Epub 2018 May 22.
504 A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling.Cell Death Dis. 2018 May 1;9(5):443. doi: 10.1038/s41419-018-0467-3.
505 Overexpression of CMTM7 inhibits cell growth and migration in liver cancer.Kaohsiung J Med Sci. 2019 Jun;35(6):332-340. doi: 10.1002/kjm2.12058. Epub 2019 Mar 23.
506 Dishevelled 1, a pivotal positive regulator of the Wnt signalling pathway, mediates 5-fluorouracil resistance in HepG2 cells.Artif Cells Nanomed Biotechnol. 2018;46(sup2):192-200. doi: 10.1080/21691401.2018.1453827. Epub 2018 Mar 27.
507 Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression.Sci Rep. 2018 Apr 26;8(1):6586. doi: 10.1038/s41598-018-24633-3.
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511 GDF11/BMP11 as a novel tumor marker for liver cancer.Exp Ther Med. 2018 Apr;15(4):3495-3500. doi: 10.3892/etm.2018.5861. Epub 2018 Feb 12.
512 Hepatitis B virus upregulates GP73 expression by activating the HIF-2 signaling pathway.Oncol Lett. 2018 Apr;15(4):5264-5270. doi: 10.3892/ol.2018.7955. Epub 2018 Feb 5.
513 GTSF1 gene may serve as a novel potential diagnostic biomarker for liver cancer.Oncol Lett. 2018 Mar;15(3):3133-3140. doi: 10.3892/ol.2017.7695. Epub 2017 Dec 27.
514 The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma.World J Surg Oncol. 2018 Feb 21;16(1):36. doi: 10.1186/s12957-018-1342-5.
515 MORC2, a novel oncogene, is upregulated in liver cancer and contributes to proliferation, metastasis and chemoresistance.Int J Oncol. 2018 Jul;53(1):59-72. doi: 10.3892/ijo.2018.4333. Epub 2018 Mar 27.
516 Overexpression of RHEB is associated with metastasis and poor prognosis in hepatocellular carcinoma.Oncol Lett. 2018 Mar;15(3):3838-3845. doi: 10.3892/ol.2018.7759. Epub 2018 Jan 10.
517 HIF-1-induced RIT1 promotes liver cancer growth and metastasis and its deficiency increases sensitivity to sorafenib.Cancer Lett. 2019 Sep 28;460:96-107. doi: 10.1016/j.canlet.2019.06.016. Epub 2019 Jun 24.
518 Analysis of long non-coding RNA (lncRNA) expression in hepatitis B patients.Bosn J Basic Med Sci. 2018 May 20;18(2):150-161. doi: 10.17305/bjbms.2018.2800.
519 Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries.Nucleic Acids Res. 2019 Feb 28;47(4):e22. doi: 10.1093/nar/gky1228.
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527 ARHI, as a novel suppressor of cell growth and downregulated in human hepatocellular carcinoma, could contribute to hepatocarcinogenesis.Mol Carcinog. 2009 Feb;48(2):130-40. doi: 10.1002/mc.20461.
528 Serum starvation induces DRAM expression in liver cancer cells via histone modifications within its promoter locus.PLoS One. 2012;7(12):e50502. doi: 10.1371/journal.pone.0050502. Epub 2012 Dec 12.
529 The role of CUGBP1 in age-dependent changes of liver functions.Ageing Res Rev. 2012 Sep;11(4):442-9. doi: 10.1016/j.arr.2012.02.007. Epub 2012 Mar 14.
530 Antisense oligonucleotide Elk-1 suppresses the tumorigenicity of human hepatocellular carcinoma cells.Cell Biol Int. 2008 Feb;32(2):210-6. doi: 10.1016/j.cellbi.2007.08.027. Epub 2007 Sep 7.
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535 Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice.Gastroenterology. 2012 Dec;143(6):1660-1669.e7. doi: 10.1053/j.gastro.2012.09.002. Epub 2012 Sep 11.
536 Transforming Growth Factor TGF Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic Ductal Adenocarcinomas.PLoS One. 2015 Nov 16;10(11):e0143150. doi: 10.1371/journal.pone.0143150. eCollection 2015.
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544 Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.Cell Death Dis. 2017 Oct 26;8(10):e3138. doi: 10.1038/cddis.2017.512.
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548 Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and -catenin pathways.Carcinogenesis. 2019 May 14;40(3):461-473. doi: 10.1093/carcin/bgy155.
549 Methylation analysis of p16, SLIT2, SCARA5, and Runx3 genes in hepatocellular carcinoma.Medicine (Baltimore). 2017 Oct;96(41):e8279. doi: 10.1097/MD.0000000000008279.
550 Splicing Regulator p54(nrb) /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma.Hepatology. 2020 Aug;72(2):548-568. doi: 10.1002/hep.31062. Epub 2020 Mar 25.
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552 Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.Med Sci Monit. 2019 Aug 5;25:5823-5832. doi: 10.12659/MSM.915754.
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554 The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras.Mol Cell. 2012 Mar 9;45(5):610-8. doi: 10.1016/j.molcel.2012.01.006. Epub 2012 Feb 8.
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556 TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells.BMC Cancer. 2006 Jun 9;6:154. doi: 10.1186/1471-2407-6-154.
557 alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.Am J Pathol. 2004 Nov;165(5):1479-88. doi: 10.1016/s0002-9440(10)63406-2.
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560 ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.Hepatology. 2003 May;37(5):1056-66. doi: 10.1053/jhep.2003.50205.
561 ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers.PLoS One. 2013 Dec 27;8(12):e81922. doi: 10.1371/journal.pone.0081922. eCollection 2013.
562 Molecular cloning and expression of rat aldolase C messenger RNA during development and hepatocarcinogenesis.Eur J Biochem. 1987 Mar 16;163(3):513-8. doi: 10.1111/j.1432-1033.1987.tb10898.x.
563 Epigenetic silencing of ALX4 regulates microcystin-LR induced hepatocellular carcinoma through the P53 pathway.Sci Total Environ. 2019 Sep 15;683:317-330. doi: 10.1016/j.scitotenv.2019.05.144. Epub 2019 May 15.
564 Angiomotin-like 2 interacts with and negatively regulates AKT.Oncogene. 2017 Aug 10;36(32):4662-4669. doi: 10.1038/onc.2017.101. Epub 2017 Apr 3.
565 Annexin A3 as a potential target for immunotherapy of liver cancer stem-like cells.Stem Cells. 2015 Feb;33(2):354-66. doi: 10.1002/stem.1850.
566 LncAPC drives Wnt/-catenin activation and liver TIC self-renewal through EZH2 mediated APC transcriptional inhibition.Mol Carcinog. 2018 Mar;57(3):408-418. doi: 10.1002/mc.22764. Epub 2017 Dec 15.
567 A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3'UTR enhances chromosomal DNA damage.Nat Commun. 2014 Oct 9;5:5129. doi: 10.1038/ncomms6129.
568 Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets.Pathol Oncol Res. 2020 Apr;26(2):615-625. doi: 10.1007/s12253-019-00646-9. Epub 2019 Mar 29.
569 Regulation of white and brown adipocyte differentiation by RhoGAP DLC1.PLoS One. 2017 Mar 30;12(3):e0174761. doi: 10.1371/journal.pone.0174761. eCollection 2017.
570 Ginsenoside Rg3 inhibits the migration and invasion of liver cancer cells by increasing the protein expression of ARHGAP9.Oncol Lett. 2019 Jan;17(1):965-973. doi: 10.3892/ol.2018.9701. Epub 2018 Nov 15.
571 Recurrent inactivating mutations of ARID2 in non-small cell lung carcinoma.Int J Cancer. 2013 May 1;132(9):2217-21. doi: 10.1002/ijc.27900. Epub 2012 Nov 20.
572 Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth.Mol Cancer Ther. 2019 Mar;18(3):602-612. doi: 10.1158/1535-7163.MCT-18-0824. Epub 2019 Jan 15.
573 Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.Nat Genet. 2016 May;48(5):500-9. doi: 10.1038/ng.3547. Epub 2016 Apr 11.
574 Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.Cancer Sci. 2019 May;110(5):1633-1643. doi: 10.1111/cas.14004. Epub 2019 Apr 11.
575 AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of -catenin activation.J Hepatol. 2018 Jun;68(6):1203-1213. doi: 10.1016/j.jhep.2017.12.018. Epub 2018 Mar 7.
576 miR-221-3p and miR-15b-5p promote cell proliferation and invasion by targeting Axin2 in liver cancer.Oncol Lett. 2019 Dec;18(6):6491-6500. doi: 10.3892/ol.2019.11056. Epub 2019 Nov 5.
577 High Expression B3GAT3 Is Related with Poor Prognosis of Liver Cancer.Open Med (Wars). 2019 Feb 26;14:251-258. doi: 10.1515/med-2019-0020. eCollection 2019.
578 The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development.Hepatology. 2019 Jun;69(6):2608-2622. doi: 10.1002/hep.30529. Epub 2019 Mar 13.
579 Silencing of the HCCR2 gene induces apoptosis and suppresses the aggressive phenotype of hepatocellular carcinoma cells in culture.J Gastrointest Surg. 2011 Oct;15(10):1807-13. doi: 10.1007/s11605-011-1633-4. Epub 2011 Jul 28.
580 Silencing of Btbd7 Inhibited Epithelial-Mesenchymal Transition and Chemoresistance in CD133(+) Lung Carcinoma A549 Cells.Oncol Res. 2017 May 24;25(5):819-829. doi: 10.3727/096504016X14772349843854. Epub 2016 Oct 26.
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582 Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment.Drug Deliv. 2019 Dec;26(1):756-764. doi: 10.1080/10717544.2019.1642418.
583 Calpain-3 gene expression is decreased during experimental cancer cachexia.Biochim Biophys Acta. 2000 Jun 1;1475(1):5-9. doi: 10.1016/s0304-4165(00)00050-7.
584 Expression Quantitative Trait Loci for CARD8 Contributes to Risk of Two Infection-Related Cancers--Hepatocellular Carcinoma and Cervical Cancer.PLoS One. 2015 Jul 6;10(7):e0132352. doi: 10.1371/journal.pone.0132352. eCollection 2015.
585 Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.Oncol Rep. 2016 Apr;35(4):2461-5. doi: 10.3892/or.2016.4605. Epub 2016 Feb 1.
586 Double mutant P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of Pim1 mediated by PKM2 and LncRNA CUDR.Oncotarget. 2016 Oct 11;7(41):66525-66539. doi: 10.18632/oncotarget.9089.
587 Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer.Oncotarget. 2016 Nov 15;7(46):75763-75773. doi: 10.18632/oncotarget.12409.
588 Liver cancer: WISP3 suppresses hepatocellular carcinoma progression by negative regulation of -catenin/TCF/LEF signalling.Cell Prolif. 2019 May;52(3):e12583. doi: 10.1111/cpr.12583. Epub 2019 Feb 22.
589 CD151 supports VCAM-1-mediated lymphocyte adhesion to liver endothelium and is upregulated in chronic liver disease and hepatocellular carcinoma.Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1;313(2):G138-G149. doi: 10.1152/ajpgi.00411.2016. Epub 2017 May 4.
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591 CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma.J Cancer. 2019 Apr 21;10(8):1846-1854. doi: 10.7150/jca.28809. eCollection 2019.
592 Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma.Hepatology. 2009 Nov;50(5):1453-63. doi: 10.1002/hep.23143.
593 Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.Carcinogenesis. 2002 Jul;23(7):1139-48. doi: 10.1093/carcin/23.7.1139.
594 RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.Mol Cell Biol. 2017 Jul 28;37(16):e00128-17. doi: 10.1128/MCB.00128-17. Print 2017 Aug 15.
595 Clinical significance of chromodomain helicase/ATPase DNA binding protein 1-like and human mutL homolog 1 gene expression in cholangiocarcinoma.Oncol Lett. 2018 Sep;16(3):2989-2994. doi: 10.3892/ol.2018.9043. Epub 2018 Jun 28.
596 Defeating EpCAM(+) liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma.J Hepatol. 2015 Nov;63(5):1164-72. doi: 10.1016/j.jhep.2015.06.009. Epub 2015 Jun 18.
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598 Cold-inducible RNA-binding protein promotes the development of liver cancer.Cancer Sci. 2015 Apr;106(4):352-8. doi: 10.1111/cas.12611. Epub 2015 Mar 3.
599 A Synthetic Dosage Lethal Genetic Interaction Between CKS1B and PLK1 Is Conserved in Yeast and Human Cancer Cells.Genetics. 2016 Oct;204(2):807-819. doi: 10.1534/genetics.116.190231. Epub 2016 Aug 24.
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601 RNAs containing mitochondrial ND6 and COI sequences present an abnormal structure in chemically induced rat hepatomas.Nucleic Acids Res. 1989 Jul 11;17(13):5191-206. doi: 10.1093/nar/17.13.5191.
602 In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe.Chem Sci. 2017 May 1;8(5):3479-3483. doi: 10.1039/c6sc05712h. Epub 2017 Mar 2.
603 CPSF7 regulates liver cancer growth and metastasis by facilitating WWP2-FL and targeting the WWP2/PTEN/AKT signaling pathway.Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118624. doi: 10.1016/j.bbamcr.2019.118624. Epub 2019 Dec 12.
604 Investigation of the role of cullin 4A overexpression in human liver cancer.Mol Med Rep. 2018 Sep;18(3):2531-2540. doi: 10.3892/mmr.2018.9233. Epub 2018 Jun 29.
605 Cytoglobin ameliorates the stemness of hepatocellular carcinoma via coupling oxidative-nitrosative stress signals.Mol Carcinog. 2019 Mar;58(3):334-343. doi: 10.1002/mc.22931. Epub 2018 Dec 4.
606 Cloning and characterization of F-LANa, upregulated in human liver cancer.Biochem Biophys Res Commun. 2001 Aug 17;286(2):394-400. doi: 10.1006/bbrc.2001.5390.
607 Clinical significance of aberrant DEUP1 promoter methylation in hepatocellular carcinoma.Oncol Lett. 2019 Aug;18(2):1356-1364. doi: 10.3892/ol.2019.10421. Epub 2019 May 30.
608 DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress.Oxid Med Cell Longev. 2018 Apr 19;2018:3570526. doi: 10.1155/2018/3570526. eCollection 2018.
609 DUSP16 ablation arrests the cell cycle and induces cellular senescence.FEBS J. 2015 Dec;282(23):4580-94. doi: 10.1111/febs.13518. Epub 2015 Oct 19.
610 The translation initiation factor eIF3i up-regulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis.J Biol Chem. 2014 Oct 10;289(41):28310-23. doi: 10.1074/jbc.M114.571356. Epub 2014 Aug 21.
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612 AGXT2L1 is down-regulated in heptocellular carcinoma and associated with abnormal lipogenesis.J Clin Pathol. 2016 Mar;69(3):215-20. doi: 10.1136/jclinpath-2015-203042. Epub 2015 Aug 20.
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677 Downregulation of nucleolar and spindle-associated protein 1 expression suppresses liver cancer cell function.Exp Ther Med. 2019 Apr;17(4):2969-2978. doi: 10.3892/etm.2019.7314. Epub 2019 Feb 26.
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683 PES1 In Liver Cancer: A Prognostic Biomarker With Tumorigenic Roles.Cancer Manag Res. 2019 Nov 14;11:9641-9653. doi: 10.2147/CMAR.S226471. eCollection 2019.
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685 A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers.Gene. 2004 Dec 8;343(1):69-78. doi: 10.1016/j.gene.2004.09.006.
686 Polymorphisms in POLG were associated with the prognosis and mtDNA content in hepatocellular carcinoma patients.Bull Cancer. 2017 Jun;104(6):500-507. doi: 10.1016/j.bulcan.2017.02.005. Epub 2017 Apr 28.
687 The POLR2E rs3787016 polymorphism is strongly associated with the risk of female breast and cervical cancer.Pathol Res Pract. 2019 May;215(5):1061-1065. doi: 10.1016/j.prp.2019.02.015. Epub 2019 Feb 27.
688 Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma.PLoS One. 2015 May 28;10(5):e0127668. doi: 10.1371/journal.pone.0127668. eCollection 2015.
689 Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis.Toxicol Sci. 2011 Jan;119(1):61-72. doi: 10.1093/toxsci/kfq307. Epub 2010 Oct 8.
690 Protein phosphatase 2 regulatory subunit B''Alpha silencing inhibits tumor cell proliferation in liver cancer.Cancer Med. 2019 Dec;8(18):7741-7753. doi: 10.1002/cam4.2620. Epub 2019 Oct 24.
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692 Expression of liver cancer associated gene HCCA3.World J Gastroenterol. 2001 Dec;7(6):821-5. doi: 10.3748/wjg.v7.i6.821.
693 Survival and inflammation promotion effect of PTPRO in fulminant hepatitis is associated with NF-B activation.J Immunol. 2014 Nov 15;193(10):5161-70. doi: 10.4049/jimmunol.1303354. Epub 2014 Oct 22.
694 PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer.J Transl Med. 2019 Oct 16;17(1):343. doi: 10.1186/s12967-019-2091-0.
695 Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression.Oncotarget. 2015 May 10;6(13):11074-86. doi: 10.18632/oncotarget.3570.
696 Long non-coding RNA TUC338 is functionally involved in sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1.Oncol Rep. 2017 Jan;37(1):273-280. doi: 10.3892/or.2016.5248. Epub 2016 Nov 15.
697 Changes in Radixin Expression and Interaction with Efflux Transporters in the Liver of Adjuvant-Induced Arthritic Rats.Inflammation. 2020 Feb;43(1):85-94. doi: 10.1007/s10753-019-01097-9.
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699 The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers.PLoS One. 2016 Dec 9;11(12):e0167534. doi: 10.1371/journal.pone.0167534. eCollection 2016.
700 Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells invitro.Int J Oncol. 2018 Sep;53(3):1313-1322. doi: 10.3892/ijo.2018.4458. Epub 2018 Jun 28.
701 Over-expression of regulator of G protein signaling 5 promotes tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma cells.J Surg Oncol. 2013 Sep;108(3):192-6. doi: 10.1002/jso.23367. Epub 2013 Jul 19.
702 8-bromo-5-hydroxy-7-methoxychrysin targeting for inhibition of the properties of liver cancer stem cells by modulation of Twist signaling.Int J Oncol. 2013 Nov;43(5):1719-29. doi: 10.3892/ijo.2013.2071. Epub 2013 Aug 21.
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706 Synthesis, Docking Studies into CDK-2 and Anticancer Activity of New Derivatives Based Pyrimidine Scaffold and Their Derived Glycosides.Mini Rev Med Chem. 2019;19(13):1093-1110. doi: 10.2174/1389557519666190312165717.
707 MicroRNA-300 inhibits the growth of hepatocellular carcinoma cells by downregulating CREPT/Wnt/-catenin signaling.Oncol Lett. 2019 Oct;18(4):3743-3753. doi: 10.3892/ol.2019.10712. Epub 2019 Aug 5.
708 Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression.Int J Cancer. 2020 Jun 15;146(12):3410-3422. doi: 10.1002/ijc.32787. Epub 2019 Nov 28.
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711 Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing.Oncogene. 2014 Sep 25;33(39):4786-94. doi: 10.1038/onc.2013.424. Epub 2013 Oct 21.
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713 Elevation of SHARPIN Protein Levels in Prostate Adenocarcinomas Promotes Metastasis and Impairs Patient Survivals.Prostate. 2017 May;77(7):718-728. doi: 10.1002/pros.23302. Epub 2017 Feb 23.
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715 SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway.J Exp Clin Cancer Res. 2019 Jun 13;38(1):252. doi: 10.1186/s13046-019-1246-4.
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725 Expression of protein TARBP1 in human hepatocellular carcinoma and its prognostic significance.Int J Clin Exp Pathol. 2015 Aug 1;8(8):9089-96. eCollection 2015.
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729 Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.Cancer Med. 2016 Mar;5(3):465-77. doi: 10.1002/cam4.611. Epub 2016 Jan 14.
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744 Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Genes.Hepatology. 2020 Jan;71(1):275-290. doi: 10.1002/hep.30807. Epub 2019 Aug 11.
745 HBV upregulates AP-1 complex subunit mu-1 expression via the JNK pathway to promote proliferation of liver cancer cells.Oncol Lett. 2019 Jul;18(1):456-464. doi: 10.3892/ol.2019.10291. Epub 2019 Apr 30.
746 HBV triggers APOBEC2 expression through miR?22 regulation and affects the proliferation of liver cancer cells.Int J Oncol. 2019 Nov;55(5):1137-1148. doi: 10.3892/ijo.2019.4870. Epub 2019 Sep 4.
747 Arf6-driven endocytic recycling of CD147 determines HCC malignant phenotypes.J Exp Clin Cancer Res. 2019 Nov 21;38(1):471. doi: 10.1186/s13046-019-1464-9.
748 Familial intrahepatic cholestasis: New and wide perspectives.Dig Liver Dis. 2019 Jul;51(7):922-933. doi: 10.1016/j.dld.2019.04.013. Epub 2019 May 16.
749 LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling.EMBO J. 2019 Sep 2;38(17):e101110. doi: 10.15252/embj.2018101110. Epub 2019 Jul 23.
750 CBX3/HP1 promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma.Aging (Albany NY). 2019 Aug 2;11(15):5483-5497. doi: 10.18632/aging.102132. Epub 2019 Aug 2.
751 CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinoma.Mol Med Rep. 2016 Aug;14(2):1509-14. doi: 10.3892/mmr.2016.5410. Epub 2016 Jun 17.
752 Upregulation of CENPM promotes hepatocarcinogenesis through mutiple mechanisms.J Exp Clin Cancer Res. 2019 Nov 8;38(1):458. doi: 10.1186/s13046-019-1444-0.
753 Role of miR-182-5p overexpression in trichloroethylene-induced abnormal cell cycle functions in human HepG2 cells.J Toxicol Environ Health A. 2019;82(16):920-927. doi: 10.1080/15287394.2019.1666550. Epub 2019 Sep 15.
754 Claudin-1 silencing increases sensitivity of liver cancer HepG2 cells to 5-fluorouracil by inhibiting autophagy.Oncol Lett. 2019 Dec;18(6):5709-5716. doi: 10.3892/ol.2019.10967. Epub 2019 Oct 8.
755 DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing.Cancer Res. 2019 Oct 1;79(19):4923-4936. doi: 10.1158/0008-5472.CAN-19-0376. Epub 2019 Jul 22.
756 Upregulation of EPS8L3 is associated with tumorigenesis and poor prognosis in patients with liver cancer.Mol Med Rep. 2019 Sep;20(3):2493-2499. doi: 10.3892/mmr.2019.10471. Epub 2019 Jul 4.
757 Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway.Ecotoxicol Environ Saf. 2019 Nov 15;183:109465. doi: 10.1016/j.ecoenv.2019.109465. Epub 2019 Jul 31.
758 Tg737 acts as a key driver of invasion and migration in liver cancer stem cells and correlates with poor prognosis in patients with hepatocellular carcinoma.Exp Cell Res. 2017 Sep 15;358(2):217-226. doi: 10.1016/j.yexcr.2017.06.021. Epub 2017 Jun 27.
759 CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein.PLoS One. 2019 Sep 25;14(9):e0222588. doi: 10.1371/journal.pone.0222588. eCollection 2019.
760 The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice.Hepatology. 2020 Jun;71(6):1988-2004. doi: 10.1002/hep.30961. Epub 2020 Feb 16.
761 Expression of La Ribonucleoprotein Domain Family Member 4B (LARP4B) in Liver Cancer and Their Clinical and Prognostic Significance.Dis Markers. 2019 Oct 22;2019:1569049. doi: 10.1155/2019/1569049. eCollection 2019.
762 Knockdown MTMR14 promotes cell apoptosis and inhibits migration in liver cancer cells.Gene. 2019 Apr 5;691:106-113. doi: 10.1016/j.gene.2018.11.099. Epub 2018 Dec 23.
763 COUP-TFII is a modulator of cell-type-specific genetic programs based on genomic localization maps.J Biotechnol. 2019 Aug 10;301:11-17. doi: 10.1016/j.jbiotec.2019.05.305. Epub 2019 May 31.
764 Nucleoporin Nup155 is part of the p53 network in liver cancer.Nat Commun. 2019 May 14;10(1):2147. doi: 10.1038/s41467-019-10133-z.
765 OGDHL Expression as a Prognostic Biomarker for Liver Cancer Patients.Dis Markers. 2019 Oct 17;2019:9037131. doi: 10.1155/2019/9037131. eCollection 2019.
766 The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein.Cancer Cell Int. 2019 Aug 27;19:222. doi: 10.1186/s12935-019-0936-5. eCollection 2019.
767 PGM5: a novel diagnostic and prognostic biomarker for liver cancer.PeerJ. 2019 Jun 11;7:e7070. doi: 10.7717/peerj.7070. eCollection 2019.
768 Phosphorylase Kinase Represents a Novel Prognostic Biomarker and Inhibits Malignant Phenotypes of Liver Cancer Cell.Int J Biol Sci. 2019 Sep 7;15(12):2596-2606. doi: 10.7150/ijbs.33278. eCollection 2019.
769 Identification and characterization of sexual dimorphismlinked gene expression profile in hepatocellular carcinoma.Oncol Rep. 2019 Sep;42(3):937-952. doi: 10.3892/or.2019.7217. Epub 2019 Jun 28.
770 Inhibition of PIKfyve using YM201636 suppresses the growth of liver cancer via the induction of autophagy.Oncol Rep. 2019 Mar;41(3):1971-1979. doi: 10.3892/or.2018.6928. Epub 2018 Dec 12.
771 RETRACTED: HBV-encoded miR-2 functions as an oncogene by downregulating TRIM35 but upregulating RAN in liver cancer cells.EBioMedicine. 2019 Oct;48:117-129. doi: 10.1016/j.ebiom.2019.09.012. Epub 2019 Sep 14.
772 Plumbagin inhibits proliferation and induces apoptosis of hepatocellular carcinoma by downregulating the expression of SIVA.Drug Des Devel Ther. 2019 Apr 23;13:1289-1300. doi: 10.2147/DDDT.S200610. eCollection 2019.
773 SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer.EBioMedicine. 2019 Feb;40:406-421. doi: 10.1016/j.ebiom.2018.12.031. Epub 2018 Dec 26.
774 Silencing stomatin-like protein 2 attenuates tumor progression and inflammatory response through repressing CD14 in liver cancer.Onco Targets Ther. 2019 Sep 9;12:7361-7373. doi: 10.2147/OTT.S215131. eCollection 2019.
775 [(18)F] Clofarabine for PET Imaging of Hepatocellular Carcinoma.Cancers (Basel). 2019 Nov 7;11(11):1748. doi: 10.3390/cancers11111748.
776 The special stemness functions of Tbx3 in stem cells and cancer development.Semin Cancer Biol. 2019 Aug;57:105-110. doi: 10.1016/j.semcancer.2018.09.010. Epub 2018 Sep 27.
777 Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of -Catenin.Stem Cells. 2019 Nov;37(11):1389-1400. doi: 10.1002/stem.3063. Epub 2019 Aug 26.
778 CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.Cell Death Dis. 2019 Sep 9;10(9):644. doi: 10.1038/s41419-019-1894-5.
779 TRIM29 prevents hepatocellular carcinoma progression by inhibiting Wnt/-catenin signaling pathway.Acta Biochim Biophys Sin (Shanghai). 2019 Jan 1;51(1):68-77. doi: 10.1093/abbs/gmy151.