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ClinicalTrials.gov (NCT01856439) Long Term Safety and Efficacy Study of ProSavin in Parkinson's Disease. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03022799) Phase I, KM-819 in Healthy Subjects for Parkinson's Disease. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT04291859) Interventional, Open-label, Exploratory Study, Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Lu AF28996 in Patients With Parkinson's Disease. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT04593511) An Open-Label Study in Healthy Volunteers to Evaluate the Safety, Tolerability and Pharmacokinetics of Four Formulations of LY03009 After a Single Intramuscular Injection. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT04802733) Phase 1 Study To Assess the Safety and Tolerability of Human Embryonic Stem Cell-Derived Midbrain Dopamine Neuron Cell Therapy (MSK-DA01) For Advanced Parkinson's Disease. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT02780895) Human OK99 Allogeneic Stem Cell Transplantation for Patients With Severe Parkinson's Disease. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT01981694) A Phase I Trial to Investigate the Safety and Tolerability of PF-06649751. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03671785) A Prospective, Randomized, Placebo-Controlled Pilot Study to Characterize the Intestinal Microbiome and to Evaluate the Safety and Fecal Microbiome Changes Following Twice Weekly Administration of Lyophilized PRIM-DJ2727 or Placebo Given Orally for 12 Weeks in Subjects With Parkinson's Disease. U.S.National Institutes of Health.
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NCEH-1 modulates cholesterol metabolism and protects against -synuclein toxicity in a C. elegans model of Parkinson's disease.Hum Mol Genet. 2017 Oct 1;26(19):3823-3836. doi: 10.1093/hmg/ddx269.
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Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson's disease model.Cell Death Dis. 2017 Feb 2;8(2):e2574. doi: 10.1038/cddis.2016.454.
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Inhibition of microRNA-505 suppressed MPP+?induced cytotoxicity of SHSY5Y cells in an in vitro Parkinson's disease model.Eur J Pharmacol. 2018 Sep 15;835:11-18. doi: 10.1016/j.ejphar.2018.07.023. Epub 2018 Jul 17.
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Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders.Curr HIV/AIDS Rep. 2019 Feb;16(1):76-81. doi: 10.1007/s11904-019-00420-1.
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Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb.Behav Brain Funct. 2017 Jan 26;13(1):1. doi: 10.1186/s12993-017-0119-2.
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The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization.J Biol Chem. 2018 Feb 2;293(5):1642-1650. doi: 10.1074/jbc.RA117.000751. Epub 2017 Dec 6.
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Neuroprotective effects of pramipexole transdermal patch in the MPTP-induced mouse model of Parkinson's disease.J Pharmacol Sci. 2018 Sep;138(1):31-37. doi: 10.1016/j.jphs.2018.08.008. Epub 2018 Aug 26.
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Clinical variations in Parkinson's disease patients with or without REM sleep behaviour disorder: a meta-analysis.Sci Rep. 2017 Jan 16;7:40779. doi: 10.1038/srep40779.
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The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking.Hum Mol Genet. 2017 Feb 15;26(4):729-741. doi: 10.1093/hmg/ddw413.
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The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.Stem Cell Reports. 2018 Sep 11;11(3):651-664. doi: 10.1016/j.stemcr.2018.07.014. Epub 2018 Aug 23.
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Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain.Brain Res. 2019 Jan 1;1702:85-95. doi: 10.1016/j.brainres.2017.12.029. Epub 2017 Dec 21.
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Synapsin III deficiency hampers -synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.Acta Neuropathol. 2018 Oct;136(4):621-639. doi: 10.1007/s00401-018-1892-1. Epub 2018 Jul 25.
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Correlation of serum levels and gene expression of tumor necrosis factor--induced protein-8 like-2 with Parkinson disease severity.Metab Brain Dis. 2018 Dec;33(6):1955-1959. doi: 10.1007/s11011-018-0302-7. Epub 2018 Aug 13.
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Salusin- mediate neuroprotective effects for Parkinson's disease.Biochem Biophys Res Commun. 2018 Sep 10;503(3):1428-1433. doi: 10.1016/j.bbrc.2018.07.059. Epub 2018 Jul 13.
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Effects of Transcranial Direct Current Stimulation (tDCS) Over the Frontal Polar Area on Motor and Executive Functions in Parkinson's Disease; A Pilot Study.Front Aging Neurosci. 2018 Jul 30;10:231. doi: 10.3389/fnagi.2018.00231. eCollection 2018.
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The E3Ubiquitin Ligases TRIM17 and TRIM41 Modulate -Synuclein Expression by Regulating ZSCAN21.Cell Rep. 2018 Nov 27;25(9):2484-2496.e9. doi: 10.1016/j.celrep.2018.11.002.
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