General Information of Disease (ID: DISQVHKL)

Disease Name Parkinson disease
Synonyms paralysis agitans; Parkinson disease; Parkinson's disease
Disease Class 8A00: Parkinsonism
Definition
A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.
Disease Hierarchy
DISHGY45: Parkinsonian disorder
DISD715V: Hereditary neurological disease
DISQVHKL: Parkinson disease
ICD Code
ICD-11
ICD-11: 8A00.0
ICD-10
ICD-10: F02.3, G20
ICD-9
ICD-9: 332
Expand ICD-9
332
Disease Identifiers
MONDO ID
MONDO_0005180
MESH ID
D010300
UMLS CUI
C0030567
MedGen ID
10590
Orphanet ID
319705
SNOMED CT ID
49049000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 37 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Apomorphine DMX38HQ Approved Small molecular drug [1]
Benztropine DMGZOVN Approved Small molecular drug [2]
Biperiden DME78OA Approved Small molecular drug [3]
Bornaprine DM2OT3L Approved Small molecular drug [3]
Botulinum Toxin Type B DM58QS1 Approved NA [4]
Bromocriptine DMVE3TK Approved Small molecular drug [5]
Carbidopa DMHRG8Q Approved Small molecular drug [6]
Clorgyline DMCEUJD Approved Small molecular drug [7]
Cycrimine DM8C43Q Approved Small molecular drug [8]
Dopamine DMPGUCF Approved Small molecular drug [9]
E-2007 DMJDYNQ Approved Small molecular drug [10]
Entacapone DMLBVKQ Approved Small molecular drug [11]
Ethopropazine DM0N3L7 Approved Small molecular drug [12]
Ioflupane i-123 DMNARJT Approved Small molecular drug [13]
Istradefylline DM20VSK Approved Small molecular drug [14]
Levodopa DMN3E57 Approved Small molecular drug [15]
Lisuride DMCME17 Approved Small molecular drug [16]
Melevodopa DMBF8GU Approved Small molecular drug [3]
Metixene DM0JE6N Approved Small molecular drug [17]
N-0923 DMSOAJ2 Approved Small molecular drug [18]
NADH DM5NM6E Approved Small molecular drug [19]
Opicapone DM1BKA6 Approved NA [20]
Orphenadrine DMW542E Approved Small molecular drug [21]
Pergolide DM14MAE Approved Small molecular drug [22]
Pimavanserin DMR7IVC Approved Small molecular drug [23]
Pramipexole DMNMW9R Approved Small molecular drug [24]
Procyclidine DMHFJDT Approved Small molecular drug [25]
Rasagiline DM3WKQ4 Approved Small molecular drug [26]
Ropinirole DMA6S1D Approved Small molecular drug [27]
Safinamide DM0YWJC Approved Small molecular drug [28]
Safinamide mesylate DM0J2ZT Approved NA [29]
Selegiline Hydrochloride DM3VR1L Approved Small molecular drug [3]
Tolcapone DM8MNVO Approved Small molecular drug [30]
Trihexyphenidyl DMB19L8 Approved Small molecular drug [31]
Zuranolone DMGR98T Approved NA [32]
Neupro DMHEAB1 Phase 4 Small molecular drug [33]
PD-01 DMTGFRB Phase 4 NA [34]
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⏷ Show the Full List of 37 Drug(s)
This Disease is Treated as An Indication in 140 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Mosquirix malaria recombinant vaccine DMQ0NDI Preregistration NA [35]
123I-iometopane DMIX6H6 Phase 3 NA [36]
ABBV-951 DMMWO7V Phase 3 Small molecular drug [37]
AP-CDLD DMZCW0C Phase 3 NA [32]
CQA 206-291 DM60TVK Phase 3 Small molecular drug [38]
Eltoprazine DMW6C81 Phase 3 Small molecular drug [32]
Ganoderma DM9OQG7 Phase 3 NA [39]
IGIV3I Grifols DMWB7KS Phase 3 NA [40]
KPS-0373 DMP5G1K Phase 3 NA [41]
NE3107 DMEZNJI Phase 3 Small molecule [42]
Nebracetam DMFD249 Phase 3 Small molecular drug [43]
OS-320 DMNMLDM Phase 3 NA [44]
OSE-300 DM4H8W7 Phase 3 NA [45]
P2B-001 DM9PVHX Phase 3 NA [32]
Patrome DM3H2U4 Phase 3 NA [46]
Semagacestat DML83IW Phase 3 Small molecular drug [47]
SEP-363856 DMG2QP4 Phase 3 NA [32]
Sumanirole DMYHV17 Phase 3 Small molecular drug [48]
Tozadenant DMATC14 Phase 3 Small molecular drug [49]
ADX-48621 DM6GTMD Phase 2/3 Small molecular drug [50]
Fosgonimeton DMXMAJA Phase 2/3 Small molecule [51]
HD-0801 DMEK19M Phase 2/3 NA [52]
Sarizotan DMH7IPW Phase 2/3 Small molecular drug [53]
AAV-GAD DMOOY9W Phase 2 Gene therapy [54]
AKST4290 DM27ZJG Phase 2 Small molecule [55]
AV-201 DMDL9WU Phase 2 NA [56]
AZD-3241 DMANC59 Phase 2 NA [57]
BIA 3-202 DMG3ON2 Phase 2 Small molecular drug [58]
BIIB014 DMH7RJ1 Phase 2 Small molecular drug [59]
BIIB054 DMZO2SY Phase 2 NA [32]
BN82451 DMUM2KA Phase 2 Small molecular drug [60]
Brasofensine DM3TRF7 Phase 2 Small molecular drug [61]
CERE-120 DMS01AX Phase 2 NA [62]
CP-101,606 DMIU19E Phase 2 Small molecular drug [63]
CVN424 DMEPQ76 Phase 2 Small molecule [64]
CX-8998 DM3GEHC Phase 2 NA [32]
Dexefaroxan DMTY4KN Phase 2 Small molecular drug [65]
DopaFuse DMCFDCO Phase 2 NA [32]
DT-1687 DMU2GP4 Phase 2 NA [32]
E2027 DMK8SY6 Phase 2 Small molecular drug [66]
Ensaculin hydrochloride DMLPRZJ Phase 2 Small molecular drug [67]
ENT-01 DM086S6 Phase 2 Small molecule [68]
EPI 589 DMZT7EP Phase 2 NA [32]
GM608 DMONQVK Phase 2 NA [69]
GPI-1485 DM64ZYM Phase 2 Small molecular drug [70]
GTS-21 DMEN5KA Phase 2 Small molecular drug [71]
INP103 DMK5DKF Phase 2 NA [32]
IPX203 DMUO1T5 Phase 2 NA [72]
JM-010 DMFYEGD Phase 2 NA [73]
KDT-3594 DMFTKSI Phase 2 NA [74]
KPAX002 DMDT5WM Phase 2 NA [32]
LTI-291 DMIUKVW Phase 2 NA [32]
LY3154207 DMVGYQ6 Phase 2 NA [32]
Mesdopetam DMZGX27 Phase 2 Small molecule [75]
ND0612 DMULLFS Phase 2 NA [32]
NeuroCell-PD DMHCN5Z Phase 2 NA [76]
NLY01 DMI9OMV Phase 2 Small molecule [77]
Nuedexta DM9DO9B Phase 2 NA [32]
NYX-458 DM0BT41 Phase 2 Small molecule [78]
Paliroden DMX8ZAQ Phase 2 Small molecular drug [79]
Pardoprunox DMD275X Phase 2 Small molecular drug [80]
PRX002 DMKTP8E Phase 2 Antibody [81]
PT320 DMZYKXN Phase 2 Peptide [82]
PTX-200 DM0ZIT2 Phase 2 NA [83]
RG7935 DME1YMX Phase 2 Antibody [32]
RP5063 DMKUE8O Phase 2 NA [84]
SAGE-324 DM5NC39 Phase 2 Small molecular drug [85]
SAGE-718 DM9RC7D Phase 2 Small molecular drug [86]
SCH 420814 DMMWCZS Phase 2 Small molecular drug [87]
Spheramine DMJW59N Phase 2 NA [88]
SPI-205 DMHC2AW Phase 2 NA [89]
SYN-120 DMPW0UL Phase 2 NA [32]
SYN120 DMDF7XB Phase 2 Small molecular drug [90]
Talampanel DMJOM5L Phase 2 Small molecular drug [91]
Tocovid Suprabio DMRD4R4 Phase 2 NA [92]
Valiloxybate DMHMUUM Phase 2 Small molecule [93]
Venglustat DMLPEZS Phase 2 NA [32]
VY-AADC DMPSBTL Phase 2 Gene therapy [94]
WIN-1001X DMCXISP Phase 2 NA [95]
Xanomeline tartrate DMXG5WU Phase 2 Small molecular drug [96]
XP-21279 DM8N3ZQ Phase 2 NA [97]
Avigen Parkinson DMP619O Phase 1/2 NA [98]
CPHPC DM1ZGUX Phase 1/2 Small molecular drug [99]
Cu(II)ATSM DM5I2CC Phase 1/2 NA [32]
Hypoestoxide DMF0HWX Phase 1/2 Small molecule [100]
ISC-hpNSC DM0OQTX Phase 1/2 NA [101]
ITI-214 DM08TH3 Phase 1/2 NA [102]
Neu-120 DMXKOUC Phase 1/2 NA [103]
OXB-102 DMXF9DM Phase 1/2 Gene therapy [104]
PR001 DMQWR4N Phase 1/2 Gene therapy [105]
ProSavin DMJ42E6 Phase 1/2 NA [106]
V81444 DMPWHU6 Phase 1/2 NA [107]
AAV-hAADC gene therapy DMG22F0 Phase 1 NA [108]
AAV2 GDNF DMH8SE5 Phase 1 NA [109]
AlloRx DMNREXZ Phase 1 Cell therapy [110]
ANAVEX 2-73 DM67OU4 Phase 1 NA [32]
Anle138b DMEC8E2 Phase 1 Small molecule [111]
Arecoline DMFJZK3 Phase 1 Small molecular drug [112]
AVE-8112 DMZNTHJ Phase 1 NA [113]
BGC-20-1259 DMED4AJ Phase 1 Small molecular drug [114]
BIIB094 DMLUO5K Phase 1 Antisense oligonucleotide [115]
DNL151 DMZT89C Phase 1 NA [32]
DNL201 DMFEORD Phase 1 NA [32]
DSP-6745 DMM86OH Phase 1 NA [32]
FB-101 DM3HL5F Phase 1 Small molecule [116]
GCC-1290K DMJ7WRI Phase 1 NA [117]
GZ404477 DMNHLZG Phase 1 NA [108]
IkT-148009 DMMJ9HY Phase 1 NA [118]
ION464 DMZAQS8 Phase 1 Antisense oligonucleotide [119]
JNJ-0376 DMFSXLQ Phase 1 NA [120]
KF-17837 DMQ6DLZ Phase 1 Small molecular drug [121]
KM-819 DMRAWGC Phase 1 NA [122]
Lu AF28996 DMY572G Phase 1 Small molecule [123]
Lu-02-750 DMQ0K95 Phase 1 NA [124]
Lu-AE04621 DMP9UO0 Phase 1 NA [125]
LY03003 DMB78EA Phase 1 NA [32]
LY03009 DM242BA Phase 1 NA [126]
MEDI1341 DMQDBSU Phase 1 NA [32]
MSK-DA01 DMHMHOO Phase 1 Cell therapy [127]
NPT200-11 DMFDBV5 Phase 1 Small molecular drug [32]
NuroPro DM9LG91 Phase 1 NA [128]
OK99 DMKDVKW Phase 1 Cell therapy [129]
PD01A DMQRD1C Phase 1 Vaccine [130]
PF-06649751 DMJ682M Phase 1 NA [131]
PF9601N DMGLEM1 Phase 1 Small molecular drug [132]
PRIM-DJ2727 DMWW1KN Phase 1 Fecal Microbiota Transplantation [133]
SAR446159 DMWAO33 Phase 1 Antibody [134]
SER-214 DMUKUIC Phase 1 NA [32]
SPN-803 DM8O2AQ Phase 1 Antisense drug [135]
SUN-K0706 DMIF8RY Phase 1 NA [32]
Talineuren DMV2G7K Phase 1 NA [136]
TPU-002 DMTCUII Phase 1 NA [32]
UB-312 DMBSAWZ Phase 1 Vaccine [137]
UCB0599 DMCNM6F Phase 1 NA [32]
UCB7853 DMD7I23 Phase 1 Monoclonal antibody [138]
VY-AADC01 DM0N71R Phase 1 Gene therapy [139]
XC130-A10H DM2JDLK Phase 1 NA [140]
YKP10461 DMUOEM4 Phase 1 NA [32]
ZT-1 DMO2WYX Phase 1 Small molecular drug [141]
AB-4166 DMVJL2W Clinical Trial Small molecular drug [142]
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⏷ Show the Full List of 140 Drug(s)
This Disease is Treated as An Indication in 6 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
Diazepinone derivative 1 DM9YD0Q Patented Small molecular drug [143]
Diazepinone derivative 2 DMLQ7PG Patented Small molecular drug [143]
Diazepinone derivative 3 DMPTZ69 Patented Small molecular drug [143]
Diazepinone derivative 4 DM389YD Patented Small molecular drug [143]
Diazepinone derivative 5 DM2U1QH Patented Small molecular drug [143]
PMID30124346-Compound-60TABLE5 DM3QX0R Patented Small molecular drug [143]
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⏷ Show the Full List of 6 Drug(s)
This Disease is Treated as An Indication in 23 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Etilevodopa DMF93U1 Discontinued in Phase 3 Small molecular drug [144]
BAM-1110 DMPMKUF Discontinued in Phase 2 Small molecular drug [145]
DMP-543 DMCNEOZ Discontinued in Phase 2 Small molecular drug [146]
HP-290 DMUMGCY Discontinued in Phase 2 Small molecular drug [147]
Naxagolide DM9K2IO Discontinued in Phase 2 Small molecular drug [148]
NLX-P101 DM6NPUJ Discontinued in Phase 2 NA [149]
SL65.0155 DMAM9BD Discontinued in Phase 2 Small molecular drug [150]
PD-151832 DMO34NQ Discontinued in Phase 1/2 Small molecular drug [151]
Besonprodil DMMAFQP Discontinued in Phase 1 Small molecular drug [152]
HT-1067 DMUPOIG Discontinued in Phase 1 NA [153]
Lu-AA47070 DML86MJ Discontinued in Phase 1 NA [154]
SCH-211803 DM92E0W Discontinued in Phase 1 Small molecular drug [155]
Z-321 DMLO2QY Discontinued in Phase 1 Small molecular drug [156]
A 77636 DM0NY6K Terminated Small molecular drug [162]
AMR-103 DMW5RNZ Terminated NA [163]
AX-208 DMPNQK1 Terminated NA [164]
BL-1825 DMOUOLS Terminated NA [165]
Etrabamine DMRQOXG Terminated Small molecular drug [166]
Gpi-1046 DMD5WK4 Terminated Small molecular drug [167]
SIB-1508Y DMT43AI Terminated Small molecular drug [168]
SKF-81297 DM4LGPT Terminated Small molecular drug [169]
SLV-307 DMCPDBS Terminated NA [170]
SPD-474 DMT8PHQ Terminated NA [171]
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⏷ Show the Full List of 23 Drug(s)
This Disease is Treated as An Indication in 5 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
GYKI-47261 DM97RV4 Preclinical Small molecular drug [157]
PHENSERINE TARTRATE DMIGH6W Preclinical Small molecular drug [158]
Rottlerin DMOQ63E Preclinical Small molecular drug [159]
S32504 DM4V8ZD Preclinical Small molecular drug [160]
TEV-56287 DMX9OIL Preclinical NA [161]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 34 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AC-8632 DM09BJ4 Investigative Small molecular drug [172]
AMG-889436 DMKP8L9 Investigative NA [173]
AT-3375 DM6UNH2 Investigative NA [174]
BDD-20617 DMVHKZV Investigative NA [174]
CDNF/MANF DM2YT92 Investigative NA [174]
CM-PK DMSFAIG Investigative NA [174]
COV08-0064 DM2LWNF Investigative Small molecular drug [175]
CX-1846 DMR2Q3P Investigative NA [174]
Cyprodine DM7T96M Investigative Small molecular drug [157]
DLO6001 DM5OYBI Investigative NA [174]
Glycolipids DMKHFZ5 Investigative NA [174]
HL-027 DM00PR3 Investigative NA [174]
INP-05 DMT0933 Investigative NA [174]
KLS-Npk DMC35XM Investigative NA [174]
LDN-22684 DMD58WR Investigative NA [174]
Modified GDNF DMD9WS5 Investigative NA [174]
MSX-3 DMF9HYI Investigative Small molecular drug [176]
NBI-80649 DMPHNLV Investigative NA [174]
NGN-9076 DMGGE0O Investigative NA [174]
NI-202 DMJ7X7Q Investigative NA [174]
NNI-PD DM9WLYX Investigative NA [174]
NP-003 DMBA9VE Investigative NA [174]
Paeoniflorin DMJ5TAU Investigative Small molecular drug [177]
PD-0805 DM731TC Investigative NA [174]
PD-AAV9 DME45PV Investigative NA [174]
PK-236 DMV564I Investigative NA [174]
PNB-03 DM60EOM Investigative NA [174]
PRX-1 DMUWNOC Investigative NA [174]
Rotigitine DMT0DW4 Investigative Small molecular drug [157]
SIG-005 DMWSRXW Investigative NA [174]
ST-4206 DMT57SP Investigative NA [174]
Synuclere DMBR77G Investigative NA [174]
TC-34 DMB3BS4 Investigative Small molecular drug [174]
WS-CoQ10 DMX94B6 Investigative NA [174]
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⏷ Show the Full List of 34 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 770 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
VPS35 OT9FYHRX Definitive Autosomal dominant [179]
ACAD9 OT4HITJ6 Limited Altered Expression [626]
ACO1 OT2VUR7L Limited Altered Expression [627]
ADI1 OT8IOD03 Limited Genetic Variation [628]
AFF1 OTT2C78E Limited Biomarker [629]
AFF2 OTMF1PZW Limited Genetic Variation [630]
AGO2 OT4JY32Q Limited Genetic Variation [203]
ANKHD1 OTVYQ7ZL Limited Altered Expression [631]
APBB1 OTZPVSSC Limited Biomarker [632]
APH1B OTQHPTGC Limited Genetic Variation [186]
ARF3 OTYYQX85 Limited Biomarker [633]
ARFGAP1 OTM3KHIE Limited Biomarker [634]
ARIH1 OTO3XDR2 Limited Biomarker [635]
ATP2C1 OTQN51T3 Limited Altered Expression [636]
AXIN2 OTRMGQNU Limited Biomarker [637]
BIN1 OTK8O0X8 Limited Genetic Variation [638]
BIN3 OTMIWWDW Limited Genetic Variation [639]
C4A OTXMOYXU Limited Genetic Variation [640]
CA8 OT9Y8GA8 Limited Genetic Variation [595]
CAST OTBXZZGF Limited Biomarker [641]
CCN6 OTRFHQ2Z Limited Genetic Variation [203]
CDCP2 OTCA9260 Limited Biomarker [642]
CHORDC1 OT3W6F1U Limited Altered Expression [206]
CHP1 OTHTXN1A Limited Altered Expression [206]
CHRNB3 OTE5XENW Limited Genetic Variation [643]
CHST1 OT2GRC5R Limited Genetic Variation [644]
CRISP2 OT8HLTV5 Limited Biomarker [645]
CSRP3 OTECBJMV Limited Genetic Variation [646]
CUL9 OTPUCLZT Limited Biomarker [647]
CWC22 OT22MEO6 Limited Biomarker [648]
CYC1 OT0962IM Limited Altered Expression [649]
DBNL OTT2OQOV Limited Genetic Variation [182]
DDX53 OTHK3EGZ Limited Biomarker [650]
DHRS11 OTU3J0ZL Limited Altered Expression [205]
DLD OT378CU9 Limited Biomarker [651]
DLG2 OTQ3BD8U Limited Biomarker [212]
DNAJA2 OTKF1VBT Limited Biomarker [652]
DNAJC14 OT7DPIVN Limited Biomarker [652]
DOCK3 OTF3YS2W Limited Biomarker [653]
DST OTHZBM4X Limited Genetic Variation [654]
DYNLT3 OT26QKCI Limited Altered Expression [655]
ECD OT3L3PCU Limited Altered Expression [206]
EEF1A1 OT00THXS Limited Altered Expression [656]
EEF2 OTZ7SZ39 Limited Altered Expression [656]
EHHADH OTBAAHL5 Limited Biomarker [600]
EIF1 OTB4GZ0V Limited Altered Expression [656]
EIF2B1 OT4NCVY1 Limited Biomarker [657]
EIF2B2 OTQQMHM1 Limited Biomarker [657]
EIF2B4 OTTM5SX1 Limited Biomarker [657]
EIF2S2 OTXF0B09 Limited Biomarker [657]
EIF3A OTFABY9G Limited Altered Expression [656]
EIF4A2 OT08H03R Limited Genetic Variation [658]
ENDOG OT5IM7B3 Limited Biomarker [659]
FA2H OT8HA13U Limited Genetic Variation [660]
FADD OTV7GFHH Limited Biomarker [661]
FAM47E OTXG216T Limited Genetic Variation [226]
FBXO42 OTHPN53C Limited Genetic Variation [662]
FBXO48 OTVMFNOK Limited Genetic Variation [203]
FBXO9 OTW5P5JF Limited Biomarker [663]
FGF13 OTHNNVSG Limited Biomarker [664]
FLVCR1 OT9XCFOC Limited Biomarker [665]
FUBP1 OT77SC9N Limited Biomarker [647]
GABBR1 OTU5A52J Limited Biomarker [666]
GET3 OTQ8KDFX Limited Biomarker [667]
GIT1 OTHO92S5 Limited Genetic Variation [194]
GLUD1 OTXKOCUH Limited Genetic Variation [668]
GNAL OTESDTEU Limited Genetic Variation [669]
GPR78 OT8TKE6F Limited Altered Expression [670]
GPRC5C OT45AJT3 Limited Biomarker [199]
GSPT1 OT18H1B0 Limited Genetic Variation [644]
HAS2 OTTD3PAL Limited Genetic Variation [671]
HEPH OTZ2F15Z Limited Biomarker [672]
HLA-DRA OT7KZMP2 Limited Genetic Variation [673]
HLA-DRB5 OTUX5TWM Limited Genetic Variation [674]
HLF OTTRK9XN Limited Biomarker [675]
HOOK2 OTPO4NQV Limited Biomarker [202]
HSPA1L OTC2V1K6 Limited Genetic Variation [676]
INPP5F OTPKUY50 Limited Genetic Variation [677]
INPP5K OTQFLQKA Limited Genetic Variation [678]
ITPKB OTSVVPAV Limited Genetic Variation [329]
JTB OT314JB6 Limited Biomarker [679]
KANSL1 OTYNSNNZ Limited Genetic Variation [323]
KIF2A OT2WQ6QD Limited Biomarker [202]
KLC1 OTSTTTW7 Limited Genetic Variation [680]
KREMEN1 OTGJFSAC Limited Biomarker [681]
KRT31 OTB6RCAH Limited Biomarker [682]
LAD1 OT6YGTVX Limited Biomarker [651]
LAMB2 OT71OI2Y Limited Biomarker [683]
LAMP3 OTN0XL3W Limited Altered Expression [684]
LHFPL2 OTDWEEBQ Limited Genetic Variation [685]
LRPAP1 OT6DVD2Q Limited Genetic Variation [686]
MAK16 OTD546E5 Limited Biomarker [687]
MAP1LC3A OTPMGIU4 Limited Altered Expression [688]
MAP1S OT5WUD4C Limited Biomarker [689]
MAP2K6 OTK13JKC Limited Altered Expression [690]
MAP3K12 OT5HODDD Limited Genetic Variation [691]
MBD5 OTFHT4MO Limited Genetic Variation [692]
MCTS1 OT7SAOJP Limited Biomarker [193]
MED1 OTOO24C4 Limited Biomarker [653]
MEFV OTRJ6S6K Limited Biomarker [693]
MEGF8 OT5G38CH Limited Biomarker [694]
MMRN1 OT7ZNYHT Limited Genetic Variation [596]
MS4A6A OTK4BXQS Limited Biomarker [695]
MT1E OTXJKU4Y Limited Biomarker [696]
MTHFD1 OTMKHVWC Limited Biomarker [697]
MTX1 OTLSDNZO Limited Genetic Variation [698]
MYO5C OTKLOCWZ Limited Altered Expression [699]
MYOC OT6DAHNF Limited Genetic Variation [700]
NANOS3 OTGX9IQU Limited Biomarker [701]
NBL1 OTT37U4O Limited Biomarker [702]
NCSTN OT5QBTA4 Limited Genetic Variation [186]
NEUROD6 OTLFL6K8 Limited Biomarker [703]
NFE2L1 OT1QHOS2 Limited Biomarker [704]
NPM3 OTIAM1A3 Limited Altered Expression [656]
NUB1 OTWA6RTX Limited Biomarker [705]
NXF1 OTEFHXG6 Limited Biomarker [706]
OR10A4 OTYYB8SY Limited Genetic Variation [707]
PAK6 OTAHPZTT Limited Biomarker [708]
PANK2 OTFBW889 Limited Biomarker [709]
PCNT OTW4Z65J Limited Biomarker [710]
PDHA1 OTGEU8IK Limited Biomarker [711]
PDIA2 OTC2WMXS Limited Biomarker [712]
PEA15 OTKCKTSX Limited Biomarker [713]
PGLYRP1 OTBTPR2T Limited Genetic Variation [714]
PGLYRP2 OTF8319A Limited Genetic Variation [714]
PGLYRP3 OT5C7PRT Limited Genetic Variation [714]
PGLYRP4 OTI115BR Limited Genetic Variation [714]
PHACTR2 OTWMX2A8 Limited Biomarker [715]
PHF1 OTW2PSIR Limited Biomarker [716]
PHYHD1 OTTKHTAC Limited Altered Expression [699]
PKD1 OT5ALRZ5 Limited Biomarker [653]
PLEK OTB73XXA Limited Genetic Variation [717]
PLXNA4 OT5XKB3Q Limited Genetic Variation [718]
PNO1 OT010GIS Limited Biomarker [687]
PPBP OT1FHGQS Limited Biomarker [653]
PPP1R17 OT19635T Limited Altered Expression [719]
PPP3R1 OTGQNFJQ Limited Biomarker [720]
PQBP1 OTXCBEAH Limited Biomarker [721]
PRDM2 OT8L7CGX Limited Genetic Variation [722]
PRDX3 OTLB2WEU Limited Biomarker [233]
PRKRA OTUTVZZU Limited Biomarker [723]
PROCR OTRHED17 Limited Biomarker [234]
PROK2 OT70IFEZ Limited Biomarker [724]
PRSS2 OTOMVUWL Limited Altered Expression [248]
PRSS55 OTXXWI5Y Limited Biomarker [645]
PSENEN OTJ7M7G9 Limited Genetic Variation [186]
PSMA2 OTJRT2ZL Limited Biomarker [683]
PSMC1 OTLHD56E Limited Biomarker [725]
PSMD11 OT8KO67V Limited Altered Expression [726]
PTPN5 OT2H1KDK Limited Biomarker [727]
PTPRA OTZA82J1 Limited Genetic Variation [728]
PXDNL OT52SSS5 Limited Altered Expression [636]
QDPR OTSKOIUX Limited Genetic Variation [607]
QRSL1 OTJDU2UG Limited Altered Expression [729]
RAB1B OTAFCUAS Limited Biomarker [633]
RAB3B OTZA4SXL Limited Altered Expression [730]
RAB6A OTLS86J5 Limited Biomarker [731]
RAB6B OT5N57RK Limited Biomarker [633]
RAI1 OTKLQU00 Limited Genetic Variation [732]
RAN OT2TER5M Limited Genetic Variation [733]
RAP1B OTHEIIMM Limited Biomarker [633]
RAP2B OTD2NDQP Limited Biomarker [633]
RBM19 OT3Q6UIM Limited Genetic Variation [692]
RBMS3 OTFSC9MR Limited Biomarker [687]
RGS10 OTQ8N1QH Limited Altered Expression [734]
RHOV OTW4N3QN Limited Genetic Variation [735]
RIC3 OTDCM6GS Limited Autosomal dominant [736]
RMC1 OT7K8MTJ Limited Biomarker [737]
RMDN3 OTKO7AUM Limited Biomarker [738]
RRAS2 OT83NCEB Limited Genetic Variation [735]
RREB1 OT62460U Limited Biomarker [739]
SAGE1 OT4H6FFA Limited Genetic Variation [740]
SART3 OTC1AM7S Limited Biomarker [741]
SEC16A OTFNQ1ZU Limited Genetic Variation [742]
SEPTIN14 OTCM6DDO Limited Biomarker [743]
SERPINA5 OTTZXPGD Limited Biomarker [248]
SGTA OTKOJ3JB Limited Altered Expression [206]
SH3GL2 OTOE443G Limited Genetic Variation [744]
SH3RF1 OT7MYGYO Limited Biomarker [745]
SHC3 OT305NPA Limited Altered Expression [746]
SMG1 OTTS3SXE Limited Altered Expression [747]
SRGAP3 OT9ZS72C Limited Biomarker [231]
ST13 OTNML6UP Limited Biomarker [748]
STUB1 OTSUYI9A Limited Biomarker [749]
TCEANC2 OTSJXAEJ Limited Genetic Variation [750]
TCIM OTARUXQF Limited Biomarker [751]
TEF OTY3LAD9 Limited Genetic Variation [752]
THAP1 OTIWUSON Limited Genetic Variation [753]
TIGAR OTR7NMRJ Limited Biomarker [202]
TIMM8A OTDX9687 Limited Altered Expression [754]
TLCD3B OTM6EPUS Limited Altered Expression [755]
TLE5 OTEH0BFG Limited Biomarker [756]
TLX2 OTPFAUM8 Limited Biomarker [757]
TPM1 OTD73X6R Limited Genetic Variation [685]
TRAM1 OT3I0H8E Limited Biomarker [758]
TRAPPC4 OT3THRCA Limited Altered Expression [231]
TRIM9 OTKYG33W Limited Biomarker [759]
AIFM1 OTKPWB7Q Disputed Biomarker [760]
ARFGEF1 OTPAU0L4 Disputed Biomarker [761]
ARID2 OTIRJXWM Disputed Biomarker [761]
CD180 OTITK5E6 Disputed Biomarker [762]
CSMD1 OTIVDSC4 Disputed Genetic Variation [763]
DLGAP3 OT0GR2F6 Disputed Biomarker [764]
EPRS1 OTXK0FLB Disputed Genetic Variation [765]
GPR151 OT7EACU6 Disputed Altered Expression [256]
HIF3A OTPWAAMC Disputed Altered Expression [766]
LGR6 OTPZ1PWR Disputed Altered Expression [256]
LYPD5 OTGP7UKA Disputed Biomarker [271]
MARK1 OTP7KL47 Disputed Biomarker [767]
MRGPRX3 OTRKCCDS Disputed Altered Expression [256]
MRGPRX4 OTOBHZVA Disputed Altered Expression [256]
NDN OTYBYJ82 Disputed Altered Expression [768]
PDIK1L OTISF4KG Disputed Biomarker [769]
PHLDA2 OTMV9DPP Disputed Biomarker [770]
PIAS2 OTJLSC3V Disputed Altered Expression [771]
PIK3C2B OTY2PROB Disputed Biomarker [772]
PPP1R1A OTGTAGCV Disputed Genetic Variation [773]
PRKACB OT6RMDCE Disputed Biomarker [261]
RING1 OTCWTAX0 Disputed Genetic Variation [774]
SETD1A OTVVWRIC Disputed Biomarker [775]
TINAGL1 OTZZO56M Disputed Altered Expression [776]
BAG5 OT0J97C6 moderate Biomarker [777]
CCDC62 OTTIAOBP moderate Genetic Variation [226]
DGKQ OT8OEPYT moderate Biomarker [547]
DNM1L OTXK1Q1G moderate Biomarker [778]
ERCC6L2 OTWFECWG moderate Genetic Variation [779]
FBP1 OTQBANEP moderate Biomarker [780]
GLUD2 OTF3GGYY moderate Genetic Variation [781]
HSPA1A OTKGIE76 moderate Therapeutic [782]
MCCC1 OTLOHEQE moderate Genetic Variation [783]
OPTN OT2UXWH9 moderate Biomarker [398]
RAB1A OTKPHRD0 moderate Altered Expression [784]
RFC1 OT3L5PK3 moderate Genetic Variation [605]
RMDN1 OTE1NB6U moderate Biomarker [738]
RMDN2 OTK5WSFI moderate Biomarker [738]
RNASE1 OTKZ7CO9 moderate Genetic Variation [785]
STH OTK8ULTH moderate Genetic Variation [786]
SYBU OT3FQV7N moderate Biomarker [738]
TCL1B OT4CSO39 moderate Biomarker [265]
TMEM175 OT6DUIYC moderate Genetic Variation [547]
TMEM230 OTAFALFV Moderate Semidominant [736]
A2M OTFTX90K Strong Biomarker [787]
ACACA OT5CQPZY Strong Biomarker [788]
ACMSD OTPSXPSF Strong Genetic Variation [789]
ACOT7 OT7C68YV Strong Biomarker [278]
ACSBG1 OTM040MW Strong Biomarker [790]
ACTBL2 OTD6B81U Strong Biomarker [278]
ACTG2 OTRDWUO0 Strong Biomarker [278]
ADAMTSL1 OTBNYF3F Strong Genetic Variation [791]
ADARB2 OTDJKS39 Strong Biomarker [265]
AGAP1 OTVX8835 Strong Genetic Variation [226]
AGFG1 OTI8ZKC4 Strong Biomarker [792]
AHSA1 OTC7AFHT Strong Biomarker [287]
AMFR OTQRX7LC Strong Biomarker [793]
AMIGO2 OTPAIT1O Strong Genetic Variation [794]
ANK2 OTWB4R1Y Strong Biomarker [795]
ANKK1 OT0OM1O0 Strong Genetic Variation [796]
ANO3 OTM34U6Q Strong Genetic Variation [797]
APAF1 OTJWIVY0 Strong Biomarker [798]
APOD OTT77XW8 Strong Biomarker [799]
AQP4 OTA9MYD5 Strong Biomarker [800]
ARC OTN2QQPG Strong Biomarker [801]
ARL6IP5 OTYZ6BEQ Strong Biomarker [802]
ARPC3 OTKWVF8P Strong Therapeutic [803]
ASCL1 OTI4X44G Strong Genetic Variation [804]
ATAD1 OTJ02XFL Strong Genetic Variation [805]
ATF2 OTNIZPEA Strong Biomarker [806]
ATG12 OTJRO09Y Strong Altered Expression [807]
ATG13 OTYMHNEJ Strong Altered Expression [531]
ATG5 OT4T5SMS Strong Biomarker [536]
ATOX1 OT05LF59 Strong Biomarker [808]
ATP13A4 OTJYVW1I Strong Biomarker [809]
ATP1A3 OTM8EG6H Strong Biomarker [341]
ATP5F1B OTLFZUQK Strong Biomarker [398]
ATP6AP2 OT0IABVV Strong Altered Expression [810]
ATXN10 OTKRDUNN Strong Biomarker [811]
B3GALT4 OTLKSMQE Strong Altered Expression [812]
BAG1 OTRQNIA4 Strong Biomarker [813]
BAG3 OTVXYUDQ Strong Biomarker [814]
BMS1 OTEGQ8ZO Strong Biomarker [788]
BNIP3L OTJKOMXE Strong Biomarker [815]
BORCS7 OTQUOZC2 Strong Genetic Variation [334]
BPIFA2 OTLFSDZD Strong Genetic Variation [431]
BRCC3 OTK0ZN7Y Strong Altered Expression [311]
BRINP1 OTEUVSCP Strong Genetic Variation [816]
C19orf12 OTVSJ1AR Strong Biomarker [817]
CAB39L OTQEBL0W Strong Genetic Variation [226]
CACYBP OTJMZD2T Strong Biomarker [614]
CADPS2 OTV1FW0M Strong Altered Expression [818]
CALB1 OTM7IXDG Strong Altered Expression [819]
CALB2 OTSNMCG9 Strong Biomarker [315]
CALCOCO2 OTRGX0OV Strong Biomarker [398]
CALD1 OTNJKJ6Q Strong Biomarker [506]
CARD16 OT4NUHWB Strong Biomarker [820]
CASK OT8EF7ZF Strong Altered Expression [821]
CASS4 OTGPIPUS Strong Genetic Variation [822]
CBLIF OTNE20WU Strong Biomarker [738]
CBLL2 OTB4AD3V Strong Altered Expression [823]
CCDC154 OTFGNMNP Strong Biomarker [824]
CCDC82 OT16EAZ7 Strong Genetic Variation [825]
CD200R1 OT65Q9M6 Strong Altered Expression [310]
CD2AP OTC76KQM Strong Genetic Variation [826]
CDH8 OTS3SRZ6 Strong Genetic Variation [827]
CDKL5 OTGL5HRV Strong Biomarker [509]
CDKN2D OT2TTZPZ Strong Biomarker [828]
CDNF OT1TP2T8 Strong Biomarker [829]
CHCHD10 OTCDHAM6 Strong Genetic Variation [830]
CHMP2B OTZA7RJB Strong Genetic Variation [831]
CISD1 OT0MTVGF Strong Biomarker [832]
CLOCK OTNEOJY7 Strong Altered Expression [833]
CLSTN3 OTPUFK4C Strong Biomarker [440]
CNKSR3 OTXP4QH8 Strong Genetic Variation [597]
CNNM2 OTZHO8WU Strong Genetic Variation [334]
CNTNAP2 OT48T2ZP Strong Biomarker [265]
COL13A1 OTM9IM6J Strong Genetic Variation [825]
COL17A1 OTID5AH2 Strong Biomarker [834]
COL19A1 OT7W3Q87 Strong Biomarker [265]
COL5A2 OT5VOSQE Strong Genetic Variation [835]
COPE OTBKHBT7 Strong Genetic Variation [836]
COX5A OTP0961M Strong Genetic Variation [837]
CTIF OT7DU7WN Strong Genetic Variation [791]
CTNNA3 OT9Z0P1E Strong Genetic Variation [791]
CUX1 OTU1LCNJ Strong Biomarker [408]
CYP20A1 OTIUZ6CF Strong Genetic Variation [838]
CYTB OTAHB98A Strong Genetic Variation [839]
DAPK2 OTWODUQG Strong Biomarker [343]
DBN1 OTZVKG8A Strong Therapeutic [840]
DCDC2 OTSUFH1H Strong Biomarker [841]
DCTN4 OTM7C943 Strong Biomarker [411]
DCUN1D1 OT8UJLZU Strong Genetic Variation [842]
DDRGK1 OT3KCK0U Strong Genetic Variation [677]
DECR1 OTCDIR6X Strong Biomarker [843]
DENR OTXP9HOY Strong Biomarker [343]
DEPDC7 OT62C942 Strong Genetic Variation [507]
DLG1 OTCRZYWT Strong Biomarker [844]
DLGAP4 OTNELLIN Strong Altered Expression [326]
DMRT1 OT5PU9U1 Strong Genetic Variation [831]
DNAJB6 OTMHIIAN Strong Biomarker [845]
DNAJB9 OT38EQT6 Strong Biomarker [440]
DNAJC1 OTCKFOZ0 Strong Genetic Variation [791]
DNER OT2GH2E5 Strong Biomarker [846]
DRAXIN OT3H5C42 Strong Biomarker [265]
DTNBP1 OT9UQT2S Strong Altered Expression [847]
DUSP2 OTH54FMR Strong Biomarker [281]
DUSP26 OTI7WIYN Strong Biomarker [848]
EIF2B3 OTG6HE7D Strong Biomarker [642]
ELAVL2 OT6EJ8MQ Strong Biomarker [849]
ELAVL4 OT3YH6J6 Strong Biomarker [850]
ENO2 OTRODL0T Strong Biomarker [851]
ERG OTOTX9VU Strong Biomarker [852]
FBRS OTUVH446 Strong Biomarker [317]
FBXO8 OTZNGJGW Strong Biomarker [317]
FEZ1 OTWCXPRE Strong Biomarker [853]
FGB OT6RKLI9 Strong Biomarker [854]
FGF9 OT2SKDGM Strong Biomarker [855]
FHL5 OT6C00Z1 Strong Biomarker [278]
FKBP1B OT8CMPB2 Strong Biomarker [354]
FKBP2 OTHBZHX0 Strong Biomarker [354]
FKBP3 OT7ETKPE Strong Biomarker [354]
FKBP9 OTGRFVKZ Strong Biomarker [354]
FOXA1 OTEBY0TD Strong Biomarker [856]
FOXA2 OTJOCVOY Strong Altered Expression [857]
FRY OT74IAG2 Strong Genetic Variation [596]
FSIP1 OTYLL6GM Strong Altered Expression [858]
FTMT OTIUX6XG Strong Altered Expression [859]
FXYD1 OTNKT6GP Strong Biomarker [860]
GABARAPL2 OTS7YVHF Strong Biomarker [861]
GBF1 OTY1KEHY Strong Genetic Variation [226]
GC OTWS63BY Strong Genetic Variation [862]
GLIS1 OTBDNB26 Strong Genetic Variation [863]
GORASP2 OTL3PLD2 Strong Biomarker [864]
GPC4 OTUJ14DW Strong Biomarker [865]
GPR143 OTWUA2AV Strong Biomarker [866]
GPR158 OTYOC1RQ Strong Biomarker [372]
GPR37 OTIMDDI3 Strong Biomarker [867]
GPR37L1 OTOV08EV Strong Biomarker [867]
GPR65 OTCF5O4G Strong Genetic Variation [226]
GPX4 OTRAFFX2 Strong Biomarker [868]
GPX7 OTINT9Z4 Strong Biomarker [869]
GRAP2 OTS5NIZ3 Strong Biomarker [287]
GRK6 OT4LZTP9 Strong Biomarker [870]
GRP OT8JDFNI Strong Biomarker [871]
GSTM2 OTG4WT05 Strong Genetic Variation [872]
GTF2H1 OTCRXC6B Strong Biomarker [411]
GTPBP6 OTY0L6K6 Strong Biomarker [873]
H3C1 OTGBGOZW Strong Biomarker [683]
HAPLN2 OT0G3KEQ Strong Biomarker [874]
HBG1 OTVL4NSU Strong Biomarker [265]
HCLS1 OTX7WGYN Strong Biomarker [408]
HCN3 OTMO1ZYQ Strong Biomarker [875]
HERPUD1 OT9EROL6 Strong Altered Expression [876]
HIP1R OTIPKEJC Strong Genetic Variation [877]
HIVEP3 OTM3QT3L Strong Biomarker [850]
HMGXB3 OTTZ1AS6 Strong Altered Expression [878]
HOMER1 OTWFD3SI Strong Genetic Variation [879]
HOXD13 OTWSC8TF Strong Biomarker [880]
HSD17B6 OTSB55D2 Strong Biomarker [519]
HSPA4 OT5HR0AR Strong Altered Expression [881]
IGFALS OTTWCZYM Strong Genetic Variation [882]
IP6K2 OTCUMUUP Strong Genetic Variation [226]
IREB2 OT747D24 Strong Biomarker [883]
ISYNA1 OT49ONSE Strong Altered Expression [884]
ITIH1 OTSXJGQF Strong Genetic Variation [226]
KCNIP4 OTB1BS0X Strong Genetic Variation [750]
KHSRP OTDHZARB Strong Biomarker [408]
KLHDC1 OTMX4YTM Strong Genetic Variation [685]
KRT7 OTLT3JFN Strong Genetic Variation [621]
LCLAT1 OTCOP0JN Strong Biomarker [885]
LCN1 OT8BWXTV Strong Genetic Variation [317]
LDOC1 OTWZH4O9 Strong Altered Expression [886]
LGALS4 OTKQCG0H Strong Biomarker [887]
LINGO2 OT3N88Q1 Strong Genetic Variation [888]
LMX1A OTEEYD5L Strong Posttranslational Modification [889]
LMX1B OTM8145D Strong Altered Expression [889]
LRPPRC OTXSK5LP Strong Genetic Variation [258]
LRRK1 OTCQMOIX Strong Genetic Variation [890]
LSAMP OTYXVQX2 Strong Altered Expression [684]
LSM2 OTHL77NY Strong Biomarker [891]
MACF1 OTVIHD77 Strong Biomarker [892]
MAFF OT9B7MX0 Strong Biomarker [893]
MAP1B OTVXW089 Strong Altered Expression [894]
MAP1LC3B OTUYHB84 Strong Biomarker [398]
MAP2 OT6UYT3X Strong Biomarker [895]
MAP3K13 OTS93BTX Strong Biomarker [896]
MAP6 OTPUI00F Strong Biomarker [897]
MATN3 OTH9H74J Strong Biomarker [898]
MCAT OTH07FIW Strong Genetic Variation [493]
MCIDAS OTK1JVAH Strong Biomarker [899]
MCPH1 OTYT3TT5 Strong Genetic Variation [493]
MCU OTQZAYWQ Strong Biomarker [900]
MDGA2 OTIJ0T5J Strong Genetic Variation [835]
MEF2C OTZGF1Y5 Strong Biomarker [901]
MEF2D OT7CEIG0 Strong Biomarker [902]
MFAP1 OTZN4FT3 Strong Biomarker [903]
MFHAS1 OTS922CJ Strong Biomarker [904]
MFN2 OTPYN8A3 Strong Altered Expression [905]
MIDN OTHE4ZEK Strong Biomarker [906]
MINDY4 OTBZ2SZB Strong Altered Expression [907]
MIP OTEBLU3E Strong Biomarker [331]
MKRN2 OTDD1V3O Strong Biomarker [908]
MLKL OTDSLC81 Strong Biomarker [479]
MOK OTQK7M9V Strong Biomarker [285]
MPHOSPH6 OT6E2S48 Strong Biomarker [909]
MPRIP OT5FV5NS Strong Biomarker [479]
MPZ OTAR2YXH Strong Biomarker [909]
MSC OTBRPZL5 Strong Biomarker [910]
MT3 OTVCZ7HI Strong Biomarker [911]
MTIF3 OTPQ7FPQ Strong Biomarker [912]
MUL1 OT2JC9YR Strong Genetic Variation [913]
MX2 OT05NF37 Strong Genetic Variation [750]
MZB1 OT071TET Strong Altered Expression [280]
NCAPD2 OT8VGE2O Strong Genetic Variation [914]
NCAPG2 OTZYENKO Strong Biomarker [265]
NCK2 OTUYPF55 Strong Altered Expression [434]
ND1 OTCLGIXV Strong Biomarker [915]
ND2 OTG9OHOX Strong Genetic Variation [916]
ND3 OT1OC3K3 Strong Biomarker [917]
ND5 OT45LW1K Strong Genetic Variation [918]
NDE1 OT2N8Q17 Strong Biomarker [919]
NDFIP1 OTIORSWF Strong Altered Expression [920]
NDRG2 OT5L6KD7 Strong Biomarker [921]
NDUFA1 OTKBUQXP Strong Biomarker [922]
NDUFA2 OTNSTATK Strong Altered Expression [923]
NDUFS4 OTJKUYEE Strong Biomarker [519]
NECTIN2 OTIE0W6O Strong Biomarker [265]
NEFH OTMSCW5I Strong Biomarker [440]
NEFL OTQESJV4 Strong Biomarker [924]
NEFM OT8VCBNF Strong Biomarker [925]
NEIL1 OTHBU5DJ Strong Biomarker [926]
NELFE OTL4E94L Strong Biomarker [341]
NFE2 OTLM94BI Strong Biomarker [927]
NHS OTKE8QAT Strong Biomarker [928]
NIF3L1 OT4MP90J Strong Biomarker [929]
NKTR OTIADJNW Strong Biomarker [354]
NLN OTFRITPU Strong Altered Expression [331]
NMS OTFYS4LO Strong Biomarker [930]
NOCT OTVSYP2D Strong Biomarker [210]
NOL3 OT1K0L0D Strong Altered Expression [447]
NOX1 OTZPJQCC Strong Altered Expression [931]
NPAS2 OTMRT2TS Strong Biomarker [932]
NPC2 OTE9UEJC Strong Genetic Variation [933]
NR2C1 OTJEL7WT Strong Genetic Variation [507]
NRF1 OTOXWNV8 Strong Biomarker [704]
NTS OTPGDNQS Strong Biomarker [934]
NUBP1 OTE8RAKZ Strong Biomarker [324]
NUCB2 OTHO6JWN Strong Biomarker [935]
NUCKS1 OTL4VJC5 Strong Genetic Variation [783]
NUFIP2 OTZBZ224 Strong Biomarker [936]
NUP62 OTMN63DH Strong Biomarker [411]
OBP2A OTBIJ5TI Strong Genetic Variation [937]
OCM OTQRML29 Strong Biomarker [938]
OGA OT7ZBWT1 Strong Altered Expression [939]
OPN1MW OTPJ7LX4 Strong Biomarker [940]
OPN3 OTON6BFU Strong Altered Expression [941]
OPN4 OT1LZ7TS Strong Biomarker [942]
OXR1 OTPIDMT3 Strong Biomarker [943]
P2RX2 OT0LF34A Strong Altered Expression [449]
P2RX5 OTLBR20R Strong Altered Expression [449]
P2RX6 OT1FNTXA Strong Altered Expression [449]
PACRG OT1NYNNW Strong Biomarker [944]
PAEP OTQA0NV4 Strong Biomarker [945]
PARL OT7DMHSA Strong Genetic Variation [946]
PCMT1 OTGYVSGU Strong Altered Expression [947]
PCP4 OTM1XXYX Strong Altered Expression [948]
PDC OT1UUVYY Strong Biomarker [949]
PDE8B OT4217NK Strong Genetic Variation [950]
PDIA3 OTHPQ0Q3 Strong Altered Expression [951]
PDSS2 OTEOQBMX Strong Biomarker [952]
PELI1 OTMLBCLC Strong Biomarker [953]
PENK OT8P3HMP Strong Altered Expression [954]
PFN3 OTXSGOQE Strong Biomarker [955]
PGK1 OT6V1ICH Strong Altered Expression [956]
PGP OT6QQ7OR Strong Biomarker [957]
PHOX2B OT3SFR2O Strong Biomarker [958]
PIEZO1 OTBG1FU4 Strong Genetic Variation [959]
PIP4P2 OT8OVB6R Strong Genetic Variation [791]
PLA2G6 OT5FL0WU Strong Genetic Variation [960]
PLB1 OTZ6TTYV Strong Biomarker [457]
PLEKHM1 OT1SLPGD Strong Genetic Variation [596]
PLPPR1 OT4A560N Strong Genetic Variation [961]
PLXNA2 OTNNBJMQ Strong Biomarker [962]
PM20D1 OTXXNQ5K Strong Genetic Variation [596]
PNOC OTJEAADN Strong Altered Expression [447]
PODXL OTPNQXF3 Strong Genetic Variation [963]
POLDIP2 OT8SZSJ6 Strong Biomarker [287]
POLR1D OTOCZQNA Strong Biomarker [964]
POTEM OT7L2HGH Strong Biomarker [278]
POU2F1 OTK7ELJ0 Strong Genetic Variation [495]
PPIG OTZ8BTTM Strong Genetic Variation [682]
PPIL1 OTS5S837 Strong Biomarker [354]
PPIL2 OTL9Y4IO Strong Biomarker [354]
PPIL3 OT0GPU73 Strong Biomarker [354]
PPIL4 OTFTLFJS Strong Biomarker [354]
PPIL6 OTOZQMQE Strong Biomarker [354]
PPM1H OTKSVU7S Strong Altered Expression [965]
PPP1R15A OTYG179K Strong Biomarker [966]
PPP1R1B OTSIJMQ9 Strong Genetic Variation [967]
PPP1R9B OTDCTHTT Strong Biomarker [968]
PPP2R2B OTSFVC82 Strong Genetic Variation [969]
PRDX2 OTLWCY9T Strong Altered Expression [970]
PRKAB1 OT1OG4QZ Strong Altered Expression [971]
PRKAR1B OT777OHS Strong Biomarker [972]
PRKAR2A OTZ7P17Z Strong Biomarker [469]
PROP1 OT8GF6N8 Strong Altered Expression [973]
PRRX2 OT8UR4AU Strong Altered Expression [970]
PRSS21 OT8ZYC7G Strong Biomarker [974]
PRSS53 OT3HUUI3 Strong Genetic Variation [597]
PSAP OTUOEKY7 Strong Genetic Variation [975]
PSMC4 OTS3XN41 Strong Biomarker [348]
PSMD6 OTX59EGK Strong Altered Expression [821]
PSMG1 OTZ5I6UM Strong Biomarker [281]
PSPH OTV1PVAX Strong Genetic Variation [431]
PSPN OT54LLZJ Strong Genetic Variation [431]
PTGES3 OTPPQWI0 Strong Biomarker [312]
PTPA OTRGFOI7 Strong Biomarker [976]
PTPN22 OTDCNTC3 Strong Biomarker [713]
PVALB OTZW1WVQ Strong Biomarker [977]
QSOX1 OT4ZPK4P Strong Biomarker [978]
RAB10 OT8ZN26V Strong Biomarker [979]
RAB32 OTTR4H7S Strong Genetic Variation [980]
RAB35 OTRH1E2T Strong Biomarker [981]
RAB3IP OT3UPQAA Strong Biomarker [982]
RAB7B OT60A0E9 Strong Biomarker [475]
RABEP2 OTO61X27 Strong Genetic Variation [323]
RAPH1 OTMQXW7S Strong Biomarker [790]
RBM3 OTAJ7R31 Strong Biomarker [983]
REG1A OTMHUH1D Strong Genetic Variation [431]
REM1 OTUXL0HC Strong Genetic Variation [984]
RER1 OTTBAUBP Strong Biomarker [985]
REST OTLL92LQ Strong Biomarker [986]
RGS9 OTRA1LOC Strong Genetic Variation [987]
RHEB OTFLTSEC Strong Genetic Variation [988]
RHOT1 OTBIRR8Q Strong Biomarker [989]
RIDA OTW4098I Strong Genetic Variation [431]
RIPK3 OTL1D484 Strong Biomarker [479]
RNASE4 OTA5SZLC Strong Altered Expression [784]
RNF11 OTFBJSKQ Strong Genetic Variation [850]
RNF146 OTE4CO7E Strong Altered Expression [823]
RNF19A OTKWCV80 Strong Biomarker [287]
RPL14 OTZZW7TK Strong Biomarker [646]
RPL23A OTPYLCCX Strong Biomarker [646]
RPL6 OTRU71O4 Strong Biomarker [646]
RPS27A OTIIGGZ2 Strong Biomarker [522]
RPS6 OTT4D1LN Strong Altered Expression [990]
RPS8 OTEBS4HZ Strong Biomarker [646]
RRAS OTBBF28C Strong Biomarker [312]
RTL10 OTHGB81W Strong Biomarker [991]
RTN1 OTCX1SMK Strong Biomarker [992]
SARM1 OTEP4I5O Strong Posttranslational Modification [993]
SATB2 OT2W80XC Strong Altered Expression [847]
SBNO1 OTNX3RL0 Strong Altered Expression [994]
SBNO2 OT1C6J3K Strong Altered Expression [994]
SCARB2 OTN929M8 Strong Genetic Variation [995]
SCGN OTGD7SKH Strong Genetic Variation [614]
SEC22A OTSAGTP6 Strong Biomarker [996]
SELENOH OTZ0QU22 Strong Genetic Variation [997]
SELENOP OT02B8IR Strong Altered Expression [998]
SELENOT OTKQGMLB Strong Biomarker [997]
SEMA5A OTUOIOJV Strong Genetic Variation [999]
SEMA6A OTDQ7QAW Strong Biomarker [495]
SEPTIN4 OTD16B30 Strong Biomarker [1000]
SEPTIN5 OT6JTJBO Strong Biomarker [1001]
SERPINA3 OT9BP2S0 Strong Biomarker [1002]
SERPINF2 OTZGAF8B Strong Biomarker [1003]
SESN2 OT889IXY Strong Biomarker [1004]
SESN3 OTJRY1Y5 Strong Biomarker [1005]
SGSM3 OTIB1P8A Strong Biomarker [1006]
SH3BP5 OTOOEGUJ Strong Biomarker [1007]
SHMT1 OTIINA3J Strong Genetic Variation [1008]
SHMT2 OT5NCAZN Strong Genetic Variation [1008]
SHOC1 OTP51XIP Strong Biomarker [594]
SIGLEC7 OTNDLURR Strong Biomarker [408]
SIPA1L2 OT8NJE5D Strong Genetic Variation [677]
SKIL OTNBXH32 Strong Altered Expression [994]
SKP1 OT5BPAZ4 Strong Genetic Variation [1009]
SMARCA1 OT0Y6PTU Strong Biomarker [1010]
SMN2 OT54RLO1 Strong Altered Expression [501]
SMPD3 OTHQBETH Strong Biomarker [1011]
SMUG1 OT2YIOCQ Strong Biomarker [1012]
SNAP23 OTY2MYBX Strong Altered Expression [819]
SNCAIP OTH8VNOK Strong Biomarker [1013]
SNRNP70 OTP52YZ3 Strong Biomarker [1014]
SNRPF OTZE5W6G Strong Altered Expression [878]
SNX3 OTXL5W8F Strong Biomarker [1015]
SNX6 OTLKQYJU Strong Biomarker [980]
SOD3 OTIOZQAB Strong Genetic Variation [274]
SORL1 OTQ8FFNS Strong Genetic Variation [1016]
SOX6 OTT0W0LE Strong Biomarker [959]
SPAG11A OTNQ9UB0 Strong Biomarker [471]
SPPL2C OTUTY2ED Strong Genetic Variation [323]
SPTSSB OTITDZW9 Strong Genetic Variation [226]
SRA1 OTYOGMTG Strong Biomarker [1017]
SRRM2 OTSIMMC9 Strong Biomarker [1018]
SRY OT516T6D Strong Biomarker [1019]
ST3GAL2 OT8WM21E Strong Altered Expression [812]
STK35 OTLEMU48 Strong Biomarker [1020]
STMN2 OT0FUHLH Strong Altered Expression [1021]
STX1B OTSW59X0 Strong Genetic Variation [789]
STXBP1 OTRYA8C3 Strong Biomarker [1022]
STXBP3 OTTTYMAQ Strong Genetic Variation [431]
SUCLA2 OTMZD4PW Strong Biomarker [684]
SV2B OTAO5WIU Strong Biomarker [1023]
SYNM OTOI8TRJ Strong Biomarker [357]
SYT17 OTTW4MI3 Strong Genetic Variation [226]
TAC1 OTM842YW Strong Biomarker [958]
TAL1 OTX4K6QZ Strong Genetic Variation [621]
TALDO1 OTDKV2S2 Strong Biomarker [854]
TAOK2 OTNUMOZ1 Strong Biomarker [509]
TAS1R2 OT53VYMN Strong Genetic Variation [507]
TAS2R13 OTSTOX5G Strong Altered Expression [1024]
TAS2R38 OTX5MM36 Strong Genetic Variation [1025]
TBC1D5 OTNHLLAX Strong Genetic Variation [226]
TCOF1 OT4BOYTM Strong Biomarker [1026]
TFEB OTJUJJQY Strong Altered Expression [1027]
TFR2 OTMYCCEO Strong Biomarker [1028]
TGS1 OTM79LML Strong Altered Expression [947]
THY1 OTVONVTB Strong Biomarker [1029]
TMC3 OTSXYLTH Strong Genetic Variation [825]
TMED10 OTUXSHH7 Strong Altered Expression [1030]
TMED9 OTYGAQS0 Strong Biomarker [1031]
TMEM106B OTUWA6NW Strong Genetic Variation [1032]
TMEM163 OTCT1Y1L Strong Genetic Variation [1033]
TMEM229B OT50LI46 Strong Genetic Variation [226]
TMEM59 OTX4EKES Strong Biomarker [1034]
TMPRSS9 OT7ETD15 Strong Genetic Variation [226]
TNMD OTHLVA9G Strong Altered Expression [210]
TOMM20 OT76TPR2 Strong Altered Expression [1035]
TOMM40 OTZDQ29F Strong Genetic Variation [1036]
TOX3 OTC9NR4W Strong Genetic Variation [1037]
TPPP OTCFMSUF Strong Biomarker [357]
TPTE2 OTR3K733 Strong Genetic Variation [827]
TRAF2 OT1MEZZN Strong Biomarker [1038]
TRAP1 OTNG0L8J Strong Genetic Variation [1039]
TRAPPC2L OT1LN60D Strong Genetic Variation [959]
TRAT1 OTMPUNPD Strong Biomarker [1040]
TRIB3 OTG5OS7X Strong Altered Expression [1024]
TRIM10 OTEO4UCZ Strong Altered Expression [1040]
TRIM3 OT704FQ0 Strong Biomarker [824]
TRIM32 OTJOV0PG Strong Biomarker [1041]
ACAD8 OT3JI5GB Definitive Biomarker [1042]
ADGRB1 OTJSEXRC Definitive Biomarker [1043]
AFDN OTTRU341 Definitive Biomarker [1044]
AMBRA1 OTY0YGT9 Definitive Biomarker [1045]
ANKRD50 OTTLA4W2 Definitive Genetic Variation [555]
ASAH1 OT1DNGXL Definitive Altered Expression [1046]
ASAP1 OT4DLRYY Definitive Biomarker [567]
ASAP2 OTGEXULW Definitive Biomarker [567]
ASPSCR1 OTXTOD10 Definitive Biomarker [1047]
AXIN1 OTRGZGZ5 Definitive Altered Expression [569]
B3GAT1 OTXFP98E Definitive Altered Expression [1048]
B4GALNT1 OTCY80HS Definitive Genetic Variation [1049]
C1R OTA0ZNIU Definitive Biomarker [292]
CACNG5 OTN4PGI5 Definitive Biomarker [1050]
CACUL1 OT6P1ZVP Definitive Genetic Variation [1009]
CAV2 OT1FGRQX Definitive Biomarker [1051]
CCL26 OT2B7HR9 Definitive Altered Expression [533]
CNBP OTTGM9NK Definitive Biomarker [1052]
CPLX1 OT7UIGTP Definitive Biomarker [1053]
CTNNBL1 OT6KLHPA Definitive Genetic Variation [1054]
CTSZ OTSCX2LL Definitive Altered Expression [1055]
CUL1 OTXPE1UZ Definitive Biomarker [1056]
DBI OT884QY9 Definitive Altered Expression [1057]
DHDDS OTVLYBUS Definitive Biomarker [1058]
DVL1 OTD67RF1 Definitive Biomarker [1059]
EBF3 OTB0IWLW Definitive Biomarker [1060]
EBPL OT59J1GY Definitive Biomarker [1061]
ELF4 OT167PR5 Definitive Biomarker [404]
ELOVL7 OT89NYVC Definitive Genetic Variation [639]
ENDOU OTB7OF7Y Definitive Altered Expression [1062]
EXOSC6 OTAC10N6 Definitive Altered Expression [1062]
FAIM2 OT6QINVO Definitive Biomarker [1063]
FBXO2 OTF3677S Definitive Genetic Variation [1064]
FBXO41 OT5MC4TZ Definitive Genetic Variation [1064]
FBXW12 OTA7XY4B Definitive Genetic Variation [1064]
FYCO1 OTKZHTZ5 Definitive Biomarker [475]
GABARAP OTAQUX6E Definitive Biomarker [536]
GBA1 OT0XMD63 Definitive Autosomal dominant [179]
GBA2 OTOZXG5D Definitive Biomarker [1065]
GDF1 OTZ1VRBH Definitive Biomarker [1066]
GK5 OT65U8L1 Definitive Biomarker [1067]
GOLGA6A OTHU9MRX Definitive Biomarker [1068]
GTF2H4 OTPD1DIU Definitive Biomarker [562]
IMMT OTBDSLE7 Definitive Biomarker [1069]
KLF9 OTBFEJRQ Definitive Biomarker [1070]
KRT10 OTSVRD3Q Definitive Biomarker [1071]
LRP10 OT8490HT Definitive Biomarker [1072]
LRRK2 OTLS7C99 Definitive Autosomal dominant [179]
MARCHF5 OTBK6BBM Definitive Biomarker [1073]
MRPS30 OTDXIAGG Definitive Biomarker [567]
MTFMT OT1OIVJL Definitive Altered Expression [1074]
MTPAP OT6HQ02S Definitive Biomarker [567]
MYL4 OTURFCSE Definitive Biomarker [1075]
NCEH1 OTZ66CKX Definitive Biomarker [1076]
NEDD4L OT1B19RU Definitive Biomarker [1077]
NPDC1 OT788NC8 Definitive Biomarker [1078]
NRGN OTVGE10W Definitive Biomarker [1079]
OMP OT7JH0DY Definitive Biomarker [1080]
PAGR1 OTXR5PQ8 Definitive Genetic Variation [548]
PAPOLA OTPHD65D Definitive Biomarker [567]
PARK7 OT0SKNTG Definitive Autosomal recessive [179]
PDAP1 OTJSWMOD Definitive Biomarker [567]
PEAK1 OTVVM637 Definitive Biomarker [1081]
PIGC OTDFW5KH Definitive Biomarker [639]
PINK1 OT50NR57 Definitive Autosomal recessive [179]
PPP1R13L OTNCPLWE Definitive Biomarker [1066]
PPP4C OT4B0TNV Definitive Biomarker [1082]
PRDM6 OTKY12D9 Definitive Biomarker [949]
PRDX1 OTZ3BEC4 Definitive Altered Expression [970]
PRKN OTJBN41W Definitive Autosomal recessive [179]
PRRX1 OTTZK5G8 Definitive Altered Expression [970]
PSG5 OTHTU98X Definitive Genetic Variation [1083]
PTPRU OTHDO0QG Definitive Biomarker [598]
RAB8A OTPB54Y3 Definitive Biomarker [1084]
RCBTB1 OTAYELI8 Definitive Biomarker [1068]
RNH1 OT6EC79B Definitive Biomarker [1066]
RPL32 OTKRQJT4 Definitive Biomarker [536]
RSPO2 OT3HHXU0 Definitive Biomarker [1085]
SALL1 OTYYZGLH Definitive Biomarker [536]
SEL1L OTC0FB7T Definitive Biomarker [505]
SNCA OTPWC1MR Definitive Autosomal dominant [179]
SV2C OTIH108W Definitive Biomarker [1086]
SYN3 OTSGYNA5 Definitive Genetic Variation [1087]
TFDP2 OTKQFX5H Definitive Biomarker [565]
TIAL1 OTV2KFZH Definitive Altered Expression [543]
TIMM23 OTAAS85T Definitive Biomarker [1035]
TNFAIP8L2 OTII0RM0 Definitive Altered Expression [1088]
TOR2A OT1EGCDU Definitive Biomarker [1089]
TPSG1 OTDESHKT Definitive Genetic Variation [1090]
TRIM17 OTUJZUOS Definitive Biomarker [1091]
TRIM41 OTU3ADNG Definitive Biomarker [1091]
------------------------------------------------------------------------------------
⏷ Show the Full List of 770 DOT(s)
This Disease Is Related to 473 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ACO2 TTMTF2P Limited Biomarker [180]
ADORA1 TTK25J1 Limited Biomarker [181]
AOC1 TTM3B5R Limited Genetic Variation [182]
APLN TT87D3J Limited Biomarker [183]
APOC3 TTXOZQ1 Limited Biomarker [184]
ASIC2 TTVMWLP Limited Altered Expression [185]
BACE2 TT69DB8 Limited Genetic Variation [186]
BCKDK TT7WD2Q Limited Genetic Variation [187]
CAPN1 TT1WBIJ Limited Biomarker [188]
CASP6 TTKW4ML Limited Genetic Variation [189]
CCKBR TTVFO0U Limited Genetic Variation [190]
CCND3 TT1JXNR Limited Altered Expression [191]
CHRNB4 TTTVAFQ Limited Biomarker [192]
CMA1 TT8VUE0 Limited Biomarker [193]
CRAT TTC8M31 Limited Genetic Variation [194]
CRY2 TTAO58M Limited Biomarker [195]
DAPK3 TTERVQN Limited Biomarker [196]
F12 TTRJSMV Limited Genetic Variation [197]
GAL TTXZAJ5 Limited Biomarker [198]
GPRC5D TTHRAPJ Limited Biomarker [199]
GRIN1 TTLD29N Limited Biomarker [200]
HEXA TTJI5JW Limited Genetic Variation [201]
HK2 TTK02H8 Limited Biomarker [202]
HPD TT8DSFC Limited Genetic Variation [203]
HPGDS TTCYE56 Limited Biomarker [204]
HSD17B13 TTDJYZR Limited Altered Expression [205]
HSP90AA1 TT78R5H Limited Altered Expression [206]
HTR6 TTJS8PY Limited Genetic Variation [207]
HTRA1 TT8POQR Limited Genetic Variation [208]
IGF2R TTPNE41 Limited Biomarker [209]
INS TTZOPHG Limited Biomarker [210]
ISG15 TTVOH3T Limited Altered Expression [211]
ITGA8 TT1FW8B Limited Biomarker [212]
JUP TTREN0G Limited Genetic Variation [213]
KCNA5 TTW0CMT Limited Biomarker [202]
KDM6B TTDIJUQ Limited Biomarker [214]
KLK2 TTJLNAW Limited Biomarker [202]
LONP1 TTM1VPZ Limited Biomarker [215]
LTF TTSZDQU Limited Altered Expression [216]
MAG TT9XFON Limited Biomarker [217]
MAPK8IP1 TTXKZ8Q Limited Biomarker [218]
MBP TT2RY5P Limited Genetic Variation [219]
MCOLN1 TT9XBVO Limited Biomarker [201]
MOG TTQAFX5 Limited Biomarker [219]
MTNR1B TT32JK8 Limited Altered Expression [220]
NACC1 TT4AQ5F Limited Biomarker [221]
NEDD8 TTNDC4K Limited Biomarker [222]
NPPB TTY63XT Limited Altered Expression [223]
NPTX2 TTNJ5A6 Limited Altered Expression [224]
PAH TTGSVH2 Limited Biomarker [225]
PAM TTF4ZPC Limited Genetic Variation [226]
PAWR TT3I4WV Limited Biomarker [227]
PDCD2 TTYOVWN Limited Biomarker [228]
PDE1B TT3ZS42 Limited Biomarker [229]
PDE7B TTWIEY9 Limited Biomarker [230]
PDXK TTXI3KF Limited Genetic Variation [231]
PNMT TT0NZIC Limited Biomarker [232]
PRDX5 TTLPJWH Limited Biomarker [233]
PROC TTZUXYS Limited Biomarker [234]
PSMB8 TTEAD9J Limited Altered Expression [235]
REL TT1ZCTH Limited Biomarker [236]
RGS2 TTKB7T3 Limited Biomarker [237]
SCN8A TT54ERL Limited Biomarker [238]
SCN9A TT4G2JS Limited Genetic Variation [239]
SLC1A1 TTG2A6F Limited Biomarker [240]
SLC7A1 TT4S150 Limited Genetic Variation [194]
SMPD1 TTJTM88 Limited Genetic Variation [241]
SPRY1 TT0PSN6 Limited Biomarker [242]
ST8SIA4 TTDP8YM Limited Genetic Variation [243]
SUGT1 TT7Q9WR Limited Altered Expression [206]
TF TT8WXAV Limited Genetic Variation [244]
TMPRSS6 TTL9KE7 Limited Altered Expression [220]
TNKS2 TTFQI4H Limited Posttranslational Modification [245]
TPCN2 TTHQJ2Y Limited Biomarker [246]
TPO TT52XDZ Limited Genetic Variation [247]
TPSD1 TTNWD8O Limited Biomarker [248]
TRPV6 TTBK14N Limited Genetic Variation [194]
UBE3A TTUZX6V Limited Biomarker [249]
UCHL3 TT23UD6 Limited Genetic Variation [250]
USP30 TTQ9EDI Limited Biomarker [251]
USP37 TTJDELN Limited Genetic Variation [243]
YWHAH TTADIOY Limited Biomarker [252]
CDA TTQ12RK Disputed Genetic Variation [253]
ESRRG TT9ZRHB Disputed Biomarker [254]
FGF18 TT6ICRA Disputed Biomarker [255]
GPRC6A TTI1PRE Disputed Altered Expression [256]
HCN1 TTNB6UQ Disputed Altered Expression [257]
HNRNPA1 TTPJ9XK Disputed Genetic Variation [258]
ITPR1 TT5HWAT Disputed Biomarker [259]
ITPR3 TTH1769 Disputed Biomarker [259]
MRGPRX1 TTIX6PK Disputed Altered Expression [256]
NPPC TTRK0B9 Disputed Biomarker [260]
OXER1 TT7WBSV Disputed Altered Expression [256]
PDPK1 TTYMGWX Disputed Biomarker [261]
SMPD2 TTE5VI6 Disputed Biomarker [262]
AIF1 TT12MEP moderate Altered Expression [263]
BCHE TT3MSAO moderate Biomarker [264]
FCER2 TTCH6MU moderate Biomarker [265]
GFAP TTI6FFX moderate Altered Expression [266]
GPNMB TT7315J moderate Genetic Variation [187]
GPX1 TTYAHBP moderate Altered Expression [267]
HGF TT4V2JM moderate Therapeutic [268]
IL6 TTT1V78 moderate Altered Expression [269]
KCNJ4 TTXF0ZW moderate Therapeutic [270]
MTA1 TTO4HUS moderate Biomarker [271]
MTHFR TTQWOU1 moderate Altered Expression [272]
NQO1 TT8XK6L moderate Biomarker [273]
SOD2 TT9O4C5 moderate Genetic Variation [274]
STK39 TTYQTIU moderate Biomarker [275]
ABL1 TT6B75U Strong Altered Expression [276]
ACHE TT1RS9F Strong Altered Expression [277]
ACTG1 TTGAZF9 Strong Biomarker [278]
ADCY5 TTN64VU Strong Biomarker [279]
ADCYAP1 TTW4LYC Strong Altered Expression [280]
ADCYAP1R1 TT5OREU Strong Biomarker [281]
ADH7 TT3LE7P Strong Genetic Variation [282]
ADORA2A TTM2AOE Strong Biomarker [283]
ADRB2 TTG8ZWP Strong Biomarker [284]
AGER TTMO9HF Strong Biomarker [285]
AGTR1 TT8DBY3 Strong Biomarker [286]
AIMP2 TTXWHGF Strong Biomarker [287]
AKR1B1 TTFBNVI Strong Biomarker [288]
ALDH2 TTFLN4T Strong Altered Expression [289]
APEX1 TTHGL48 Strong Biomarker [290]
APLNR TTJ8E43 Strong Biomarker [291]
APOA1 TT5S8DR Strong Altered Expression [292]
APOB TTN1IE2 Strong Biomarker [293]
APP TTE4KHA Strong Genetic Variation [294]
AQP9 TTQEI32 Strong Biomarker [295]
ARRB1 TTMVD4A Strong Biomarker [281]
ARSA TTYQANR Strong Biomarker [296]
ATF4 TTQCKWT Strong Biomarker [297]
ATG7 TTLVB9Z Strong Altered Expression [298]
BACE1 TTJUNZF Strong Genetic Variation [186]
BMX TTN2I9E Strong Altered Expression [299]
CA12 TTSYM0R Strong Genetic Variation [300]
CACNA1A TTX4QDJ Strong Biomarker [301]
CALCA TTVSFJW Strong Biomarker [302]
CASP1 TTCQIBE Strong Biomarker [303]
CASP9 TTB6T7O Strong Altered Expression [304]
CBS TTVZJ7G Strong Biomarker [305]
CCK TT90CMU Strong Genetic Variation [306]
CCKAR TTCG0AL Strong Genetic Variation [307]
CCN2 TTIL516 Strong Biomarker [308]
CD19 TTW640A Strong Biomarker [309]
CD200 TT0BE68 Strong Altered Expression [310]
CD38 TTPURFN Strong Biomarker [309]
CD55 TT5Z9WY Strong Biomarker [210]
CD69 TTPQE9F Strong Biomarker [309]
CDK5 TTL4Q97 Strong Altered Expression [311]
CDK5R1 TTBYM6V Strong Biomarker [312]
CEACAM6 TTIGH2W Strong Biomarker [265]
CEBPB TTUI35N Strong Biomarker [313]
CFP TTLA0VS Strong Genetic Variation [314]
CHAT TTKYFSB Strong Biomarker [315]
CHIT1 TTDYX6T Strong Altered Expression [316]
CHRM3 TTQ13Z5 Strong Biomarker [317]
CHRNA4 TT4H1MQ Strong Biomarker [318]
CHRNA5 TTH2QRX Strong Genetic Variation [319]
CIT TT3BKTU Strong Biomarker [320]
CLK1 TTE6YDG Strong Biomarker [321]
CNR2 TTMSFAW Strong Biomarker [322]
CNTN1 TTPR8FK Strong Genetic Variation [323]
COASY TT4YO0Z Strong Biomarker [324]
COPS5 TTSTNJR Strong Biomarker [325]
CREB1 TTH4AN3 Strong Biomarker [326]
CRHR1 TT7EFHR Strong Genetic Variation [323]
CRK TTFEUYR Strong Biomarker [287]
CRP TTWRN6M Strong Altered Expression [327]
CRY1 TT5MLZR Strong Genetic Variation [328]
CRYZ TTP6UO8 Strong Biomarker [273]
CTNS TT1W2ZS Strong Biomarker [210]
CTSB TTF2LRI Strong Biomarker [329]
CTSC TT4H0V2 Strong Biomarker [330]
CTSL TT36ETB Strong Altered Expression [331]
CX3CL1 TT1OFBQ Strong Biomarker [332]
CX3CR1 TT2T98G Strong Biomarker [332]
CYBB TT5T8MR Strong Biomarker [333]
CYP17A1 TTRA5BZ Strong Genetic Variation [334]
CYP2B6 TTMH124 Strong Altered Expression [335]
CYP2C9 TTR40YJ Strong Biomarker [336]
CYP3A4 TTWP7HQ Strong Biomarker [337]
CYP3A5 TTHS0OK Strong Biomarker [336]
DDC TTN451K Strong Biomarker [338]
DDIT4 TTVEOY6 Strong Altered Expression [339]
DNAJB1 TTPXAWS Strong Altered Expression [340]
DPEP1 TTYUENF Strong Biomarker [341]
DPYSL2 TTZCW3T Strong Posttranslational Modification [342]
DRD1 TTZFYLI Strong Biomarker [343]
DYRK1A TTSBVFO Strong Biomarker [344]
EDN1 TTJR60Z Strong Biomarker [345]
EGLN1 TT9ISBX Strong Biomarker [312]
EHMT1 TTOFXD7 Strong Biomarker [346]
ELK3 TT5OJMV Strong Biomarker [347]
EPHB1 TT8MDAC Strong Biomarker [347]
ERN1 TTKIAT3 Strong Biomarker [298]
F9 TTFEZ5Q Strong Genetic Variation [348]
FABP3 TT3TGLR Strong Biomarker [349]
FAF1 TTSKL3G Strong Biomarker [350]
FASLG TTO7014 Strong Biomarker [351]
FDXR TT3W4IX Strong Biomarker [352]
FGF8 TTIUF3J Strong Altered Expression [353]
FKBP10 TT4P8O2 Strong Biomarker [354]
FKBP1A TTMW94E Strong Biomarker [354]
FKBP4 TTHY0FT Strong Biomarker [354]
FKBP5 TT0J5KQ Strong Biomarker [354]
FKBP7 TTO1ENI Strong Biomarker [354]
FOSL2 TT689IR Strong Altered Expression [355]
FPR2 TTOJ1NF Strong Biomarker [210]
FTH1 TT975ZT Strong Biomarker [356]
FYN TT2B9KF Strong Biomarker [357]
G3BP1 TTG0R8Z Strong Biomarker [358]
GAD1 TTKGEP3 Strong Biomarker [359]
GAD2 TT7UY6K Strong Biomarker [360]
GALC TT5IZRB Strong Altered Expression [361]
GAP43 TTSGLN5 Strong Biomarker [362]
GAPDH TTUGSWA Strong Biomarker [363]
GCG TT6Y4PN Strong Biomarker [364]
GCH1 TTLSWP6 Strong Biomarker [365]
GDF15 TT4MXVG Strong Biomarker [366]
GDF5 TT37XV9 Strong Biomarker [367]
GIP TT40HS5 Strong Biomarker [368]
GJC2 TTPOCAL Strong Therapeutic [369]
GLA TTIS03D Strong Biomarker [370]
GLP1R TTVIMDE Strong Biomarker [364]
GLRX TTRJCNG Strong Biomarker [371]
GLUL TTURQ2G Strong Biomarker [372]
GPER1 TTDSB34 Strong Biomarker [373]
GPR139 TTOL9B0 Strong Biomarker [374]
GPR17 TTMPART Strong Biomarker [375]
GPR3 TTHZVSK Strong Biomarker [376]
GPR55 TTNET8J Strong Biomarker [377]
GPR6 TTSDWS5 Strong Biomarker [376]
GPR88 TTMRQY1 Strong Biomarker [378]
GRIA2 TTWM461 Strong Biomarker [363]
GRIK3 TTNP6O2 Strong Biomarker [379]
GRIN2A TTKJEMQ Strong Biomarker [380]
GRIN2B TTN9D8E Strong Biomarker [381]
GRIN2D TT5POTG Strong Biomarker [382]
GRK2 TTAZ3MN Strong Biomarker [383]
GRK3 TT5A4DX Strong Biomarker [383]
GRK5 TTTCXO0 Strong Genetic Variation [384]
GRM2 TTXJ47W Strong Biomarker [385]
GRM4 TTICZ1O Strong Biomarker [386]
GRM5 TTHS256 Strong Biomarker [387]
GSK3B TTRSMW9 Strong Biomarker [388]
HCAR2 TTWNV8U Strong Biomarker [389]
HCN2 TT9EUT4 Strong Biomarker [390]
HCRT TTU5HJP Strong Biomarker [391]
HDAC4 TTTQGH8 Strong Biomarker [392]
HDAC6 TT5ZKDI Strong Genetic Variation [393]
HLA-DRB1 TTUXSTW Strong Genetic Variation [394]
HMOX2 TTWZRL4 Strong Genetic Variation [395]
HRH3 TT9JNIC Strong Biomarker [396]
HSF1 TTN6STZ Strong Biomarker [397]
HSPA5 TTW26OG Strong Biomarker [297]
HSPD1 TT9HL5R Strong Biomarker [398]
HTR1A TTSQIFT Strong Biomarker [399]
HTR1B TTK8CXU Strong Altered Expression [400]
HTR2A TTJQOD7 Strong Altered Expression [401]
HTT TTIWZ0O Strong Biomarker [402]
IAPP TTHN8EM Strong Biomarker [403]
IDE TT2EDHU Strong Biomarker [404]
IGF1R TTQFBMY Strong Biomarker [405]
IGF2 TTE8WGO Strong Biomarker [406]
IL13RA1 TTNEAMG Strong Biomarker [407]
IL2RB TT9721Y Strong Biomarker [408]
INSR TTCBFJO Strong Biomarker [345]
KCNJ6 TTTIBVP Strong Biomarker [409]
KEAP1 TT3Z6Y9 Strong Biomarker [410]
KHDRBS1 TTAT6C7 Strong Biomarker [411]
KLK6 TTLPF4X Strong Biomarker [188]
KLK7 TTE6GTB Strong Biomarker [412]
LAG3 TTNVXAW Strong Biomarker [413]
LAMP1 TTC214J Strong Biomarker [398]
LBP TTVQJLY Strong Biomarker [414]
LEP TTBJEZ5 Strong Biomarker [415]
LIFR TTID542 Strong Biomarker [416]
LILRB1 TTC0QRJ Strong Biomarker [417]
LIN28A TTO50LN Strong Biomarker [418]
MANF TT56RYE Strong Biomarker [419]
MAP2K2 TT8H9GB Strong Biomarker [420]
MAP3K11 TTETX6Q Strong Biomarker [421]
MAP3K3 TTJZNIG Strong Altered Expression [422]
MAP4K4 TT6NI13 Strong Genetic Variation [226]
MAPK10 TT056SO Strong Altered Expression [423]
MAPK14 TTQBR95 Strong Biomarker [287]
MAPK8 TT0K6EO Strong Genetic Variation [424]
MARK2 TTAJ45Y Strong Genetic Variation [425]
MAS1 TTOISYB Strong Altered Expression [426]
MFGE8 TT1GLAJ Strong Biomarker [427]
MGAM TTXWASR Strong Biomarker [428]
MGLL TTZ963I Strong Altered Expression [429]
MPO TTVCZPI Strong Biomarker [430]
MSMB TTYH1ZK Strong Genetic Variation [431]
MTR TTUTO39 Strong Genetic Variation [432]
NAGLU TTDM6HZ Strong Biomarker [433]
NCL TTK1V5Q Strong Biomarker [434]
NDUFAF2 TTCHGVF Strong Genetic Variation [226]
NEDD4 TT1QU6G Strong Altered Expression [435]
NEDD9 TT1UREA Strong Biomarker [436]
NES TTHZ752 Strong Biomarker [437]
NGF TTDN3LF Strong Biomarker [438]
NGFR TTEDJN4 Strong Genetic Variation [408]
NLRP1 TTQX29T Strong Biomarker [404]
NLRP3 TT4EN8X Strong Biomarker [439]
NOTCH4 TTXDIK2 Strong Biomarker [440]
NPEPPS TT371QC Strong Biomarker [441]
NQO2 TTJLP0R Strong Altered Expression [442]
NR4A1 TTMXE2Q Strong Biomarker [443]
NT5E TTK0O6Y Strong Biomarker [283]
NTF3 TTZHKV9 Strong Biomarker [444]
NTF4 TTIM2WO Strong Biomarker [445]
OGDH TTH8T6I Strong Altered Expression [446]
OPRL1 TTNT7K8 Strong Altered Expression [447]
OSMR TTAH0KM Strong Biomarker [448]
P2RX1 TTJW7B3 Strong Altered Expression [449]
P2RX3 TT2THBD Strong Altered Expression [449]
P2RX4 TT1NLOA Strong Altered Expression [449]
P2RY1 TTA93TL Strong Altered Expression [449]
P2RY2 TTOZHQC Strong Altered Expression [449]
P2RY6 TTNVSKA Strong Biomarker [450]
PDE10A TTJW4LU Strong Altered Expression [451]
PDE4A TTZ97H5 Strong Biomarker [452]
PDE7A TT1BC3A Strong Altered Expression [453]
PEBP1 TT1BGU8 Strong Biomarker [454]
PIK3CB TT9H4P3 Strong Biomarker [455]
PIN1 TTJNTSI Strong Altered Expression [456]
PLA2G1B TT9V5JH Strong Biomarker [457]
PLD1 TT3T17P Strong Altered Expression [458]
PLD2 TTRLMKF Strong Altered Expression [459]
PLK2 TT976FS Strong Genetic Variation [460]
POLB TTA0XPV Strong Biomarker [461]
PPARD TT2JWF6 Strong Biomarker [462]
PPID TTNAFOU Strong Biomarker [463]
PPIF TTRFQTB Strong Biomarker [463]
PREP TTNGKET Strong Biomarker [464]
PRKACA TT5U49F Strong Biomarker [465]
PRKCG TTRFOXJ Strong Biomarker [466]
PRKD1 TTSLUMT Strong Biomarker [467]
PRNP TTY5F9C Strong Biomarker [468]
PROKR2 TTM67AX Strong Biomarker [469]
PSEN1 TTZ3S8C Strong Genetic Variation [186]
PSEN2 TTWN3F4 Strong Genetic Variation [186]
PSIP1 TTH9LDP Strong Biomarker [408]
PTBP1 TTWMX0U Strong Biomarker [470]
PTGER2 TT1ZAVI Strong Biomarker [471]
PTGES TTYLQ8V Strong Biomarker [472]
PTK2B TTTEFBV Strong Biomarker [455]
PTN TTA9EJK Strong Altered Expression [473]
PTPRC TTUS45N Strong Altered Expression [474]
RAB7A TTF6WAQ Strong Biomarker [475]
RENBP TTZCG0Q Strong Biomarker [476]
RET TT4DXQT Strong Biomarker [477]
RGS4 TTGTKX9 Strong Biomarker [478]
RIPK1 TTVJHX8 Strong Altered Expression [479]
ROCK2 TTGWKQJ Strong Biomarker [480]
ROS1 TTSZ6Y3 Strong Biomarker [481]
RPH3A TT9L4J8 Strong Biomarker [482]
RTN4R TTVRZUO Strong Biomarker [483]
SCD TT6RIOV Strong Biomarker [484]
SCG3 TTY5R9H Strong Biomarker [485]
SCN2A TTLJTUF Strong Genetic Variation [226]
SGCA TTS9Q5V Strong Biomarker [486]
SIGMAR1 TT5TPI6 Strong Biomarker [487]
SIRPA TTBRJS9 Strong Altered Expression [488]
SIRT2 TTLKF5M Strong Biomarker [489]
SIRT3 TTVZLIJ Strong Altered Expression [490]
SIRT5 TTH0IOD Strong Altered Expression [491]
SLC11A2 TT2IS7P Strong Biomarker [492]
SLC16A1 TTN1J82 Strong Genetic Variation [493]
SLC18A3 TTV8KWS Strong Biomarker [494]
SLC22A1 TTM5Q4V Strong Genetic Variation [495]
SLC2A4 TTP6MT5 Strong Genetic Variation [496]
SLC52A2 TT6TKEN Strong Genetic Variation [425]
SLC6A2 TTAWNKZ Strong Biomarker [497]
SLC7A11 TTBZMIO Strong Genetic Variation [498]
SLC8A1 TTCF82X Strong Biomarker [499]
SLC8B1 TTJN46R Strong Biomarker [500]
SMN1 TT8QL6X Strong Altered Expression [501]
SNAP25 TTYQWA0 Strong Biomarker [502]
SP1 TTZEP6S Strong Altered Expression [503]
SPTBN1 TTS9BDA Strong Biomarker [504]
SQSTM1 TTOT2RY Strong Biomarker [411]
SYVN1 TT8XKYM Strong Biomarker [505]
TCF3 TTULOD8 Strong Biomarker [408]
TLN1 TTQSMFG Strong Biomarker [506]
TNFRSF14 TTWGTC1 Strong Genetic Variation [507]
TNFRSF4 TTL31H0 Strong Altered Expression [508]
TNIK TTPB1W3 Strong Biomarker [509]
TOR1A TTF85KW Strong Genetic Variation [510]
TPH2 TT3KLDP Strong Altered Expression [400]
TPT1 TT3PTB6 Strong Biomarker [312]
TREM1 TTHZQP0 Strong Biomarker [511]
TRH TT2Z39D Strong Biomarker [512]
TRIM27 TTTO3QN Strong Biomarker [210]
TRPC1 TTA76X0 Strong Biomarker [513]
TRPM2 TTEBMN7 Strong Biomarker [514]
TRPM7 TTFPVZO Strong Biomarker [515]
TRPV1 TTMI6F5 Strong Altered Expression [516]
TST TT51OTS Strong Biomarker [517]
TXNIP TTTLDZK Strong Biomarker [518]
TXNRD1 TTR7UJ3 Strong Biomarker [519]
TXNRD3 TTDYFVB Strong Genetic Variation [520]
TYR TTULVH8 Strong Altered Expression [521]
UBC TTBP3XA Strong Biomarker [522]
UCP2 TTSC2YM Strong Altered Expression [523]
ULK1 TT4D7MJ Strong Biomarker [524]
USP1 TTG9MT5 Strong Biomarker [525]
USP10 TT5IH09 Strong Biomarker [358]
USP13 TTVJIO2 Strong Altered Expression [526]
UTRN TTNO1VA Strong Biomarker [343]
VCP TTHNLSB Strong Genetic Variation [527]
VDAC1 TTAMKGB Strong Biomarker [528]
VIPR2 TT4O5P0 Strong Altered Expression [529]
YOD1 TTFSH0K Strong Altered Expression [530]
ZUP1 TTZC0KV Strong Biomarker [531]
CASP7 TTM7Y45 Definitive Biomarker [532]
CCR3 TTD3XFU Definitive Biomarker [533]
CEL TTTRNQW Definitive Genetic Variation [534]
CLN3 TTORF9W Definitive Biomarker [535]
CNGA1 TTHIQMC Definitive Biomarker [536]
CNTF TTGEM5Q Definitive Biomarker [537]
CNTN2 TT2Z1WB Definitive Biomarker [538]
CSNK1D TTH30UI Definitive Biomarker [539]
DMPK TTZQTY2 Definitive Biomarker [540]
DPP7 TTOYT5L Definitive Biomarker [541]
EEF2K TT1QFLA Definitive Biomarker [542]
ELAVL1 TTPC9D0 Definitive Altered Expression [543]
FCGR2B TT5RWKQ Definitive Biomarker [544]
FFAR1 TTB8FUC Definitive Biomarker [545]
FGG TTR31L7 Definitive Biomarker [292]
FST TTDNM9W Definitive Genetic Variation [546]
GAK TT0AGBL Definitive Biomarker [547]
GALNS TTT9YPO Definitive Genetic Variation [548]
GBA1 TTCYHJ4 Definitive Autosomal dominant [179]
GJB6 TTAU8SJ Definitive Biomarker [549]
GNAQ TTL1SRG Definitive Biomarker [416]
GRIN2C TT1M8OW Definitive Biomarker [550]
GRM8 TT0IFKL Definitive Biomarker [551]
HCRTR1 TT60Q8D Definitive Biomarker [552]
HIPK2 TTOB49C Definitive Biomarker [553]
IFNAR1 TTSYFMA Definitive Biomarker [554]
KCNMA1 TTE87WJ Definitive Genetic Variation [555]
LGMN TTPTWV5 Definitive Biomarker [556]
LGR5 TTTSGRH Definitive Biomarker [557]
LRP6 TTSXOWE Definitive Biomarker [558]
LRRK2 TTK0FEA Definitive Autosomal dominant [179]
MCHR1 TTX4RTB Definitive Biomarker [559]
MMP8 TTGA1IV Definitive Genetic Variation [560]
NEK1 TTO5QT2 Definitive Genetic Variation [561]
NFKB2 TTKLNRV Definitive Biomarker [562]
NUCB1 TT6A5ZL Definitive Genetic Variation [563]
PNPLA6 TTWAQU2 Definitive Biomarker [416]
PPY TTIB95A Definitive Biomarker [564]
PTGDR2 TTQDMX5 Definitive Biomarker [565]
PTGER4 TT79WV3 Definitive Biomarker [566]
REG3A TTL4H8N Definitive Biomarker [567]
RGMA TTURJV4 Definitive Biomarker [568]
SLC1A6 TT6KMPN Definitive Altered Expression [569]
SLC33A1 TTL69WB Definitive Biomarker [570]
SLC40A1 TT6Y1PG Definitive Altered Expression [571]
SLC6A11 TT8RXO5 Definitive Altered Expression [572]
SNCA TT08OSU Definitive Autosomal dominant [179]
SPN TTOZAX0 Definitive Biomarker [573]
TBK1 TTMP03S Definitive Posttranslational Modification [574]
TKT TT04R7I Definitive Biomarker [575]
TMBIM6 TT7QSMG Definitive Biomarker [576]
TUSC2 TTJ8O14 Definitive Biomarker [567]
UCP1 TTI12YJ Definitive Altered Expression [577]
UTS2R TTW5UDX Definitive Genetic Variation [578]
VIPR1 TTCL30I Definitive Altered Expression [579]
WAS TTE8T73 Definitive Biomarker [580]
------------------------------------------------------------------------------------
⏷ Show the Full List of 473 DTT(s)
This Disease Is Related to 23 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCA5 DT195NK Limited Altered Expression [581]
SLC16A7 DTLT3UG Limited Biomarker [193]
SLC20A2 DTFD4VB Limited Genetic Variation [582]
SLC25A28 DT4NW1F Limited Biomarker [583]
SLC41A1 DTB37ZE Limited Genetic Variation [584]
SLC11A1 DT650XW Disputed Biomarker [585]
ABCA7 DTDVSJA moderate Genetic Variation [586]
ATP7A DT0LT17 Strong Genetic Variation [587]
SLC17A6 DT5LHCR Strong Biomarker [588]
SLC22A5 DT3HUVD Strong Genetic Variation [589]
SLC25A27 DT0HW5C Strong Altered Expression [590]
SLC2A13 DT0NSKB Strong Genetic Variation [591]
SLC2A14 DT18YD9 Strong Biomarker [265]
SLC2A6 DTS4MKQ Strong Biomarker [592]
SLC30A10 DTYBI73 Strong Biomarker [593]
SLC39A2 DTL8VXO Strong Biomarker [594]
SLC39A8 DTLPQGT Strong Genetic Variation [595]
SLC45A3 DTGEFXH Strong Genetic Variation [596]
SLC50A1 DTI9CQU Strong Genetic Variation [597]
SLC14A2 DT8QC7K Definitive Genetic Variation [578]
SLC25A3 DTCRIWV Definitive Biomarker [598]
SLC6A13 DTX8KP0 Definitive Altered Expression [572]
SLC8A3 DTYFRQT Definitive Genetic Variation [599]
------------------------------------------------------------------------------------
⏷ Show the Full List of 23 DTP(s)
This Disease Is Related to 34 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
HK1 DEDMAGE Limited Biomarker [202]
HSD17B10 DEGSPC9 Limited Biomarker [600]
HSD17B7 DEDMWFX Limited Altered Expression [205]
LPO DEHX1DZ Limited Biomarker [601]
MAT2B DEKF1OH Limited Genetic Variation [520]
MT2A DEFKGT7 Limited Altered Expression [220]
PER1 DE9HF0I Limited Genetic Variation [602]
SAT1 DEMWO83 Limited Altered Expression [603]
THOP1 DE95LJC Limited Biomarker [604]
MTRR DE6NIY9 moderate Genetic Variation [605]
NNMT DECVGJ3 moderate Biomarker [606]
SPR DEJVDAT moderate Genetic Variation [607]
ACP3 DEDW5H6 Strong Biomarker [608]
ADH1C DEM1HNL Strong Genetic Variation [282]
ADH4 DEOCWU3 Strong Genetic Variation [609]
ALDH1A1 DE2JP1Y Strong Altered Expression [610]
CRMP1 DE0EUXB Strong Biomarker [343]
CYP4F3 DEFCMPI Strong Genetic Variation [611]
FAAH DEUM1EX Strong Biomarker [612]
FXN DEXVHDB Strong Biomarker [613]
GNPDA2 DEPJGQB Strong Altered Expression [614]
GPX6 DEOS3FD Strong Biomarker [615]
GSTA4 DEH7XYP Strong Biomarker [616]
MSRA DEU2ZBY Strong Biomarker [617]
NAT2 DER7TA0 Strong Genetic Variation [618]
NDUFS3 DE741FI Strong Biomarker [619]
PON2 DEHJU7E Strong Altered Expression [620]
SCLY DEH4TD6 Strong Genetic Variation [621]
SI DE5EO4Y Strong Biomarker [428]
UGT1A9 DE85D2P Strong Genetic Variation [622]
CHDH DEAHED0 Definitive Biomarker [623]
MT1A DE5ME8A Definitive Biomarker [624]
NDUFS7 DEIW03B Definitive Genetic Variation [625]
PARK7 DEPOVCH Definitive Autosomal recessive [179]
------------------------------------------------------------------------------------
⏷ Show the Full List of 34 DME(s)

References

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40 ClinicalTrials.gov (NCT00511147) IGIV Study for Chronic ITP Patients Ages 3-70. U.S. National Institutes of Health.
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63 ClinicalTrials.gov (NCT00073476) A Study to Evaluate the Efficacy and Safety of CP-101,606 in Subjects With an Acute Stroke. U.S. National Institutes of Health.
64 ClinicalTrials.gov (NCT04191577) A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of CVN424 in Parkinson's Disease Patients With Motor Fluctuations. U.S.National Institutes of Health.
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66 ClinicalTrials.gov (NCT04764669) A Study of E2027 in Participants With Dementia With Lewy Bodies (DLB) or Parkinson's Disease Dementia (PDD) With or Without Amyloid Copathology. U.S. National Institutes of Health.
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68 ClinicalTrials.gov (NCT04483479) A Multicenter, Non-Randomized, Open-Label Study to Evaluate the Safety and Efficacy of Orally Administered ENT-01 in Improving Constipation and Neurologic Symptoms in Patients With Parkinson's Disease and Constipation Over a 14-week Period. U.S.National Institutes of Health.
69 ClinicalTrials.gov (NCT01850381) Phase 2A Study of GM 608 in Mild to Moderate Parkinson Disease. U.S. National Institutes of Health.
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71 ClinicalTrials.gov (NCT02432066) Effects of GTS-21 on Smoking Behavior and Neurocognitive Functions. U.S. National Institutes of Health.
72 ClinicalTrials.gov (NCT02271503) A Study to Assess the PK and Pharmacodynamics (PD) of IPX203 in Patients With Advanced Parkinsons Disease. U.S. National Institutes of Health.
73 ClinicalTrials.gov (NCT04377945) A Randomized, Double-Blind, Placebo-Controlled, Two-Part Study in Parkinson's Disease Patients With Dyskinesia to Assess the Efficacy and Safety/Tolerability of Fixed Dose Combinations of JM-010 and Its Individual Components. U.S.National Institutes of Health.
74 ClinicalTrials.gov (NCT04867551) A Phase II Clinical Study of KDT-3594 in Japanese Patients With Early Parkinson's Disease. U.S.National Institutes of Health.
75 ClinicalTrials.gov (NCT04435431) A Randomized, Double-blind, Placebo-controlled Phase IIB Study Evaluating the Efficacy of Mesdopetam on Daily ON-time Without Troublesome Dyskinesia in Patients With Parkinson's Disease. U.S.National Institutes of Health.
76 ClinicalTrials.gov (NCT00226460) Phase 2, Double-blind, Randomized, Controlled Multi-center Clinical Trial of the Safety and Efficacy of Transplanted Fetal Porcine Cells in Patients With Parkinson's Disease.. U.S. National Institutes of Health.
77 ClinicalTrials.gov (NCT04154072) Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of 36 Weeks of Treatment With NLY01 in Early-stage Parkinson's Disease. U.S.National Institutes of Health.
78 ClinicalTrials.gov (NCT04148391) A Study to Evaluate NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Associated With Parkinson's Disease or Prodromal or Manifest Lewy Body Dementia. U.S.National Institutes of Health.
79 ClinicalTrials.gov (NCT00285025) Study of the Effect of SR57667B in Patients With Alzheimer's Disease. U.S. National Institutes of Health.
80 Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
81 ClinicalTrials.gov (NCT03100149) A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease (PASADENA). U.S. National Institutes of Health.
82 ClinicalTrials.gov (NCT04269642) Phase IIa Study to Evaluate the Efficacy and Safety of Subcutaneous SR-Exenatide (PT320) in Patients With Early Parkinson's Disease. U.S.National Institutes of Health.
83 PTX-200 Phase 1b/2 clinical trial update. Prescient Therapeutics. 26 August 2015.
84 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
85 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
86 ClinicalTrials.gov (NCT04476017) A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Parkinson's Disease Mild Cognitive Impairment (PD-MCI). U.S. National Institutes of Health.
87 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5614).
88 ClinicalTrials.gov (NCT00206687) STEPS Trial - Spheramine Safety and Efficacy Study. U.S. National Institutes of Health.
89 ClinicalTrials.gov (NCT00041795) Neotrofin for Treatment of Chemotherapy-Induced Peripheral Neuropathy. U.S. National Institutes of Health.
90 ClinicalTrials.gov (NCT02258152) SYN120 Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE) (SYNAPSE). U.S. National Institutes of Health.
91 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8279).
92 ClinicalTrials.gov (NCT04491383) Tocotrienols in Parkinson's Disease (PD): A Pilot, Randomised, Placebo-controlled Trial. U.S.National Institutes of Health.
93 ClinicalTrials.gov (NCT05056194) A Double-blind, Randomized, Placebo-controlled, Parallel, Study to Assess the Efficacy and Safety of XW10172 MR for the Treatment of Excessive Daytime Sleepiness in Patients With Parkinson's Disease. U.S.National Institutes of Health.
94 ClinicalTrials.gov (NCT03562494) VY-AADC02 for Parkinson's Disease With Motor Fluctuations (RESTORE-1). U.S. National Institutes of Health.
95 ClinicalTrials.gov (NCT04220762) A Clinical Study to Determine the Optimal Dose of WIN-1001X by Evaluating Its Efficacy and Safety in Patients With Early Parkinson's Disease: Double-blind, Randomized, Placebo-controlled, Multicenter, Phase II Study. U.S.National Institutes of Health.
96 The M1/M4 preferring agonist xanomeline is analgesic in rodent models of chronic inflammatory and neuropathic pain via central site of action. Pain. 2011 Dec;152(12):2852-60.
97 ClinicalTrials.gov (NCT01171313) A Efficacy, Safety and Pharmacokinetic Study of XP21279 and Sinemet in Parkinson's Disease Subjects. U.S. National Institutes of Health.
98 The Future of Gene Therapy. Biotechnol Healthc. 2005 June; 2(3): 52-54, 56-60.
99 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8256).
100 ClinicalTrials.gov (NCT04858074) A Proof of Concept (POC) Study to Investigate the Effect of 100% Hypoestes Rosea Powder in Parkinson's Disease Using ActiGraph Wearable as a Quantitative Assessment Tool.. U.S.National Institutes of Health.
101 Clinical pipeline report, company report or official report of International Stem Cell.
102 ClinicalTrials.gov (NCT03257046) Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ITI-214 in Parkinson's Disease. U.S. National Institutes of Health.
103 ClinicalTrials.gov (NCT00607451) Safety, Tolerability, PK and PD Study of Neu-120 in the Treatment of Levodopa-induced Dyskinesia. U.S. National Institutes of Health.
104 ClinicalTrials.gov (NCT03720418) Study of OXB-102 (AXO-Lenti-PD) in Patients With Bilateral, Idiopathic Parkinson's Disease (SUNRISE-PD). U.S. National Institutes of Health.
105 ClinicalTrials.gov (NCT04127578) A Phase 1/2a Open-Label Ascending Dose Study to Evaluate the Safety and Effects of LY3884961 in Patients With Parkinson's Disease With at Least One GBA1 Mutation (PROPEL). U.S.National Institutes of Health.
106 ClinicalTrials.gov (NCT01856439) Long Term Safety and Efficacy Study of ProSavin in Parkinson's Disease. U.S. National Institutes of Health.
107 ClinicalTrials.gov (NCT02253745) Safety, Tolerability, PK & Efficacy of V81444 in Volunteers With Attention Deficit/ Hyperactivity Disorder (ADHD). U.S. National Institutes of Health.
108 ClinicalTrials.gov (NCT00229736) A Study of AAV-hAADC-2 in Subjects With Parkinson's Disease. U.S. National Institutes of Health.
109 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800038467)
110 ClinicalTrials.gov (NCT05152394) Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for the Treatment of Parkinson's Disease. U.S.National Institutes of Health.
111 ClinicalTrials.gov (NCT04685265) A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Oral Doses of anle138b, and to Characterise the Effect of Food of anle138b in Mild to Moderate Parkinson's Disease. U.S.National Institutes of Health.
112 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 296).
113 ClinicalTrials.gov (NCT01803945) A Multiple Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AVE8112 in Patients With Parkinson's Disease. U.S. National Institutes of Health.
114 Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. J Pharmacol Sci.2003 Sep;93(1):95-105.
115 ClinicalTrials.gov (NCT03976349) A Phase 1 Single- and Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB094 Administered Intrathecally to Adults With Parkinson's Disease. U.S.National Institutes of Health.
116 ClinicalTrials.gov (NCT04165837) A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral FB-101 in Healthy Subjects. U.S.National Institutes of Health.
117 Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochem Int. 2009 Jul;54(8):526-34.
118 ClinicalTrials.gov (NCT04350177) A Phase I, Randomized Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) Study to Determine the Safety, Tolerability and Pharmacokinetics (PK) of IkT-148009 in Older Adult and Elderly Healthy Volunteers With Extension Into Parkinson's Patients. U.S.National Institutes of Health.
119 ClinicalTrials.gov (NCT04165486) A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of ION464 Administered Intrathecally to Adults With Multiple System Atrophy. U.S.National Institutes of Health.
120 Clinical pipeline report, company report or official report of JOHNSON & JOHNSON
121 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005980)
122 ClinicalTrials.gov (NCT03022799) Phase I, KM-819 in Healthy Subjects for Parkinson's Disease. U.S. National Institutes of Health.
123 ClinicalTrials.gov (NCT04291859) Interventional, Open-label, Exploratory Study, Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Lu AF28996 in Patients With Parkinson's Disease. U.S.National Institutes of Health.
124 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031195)
125 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031909)
126 ClinicalTrials.gov (NCT04593511) An Open-Label Study in Healthy Volunteers to Evaluate the Safety, Tolerability and Pharmacokinetics of Four Formulations of LY03009 After a Single Intramuscular Injection. U.S.National Institutes of Health.
127 ClinicalTrials.gov (NCT04802733) Phase 1 Study To Assess the Safety and Tolerability of Human Embryonic Stem Cell-Derived Midbrain Dopamine Neuron Cell Therapy (MSK-DA01) For Advanced Parkinson's Disease. U.S.National Institutes of Health.
128 Amarantus Biosciences and RBCC Outline Terms for NuroPro Parkinson's Blood Test Joint Venture
129 ClinicalTrials.gov (NCT02780895) Human OK99 Allogeneic Stem Cell Transplantation for Patients With Severe Parkinson's Disease. U.S.National Institutes of Health.
130 ClinicalTrials.gov (NCT02216188) Follow-up Study to Assess One Boost Immunization With AFFITOPE PD01A With Regard to Safety and Clinical Activity (AFF008A). U.S. National Institutes of Health.
131 ClinicalTrials.gov (NCT01981694) A Phase I Trial to Investigate the Safety and Tolerability of PF-06649751. U.S. National Institutes of Health.
132 CYP-dependent metabolism of PF9601N, a new monoamine oxidase-B inhibitor, by C57BL/6 mouse and human liver microsomes. J Pharm Pharm Sci. 2007;10(4):473-85.
133 ClinicalTrials.gov (NCT03671785) A Prospective, Randomized, Placebo-Controlled Pilot Study to Characterize the Intestinal Microbiome and to Evaluate the Safety and Fecal Microbiome Changes Following Twice Weekly Administration of Lyophilized PRIM-DJ2727 or Placebo Given Orally for 12 Weeks in Subjects With Parkinson's Disease. U.S.National Institutes of Health.
134 Clinical pipeline report, company report or official report of Sanofi
135 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029757)
136 ClinicalTrials.gov (NCT04976127) Safety Evaluation of Intravenous Talineuren (TLN) in Parkinson's Disease-affected Patients. U.S.National Institutes of Health.
137 ClinicalTrials.gov (NCT04075318) A Phase 1 Study to Evaluate the Safety, Tolerability, and Immunogenicity of UBITh? PD Immunotherapeutic Vaccine (UB-312) in Healthy Participants and Participants With Parkinson's Disease. U.S.National Institutes of Health.
138 ClinicalTrials.gov (NCT04651153) A Multicenter, Participant-Blind, Investigator-Blind, Randomized, Placebo-Controlled Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of UCB7853 in Healthy Male Study Participants and Multiple Ascending Doses in Patients With Parkinson's Disease. U.S.National Institutes of Health.
139 ClinicalTrials.gov (NCT03065192) An Open-label Safety and Efficacy Study of VY-AADC01 Administered by MRI-Guided Convective Infusion Using a Posterior Trajectory Into the Putamen of Participants With Parkinson's Disease With Fluctuating Responses to Levodopa. U.S.National Institutes of Health.
140 ClinicalTrials.gov (NCT04043338) A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Single Ascending Dose Study Investigating the Safety, Tolerability, and Pharmacokinetics of XC130-A10H in Healthy Adult Subjects. U.S.National Institutes of Health.
141 Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2013 Jul;34(7):976-82.
142 Microbiome therapeutics go small molecule. Nat Rev Drug Discov. 2019 Jul;18(8):569-572.
143 mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706.
144 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010329)
145 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005232)
146 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009278)
147 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006532)
148 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002657)
149 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017938)
150 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 29).
151 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006926)
152 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013599)
153 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034020)
154 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027391)
155 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015639)
156 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003089)
157 Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54.
158 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012344)
159 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2611).
160 S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity ... J Pharmacol Exp Ther. 2004 Jun;309(3):921-35.
161 Clinical pipeline report, company report or official report of Teva Pharmaceutical
162 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002413)
163 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025731)
164 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022461)
165 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014899)
166 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003368)
167 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008349)
168 Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist. Brain Res. 2008 Oct 9;1234:16-24.
169 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 938).
170 Pharmacokinetics, Pharmacodynamics and Tolerance of SLV 307 After Single Oral Administration in Healthy Male Volunteers. Clinical Pharmacology &#38 Therapeutics. 02/1999; 65(2).
171 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017359)
172 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264).
173 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447).
174 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
175 The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers. Biochem Pharmacol. 2016 Jul 15;112:90-101.
176 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5610).
177 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 18).
178 Optimizing levodopa therapy for Parkinson's disease with levodopa/carbidopa/entacapone: implications from a clinical and patient perspective. Neuropsychiatr Dis Treat. 2008 February; 4(1): 39-47.
179 Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen). Genet Med. 2020 Feb;22(2):245-257. doi: 10.1038/s41436-019-0686-8. Epub 2019 Nov 6.
180 Characterization of the human mitochondrial aconitase gene (ACO2).Gene. 1998 Jun 15;213(1-2):205-18. doi: 10.1016/s0378-1119(98)00188-7.
181 Mutation in ADORA1 identified as likely cause of early-onset parkinsonism and cognitive dysfunction.Mov Disord. 2016 Jul;31(7):1004-11. doi: 10.1002/mds.26627. Epub 2016 May 2.
182 Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease.Neuromolecular Med. 2008;10(1):10-6. doi: 10.1007/s12017-007-8017-7. Epub 2007 Nov 6.
183 Apelin/APJ system: A novel promising target for neurodegenerative diseases.J Cell Physiol. 2020 Feb;235(2):638-657. doi: 10.1002/jcp.29001. Epub 2019 Jun 28.
184 Microheterogeneity of some serum glycoproteins in neurodegenerative diseases.J Neurol Sci. 2012 Mar 15;314(1-2):20-5. doi: 10.1016/j.jns.2011.11.006. Epub 2011 Nov 26.
185 Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels.Mol Biol Cell. 2007 Aug;18(8):3105-18. doi: 10.1091/mbc.e05-11-1027. Epub 2007 Jun 6.
186 Cerebrospinal fluid A42 levels and APP processing pathway genes in Parkinson's disease.Mov Disord. 2015 Jun;30(7):936-44. doi: 10.1002/mds.26172. Epub 2015 Mar 24.
187 Association of three candidate genetic variants in ACMSD/TMEM163, GPNMB and BCKDK /STX1B with sporadic Parkinson's disease in Han Chinese.Neurosci Lett. 2019 Jun 11;703:45-48. doi: 10.1016/j.neulet.2019.03.019. Epub 2019 Mar 14.
188 Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of -synuclein in multiple system atrophy.Neuropathol Appl Neurobiol. 2019 Jun;45(4):347-360. doi: 10.1111/nan.12512. Epub 2018 Aug 29.
189 Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.Cell Death Differ. 2010 Jan;17(1):158-69. doi: 10.1038/cdd.2009.116.
190 Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease.Pharmacogenetics. 2003 Jun;13(6):365-9. doi: 10.1097/00008571-200306000-00008.
191 G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients.Mol Neurobiol. 2015 Aug;52(1):386-98. doi: 10.1007/s12035-014-8870-y. Epub 2014 Sep 3.
192 An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease.Neurodegener Dis. 2011;8(5):296-9. doi: 10.1159/000323190. Epub 2011 Jan 13.
193 Unaltered lactate and glucose transporter levels in the MPTP mouse model of Parkinson's disease.J Parkinsons Dis. 2013 Jan 1;3(3):371-85. doi: 10.3233/JPD-130190.
194 Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models.J Mol Neurosci. 2010 May;41(1):210-8. doi: 10.1007/s12031-009-9325-1. Epub 2010 Jan 21.
195 Association of Tef polymorphism with depression in Parkinson disease.Mov Disord. 2012 Nov;27(13):1694-7. doi: 10.1002/mds.25195. Epub 2012 Nov 8.
196 Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease.Brain Res. 2004 Jun 25;1012(1-2):42-51. doi: 10.1016/j.brainres.2004.03.029.
197 Association of Parkinson's disease with six single nucleotide polymorphisms located in four PARK genes in the northern Han Chinese population.J Clin Neurosci. 2012 Jul;19(7):1011-5. doi: 10.1016/j.jocn.2011.09.028. Epub 2012 May 8.
198 Cholinergic deficits and galaninergic hyperinnervation of the nucleus basalis of Meynert in Alzheimer's disease and Lewy body disorders.Neuropathol Appl Neurobiol. 2020 Apr;46(3):264-278. doi: 10.1111/nan.12577. Epub 2019 Oct 1.
199 Induction of macroautophagy by overexpression of the Parkinson's disease-associated GPR37 receptor.FASEB J. 2009 Jun;23(6):1978-87. doi: 10.1096/fj.08-121210. Epub 2009 Feb 13.
200 Association analysis of GRIN1 and GRIN2B polymorphisms and Parkinson's disease in a hospital-based case-control study.Neurosci Lett. 2010 Jul 5;478(2):61-5. doi: 10.1016/j.neulet.2010.04.063. Epub 2010 May 10.
201 The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease.Neurology. 2013 Apr 23;80(17):1606-10. doi: 10.1212/WNL.0b013e31828f180e. Epub 2013 Mar 27.
202 TIGAR inclusion pathology is specific for Lewy body diseases.Brain Res. 2019 Mar 1;1706:218-223. doi: 10.1016/j.brainres.2018.09.032. Epub 2018 Sep 26.
203 Genetic analysis of the FBXO48 gene in Chinese Han patients with Parkinson disease.Neurosci Lett. 2013 Apr 29;541:224-6. doi: 10.1016/j.neulet.2013.02.031. Epub 2013 Feb 26.
204 Inhibition of glutathione S-transferase-pi triggers c-jun N-terminal kinase-dependent neuronal death in Zn-induced Parkinsonism.Mol Cell Biochem. 2019 Feb;452(1-2):95-104. doi: 10.1007/s11010-018-3415-8. Epub 2018 Aug 3.
205 Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17- hydroxysteroid dehydrogenase type 10.Cell Death Differ. 2015 Oct;22(10):1563-76. doi: 10.1038/cdd.2014.224. Epub 2015 Jan 16.
206 HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson's Disease and Dementia with Lewy Bodies.J Parkinsons Dis. 2019;9(1):97-107. doi: 10.3233/JPD-181443.
207 Association of the 5-HT6 receptor gene polymorphism C267T with Parkinson's disease.Neurology. 2002 Mar 12;58(5):828-9. doi: 10.1212/wnl.58.5.828.
208 Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease.Neurobiol Aging. 2005 Aug-Sep;26(8):1161-5. doi: 10.1016/j.neurobiolaging.2004.11.001. Epub 2004 Dec 18.
209 Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.PLoS One. 2016 Aug 10;11(8):e0160501. doi: 10.1371/journal.pone.0160501. eCollection 2016.
210 Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading.Autophagy. 2020 May;16(5):878-899. doi: 10.1080/15548627.2019.1643657. Epub 2019 Jul 29.
211 Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin.Open Biol. 2016 Aug;6(8):160193. doi: 10.1098/rsob.160193.
212 DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population.Neurobiol Aging. 2018 Apr;64:158.e1-158.e6. doi: 10.1016/j.neurobiolaging.2017.11.016. Epub 2017 Dec 8.
213 Identification of regulatory relationships in Parkinson's disease.J Mol Neurosci. 2013 Sep;51(1):9-12. doi: 10.1007/s12031-012-9937-8. Epub 2013 Feb 21.
214 Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease.Cell Death Differ. 2014 Mar;21(3):369-80. doi: 10.1038/cdd.2013.159. Epub 2013 Nov 8.
215 Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson's, Alzheimer's and ALS disease.BMC Med Genomics. 2019 May 9;12(1):60. doi: 10.1186/s12920-019-0509-4.
216 Iron transport in Parkinson's disease.Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S209-11. doi: 10.1016/S1353-8020(09)70816-8.
217 Anti-MAG autoantibodies are increased in Parkinson's disease but not in atypical parkinsonism.J Neural Transm (Vienna). 2017 Feb;124(2):209-216. doi: 10.1007/s00702-016-1632-4. Epub 2016 Oct 20.
218 Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease.Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10433-8. doi: 10.1073/pnas.181182298. Epub 2001 Aug 14.
219 Comparable autoantibody serum levels against amyloid- and inflammation-associated proteins in Parkinson's disease patients and controls.PLoS One. 2014 Feb 21;9(2):e88604. doi: 10.1371/journal.pone.0088604. eCollection 2014.
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225 Phenylalanine hydroxylase: A biomarker of disease susceptibility in Parkinson's disease and Amyotrophic lateral sclerosis.Med Hypotheses. 2018 Sep;118:29-33. doi: 10.1016/j.mehy.2018.06.018. Epub 2018 Jun 20.
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229 Phosphodiesterases in neurodegenerative disorders.IUBMB Life. 2012 Dec;64(12):965-70. doi: 10.1002/iub.1104. Epub 2012 Nov 5.
230 Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.Neurobiol Aging. 2015 Feb;36(2):1160-73. doi: 10.1016/j.neurobiolaging.2014.10.008. Epub 2014 Oct 13.
231 Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene.Ann Neurol. 2009 Dec;66(6):792-8. doi: 10.1002/ana.21780.
232 Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): historical overview and future prospects.J Neural Transm (Vienna). 2016 Nov;123(11):1255-1278. doi: 10.1007/s00702-016-1596-4. Epub 2016 Aug 4.
233 Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+.Neurosci Lett. 2008 Mar 15;433(3):219-24. doi: 10.1016/j.neulet.2007.12.068. Epub 2008 Jan 17.
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235 Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in -Synuclein Aggregation Disorders.EBioMedicine. 2018 May;31:307-319. doi: 10.1016/j.ebiom.2018.05.007.
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240 N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1-/- mouse.Ann Neurol. 2011 Mar;69(3):509-20. doi: 10.1002/ana.22162. Epub 2010 Nov 23.
241 SMPD1 mutations, activity, and -synuclein accumulation in Parkinson's disease.Mov Disord. 2019 Apr;34(4):526-535. doi: 10.1002/mds.27642. Epub 2019 Feb 20.
242 Targeted methylation sequencing reveals dysregulated Wnt signaling in Parkinson disease.J Genet Genomics. 2016 Oct 20;43(10):587-592. doi: 10.1016/j.jgg.2016.05.002. Epub 2016 May 13.
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244 Association study of the G258S transferrin gene polymorphism and Parkinson's disease in the Spanish population.J Neurol. 2005 Oct;252(10):1269-70. doi: 10.1007/s00415-005-0695-1. Epub 2005 Aug 1.
245 Epigenome-wide association study for Parkinson's disease.Neuromolecular Med. 2014 Dec;16(4):845-55. doi: 10.1007/s12017-014-8332-8. Epub 2014 Oct 11.
246 Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition.J Cell Sci. 2015 Jan 15;128(2):232-8. doi: 10.1242/jcs.164152. Epub 2014 Nov 21.
247 PET Imaging of Astrogliosis and Tau Facilitates Diagnosis of Parkinsonian Syndromes.Front Aging Neurosci. 2019 Sep 11;11:249. doi: 10.3389/fnagi.2019.00249. eCollection 2019.
248 Altered Expression of Brain Proteinase-Activated Receptor-2, Trypsin-2 and Serpin Proteinase Inhibitors in Parkinson's Disease.J Mol Neurosci. 2015 Sep;57(1):48-62. doi: 10.1007/s12031-015-0576-8. Epub 2015 May 17.
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250 Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's diseas... Clin Chim Acta. 2010 Jul 4;411(13-14):955-8.
251 The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.Nature. 2014 Jun 19;510(7505):370-5. doi: 10.1038/nature13418. Epub 2014 Jun 4.
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253 Colonic diverticular disease: A new risk factor for Parkinson's disease?.Parkinsonism Relat Disord. 2017 Sep;42:61-65. doi: 10.1016/j.parkreldis.2017.06.011. Epub 2017 Jun 20.
254 ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease.EBioMedicine. 2017 Aug;22:225-241. doi: 10.1016/j.ebiom.2017.07.024. Epub 2017 Jul 25.
255 FGF18 protects against 6-hydroxydopamine-induced nigrostriatal damage in a rat model of Parkinson's disease.Neuroscience. 2017 Jul 25;356:229-241. doi: 10.1016/j.neuroscience.2017.05.007. Epub 2017 May 11.
256 Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand.Sci Rep. 2017 Jul 10;7(1):4944. doi: 10.1038/s41598-017-05095-5.
257 SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current.Front Mol Neurosci. 2017 Jan 12;9:168. doi: 10.3389/fnmol.2016.00168. eCollection 2016.
258 Parkinson's disease-related gene variants influence pre-mRNA splicing processes.Neurobiol Aging. 2016 Nov;47:127-138. doi: 10.1016/j.neurobiolaging.2016.07.014. Epub 2016 Jul 28.
259 Determining the Roles of Inositol Trisphosphate Receptors in Neurodegeneration: Interdisciplinary Perspectives on a Complex Topic.Mol Neurobiol. 2017 Nov;54(9):6870-6884. doi: 10.1007/s12035-016-0205-8. Epub 2016 Oct 22.
260 Central and systemic C-type Natriuretic Peptide are both reduced in Parkinson's Disease.Parkinsonism Relat Disord. 2017 Oct;43:15-19. doi: 10.1016/j.parkreldis.2017.06.019. Epub 2017 Jun 27.
261 Identification of key genes and pathways in Parkinson's disease through integrated analysis.Mol Med Rep. 2017 Oct;16(4):3769-3776. doi: 10.3892/mmr.2017.7112. Epub 2017 Jul 31.
262 Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson's Disease and in Embryonic Hippocampal Cells.Mediators Inflamm. 2017;2017:2470950. doi: 10.1155/2017/2470950. Epub 2017 Nov 16.
263 Glatiramer Acetate Reverses Motor Dysfunction and the Decrease in Tyrosine Hydroxylase Levels in a Mouse Model of Parkinson's Disease.Neuroscience. 2019 Aug 21;414:8-27. doi: 10.1016/j.neuroscience.2019.06.006. Epub 2019 Jun 18.
264 Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta-analysis.Exp Ther Med. 2019 Mar;17(3):1611-1624. doi: 10.3892/etm.2018.7129. Epub 2018 Dec 24.
265 Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls.Neurobiol Aging. 2015 Feb;36(2):1105-9. doi: 10.1016/j.neurobiolaging.2014.10.039. Epub 2014 Nov 5.
266 Salivary microR-153 and microR-223 Levels as Potential Diagnostic Biomarkers of Idiopathic Parkinson's Disease.Mov Disord. 2020 Mar;35(3):468-477. doi: 10.1002/mds.27935. Epub 2019 Dec 4.
267 Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies.Acta Neuropathol. 2009 Jan;117(1):63-73. doi: 10.1007/s00401-008-0438-3. Epub 2008 Oct 14.
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269 Tremor-Dominant in Parkinson Disease: The Relevance to Iron Metabolism and Inflammation.Front Neurosci. 2019 Mar 27;13:255. doi: 10.3389/fnins.2019.00255. eCollection 2019.
270 Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway.Biochem Biophys Res Commun. 2008 Sep 19;374(2):204-9. doi: 10.1016/j.bbrc.2008.07.003. Epub 2008 Jul 11.
271 Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor.J Biol Chem. 2016 Jun 3;291(23):12310-21. doi: 10.1074/jbc.M115.707224. Epub 2016 Apr 4.
272 Paraquat Exposure Increases Oxidative Stress Within the Dorsal Striatum of Male Mice With a Genetic Deficiency in One-carbon Metabolism.Toxicol Sci. 2019 May 1;169(1):25-33. doi: 10.1093/toxsci/kfz034.
273 Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease.J Neurosci. 2019 Sep 11;39(37):7291-7305. doi: 10.1523/JNEUROSCI.0625-19.2019. Epub 2019 Jul 29.
274 Superoxide dismutase coding of gene polymorphisms associated with susceptibility to Parkinson's disease.J Integr Neurosci. 2019 Sep 30;18(3):299-303. doi: 10.31083/j.jin.2019.03.127.
275 STK39, overexpressed in osteosarcoma, regulates osteosarcoma cell invasion and proliferation.Oncol Lett. 2017 Oct;14(4):4599-4604. doi: 10.3892/ol.2017.6728. Epub 2017 Aug 7.
276 The c-Abl inhibitor in Parkinson disease.Neurol Sci. 2017 Apr;38(4):547-552. doi: 10.1007/s10072-016-2808-2. Epub 2017 Jan 11.
277 7-chloro-4-(phenylselanyl) quinoline prevents dopamine depletion in a Drosophila melanogaster model of Parkinson's-like disease.J Trace Elem Med Biol. 2019 Jul;54:232-243. doi: 10.1016/j.jtemb.2018.10.015. Epub 2018 Oct 15.
278 Genetic study of apolipoprotein E gene, alpha-1 antichymotrypsin gene in sporadic Parkinson disease.Am J Med Genet. 2002 May 8;114(4):446-9. doi: 10.1002/ajmg.10249.
279 Motor dysfunction in type 5 adenylyl cyclase-null mice.J Biol Chem. 2003 May 9;278(19):16936-40. doi: 10.1074/jbc.C300075200. Epub 2003 Mar 28.
280 Alteration of the PAC1 Receptor Expression in the Basal Ganglia of MPTP-Induced Parkinsonian Macaque Monkeys.Neurotox Res. 2018 May;33(4):702-715. doi: 10.1007/s12640-017-9841-7. Epub 2017 Dec 11.
281 New insights about the peculiar role of the 28-38 C-terminal segment and some selected residues in PACAP for signaling and neuroprotection.Biochem Pharmacol. 2018 Aug;154:193-202. doi: 10.1016/j.bcp.2018.04.024. Epub 2018 Apr 25.
282 No genetic evidence for involvement of alcohol dehydrogenase genes in risk for Parkinson's disease.Neurobiol Aging. 2020 Mar;87:140.e19-140.e22. doi: 10.1016/j.neurobiolaging.2019.11.006. Epub 2019 Nov 14.
283 CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling.Brain. 2019 Mar 1;142(3):700-718. doi: 10.1093/brain/awy351.
284 Modifiable risk and protective factors in disease development, progression and clinical subtypes of Parkinson's disease: What do prospective studies suggest?.Neurobiol Dis. 2020 Feb;134:104671. doi: 10.1016/j.nbd.2019.104671. Epub 2019 Nov 6.
285 RAGE and its emerging role in the pathogenesis of Parkinson's disease.Neurosci Lett. 2018 Apr 13;672:65-69. doi: 10.1016/j.neulet.2018.02.049. Epub 2018 Mar 21.
286 Telmisartan Ameliorates Astroglial and Dopaminergic Functions in a Mouse Model of Chronic Parkinsonism.Neurotox Res. 2018 Oct;34(3):597-612. doi: 10.1007/s12640-018-9921-3. Epub 2018 Jul 13.
287 MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease.FASEB J. 2019 Jul;33(7):8648-8665. doi: 10.1096/fj.201900363R. Epub 2019 Apr 17.
288 Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease.Neurobiol Aging. 2017 Feb;50:119-133. doi: 10.1016/j.neurobiolaging.2016.11.008. Epub 2016 Nov 23.
289 Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells: A possible role in neurotoxicity. Toxicology. 2019 Jan 1;411:110-121.
290 Ape1 protects against MPP+-induced neurotoxicity through ERK1/2 signaling in PC12 cells.Neuroreport. 2017 Jan 1;28(1):10-16. doi: 10.1097/WNR.0000000000000712.
291 The effect of docosahexaenoic acid on apelin distribution of nervous system in the experimental mouse model of Parkinson's disease.Tissue Cell. 2019 Feb;56:41-51. doi: 10.1016/j.tice.2018.12.002. Epub 2018 Dec 6.
292 Proteomic Profiling of Exosomal Proteins for Blood-based Biomarkers in Parkinson's Disease.Neuroscience. 2018 Nov 10;392:121-128. doi: 10.1016/j.neuroscience.2018.09.017. Epub 2018 Sep 26.
293 Correlations between blood lipid, serum cystatin C, and homocysteine levels in patients with Parkinson's disease.Psychogeriatrics. 2020 Mar;20(2):180-188. doi: 10.1111/psyg.12483. Epub 2019 Dec 11.
294 Serotonin, -amyloid, and cognition in Parkinson disease.Ann Neurol. 2018 May;83(5):994-1002. doi: 10.1002/ana.25236. Epub 2018 May 11.
295 Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease.PLoS One. 2018 Mar 22;13(3):e0194896. doi: 10.1371/journal.pone.0194896. eCollection 2018.
296 Association of Parkinson's disease and treatment with aminosalicylates in inflammatory bowel disease: a cross-sectional study in a Spain drug dispensation records.BMJ Open. 2019 Jun 19;9(6):e025574. doi: 10.1136/bmjopen-2018-025574.
297 Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.Nutr Neurosci. 2021 Mar;24(3):181-196. doi: 10.1080/1028415X.2019.1613764. Epub 2019 May 17.
298 IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.Cell Death Dis. 2019 Oct 22;10(11):800. doi: 10.1038/s41419-019-2039-6.
299 Voluntary Physical Exercise Improves Subsequent Motor and Cognitive Impairments in a Rat Model of Parkinson's Disease.Int J Mol Sci. 2018 Feb 8;19(2):508. doi: 10.3390/ijms19020508.
300 Association between common genetic risk variants and depression in Parkinson's disease: A dPD study in Chinese.Parkinsonism Relat Disord. 2016 Dec;33:122-126. doi: 10.1016/j.parkreldis.2016.09.029. Epub 2016 Sep 29.
301 Parkinsonism in spinocerebellar ataxia.Biomed Res Int. 2015;2015:125273. doi: 10.1155/2015/125273. Epub 2015 Mar 19.
302 Neuropeptide Y and Calcitonin Gene-Related Peptide in Cerebrospinal Fluid in Parkinson's Disease with Comorbid Depression versus Patients with Major Depressive Disorder.Front Psychiatry. 2017 Jun 12;8:102. doi: 10.3389/fpsyt.2017.00102. eCollection 2017.
303 C-terminal truncation exacerbates the aggregation and cytotoxicity of -Synuclein: A vicious cycle in Parkinson's disease.Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3714-3725. doi: 10.1016/j.bbadis.2018.10.003. Epub 2018 Oct 2.
304 Effect of cabergoline alginate nanocomposite on the transgenic Drosophila melanogaster model of Parkinson's disease.Toxicol Mech Methods. 2018 Nov;28(9):699-708. doi: 10.1080/15376516.2018.1502386. Epub 2018 Oct 2.
305 Impaired CBS-H(2)S signaling axis contributes to MPTP-induced neurodegeneration in a mouse model of Parkinson's disease.Brain Behav Immun. 2018 Jan;67:77-90. doi: 10.1016/j.bbi.2017.07.159. Epub 2017 Aug 1.
306 Psychosis in Parkinson's disease: From the soft signs to the hard science.J Neurol Sci. 2017 Aug 15;379:169-176. doi: 10.1016/j.jns.2017.06.011. Epub 2017 Jun 12.
307 Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system.Arch Neurol. 2004 Aug;61(8):1280-4. doi: 10.1001/archneur.61.8.1280.
308 Increased MMP-3 and CTGF expression during lipopolysaccharide-induced dopaminergic neurodegeneration.Neurosci Lett. 2009 Aug 21;460(1):27-31. doi: 10.1016/j.neulet.2009.05.044. Epub 2009 May 20.
309 Peripheral blood lymphocyte phenotypes in Alzheimer and Parkinson's diseases.Neurologia (Engl Ed). 2022 Mar;37(2):110-121. doi: 10.1016/j.nrl.2018.10.004. Epub 2019 Mar 11.
310 Analysis of the Impact of CD200 on Phagocytosis.Mol Neurobiol. 2017 Sep;54(7):5730-5739. doi: 10.1007/s12035-016-0223-6. Epub 2016 Nov 9.
311 The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.Biochem Biophys Res Commun. 2020 Feb 12;522(3):647-654. doi: 10.1016/j.bbrc.2019.11.141. Epub 2019 Nov 29.
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313 CCAAT/Enhancer binding protein silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease.Sci Rep. 2017 Oct 19;7(1):13526. doi: 10.1038/s41598-017-13269-4.
314 Parkinson's disease and multiple system atrophy have distinct -synuclein seed characteristics.J Biol Chem. 2019 Jan 18;294(3):1045-1058. doi: 10.1074/jbc.RA118.004471. Epub 2018 Nov 26.
315 Thecalretinin interneurons of the striatum: comparisons between rodents and primates under normal and pathological conditions.J Neural Transm (Vienna). 2018 Mar;125(3):279-290. doi: 10.1007/s00702-017-1687-x. Epub 2017 Feb 6.
316 Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):239-247. doi: 10.1136/jnnp-2017-317138. Epub 2017 Nov 15.
317 Bioassay-guided Isolation of Neuroprotective Fatty Acids from Nigella sativa against 1-methyl-4-phenylpyridinium-induced Neurotoxicity.Pharmacogn Mag. 2017 Oct-Dec;13(52):627-633. doi: 10.4103/pm.pm_470_16. Epub 2017 Nov 13.
318 Activation of 7-nAChRs protects SH-SY5Y cells from 1-methyl-4-phenylpyridinium-induced apoptotic cell death via ERK/p53 signaling pathway.J Cell Physiol. 2019 Aug;234(10):18480-18491. doi: 10.1002/jcp.28484. Epub 2019 Mar 25.
319 Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: gene and smoking status interaction.Parkinsonism Relat Disord. 2013 Jan;19(1):72-6. doi: 10.1016/j.parkreldis.2012.07.007. Epub 2012 Aug 9.
320 Progressive loss of raphe nuclei serotonin transporter in early Parkinson's disease: A longitudinal (123)I-FP-CIT SPECT study.Parkinsonism Relat Disord. 2020 Aug;77:170-175. doi: 10.1016/j.parkreldis.2019.03.025. Epub 2019 Apr 5.
321 Clk1 deficiency promotes neuroinflammation and subsequent dopaminergic cell death through regulation of microglial metabolic reprogramming.Brain Behav Immun. 2017 Feb;60:206-219. doi: 10.1016/j.bbi.2016.10.018. Epub 2016 Oct 18.
322 The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease.Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jan 10;96:109745. doi: 10.1016/j.pnpbp.2019.109745. Epub 2019 Aug 20.
323 Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.Hum Mol Genet. 2014 Sep 1;23(17):4693-702. doi: 10.1093/hmg/ddu158. Epub 2014 May 19.
324 L-3-n-butylphthalide soft capsules in the treatment of Parkinson disease dementia: A systematic review and meta-analysis of randomized controlled trials.Medicine (Baltimore). 2019 Jun;98(24):e16082. doi: 10.1097/MD.0000000000016082.
325 The neuronal POU transcription factor Brn-2 interacts with Jab1, a gene involved in the onset of neurodegenerative diseases.Neurosci Lett. 2005 Jul 1-8;382(1-2):175-8. doi: 10.1016/j.neulet.2005.03.008. Epub 2005 Apr 2.
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327 Blood biomarkers with Parkinson's disease clusters and prognosis: The oxford discovery cohort.Mov Disord. 2020 Feb;35(2):279-287. doi: 10.1002/mds.27888. Epub 2019 Nov 6.
328 Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson's disease.Acta Neuropsychiatr. 2020 Feb;32(1):10-22. doi: 10.1017/neu.2019.28. Epub 2019 Aug 27.
329 ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians.Neurobiol Aging. 2020 Feb;86:201.e15-201.e17. doi: 10.1016/j.neurobiolaging.2019.01.026. Epub 2019 Feb 2.
330 Serum uric acid level and its association with motor subtypes and non-motor symptoms in early Parkinson's disease: PALS study.Parkinsonism Relat Disord. 2018 Oct;55:50-54. doi: 10.1016/j.parkreldis.2018.05.010. Epub 2018 May 17.
331 Respiratory muscle strength and lung function in the stages of Parkinson's disease.J Bras Pneumol. 2019 Sep 30;45(6):e20180148. doi: 10.1590/1806-3713/e20180148. eCollection 2019.
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336 Pharmacogenetics of Atremorine-Induced Neuroprotection and Dopamine Response in Parkinson's Disease.Planta Med. 2019 Nov;85(17):1351-1362. doi: 10.1055/a-1013-7686. Epub 2019 Sep 26.
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338 Magnetic resonance imaging-guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease.Ann Neurol. 2019 May;85(5):704-714. doi: 10.1002/ana.25450. Epub 2019 Mar 26.
339 RTP801 is a critical factor in the neurodegeneration process of A53T -synuclein in a mouse model of Parkinson's disease under chronic restraint stress.Br J Pharmacol. 2018 Feb;175(4):590-605. doi: 10.1111/bph.14091. Epub 2018 Jan 17.
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341 A novel peptide delivers plasmids across blood-brain barrier into neuronal cells as a single-component transfer vector.PLoS One. 2013;8(3):e59642. doi: 10.1371/journal.pone.0059642. Epub 2013 Mar 29.
342 Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's model mice.Genes Cells. 2019 Jan;24(1):31-40. doi: 10.1111/gtc.12651. Epub 2018 Nov 18.
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465 Identification of Differentially Expressed Genes and Long Noncoding RNAs Associated with Parkinson's Disease.Parkinsons Dis. 2019 Feb 5;2019:6078251. doi: 10.1155/2019/6078251. eCollection 2019.
466 The Role of Cysteine String Protein Phosphorylation at Serine 10 and 34 by Protein Kinase C for Presynaptic Maintenance.J Neurosci. 2018 Jan 10;38(2):278-290. doi: 10.1523/JNEUROSCI.1649-17.2017. Epub 2017 Nov 22.
467 Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease.J Neurochem. 2017 Jun;141(5):766-782. doi: 10.1111/jnc.14033. Epub 2017 May 9.
468 Could it be that neurodegenerative diseases are infectious?.Rev Neurol (Paris). 2019 Sep-Oct;175(7-8):427-430. doi: 10.1016/j.neurol.2019.07.003. Epub 2019 Jul 26.
469 Effects of Silibinin Against Prothrombin Kringle-2-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System In Vivo.J Med Food. 2019 Mar;22(3):277-285. doi: 10.1089/jmf.2018.4266. Epub 2019 Jan 11.
470 Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease.Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2257-62. doi: 10.1073/pnas.1423573112. Epub 2015 Feb 2.
471 Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons.Mol Neurobiol. 2018 Jun;55(6):4763-4776. doi: 10.1007/s12035-017-0681-5. Epub 2017 Jul 17.
472 Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease.Neurobiol Dis. 2019 Apr;124:81-92. doi: 10.1016/j.nbd.2018.11.004. Epub 2018 Nov 10.
473 Regulation of Pleiotrophin and Fyn in the striatum of rats undergoing L-DOPA-induced dyskinesia.Neurosci Lett. 2018 Feb 14;666:5-10. doi: 10.1016/j.neulet.2017.12.024. Epub 2017 Dec 11.
474 PTPRC Expression in Blood is Downregulated in Parkinson's and Progressive Supranuclear Palsy Disorders.J Parkinsons Dis. 2018;8(4):529-537. doi: 10.3233/JPD-181391.
475 FYCO1 mediates clearance of -synuclein aggregates through a Rab7-dependent mechanism.J Neurochem. 2018 Aug;146(4):474-492. doi: 10.1111/jnc.14461. Epub 2018 Jul 23.
476 PARK2 gene mutations in early onset Parkinson's disease patients of South India.Neurosci Lett. 2012 Aug 15;523(2):145-7. doi: 10.1016/j.neulet.2012.06.062. Epub 2012 Jul 3.
477 Glial cell line-derived neurotrophic factor receptor Rearranged during transfection agonist supports dopamine neurons in Vitro and enhances dopamine release In Vivo.Mov Disord. 2020 Feb;35(2):245-255. doi: 10.1002/mds.27943. Epub 2019 Dec 16.
478 Absence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease.Neurobiol Aging. 2017 Oct;58:30-33. doi: 10.1016/j.neurobiolaging.2017.06.008. Epub 2017 Jun 19.
479 RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease.Lab Invest. 2020 Mar;100(3):503-511. doi: 10.1038/s41374-019-0319-5. Epub 2019 Sep 10.
480 miR-135b Plays a Neuroprotective Role by Targeting GSK3 in MPP(+)-Intoxicated SH-SY5Y Cells.Dis Markers. 2017;2017:5806146. doi: 10.1155/2017/5806146. Epub 2017 Apr 17.
481 Neuroprotective effects of Bacopa monnieri in Parkinson's disease model.Metab Brain Dis. 2020 Mar;35(3):517-525. doi: 10.1007/s11011-019-00526-w. Epub 2019 Dec 13.
482 Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias. Neurobiol Dis. 2017 Dec;108:54-64.
483 Antagonization of the Nogo-Receptor 1 Enhances Dopaminergic Fiber Outgrowth of Transplants in a Rat Model of Parkinson's Disease.Front Cell Neurosci. 2017 May 26;11:151. doi: 10.3389/fncel.2017.00151. eCollection 2017.
484 Subjective cognitive decline and progression to dementia in Parkinson's disease: a long-term follow-up study.J Neurol. 2019 Mar;266(3):745-754. doi: 10.1007/s00415-019-09197-0. Epub 2019 Jan 11.
485 Dysregulated expression of secretogranin III is involved in neurotoxin-induced dopaminergic neuron apoptosis. J Neurosci Res. 2012 Dec;90(12):2237-46. doi: 10.1002/jnr.23121. Epub 2012 Sep 18.
486 Factors associated with life satisfaction in Parkinson's disease.Acta Neurol Scand. 2017 Jul;136(1):64-71. doi: 10.1111/ane.12695. Epub 2016 Oct 10.
487 Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.Neurotherapeutics. 2019 Apr;16(2):465-479. doi: 10.1007/s13311-018-00699-9.
488 SIRP deficiency accelerates the pathologic process in models of Parkinson disease.Glia. 2019 Dec;67(12):2343-2359. doi: 10.1002/glia.23689. Epub 2019 Jul 19.
489 Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.Eur J Pharmacol. 2020 Jan 15;867:172847. doi: 10.1016/j.ejphar.2019.172847. Epub 2019 Dec 5.
490 Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells.J Neural Transm (Vienna). 2019 May;126(5):559-568. doi: 10.1007/s00702-019-02005-z. Epub 2019 Apr 19.
491 Sirtuin 5: a review of structure, known inhibitors and clues for developing new inhibitors. Sci China Life Sci. 2017 Mar;60(3):249-256.
492 S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit.J Neurosci. 2018 Sep 26;38(39):8364-8377. doi: 10.1523/JNEUROSCI.3262-17.2018. Epub 2018 Aug 13.
493 Dynamics of Parkinson's Disease Multimodal Complex Treatment in Germany from 2010?016: Patient Characteristics, Access to Treatment, and Formation of Regional Centers.Cells. 2019 Feb 11;8(2):151. doi: 10.3390/cells8020151.
494 Cholinergic system changes of falls and freezing of gait in Parkinson's disease.Ann Neurol. 2019 Apr;85(4):538-549. doi: 10.1002/ana.25430. Epub 2019 Mar 13.
495 Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.Lancet Neurol. 2019 Dec;18(12):1091-1102. doi: 10.1016/S1474-4422(19)30320-5.
496 The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4.Sci Rep. 2019 Mar 14;9(1):4515. doi: 10.1038/s41598-019-40808-y.
497 Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia.Neuroscience. 2020 Jan 1;424:58-71. doi: 10.1016/j.neuroscience.2019.08.046. Epub 2019 Nov 1.
498 Modulation of Autophagy by a Small Molecule Inverse Agonist of ERR Is Neuroprotective.Front Mol Neurosci. 2018 Apr 9;11:109. doi: 10.3389/fnmol.2018.00109. eCollection 2018.
499 Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from -synuclein plus rotenone induced toxicity.Cell Death Dis. 2019 Jan 28;10(2):80. doi: 10.1038/s41419-018-1290-6.
500 Mitochondrial calcium imbalance in Parkinson's disease.Neurosci Lett. 2018 Jan 10;663:86-90. doi: 10.1016/j.neulet.2017.08.044. Epub 2017 Aug 26.
501 Functional MRI to Study Gait Impairment in Parkinson's Disease: a Systematic Review and Exploratory ALE Meta-Analysis.Curr Neurol Neurosci Rep. 2019 Jun 18;19(8):49. doi: 10.1007/s11910-019-0967-2.
502 SNAP25 Gene Polymorphisms Protect Against Parkinson's Disease and Modulate Disease Severity in Patients.Mol Neurobiol. 2019 Jun;56(6):4455-4463. doi: 10.1007/s12035-018-1386-0. Epub 2018 Oct 17.
503 Inhibition of transcription factor SP1 produces neuroprotective effects through decreasing MAO B activity in MPTP/MPP(+) Parkinson's disease models.J Neurosci Res. 2018 Oct;96(10):1663-1676. doi: 10.1002/jnr.24266. Epub 2018 Jul 13.
504 50-Hz MF does not affect global DNA methylation of SH-SY5Y cells treated with the neurotoxin MPP().Bioelectromagnetics. 2019 Jan;40(1):33-41. doi: 10.1002/bem.22158. Epub 2018 Dec 7.
505 Ubiquitin ligase HMG-CoA reductase degradation 1 (HRD1) prevents cell death in a cellular model of Parkinson's disease.Biochem Biophys Res Commun. 2018 Nov 30;506(3):516-521. doi: 10.1016/j.bbrc.2018.10.094. Epub 2018 Oct 22.
506 Improved detection of prostate cancer using a magneto-nanosensor assay for serum circulating autoantibodies.PLoS One. 2019 Aug 12;14(8):e0221051. doi: 10.1371/journal.pone.0221051. eCollection 2019.
507 Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain.J Neurochem. 2006 Jul;98(1):34-44. doi: 10.1111/j.1471-4159.2006.03801.x.
508 OX40 Gene and Serum Protein Expression Profiles in Patients with Parkinson's Disease.Cell J. 2018 Jul;20(2):177-182. doi: 10.22074/cellj.2018.5038. Epub 2018 Mar 18.
509 Kinases in synaptic development and neurological diseases.Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt B):343-352. doi: 10.1016/j.pnpbp.2017.12.006. Epub 2017 Dec 11.
510 DYT1 mutations in early onset primary torsion dystonia and Parkinson disease patients in Chinese populations.Neurosci Lett. 2009 Jan 30;450(2):117-21. doi: 10.1016/j.neulet.2008.10.111. Epub 2008 Nov 20.
511 Therapeutic Effect of Modulating TREM-1 via Anti-inflammation and Autophagy in Parkinson's Disease.Front Neurosci. 2019 Aug 2;13:769. doi: 10.3389/fnins.2019.00769. eCollection 2019.
512 TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.Front Cell Neurosci. 2018 Nov 13;12:417. doi: 10.3389/fncel.2018.00417. eCollection 2018.
513 The role of Ca(2+) in cell death caused by oxidative glutamate toxicity and ferroptosis.Cell Calcium. 2018 Mar;70:47-55. doi: 10.1016/j.ceca.2017.05.007. Epub 2017 May 12.
514 Long non-coding RNA-p21 regulates MPP(+)-induced neuronal injury by targeting miR-625 and derepressing TRPM2 in SH-SY5Y cells.Chem Biol Interact. 2019 Jul 1;307:73-81. doi: 10.1016/j.cbi.2019.04.017. Epub 2019 Apr 18.
515 Neuroprotective Role of MicroRNA-22 in a 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease via Regulation of Its Target Gene TRPM7.J Mol Neurosci. 2016 Dec;60(4):445-452. doi: 10.1007/s12031-016-0828-2. Epub 2016 Sep 8.
516 Sensation of TRPV1 via 5-hydroxytryptamine signaling modulates pain hypersensitivity in a 6-hydroxydopamine induced mice model of Parkinson's disease.Biochem Biophys Res Commun. 2020 Jan 22;521(4):868-873. doi: 10.1016/j.bbrc.2019.10.204. Epub 2019 Nov 7.
517 Discovery of Potent and Selective A(2A) Antagonists with Efficacy in Animal Models of Parkinson's Disease and Depression.ACS Med Chem Lett. 2017 Jul 5;8(8):835-840. doi: 10.1021/acsmedchemlett.7b00175. eCollection 2017 Aug 10.
518 Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids.Stem Cell Reports. 2019 Mar 5;12(3):518-531. doi: 10.1016/j.stemcr.2019.01.020. Epub 2019 Feb 21.
519 Age-dependent accumulation of oligomeric SNCA/-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).Autophagy. 2020 Feb;16(2):347-370. doi: 10.1080/15548627.2019.1603545. Epub 2019 Apr 14.
520 Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain.Neurobiol Learn Mem. 2007 Jan;87(1):42-56. doi: 10.1016/j.nlm.2006.05.004. Epub 2006 Jul 7.
521 Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.Nat Commun. 2019 Mar 7;10(1):973. doi: 10.1038/s41467-019-08858-y.
522 Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson's Disease.Sci Rep. 2018 Mar 13;8(1):4468. doi: 10.1038/s41598-018-22804-w.
523 Does uncoupling protein 2 expression qualify as marker of disease status in LRRK2-associated Parkinson's disease?.Antioxid Redox Signal. 2014 May 1;20(13):1955-60. doi: 10.1089/ars.2013.5737. Epub 2014 Mar 7.
524 AAV-Mediated Expression of Dominant-Negative ULK1 Increases Neuronal Survival and Enhances Motor Performance in the MPTP Mouse Model of Parkinson's Disease.Mol Neurobiol. 2020 Feb;57(2):685-697. doi: 10.1007/s12035-019-01744-0. Epub 2019 Aug 24.
525 Unilateral ultra-brief pulse electroconvulsive therapy for depression in Parkinson's disease.Acta Neurol Scand. 2017 Apr;135(4):407-411. doi: 10.1111/ane.12614. Epub 2016 May 31.
526 Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies.Hum Mol Genet. 2019 Feb 15;28(4):548-560. doi: 10.1093/hmg/ddy365.
527 Genotype-phenotype study in patients with valosin-containing protein mutations associated with multisystem proteinopathy.Clin Genet. 2018 Jan;93(1):119-125. doi: 10.1111/cge.13095.
528 MicroRNA Expression Profiling Screen miR-3557/324-Targeted CaMK/mTOR in the Rat Striatum of Parkinson's Disease in Regular Aerobic Exercise.Biomed Res Int. 2019 Jun 12;2019:7654798. doi: 10.1155/2019/7654798. eCollection 2019.
529 A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson's Disease.Front Cell Neurosci. 2019 Sep 18;13:421. doi: 10.3389/fncel.2019.00421. eCollection 2019.
530 YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity.Neurobiol Dis. 2018 Apr;112:14-23. doi: 10.1016/j.nbd.2018.01.006. Epub 2018 Jan 10.
531 The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.Autophagy. 2020 Jan;16(1):140-153. doi: 10.1080/15548627.2019.1598754. Epub 2019 Apr 7.
532 Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease.Mol Neurobiol. 2017 Aug;54(6):4292-4302. doi: 10.1007/s12035-016-9980-5. Epub 2016 Jun 23.
533 Eotaxins and C-C chemokine receptor type 3 in Parkinson's disease.Acta Neurol Belg. 2020 Jun;120(3):589-594. doi: 10.1007/s13760-018-01061-8. Epub 2018 Dec 13.
534 Genetics of early-onset Parkinson's disease in Finland: exome sequencing and genome-wide association study.Neurobiol Aging. 2017 May;53:195.e7-195.e10. doi: 10.1016/j.neurobiolaging.2017.01.019. Epub 2017 Feb 2.
535 What About the Role of Virtual Reality in Parkinson Disease's Cognitive Rehabilitation? Preliminary Findings From a Randomized Clinical Trial.J Geriatr Psychiatry Neurol. 2018 Nov;31(6):312-318. doi: 10.1177/0891988718807973. Epub 2018 Oct 25.
536 The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain.Autophagy. 2018;14(11):1898-1910. doi: 10.1080/15548627.2018.1491489. Epub 2018 Aug 10.
537 Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP?Neurotoxicity.Int J Mol Sci. 2018 Nov 10;19(11):3543. doi: 10.3390/ijms19113543.
538 Discovery of Novel Cell Surface Markers for Purification of Embryonic Dopamine Progenitors for Transplantation in Parkinson's Disease Animal Models.Mol Cell Proteomics. 2018 Sep;17(9):1670-1684. doi: 10.1074/mcp.RA118.000809. Epub 2018 May 29.
539 Biological and Pharmacological Characterization of Benzothiazole-Based CK-1 Inhibitors in Models of Parkinson's Disease.ACS Omega. 2017 Aug 31;2(8):5215-5220. doi: 10.1021/acsomega.7b00869. Epub 2017 Aug 30.
540 Optimization of M(4) positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology.Bioorg Med Chem Lett. 2017 Jun 1;27(11):2296-2301. doi: 10.1016/j.bmcl.2017.04.043. Epub 2017 Apr 13.
541 Prolyl oligopeptidase and dipeptidyl peptidase II/dipeptidyl peptidase IV ratio in the cerebrospinal fluid in Parkinson's disease: historical overview and future prospects.J Neural Transm (Vienna). 2017 Jun;124(6):739-744. doi: 10.1007/s00702-016-1604-8. Epub 2016 Aug 8.
542 Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.Acta Neuropathol Commun. 2018 Jul 2;6(1):54. doi: 10.1186/s40478-018-0554-9.
543 Discovering the 3' UTR-mediated regulation of alpha-synuclein.Nucleic Acids Res. 2017 Dec 15;45(22):12888-12903. doi: 10.1093/nar/gkx1048.
544 Prion-like Propagation of -Synuclein Is Regulated by the FcRIIB-SHP-1/2 Signaling Pathway in Neurons.Cell Rep. 2018 Jan 2;22(1):136-148. doi: 10.1016/j.celrep.2017.12.009.
545 The role of polyunsaturated fatty acids and GPR40 receptor in brain.Neuropharmacology. 2017 Feb;113(Pt B):639-651. doi: 10.1016/j.neuropharm.2015.05.013. Epub 2015 May 22.
546 Changes in self-perception in patients treated with neurostimulating devices.Epilepsy Behav. 2019 Jan;90:25-30. doi: 10.1016/j.yebeh.2018.10.012. Epub 2018 Nov 27.
547 Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies.Ann Neurol. 2020 Jan;87(1):139-153. doi: 10.1002/ana.25629. Epub 2019 Nov 18.
548 Measuring Anxiety in Older Adults: Development, Diagnostic Accuracy, and Preliminary Validation of a Short-Form of the German Geriatric Anxiety Scale (GAS-G-SF).J Pers Assess. 2020 Mar-Apr;102(2):196-204. doi: 10.1080/00223891.2019.1677679. Epub 2019 Oct 18.
549 Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson's disease animal model.J Neuroinflammation. 2018 Aug 13;15(1):227. doi: 10.1186/s12974-018-1251-0.
550 CIQ, a positive allosteric modulator of GluN2C/D-containing N-methyl-d-aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease.CNS Neurosci Ther. 2018 Feb;24(2):144-153. doi: 10.1111/cns.12784. Epub 2017 Dec 11.
551 Effects of Sub-Chronic MPTP Exposure on Behavioral and Cognitive Performance and the Microbiome of Wild-Type and mGlu8 Knockout Female and Male Mice.Front Behav Neurosci. 2018 Jul 18;12:140. doi: 10.3389/fnbeh.2018.00140. eCollection 2018.
552 Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson's Disease.Front Neurosci. 2018 Nov 15;12:835. doi: 10.3389/fnins.2018.00835. eCollection 2018.
553 A natural product from Cannabis sativa subsp. sativa inhibits homeodomain-interacting protein kinase 2 (HIPK2), attenuating MPP(+)-induced apoptosis in human neuroblastoma SH-SY5Y cells.Bioorg Chem. 2017 Jun;72:64-73. doi: 10.1016/j.bioorg.2017.03.011. Epub 2017 Mar 30.
554 Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone.J Neurochem. 2017 Apr;141(1):75-85. doi: 10.1111/jnc.13940.
555 Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.J Cell Sci. 2017 Jan 15;130(2):382-395. doi: 10.1242/jcs.196758. Epub 2016 Dec 1.
556 -Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.EMBO J. 2018 Jun 15;37(12):e98878. doi: 10.15252/embj.201798878. Epub 2018 May 16.
557 RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer's Disease and Parkinson's Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia.Front Neurosci. 2019 Mar 28;13:235. doi: 10.3389/fnins.2019.00235. eCollection 2019.
558 Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.EMBO Rep. 2017 May;18(5):712-725. doi: 10.15252/embr.201643585. Epub 2017 Mar 24.
559 Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson's Disease.Mol Neurobiol. 2017 Dec;54(10):7706-7721. doi: 10.1007/s12035-016-0258-8. Epub 2016 Nov 14.
560 Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide.Biochem Biophys Res Commun. 2017 Nov 18;493(2):879-886. doi: 10.1016/j.bbrc.2017.09.129. Epub 2017 Sep 25.
561 Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNF-mediated apoptosis.Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5944-E5953. doi: 10.1073/pnas.1806973115. Epub 2018 Jun 11.
562 Neuroprotective Effects of Echinacoside on Regulating the Stress-Active p38MAPK and NF-B p52 Signals in the Mice Model of Parkinson's Disease.Neurochem Res. 2017 Apr;42(4):975-985. doi: 10.1007/s11064-016-2130-7. Epub 2016 Dec 15.
563 Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization.Sci Rep. 2017 Feb 21;7:42880. doi: 10.1038/srep42880.
564 Pancreatic Polypeptide in Parkinson's Disease: A Potential Marker of Parasympathetic Denervation.J Parkinsons Dis. 2017;7(4):645-652. doi: 10.3233/JPD-171189.
565 Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets.J Neuroinflammation. 2018 Sep 20;15(1):272. doi: 10.1186/s12974-018-1305-3.
566 Anti-Inflammatory and Neuroprotective Effects of PGE(2) EP4 Signaling in Models of Parkinson's Disease.J Neuroimmune Pharmacol. 2017 Jun;12(2):292-304. doi: 10.1007/s11481-016-9713-6. Epub 2016 Oct 12.
567 Treating sleep apnea in Parkinson's disease with C-PAP: feasibility concerns and effects on cognition and alertness.Sleep Med. 2017 May;33:114-118. doi: 10.1016/j.sleep.2017.01.009. Epub 2017 Jan 27.
568 Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease.J Neurosci. 2017 Sep 27;37(39):9361-9379. doi: 10.1523/JNEUROSCI.0084-17.2017. Epub 2017 Aug 21.
569 MicroRNA-128 Protects Dopamine Neurons from Apoptosis and Upregulates the Expression of Excitatory Amino Acid Transporter 4 in Parkinson's Disease by Binding to AXIN1.Cell Physiol Biochem. 2018;51(5):2275-2289. doi: 10.1159/000495872. Epub 2018 Dec 7.
570 Renin-angiotensin system as a potential target for new therapeutic approaches in Parkinson's disease.Expert Opin Investig Drugs. 2017 Oct;26(10):1163-1173. doi: 10.1080/13543784.2017.1371133. Epub 2017 Aug 29.
571 Aspirin increases ferroportin 1 expression by inhibiting hepcidin via the JAK/STAT3 pathway in interleukin 6-treated PC-12 cells.Neurosci Lett. 2018 Jan 1;662:1-5. doi: 10.1016/j.neulet.2017.10.001. Epub 2017 Oct 4.
572 GAT-3 Dysfunction Generates Tonic Inhibition in External Globus Pallidus Neurons in Parkinsonian Rodents.Cell Rep. 2018 May 8;23(6):1678-1690. doi: 10.1016/j.celrep.2018.04.014.
573 Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson's disease therapy.J Clin Invest. 2017 Feb 1;127(2):720-734. doi: 10.1172/JCI90132. Epub 2017 Jan 23.
574 Expanding the ubiquitin code through post-translational modification.EMBO Rep. 2015 Sep;16(9):1071-83. doi: 10.15252/embr.201540891. Epub 2015 Aug 12.
575 Identification of transketolase as a target of PARIS in substantia nigra.Biochem Biophys Res Commun. 2017 Nov 18;493(2):1050-1056. doi: 10.1016/j.bbrc.2017.09.090. Epub 2017 Sep 20.
576 Bax-inhibitor-1 knockdown phenotypes are suppressed by Buffy and exacerbate degeneration in a Drosophila model of Parkinson disease.PeerJ. 2017 Feb 21;5:e2974. doi: 10.7717/peerj.2974. eCollection 2017.
577 Brown adipose tissue activation in a rat model of Parkinson's disease.Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E731-E736. doi: 10.1152/ajpendo.00049.2017. Epub 2017 Aug 29.
578 SNCA 3'UTR genetic variants in patients with Parkinson's disease and REM sleep behavior disorder.Neurol Sci. 2017 Jul;38(7):1233-1240. doi: 10.1007/s10072-017-2945-2. Epub 2017 Apr 13.
579 Downregulation of neuronal vasoactive intestinal polypeptide in Parkinson's disease and chronic constipation.Neurogastroenterol Motil. 2017 May;29(5):10.1111/nmo.12995. doi: 10.1111/nmo.12995. Epub 2016 Nov 27.
580 Long-term exposure to air pollution and the incidence of Parkinson's disease: A nested case-control study.PLoS One. 2017 Aug 15;12(8):e0182834. doi: 10.1371/journal.pone.0182834. eCollection 2017.
581 Changes in sphingomyelin level affect alpha-synuclein and ABCA5 expression.J Parkinsons Dis. 2012;2(1):41-6. doi: 10.3233/JPD-2012-11059.
582 Genetics of Parkinson disease and other movement disorders.Curr Opin Neurol. 2012 Aug;25(4):466-74. doi: 10.1097/WCO.0b013e3283547627.
583 Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson's disease.Neurochem Int. 2011 Aug;59(1):73-80. doi: 10.1016/j.neuint.2011.05.006. Epub 2011 Jun 6.
584 Associations of rs823128, rs1572931, and rs823156 polymorphisms with reduced Parkinson's disease risks.Neuroreport. 2017 Sep 27;28(14):936-941. doi: 10.1097/WNR.0000000000000846.
585 The critical role of Nramp1 in degrading -synuclein oligomers in microglia under iron overload condition.Neurobiol Dis. 2017 Aug;104:61-72. doi: 10.1016/j.nbd.2017.05.001. Epub 2017 May 2.
586 Mutation analysis of patients with neurodegenerative disorders using NeuroX array.Neurobiol Aging. 2015 Jan;36(1):545.e9-14. doi: 10.1016/j.neurobiolaging.2014.07.038. Epub 2014 Aug 1.
587 Wilson's disease and other neurological copper disorders.Lancet Neurol. 2015 Jan;14(1):103-13. doi: 10.1016/S1474-4422(14)70190-5.
588 Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice.Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11532-E11541. doi: 10.1073/pnas.1800886115. Epub 2018 Nov 15.
589 Carnitine levels and mutations in the SLC22A5 gene in Faroes patients with Parkinson's disease.Neurosci Lett. 2018 May 14;675:116-119. doi: 10.1016/j.neulet.2018.03.064. Epub 2018 Mar 31.
590 Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.J Neurochem. 2018 May;145(4):312-322. doi: 10.1111/jnc.14297. Epub 2018 Apr 15.
591 Genome-wide association study of Parkinson's disease in East Asians.Hum Mol Genet. 2017 Jan 1;26(1):226-232. doi: 10.1093/hmg/ddw379.
592 Glut9-mediated Urate Uptake Is Responsible for Its Protective Effects on Dopaminergic Neurons in Parkinson's Disease Models.Front Mol Neurosci. 2018 Jan 26;11:21. doi: 10.3389/fnmol.2018.00021. eCollection 2018.
593 Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.Neurotoxicology. 2014 Sep;44:314-25. doi: 10.1016/j.neuro.2014.08.006. Epub 2014 Aug 19.
594 Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson's Disease.Mol Neurobiol. 2018 Aug;55(8):6914-6926. doi: 10.1007/s12035-018-0903-5. Epub 2018 Jan 23.
595 Detection and interpretation of shared genetic influences on 42 human traits.Nat Genet. 2016 Jul;48(7):709-17. doi: 10.1038/ng.3570. Epub 2016 May 16.
596 Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.PLoS Genet. 2012;8(3):e1002548. doi: 10.1371/journal.pgen.1002548. Epub 2012 Mar 15.
597 Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.Ann Neurol. 2012 Mar;71(3):370-84. doi: 10.1002/ana.22687.
598 Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson's disease.Protoplasma. 2017 Jan;254(1):33-42. doi: 10.1007/s00709-015-0930-2. Epub 2016 Jan 29.
599 NCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson's Disease.Cell Death Dis. 2018 Jun 25;9(7):725. doi: 10.1038/s41419-018-0775-7.
600 L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease.Ann Neurol. 2004 Jul;56(1):51-60. doi: 10.1002/ana.20133.
601 The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds.Free Radic Biol Med. 2004 Sep 15;37(6):839-49. doi: 10.1016/j.freeradbiomed.2004.06.017.
602 Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese.Sci Rep. 2015 Oct 28;5:15891. doi: 10.1038/srep15891.
603 Polyamine pathway contributes to the pathogenesis of Parkinson disease.Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16970-5. doi: 10.1073/pnas.1011751107. Epub 2010 Sep 13.
604 Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease.Mol Neurodegener. 2016 Apr 19;11:29. doi: 10.1186/s13024-016-0097-0.
605 Multifactor dimensionality reduction analysis to elucidate the cross-talk between one-carbon and xenobiotic metabolic pathways in multi-disease models.Mol Biol Rep. 2015 Jul;42(7):1211-24. doi: 10.1007/s11033-015-3856-z. Epub 2015 Feb 4.
606 Citrullination Inactivates Nicotinamide- N-methyltransferase.ACS Chem Biol. 2018 Sep 21;13(9):2663-2672. doi: 10.1021/acschembio.8b00578. Epub 2018 Aug 8.
607 Genetic causes of Parkinson's disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR.BMC Med Genet. 2016 Sep 9;17(1):65. doi: 10.1186/s12881-016-0327-x.
608 Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A(2A) receptor over-activation in a rat model of Parkinson's disease.Br J Pharmacol. 2019 Sep;176(18):3666-3680. doi: 10.1111/bph.14771. Epub 2019 Aug 1.
609 High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease.FEBS J. 2007 Mar;274(5):1212-23. doi: 10.1111/j.1742-4658.2007.05665.x. Epub 2007 Jan 25.
610 ALDH1A1 regulates postsynaptic -opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling.Sci Rep. 2019 Mar 5;9(1):3602. doi: 10.1038/s41598-019-40326-x.
611 Parkinson's disease risk factors: genetic, environmental, or both?.Neurol Res. 2005 Mar;27(2):206-8. doi: 10.1179/016164105X22057.
612 Contrasting effects of selective MAGL and FAAH inhibition on dopamine depletion and GDNF expression in a chronic MPTP mouse model of Parkinson's disease.Neurochem Int. 2017 Nov;110:14-24. doi: 10.1016/j.neuint.2017.08.003. Epub 2017 Aug 5.
613 Tat-Frataxin protects dopaminergic neuronal cells against MPTP-induced toxicity in a mouse model of Parkinson's disease.Biochimie. 2012 Nov;94(11):2448-56. doi: 10.1016/j.biochi.2012.07.005. Epub 2012 Jul 15.
614 Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling.Neurobiol Aging. 2019 Jan;73:123-134. doi: 10.1016/j.neurobiolaging.2018.09.018. Epub 2018 Sep 25.
615 An Enriched Environment Ameliorates Oxidative Stress and Olfactory Dysfunction in Parkinson's Disease with -Synucleinopathy.Cell Transplant. 2018 May;27(5):831-839. doi: 10.1177/0963689717742662. Epub 2018 Apr 30.
616 Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson's Disease.Front Neurol. 2018 Apr 6;9:222. doi: 10.3389/fneur.2018.00222. eCollection 2018.
617 Methionine sulfoxide reductase (Msr) dysfunction in human brain disease.Free Radic Res. 2019 Dec;53(11-12):1144-1154. doi: 10.1080/10715762.2019.1662899. Epub 2019 Nov 27.
618 NAT2 polymorphisms and risk for Parkinson's disease: a systematic review and meta-analysis.Expert Opin Drug Metab Toxicol. 2016 Aug;12(8):937-46. doi: 10.1080/17425255.2016.1192127. Epub 2016 Jun 3.
619 MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure.Mol Cell. 2019 Aug 22;75(4):835-848.e8. doi: 10.1016/j.molcel.2019.06.031. Epub 2019 Aug 1.
620 Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
621 The prevalence of psychological distress in Parkinson's disease patients: The brief symptom inventory (BSI-18) versus the Hopkins symptom checklist (SCL-90-R).Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10;88:96-101. doi: 10.1016/j.pnpbp.2018.07.012. Epub 2018 Jul 12.
622 Association of UDP-glucuronosyltransferase 1A9 polymorphisms with adverse reactions to catechol-O-methyltransferase inhibitors in Parkinson's disease patients.Eur J Clin Pharmacol. 2012 Nov;68(11):1493-9. doi: 10.1007/s00228-012-1281-y. Epub 2012 Apr 15.
623 Depressive symptoms predict incident chronic disease burden 10years later: Findings from the English Longitudinal Study of Ageing (ELSA).J Psychosom Res. 2018 Oct;113:30-36. doi: 10.1016/j.jpsychores.2018.07.009. Epub 2018 Jul 21.
624 Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson's disease models.Exp Mol Med. 2018 Aug 17;50(8):1-13. doi: 10.1038/s12276-018-0124-z.
625 Hyperechogenicity of substantia nigra for differential diagnosis of Parkinson's disease: A meta-analysis.Parkinsonism Relat Disord. 2017 Sep;42:1-11. doi: 10.1016/j.parkreldis.2017.06.006. Epub 2017 Jun 15.
626 Impaired complex-I mitochondrial biogenesis in Parkinson disease frontal cortex.J Parkinsons Dis. 2012;2(1):67-76. doi: 10.3233/JPD-2012-11074.
627 Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease.J Neurochem. 2002 Oct;83(2):320-30. doi: 10.1046/j.1471-4159.2002.01118.x.
628 Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia.Hum Genet. 2004 Jun;115(1):29-35. doi: 10.1007/s00439-004-1123-9. Epub 2004 Apr 24.
629 Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.Acta Neuropathol. 2014;127(6):861-79. doi: 10.1007/s00401-014-1256-4. Epub 2014 Feb 14.
630 Intermediate alleles at the FRAXA and FRAXE loci in Parkinson's disease.Parkinsonism Relat Disord. 2011 May;17(4):281-4. doi: 10.1016/j.parkreldis.2010.12.013. Epub 2011 Jan 22.
631 Mask loss-of-function rescues mitochondrial impairment and muscle degeneration of Drosophila pink1 and parkin mutants.Hum Mol Genet. 2015 Jun 1;24(11):3272-85. doi: 10.1093/hmg/ddv081. Epub 2015 Mar 5.
632 Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers.Hum Genet. 2008 Nov;124(4):393-8. doi: 10.1007/s00439-008-0558-9. Epub 2008 Sep 7.
633 GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.Biochemistry. 2007 Feb 6;46(5):1380-8. doi: 10.1021/bi061960m.
634 GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.PLoS Genet. 2012;8(2):e1002526. doi: 10.1371/journal.pgen.1002526. Epub 2012 Feb 9.
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637 Dopamine D1 receptor activation improves adult hippocampal neurogenesis and exerts anxiolytic and antidepressant-like effect via activation of Wnt/-catenin pathways in rat model of Parkinson's disease.Neurochem Int. 2019 Jan;122:170-186. doi: 10.1016/j.neuint.2018.11.020. Epub 2018 Nov 28.
638 The Alzheimer disease BIN1 locus as a modifier of GBA-associated Parkinson disease.J Neurol. 2015 Nov;262(11):2443-7. doi: 10.1007/s00415-015-7868-3. Epub 2015 Aug 2.
639 Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological Relevance.Front Genet. 2019 Jan 25;9:701. doi: 10.3389/fgene.2018.00701. eCollection 2018.
640 HLA-linked complement markers in Alzheimer's and Parkinson's disease: C4 variant (C4B2) a possible marker for senile dementia of the Alzheimer type.Neurology. 1984 Mar;34(3):310-4. doi: 10.1212/wnl.34.3.310.
641 SNPs in CAST are associated with Parkinson disease: a confirmation study.Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):973-9. doi: 10.1002/ajmg.b.31061.
642 Investigation of the PARK10 gene in Parkinson disease.Ann Hum Genet. 2007 Sep;71(Pt 5):639-47. doi: 10.1111/j.1469-1809.2007.00353.x. Epub 2007 Mar 27.
643 CHRNB3 c.-57A>G functional promoter change affects Parkinson's disease and smoking.Neurobiol Aging. 2014 Sep;35(9):2179.e1-6. doi: 10.1016/j.neurobiolaging.2014.03.014. Epub 2014 Mar 20.
644 Glutathione-S-transferase-1 and interleukin-1beta gene polymorphisms in Japanese patients with Parkinson's disease.Mov Disord. 2005 Jul;20(7):901-2. doi: 10.1002/mds.20477.
645 Plasma-based circulating MicroRNA biomarkers for Parkinson's disease.J Parkinsons Dis. 2012;2(4):321-31. doi: 10.3233/JPD-012144.
646 Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.Mol Cell Proteomics. 2008 Jul;7(7):1191-203. doi: 10.1074/mcp.M700467-MCP200. Epub 2008 Mar 18.
647 Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.J Biol Chem. 2006 Jun 16;281(24):16193-6. doi: 10.1074/jbc.C600041200. Epub 2006 May 3.
648 A high-efficiency induction of dopaminergic cells from human umbilical mesenchymal stem cells for the treatment of hemiparkinsonian rats.Cell Transplant. 2015;24(11):2251-62. doi: 10.3727/096368914X685078. Epub 2014 Oct 6.
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650 Alpha-synuclein, alcohol use disorders, and Parkinson disease: a case-control study.Parkinsonism Relat Disord. 2009 Jul;15(6):430-4. doi: 10.1016/j.parkreldis.2008.11.011. Epub 2009 Feb 4.
651 CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients.Neurobiol Aging. 2017 Nov;59:1-9. doi: 10.1016/j.neurobiolaging.2017.06.028. Epub 2017 Jul 11.
652 Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease.Neurogenetics. 2006 Mar;7(1):1-11. doi: 10.1007/s10048-005-0020-2. Epub 2006 Jan 12.
653 Peripheral assessment of the genes AQP4, PBP and TH in patients with Parkinson's disease.Neurochem Res. 2012 Mar;37(3):512-5. doi: 10.1007/s11064-011-0637-5. Epub 2011 Nov 15.
654 Leucine-rich repeat kinase 2 and alternative splicing in Parkinson's disease.Mov Disord. 2012 Jul;27(8):1004-11. doi: 10.1002/mds.25005. Epub 2012 Apr 23.
655 Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.Brain. 2012 Jul;135(Pt 7):2058-73. doi: 10.1093/brain/aws133. Epub 2012 Jun 19.
656 Altered machinery of protein synthesis is region- and stage-dependent and is associated with -synuclein oligomers in Parkinson's disease.Acta Neuropathol Commun. 2015 Dec 1;3:76. doi: 10.1186/s40478-015-0257-4.
657 Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.Am J Hum Genet. 2005 Aug;77(2):252-64. doi: 10.1086/432588. Epub 2005 Jun 28.
658 EIF4G1 in familial Parkinson's disease: pathogenic mutations or rare benign variants?.Neurobiol Aging. 2012 Sep;33(9):2233.e1-2233.e5. doi: 10.1016/j.neurobiolaging.2012.05.006. Epub 2012 Jun 1.
659 Endonuclease G mediates -synuclein cytotoxicity during Parkinson's disease.EMBO J. 2013 Nov 27;32(23):3041-54. doi: 10.1038/emboj.2013.228. Epub 2013 Oct 15.
660 Genetic and phenotypic characterization of complex hereditary spastic paraplegia.Brain. 2016 Jul;139(Pt 7):1904-18. doi: 10.1093/brain/aww111. Epub 2016 May 23.
661 FADD: A link between TNF family receptors and caspases in Parkinson's disease.Neurology. 2002 Jan 22;58(2):308-10. doi: 10.1212/wnl.58.2.308.
662 Genetic analysis of the FBXO42 gene in Chinese Han patients with Parkinson's disease.BMC Neurol. 2013 Sep 25;13:125. doi: 10.1186/1471-2377-13-125.
663 Altered expression of CG5961, a putative Drosophila melanogaster homologue of FBXO9, provides a new model of Parkinson disease.Genet Mol Res. 2016 May 9;15(2). doi: 10.4238/gmr.15028579.
664 Neurotrophic support of midbrain dopaminergic neurons.Adv Exp Med Biol. 2009;651:73-80. doi: 10.1007/978-1-4419-0322-8_7.
665 Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson's disease patients.J Neuroimmunol. 2008 Sep 15;201-202:227-36. doi: 10.1016/j.jneuroim.2008.06.019. Epub 2008 Aug 8.
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667 A systematic screening to identify de novo mutations causing sporadic early-onset Parkinson's disease.Hum Mol Genet. 2015 Dec 1;24(23):6711-20. doi: 10.1093/hmg/ddv376. Epub 2015 Sep 11.
668 The human GLUD2 glutamate dehydrogenase and its regulation in health and disease.Neurochem Int. 2011 Sep;59(4):495-509. doi: 10.1016/j.neuint.2011.03.015. Epub 2011 Mar 21.
669 Mutations in GNAL: a novel cause of craniocervical dystonia.JAMA Neurol. 2014 Apr;71(4):490-4. doi: 10.1001/jamaneurol.2013.4677.
670 GRP78 Level Is Altered in the Brain, but Not in Plasma or Cerebrospinal Fluid in Parkinson's Disease Patients.Front Neurosci. 2019 Jul 5;13:697. doi: 10.3389/fnins.2019.00697. eCollection 2019.
671 Marginal association between SNP rs2046571 of the HAS2 gene and Parkinson's disease in the Chinese female population.Neurosci Lett. 2013 Sep 27;552:58-61. doi: 10.1016/j.neulet.2013.07.031. Epub 2013 Jul 31.
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677 Association analyses of variants of SIPA1L2, MIR4697, GCH1, VPS13C, and DDRGK1 with Parkinson's disease in East Asians.Neurobiol Aging. 2018 Aug;68:159.e7-159.e14. doi: 10.1016/j.neurobiolaging.2018.03.005. Epub 2018 Mar 10.
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680 Kinesin light chain 1 gene haplotypes in three conformational diseases.Neuromolecular Med. 2010 Sep;12(3):229-36. doi: 10.1007/s12017-009-8103-0. Epub 2009 Nov 13.
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684 Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review.Eur J Med Chem. 2019 May 1;169:185-199. doi: 10.1016/j.ejmech.2019.03.009. Epub 2019 Mar 8.
685 Identification of genetic modifiers of age-at-onset for familial Parkinson's disease.Hum Mol Genet. 2016 Sep 1;25(17):3849-3862. doi: 10.1093/hmg/ddw206. Epub 2016 Jul 11.
686 APOE and LRPAP1 gene polymorphism and risk of Parkinson's disease.Neurol Sci. 2014 Jul;35(7):1075-81. doi: 10.1007/s10072-014-1651-6. Epub 2014 Feb 7.
687 Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease.Hum Genet. 2005 Jun;117(1):27-33. doi: 10.1007/s00439-005-1259-2. Epub 2005 Apr 13.
688 Altered expression of autophagic genes in the peripheral leukocytes of patients with sporadic Parkinson's disease.Brain Res. 2011 Jun 7;1394:105-11. doi: 10.1016/j.brainres.2011.04.013. Epub 2011 Apr 13.
689 Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation.J Biol Chem. 2011 Mar 25;286(12):10367-77. doi: 10.1074/jbc.M110.206532. Epub 2011 Jan 24.
690 MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.J Neurochem. 2010 Mar;112(6):1593-604. doi: 10.1111/j.1471-4159.2010.06568.x. Epub 2010 Jan 7.
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692 Association between MDR1 gene polymorphisms and Parkinson's disease in Asian and Caucasian populations: a meta-analysis.J Neurol Sci. 2016 Sep 15;368:255-62. doi: 10.1016/j.jns.2016.07.041. Epub 2016 Jul 18.
693 Phytochemicals as Novel Therapeutic Strategies for NLRP3 Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases.Int J Mol Sci. 2019 Jun 13;20(12):2876. doi: 10.3390/ijms20122876.
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697 Oxidative DNA damage and level of thiols as related to polymorphisms of MTHFR, MTR, MTHFD1 in Alzheimer's and Parkinson's diseases.Acta Neurobiol Exp (Wars). 2007;67(2):113-29. doi: 10.55782/ane-2007-1639.
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719 An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease.J Neurosci. 2007 Aug 1;27(31):8314-23. doi: 10.1523/JNEUROSCI.1972-07.2007.
720 Neuroprotective effect of CNB-001, a novel pyrazole derivative of curcumin on biochemical and apoptotic markers against rotenone-induced SK-N-SH cellular model of Parkinson's disease.J Mol Neurosci. 2013 Nov;51(3):863-70. doi: 10.1007/s12031-013-0075-8. Epub 2013 Jul 31.
721 A ratiometric two-photon fluorescent probe reveals reduction in mitochondrial H2S production in Parkinson's disease gene knockout astrocytes.J Am Chem Soc. 2013 Jul 3;135(26):9915-23. doi: 10.1021/ja404004v. Epub 2013 Jun 18.
722 Variants in estrogen-related genes and risk of Parkinson's disease.Mov Disord. 2011 Jun;26(7):1234-42. doi: 10.1002/mds.23604. Epub 2011 Apr 5.
723 Novel DYT11 gene mutation in patients without dopaminergic deficit (SWEDD) screened for dystonia.Neurology. 2014 Sep 23;83(13):1155-62. doi: 10.1212/WNL.0000000000000821. Epub 2014 Aug 22.
724 Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.Nat Commun. 2016 Oct 5;7:12932. doi: 10.1038/ncomms12932.
725 PSMC1 Gene in Parkinson's Disease.Eur Neurol. 2012;68(4):193-8. doi: 10.1159/000339003. Epub 2012 Aug 29.
726 n-butylidenephthalide protects against dopaminergic neuron degeneration and -synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease.PLoS One. 2014 Jan 8;9(1):e85305. doi: 10.1371/journal.pone.0085305. eCollection 2014.
727 STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1202-7. doi: 10.1073/pnas.1417423112. Epub 2015 Jan 12.
728 Low-density lipoprotein receptor-related protein (LRP) gene 766T polymorphism and Parkinson's disease.Mov Disord. 1999 Sep;14(5):839-41. doi: 10.1002/1531-8257(199909)14:5<839::aid-mds1019>3.0.co;2-v.
729 GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10907-12. doi: 10.1073/pnas.0802437105. Epub 2008 Jul 31.
730 Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22474-9. doi: 10.1073/pnas.0912193106. Epub 2009 Dec 10.
731 Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.EMBO J. 2015 Nov 12;34(22):2840-61. doi: 10.15252/embj.201591593. Epub 2015 Oct 15.
732 Genome-wide assessment of Parkinson's disease in a Southern Spanish population.Neurobiol Aging. 2016 Sep;45:213.e3-213.e9. doi: 10.1016/j.neurobiolaging.2016.06.001. Epub 2016 Jun 11.
733 An association analysis of the rs1572931 polymorphism of the RAB7L1 gene in Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy in China.Eur J Neurol. 2014 Oct;21(10):1337-43. doi: 10.1111/ene.12490. Epub 2014 Jul 12.
734 Regulator of G-protein signaling-10 negatively regulates NF-B in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats.J Neurosci. 2011 Aug 17;31(33):11879-88. doi: 10.1523/JNEUROSCI.1002-11.2011.
735 SNPs in axon guidance pathway genes and susceptibility for Parkinson's disease in the Korean population.J Hum Genet. 2011 Feb;56(2):125-9. doi: 10.1038/jhg.2010.130. Epub 2010 Nov 18.
736 Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
737 GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia.PLoS One. 2016 Mar 3;11(3):e0149349. doi: 10.1371/journal.pone.0149349. eCollection 2016.
738 Autophagy: a potential key contributor to the therapeutic action of mesenchymal stem cells.Autophagy. 2020 Jan;16(1):28-37. doi: 10.1080/15548627.2019.1630223. Epub 2019 Jun 18.
739 Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons.Cell Stem Cell. 2019 Oct 3;25(4):514-530.e8. doi: 10.1016/j.stem.2019.08.013. Epub 2019 Sep 19.
740 Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra.Mov Disord. 2005 Oct;20(10):1299-309. doi: 10.1002/mds.20573.
741 A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.J Cell Sci. 2013 Feb 1;126(Pt 3):789-802. doi: 10.1242/jcs.114439. Epub 2012 Dec 13.
742 Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.EMBO J. 2014 Oct 16;33(20):2314-31. doi: 10.15252/embj.201487807. Epub 2014 Sep 8.
743 SEPT14 Is Associated with a Reduced Risk for Parkinson's Disease and Expressed in Human Brain.J Mol Neurosci. 2016 Jul;59(3):343-50. doi: 10.1007/s12031-016-0738-3. Epub 2016 Apr 26.
744 Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson's Disease.Trends Neurosci. 2019 Feb;42(2):140-149. doi: 10.1016/j.tins.2018.11.001. Epub 2018 Nov 30.
745 Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model.J Biol Chem. 2007 Jan 12;282(2):1288-95. doi: 10.1074/jbc.M607038200. Epub 2006 Nov 9.
746 Lentiviral Vector-Mediated SHC3 Silencing Exacerbates Oxidative Stress Injury in Nigral Dopamine Neurons by Regulating the PI3K-AKT-FoxO Signaling Pathway in Rats with Parkinson's Disease.Cell Physiol Biochem. 2018;49(3):971-984. doi: 10.1159/000493228. Epub 2018 Sep 5.
747 SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.PLoS One. 2013 Oct 30;8(10):e77711. doi: 10.1371/journal.pone.0077711. eCollection 2013.
748 Molecular markers of early Parkinson's disease based on gene expression in blood.Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):955-60. doi: 10.1073/pnas.0610204104. Epub 2007 Jan 10.
749 CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.Mol Cell. 2002 Jul;10(1):55-67. doi: 10.1016/s1097-2765(02)00583-x.
750 PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.Neurology. 2015 Mar 10;84(10):972-80. doi: 10.1212/WNL.0000000000001332. Epub 2015 Feb 6.
751 Genomic determinants of motor and cognitive outcomes in Parkinson's disease.Parkinsonism Relat Disord. 2012 Aug;18(7):881-6. doi: 10.1016/j.parkreldis.2012.04.025. Epub 2012 May 30.
752 Tef polymorphism is associated with sleep disturbances in patients with Parkinson's disease.Sleep Med. 2012 Mar;13(3):297-300. doi: 10.1016/j.sleep.2011.06.023. Epub 2012 Jan 17.
753 Novel THAP1 sequence variants in primary dystonia.Neurology. 2010 Jan 19;74(3):229-38. doi: 10.1212/WNL.0b013e3181ca00ca.
754 NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease.PLoS One. 2011;6(7):e21907. doi: 10.1371/journal.pone.0021907. Epub 2011 Jul 1.
755 Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinsons disease.Mov Disord. 2014 Apr;29(4):518-26. doi: 10.1002/mds.25729.
756 Metallomic profiling and linkage map analysis of early Parkinson's disease: a new insight to aluminum marker for the possible diagnosis.PLoS One. 2010 Jun 22;5(6):e11252. doi: 10.1371/journal.pone.0011252.
757 The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.Adv Exp Med Biol. 2013;961:241-9. doi: 10.1007/978-1-4614-4756-6_20.
758 Meta-Analysis of Parkinson's Disease Transcriptome Data Using TRAM Software: Whole Substantia Nigra Tissue and Single Dopamine Neuron Differential Gene Expression.PLoS One. 2016 Sep 9;11(9):e0161567. doi: 10.1371/journal.pone.0161567. eCollection 2016.
759 TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies.Neurobiol Dis. 2010 May;38(2):210-8. doi: 10.1016/j.nbd.2010.01.007. Epub 2010 Jan 18.
760 Expression changes of genes associated with apoptosis and survival processes in Parkinson's disease.Neurosci Lett. 2016 Feb 26;615:72-7. doi: 10.1016/j.neulet.2016.01.029. Epub 2016 Jan 22.
761 Altered N100-potential associates with working memory impairment in Parkinson's disease.J Neural Transm (Vienna). 2017 Oct;124(10):1197-1203. doi: 10.1007/s00702-017-1758-z. Epub 2017 Jul 14.
762 Down-regulation of B cell-related genes in peripheral blood leukocytes of Parkinson's disease patients with and without GBA mutations.Mol Genet Metab. 2016 Feb;117(2):179-85. doi: 10.1016/j.ymgme.2015.09.005. Epub 2015 Sep 14.
763 The analysis of association between SNCA, HUSEYO and CSMD1 gene variants and Parkinson's disease in Iranian population.Neurol Sci. 2016 May;37(5):731-6. doi: 10.1007/s10072-015-2420-x. Epub 2016 Jan 5.
764 Gene expression profiling predicts pathways and genes associated with Parkinson's disease.Neurol Sci. 2016 Jan;37(1):73-79. doi: 10.1007/s10072-015-2360-5. Epub 2015 Aug 13.
765 Conversion to Parkinson Disease in the PARS Hyposmic and Dopamine Transporter-Deficit Prodromal Cohort.JAMA Neurol. 2017 Aug 1;74(8):933-940. doi: 10.1001/jamaneurol.2017.0985.
766 Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2.FEBS J. 2017 Dec;284(23):4115-4127. doi: 10.1111/febs.14300. Epub 2017 Nov 13.
767 Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.J Neurosci. 2017 Jun 14;37(24):5870-5884. doi: 10.1523/JNEUROSCI.2705-16.2017. Epub 2017 May 18.
768 Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.Nat Commun. 2016 Mar 14;7:10943. doi: 10.1038/ncomms10943.
769 CK2 Oppositely Modulates l-DOPA-Induced Dyskinesia via Striatal Projection Neurons Expressing D1 or D2 Receptors.J Neurosci. 2017 Dec 6;37(49):11930-11946. doi: 10.1523/JNEUROSCI.0443-17.2017. Epub 2017 Nov 2.
770 Altered praxis network underlying limb kinetic apraxia in Parkinson's disease - an fMRI study.Neuroimage Clin. 2017 Jul 18;16:88-97. doi: 10.1016/j.nicl.2017.07.007. eCollection 2017.
771 SUMOylation and ubiquitination reciprocally regulate -synuclein degradation and pathological aggregation.Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13176-13181. doi: 10.1073/pnas.1704351114. Epub 2017 Nov 27.
772 Ropinirole alters gene expression profiles in SH-SY5Y cells: a whole genome microarray study.Braz J Med Biol Res. 2016 Feb;49(2):e4857. doi: 10.1590/1414-431X20154857. Epub 2016 Jan 19.
773 Mitochondrial division inhibitor-1 is neuroprotective in the A53T--synuclein rat model of Parkinson's disease.Sci Rep. 2017 Aug 8;7(1):7495. doi: 10.1038/s41598-017-07181-0.
774 Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.J Biol Chem. 2016 Jan 22;291(4):1803-1816. doi: 10.1074/jbc.M115.687319. Epub 2015 Dec 2.
775 Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.JAMA Neurol. 2017 Jul 1;74(7):780-792. doi: 10.1001/jamaneurol.2017.0469.
776 Mild Inflammatory Profile without Gliosis in the c-Rel Deficient Mouse Modeling a Late-Onset Parkinsonism.Front Aging Neurosci. 2017 Jul 19;9:229. doi: 10.3389/fnagi.2017.00229. eCollection 2017.
777 BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage.Oxid Med Cell Longev. 2017;2017:5094934. doi: 10.1155/2017/5094934. Epub 2017 Mar 2.
778 Dynamin-related protein 1: A protein critical for mitochondrial fission, mitophagy, and neuronal death in Parkinson's disease.Pharmacol Res. 2020 Jan;151:104553. doi: 10.1016/j.phrs.2019.104553. Epub 2019 Nov 21.
779 ERCC6L2 rs591486 polymorphism and risk for amyotrophic lateral sclerosis in Greek population.Neurol Sci. 2019 Jun;40(6):1237-1244. doi: 10.1007/s10072-019-03825-3. Epub 2019 Mar 16.
780 Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16691-6. doi: 10.1073/pnas.1006083107. Epub 2010 Sep 7.
781 Deregulation of glutamate dehydrogenase in human neurologic disorders.J Neurosci Res. 2013 Aug;91(8):1007-17. doi: 10.1002/jnr.23176. Epub 2013 Mar 6.
782 Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease.Mol Ther. 2005 Jan;11(1):80-8. doi: 10.1016/j.ymthe.2004.09.007.
783 Association of Parkinson's Disease GWAS-Linked Loci with Alzheimer's Disease in Han Chinese.Mol Neurobiol. 2017 Jan;54(1):308-318. doi: 10.1007/s12035-015-9649-5. Epub 2016 Jan 6.
784 Rab1 in cell signaling, cancer and other diseases.Oncogene. 2016 Nov 3;35(44):5699-5704. doi: 10.1038/onc.2016.81. Epub 2016 Apr 4.
785 Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.Sci Rep. 2017 Feb 8;7:41996. doi: 10.1038/srep41996.
786 Association of rs62063857 variant of the saitohin gene with Parkinson's disease.Cell Mol Neurobiol. 2015 Jan;35(1):115-21. doi: 10.1007/s10571-014-0102-5. Epub 2014 Aug 29.
787 Cerebrospinal Fluid Proteomics For Identification Of 2-Macroglobulin As A Potential Biomarker To Monitor Pharmacological Therapeutic Efficacy In Dopamine Dictated Disease States Of Parkinson's Disease And Schizophrenia.Neuropsychiatr Dis Treat. 2019 Oct 2;15:2853-2867. doi: 10.2147/NDT.S214217. eCollection 2019.
788 Postural sway in patients with early Parkinson's disease performing cognitive tasks while standing.Neurol Res. 2018 Jun;40(6):491-498. doi: 10.1080/01616412.2018.1451017. Epub 2018 Jun 5.
789 Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson's Disease in Taiwan.Parkinsons Dis. 2019 Jan 2;2019:3489638. doi: 10.1155/2019/3489638. eCollection 2019.
790 Clinical characteristics and quality of life in Chinese patients with Parkinson's disease beyond 20years.Neurol Res. 2018 Apr;40(4):312-317. doi: 10.1080/01616412.2018.1438227. Epub 2018 Feb 15.
791 Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.Lancet Neurol. 2006 Nov;5(11):911-6. doi: 10.1016/S1474-4422(06)70578-6.
792 Phosphorylation of Ser111 in Rab8a Modulates Rabin8-Dependent Activation by Perturbation of Side Chain Interaction Networks.Biochemistry. 2019 Aug 20;58(33):3546-3554. doi: 10.1021/acs.biochem.9b00516. Epub 2019 Aug 8.
793 CDK5-Mediated Phosphorylation-Dependent Ubiquitination and Degradation of E3 Ubiquitin Ligases GP78 Accelerates Neuronal Death in Parkinson's Disease.Mol Neurobiol. 2018 May;55(5):3709-3717. doi: 10.1007/s12035-017-0579-2. Epub 2017 May 20.
794 Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons.J Neurosci. 2003 Jul 2;23(13):5887-96. doi: 10.1523/JNEUROSCI.23-13-05887.2003.
795 SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes.Int J Mol Sci. 2019 Jul 4;20(13):3284. doi: 10.3390/ijms20133284.
796 The influence of SLC6A3 and DRD2 polymorphisms on levodopa-therapy in patients with sporadic Parkinson's disease.J Pharm Pharmacol. 2019 Feb;71(2):206-212. doi: 10.1111/jphp.13031. Epub 2018 Oct 23.
797 Role of ANO3 mutations in dystonia: A large-scale mutational screening study.Parkinsonism Relat Disord. 2019 May;62:196-200. doi: 10.1016/j.parkreldis.2018.12.030. Epub 2019 Jan 2.
798 Gene therapy for Parkinson's disease.J Neural Transm Suppl. 2003;(65):205-13. doi: 10.1007/978-3-7091-0643-3_13.
799 Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson's Disease: A Cross-Sectional Study.Parkinsons Dis. 2018 Mar 26;2018:3751516. doi: 10.1155/2018/3751516. eCollection 2018.
800 Aquaporin-4 deficiency reduces TGF-1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease.J Cell Mol Med. 2019 Apr;23(4):2568-2582. doi: 10.1111/jcmm.14147. Epub 2019 Jan 25.
801 The Impact of Short and Long-Term Exercise on the Expression of Arc and AMPARs During Evolution of the 6-Hydroxy-Dopamine Animal Model of Parkinson's Disease.J Mol Neurosci. 2017 Apr;61(4):542-552. doi: 10.1007/s12031-017-0896-y. Epub 2017 Feb 28.
802 Astrocytic JWA deletion exacerbates dopaminergic neurodegeneration by decreasing glutamate transporters in mice.Cell Death Dis. 2018 Mar 2;9(3):352. doi: 10.1038/s41419-018-0381-8.
803 Antiparkinsonian trophic action of glial cell line-derived neurotrophic factor and transforming growth factor 1 is enhanced after co-infusion in rats.Exp Neurol. 2010 Nov;226(1):136-47. doi: 10.1016/j.expneurol.2010.08.016. Epub 2010 Aug 14.
804 Examination of the MASH1 gene in patients with Parkinson's disease.Biochem Biophys Res Commun. 2010 Feb 19;392(4):548-50. doi: 10.1016/j.bbrc.2010.01.061. Epub 2010 Jan 25.
805 Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson's disease.Neurosci Lett. 2004 Jan 30;355(3):193-6. doi: 10.1016/j.neulet.2003.11.006.
806 Activation of the ATF2/CREB-PGC-1 pathway by metformin leads to dopaminergic neuroprotection.Oncotarget. 2017 Jul 25;8(30):48603-48618. doi: 10.18632/oncotarget.18122.
807 Chinese Herbal Complex 'Bu Shen Jie Du Fang' (BSJDF) Modulated Autophagy in an MPP(+)-Induced Cell Model of Parkinson's Disease.Evid Based Complement Alternat Med. 2019 Mar 13;2019:8920813. doi: 10.1155/2019/8920813. eCollection 2019.
808 Neuroprotective effects of Tat-ATOX1 protein against MPP(+)-induced SH-SY5Y cell deaths and in MPTP-induced mouse model of Parkinson's disease.Biochimie. 2019 Jan;156:158-168. doi: 10.1016/j.biochi.2018.10.010. Epub 2018 Oct 21.
809 Parkinson disease related ATP13A2 evolved early in animal evolution.PLoS One. 2018 Mar 5;13(3):e0193228. doi: 10.1371/journal.pone.0193228. eCollection 2018.
810 Renin-angiotensin system gene expression and neurodegenerative diseases.J Renin Angiotensin Aldosterone Syst. 2016 Sep 9;17(3):1470320316666750. doi: 10.1177/1470320316666750. Print 2016 Jul.
811 Olfactory Function in SCA10.Cerebellum. 2019 Feb;18(1):85-90. doi: 10.1007/s12311-018-0954-1.
812 siRNA-mediated knockdown of B3GALT4 decreases GM1 ganglioside expression and enhances vulnerability for neurodegeneration.Mol Cell Neurosci. 2019 Mar;95:25-30. doi: 10.1016/j.mcn.2019.01.001. Epub 2019 Jan 3.
813 BAG1 is neuroprotective in in vivo and in vitro models of Parkinson's disease.J Mol Neurosci. 2015 Mar;55(3):587-95. doi: 10.1007/s12031-014-0396-2. Epub 2014 Aug 9.
814 A search for cortical correlates of trait impulsivity in Parkinsons disease.Behav Brain Res. 2019 Sep 2;369:111911. doi: 10.1016/j.bbr.2019.111911. Epub 2019 Apr 13.
815 Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease.Sci Rep. 2017 Mar 10;7:44373. doi: 10.1038/srep44373.
816 Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.Ann Hum Genet. 2010 Mar;74(2):97-109. doi: 10.1111/j.1469-1809.2009.00560.x. Epub 2010 Jan 8.
817 Mutations in C19orf12 and intronic repeat expansions in C9orf72 not observed in Iranian Parkinson's disease patients.Neurobiol Aging. 2017 Jun;54:214.e11-214.e12. doi: 10.1016/j.neurobiolaging.2017.03.020. Epub 2017 Mar 18.
818 CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.Biochem Biophys Res Commun. 2017 Aug 26;490(3):876-881. doi: 10.1016/j.bbrc.2017.06.134. Epub 2017 Jun 21.
819 Proteomic analysis of urinary extracellular vesicles reveal biomarkers for neurologic disease.EBioMedicine. 2019 Jul;45:351-361. doi: 10.1016/j.ebiom.2019.06.021. Epub 2019 Jun 20.
820 Postural control deficit during sit-to-walk in patients with Parkinson's disease and freezing of gait.Gait Posture. 2018 Mar;61:325-330. doi: 10.1016/j.gaitpost.2018.01.032. Epub 2018 Feb 2.
821 Gene co-expression network analysis for identifying genetic markers in Parkinson's disease - a three-way comparative approach.Genomics. 2019 Jul;111(4):819-830. doi: 10.1016/j.ygeno.2018.05.005. Epub 2018 May 28.
822 Dysautonomia is associated with structural and functional alterations in Parkinson disease.Neurology. 2019 Mar 26;92(13):e1456-e1467. doi: 10.1212/WNL.0000000000007181. Epub 2019 Feb 22.
823 Rhododendrin-Induced RNF146 Expression via Estrogen Receptor Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.Int J Mol Sci. 2019 Apr 10;20(7):1772. doi: 10.3390/ijms20071772.
824 Proteomics and bioinformatics approaches for the identification of plasma biomarkers to detect Parkinson's disease.Exp Ther Med. 2019 Oct;18(4):2833-2842. doi: 10.3892/etm.2019.7888. Epub 2019 Aug 14.
825 Parkinson disease loci in the mid-western Amish.Hum Genet. 2013 Nov;132(11):1213-21. doi: 10.1007/s00439-013-1316-1. Epub 2013 Jun 21.
826 Alzheimer's disease susceptibility genes modify the risk of Parkinson disease and Parkinson's disease-associated cognitive impairment.Neurosci Lett. 2018 Jun 11;677:55-59. doi: 10.1016/j.neulet.2018.04.042. Epub 2018 Apr 24.
827 Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population.BMC Med Genet. 2011 Aug 3;12:104. doi: 10.1186/1471-2350-12-104.
828 Downregulated expression of microRNA-329 inhibits apoptosis of nigral dopaminergic neurons by regulating CDKN2D expression via the FoxO3a signaling pathway in rats with Parkinson's disease.J Cell Physiol. 2018 Nov;233(11):8617-8629. doi: 10.1002/jcp.26608. Epub 2018 May 15.
829 Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice.Neurobiol Dis. 2020 Feb;134:104696. doi: 10.1016/j.nbd.2019.104696. Epub 2019 Nov 26.
830 CHCHD10 is involved in the development of Parkinson's disease caused by CHCHD2 loss-of-function mutation p.T61I.Neurobiol Aging. 2019 Mar;75:38-41. doi: 10.1016/j.neurobiolaging.2018.10.020. Epub 2018 Oct 23.
831 Is the 1254T>C polymorphism in the DMT1 gene associated with Parkinson's disease?.Neurosci Lett. 2015 May 6;594:51-4. doi: 10.1016/j.neulet.2015.03.054. Epub 2015 Mar 26.
832 4-Hydroxynonenal and 4-Oxononenal Differentially Bind to the Redox Sensor MitoNEET.Chem Res Toxicol. 2019 Jun 17;32(6):977-981. doi: 10.1021/acs.chemrestox.9b00166. Epub 2019 May 29.
833 Parkin Mutation Affects Clock Gene-Dependent Energy Metabolism.Int J Mol Sci. 2019 Jun 5;20(11):2772. doi: 10.3390/ijms20112772.
834 Neurological and psychiatric associations in bullous pemphigoid-more than skin deep?.Exp Dermatol. 2017 Dec;26(12):1228-1234. doi: 10.1111/exd.13401. Epub 2017 Sep 24.
835 A Pooling Genome-Wide Association Study Combining a Pathway Analysis for Typical Sporadic Parkinson's Disease in the Han Population of Chinese Mainland.Mol Neurobiol. 2016 Sep;53(7):4302-18. doi: 10.1007/s12035-015-9331-y. Epub 2015 Jul 31.
836 Optimism, Pessimism, Coping, and Depression: A Study on Individuals With Parkinson's Disease.Int J Aging Hum Dev. 2019 Apr;88(3):231-249. doi: 10.1177/0091415018763401. Epub 2018 Mar 20.
837 Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease.Neuropsychopharmacology. 2019 Apr;44(5):837-849. doi: 10.1038/s41386-018-0090-0. Epub 2018 May 16.
838 Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson's disease.Ann Neurol. 1996 Sep;40(3):463-5. doi: 10.1002/ana.410400319.
839 Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease.J Neurosci Res. 2002 Nov 1;70(3):347-55. doi: 10.1002/jnr.10444.
840 Drebrin immunoreactivity in the striatum of a rat model of levodopa-induced dyskinesia.Neuropathology. 2013 Aug;33(4):391-6. doi: 10.1111/neup.12009. Epub 2012 Dec 13.
841 The protective effect of human platelet lysate in models of neurodegenerative disease: involvement of the Akt and MEK pathways.J Tissue Eng Regen Med. 2017 Nov;11(11):3236-3240. doi: 10.1002/term.2222. Epub 2016 Dec 12.
842 Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.PLoS Genet. 2011 Jun;7(6):e1002141. doi: 10.1371/journal.pgen.1002141. Epub 2011 Jun 23.
843 Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model.Redox Biol. 2019 Apr;22:101134. doi: 10.1016/j.redox.2019.101134. Epub 2019 Feb 8.
844 Subcellular redistribution of the synapse-associated proteins PSD-95 and SAP97 in animal models of Parkinson's disease and L-DOPA-induced dyskinesia.FASEB J. 2005 Apr;19(6):583-5. doi: 10.1096/fj.04-1854fje. Epub 2005 Feb 9.
845 The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss.Oxid Med Cell Longev. 2017;2017:7982389. doi: 10.1155/2017/7982389. Epub 2017 Feb 9.
846 Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes.J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):768-773. doi: 10.1136/jnnp-2018-320151. Epub 2019 Mar 13.
847 Investigation of the roles of dysbindin-1 and SATB2 in the progression of Parkinson's disease.Eur Rev Med Pharmacol Sci. 2019 Sep;23(17):7510-7516. doi: 10.26355/eurrev_201909_18865.
848 Lesion of the Locus Coeruleus Damages Learning and Memory Performance in Paraquat and Maneb-induced Mouse Parkinson's Disease Model.Neuroscience. 2019 Nov 1;419:129-140. doi: 10.1016/j.neuroscience.2019.09.006. Epub 2019 Oct 18.
849 Aberrantly expressed long noncoding RNAs and genes in Parkinson's disease.Neuropsychiatr Dis Treat. 2018 Nov 22;14:3219-3229. doi: 10.2147/NDT.S178435. eCollection 2018.
850 Association mapping of the PARK10 region for Parkinson's disease susceptibility genes.Parkinsonism Relat Disord. 2014 Jan;20(1):93-8. doi: 10.1016/j.parkreldis.2013.10.001. Epub 2013 Oct 11.
851 Cerebrospinal fluid levels of alpha-synuclein, amyloid , tau, phosphorylated tau, and neuron-specific enolase in patients with Parkinson's disease, dementia with Lewy bodies or other neurological disorders: Their relationships with cognition and nuclear medicine imaging findings.Neurosci Lett. 2020 Jan 10;715:134564. doi: 10.1016/j.neulet.2019.134564. Epub 2019 Nov 13.
852 Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson's Disease.Parkinsons Dis. 2018 Mar 1;2018:4163239. doi: 10.1155/2018/4163239. eCollection 2018.
853 Fasciculation and elongation protein zeta-1 (FEZ1) expression in reactive astrocytes in a rat model of Parkinson's disease.Neuropathol Appl Neurobiol. 2014 Feb;40(2):164-76. doi: 10.1111/nan.12077.
854 Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease.Sci Rep. 2012;2:953. doi: 10.1038/srep00953. Epub 2012 Dec 11.
855 Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's Disease.Cell Physiol Biochem. 2018;48(2):605-617. doi: 10.1159/000491889. Epub 2018 Jul 18.
856 MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients.Neurobiol Aging. 2018 Sep;69:283-291. doi: 10.1016/j.neurobiolaging.2018.05.032. Epub 2018 May 31.
857 Creating a graft-friendly environment for stem cells in diseased brains.J Clin Invest. 2018 Jan 2;128(1):116-119. doi: 10.1172/JCI98490. Epub 2017 Dec 11.
858 Overexpression of 17-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death.BMC Cancer. 2015 Mar 22;15:166. doi: 10.1186/s12885-015-1173-5.
859 Mitochondrial ferritin protects SH-SY5Y cells against H(2)O(2)-induced oxidative stress and modulates -synuclein expression.Exp Neurol. 2017 May;291:51-61. doi: 10.1016/j.expneurol.2017.02.001. Epub 2017 Feb 3.
860 Asymmetry of Periodic Leg Movements in Sleep (PLMS) in Parkinson's Disease.J Parkinsons Dis. 2020;10(1):255-266. doi: 10.3233/JPD-191667.
861 A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.Neurosci Lett. 2018 Apr 23;673:12-18. doi: 10.1016/j.neulet.2018.02.055. Epub 2018 Feb 26.
862 GC and VDR SNPs and Vitamin D Levels in Parkinson's Disease: The Relevance to Clinical Features.Neuromolecular Med. 2017 Mar;19(1):24-40. doi: 10.1007/s12017-016-8415-9. Epub 2016 Jun 9.
863 GLIS1 rs797906: an increased risk factor for late-onset Parkinson's disease in the Han Chinese population.Eur Neurol. 2012;68(2):89-92. doi: 10.1159/000337955. Epub 2012 Jul 3.
864 Effect of polygenic load on striatal dopaminergic deterioration in Parkinson disease.Neurology. 2019 Aug 13;93(7):e665-e674. doi: 10.1212/WNL.0000000000007939. Epub 2019 Jul 9.
865 Reducing glypican-4 in ES cells improves recovery in a rat model of Parkinson's disease by increasing the production of dopaminergic neurons and decreasing teratoma formation.J Neurosci. 2014 Jun 11;34(24):8318-23. doi: 10.1523/JNEUROSCI.2501-13.2014.
866 Immunoreactivity of a G protein-coupled l-DOPA receptor GPR143, in Lewy bodies.Neurosci Res. 2019 Nov;148:49-53. doi: 10.1016/j.neures.2018.12.004. Epub 2018 Dec 24.
867 GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells.Neuropharmacology. 2019 Jul 1;152:51-57. doi: 10.1016/j.neuropharm.2018.11.009. Epub 2018 Nov 10.
868 Prioritized brain selenium retention and selenoprotein expression: Nutritional insights into Parkinson's disease.Mech Ageing Dev. 2019 Jun;180:89-96. doi: 10.1016/j.mad.2019.04.004. Epub 2019 Apr 15.
869 Identification of Shared Genes Between Ischemic Stroke and Parkinson's Disease Using Genome-Wide Association Studies.Front Neurol. 2019 Mar 28;10:297. doi: 10.3389/fneur.2019.00297. eCollection 2019.
870 Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease.Sci Transl Med. 2010 Apr 21;2(28):28ra28. doi: 10.1126/scitranslmed.3000664.
871 Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease.Sci Rep. 2016 Oct 20;6:35203. doi: 10.1038/srep35203.
872 Glutathione S-transferase M1 polymorphisms and Parkinson's disease risk: a meta-analysis.Neurol Res. 2016 Feb;38(2):144-50. doi: 10.1080/01616412.2015.1126996. Epub 2016 Mar 16.
873 Simultaneous Relative Quantification of Various Polyglycerophospholipids with Isotope-Labeled Methylation by Nanoflow Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry.Anal Chem. 2019 May 21;91(10):6716-6723. doi: 10.1021/acs.analchem.9b00800. Epub 2019 Apr 30.
874 Hapln2 in Neurological Diseases and Its Potential as Therapeutic Target.Front Aging Neurosci. 2019 Mar 21;11:60. doi: 10.3389/fnagi.2019.00060. eCollection 2019.
875 Dopamine depletion induced up-regulation of HCN3 enhances rebound excitability of basal ganglia output neurons.Neurobiol Dis. 2009 Apr;34(1):178-88. doi: 10.1016/j.nbd.2009.01.007.
876 Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinsonian substantia nigra and present in the core of Lewy bodies.Clin Neuropathol. 2009 Sep-Oct;28(5):333-43.
877 The single nucleotide polymorphism Rs12817488 is associated with Parkinson's disease in the Chinese population.J Clin Neurosci. 2015 Jun;22(6):1002-4. doi: 10.1016/j.jocn.2014.11.024. Epub 2015 Mar 26.
878 The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration. J Neurochem. 2013 Jan;124(1):147-57. doi: 10.1111/jnc.12072. Epub 2012 Nov 21.
879 Association of common genetic variants of HOMER1 gene with levodopa adverse effects in Parkinson's disease patients. Pharmacogenomics J. 2014 Jun;14(3):289-94. doi: 10.1038/tpj.2013.37. Epub 2013 Oct 15.
880 Study of metabolic disorders associated with BDE-47 exposure in Drosophila model by MS-based metabolomics.Ecotoxicol Environ Saf. 2019 Nov 30;184:109606. doi: 10.1016/j.ecoenv.2019.109606. Epub 2019 Aug 28.
881 Effects of Exercise and Ferulic Acid on Alpha Synuclein and Neuroprotective Heat Shock Protein 70 in An Experimental Model of Parkinsonism Disease.CNS Neurol Disord Drug Targets. 2019;18(2):156-169. doi: 10.2174/1871527317666180816095707.
882 Neuronal specific and non-specific responses to cadmium possibly involved in neurodegeneration: A toxicogenomics study in a human neuronal cell model.Neurotoxicology. 2020 Jan;76:162-173. doi: 10.1016/j.neuro.2019.11.002. Epub 2019 Nov 16.
883 Possible involvement of iron-induced oxidative insults in neurodegeneration.Neurosci Lett. 2015 Feb 19;588:29-35. doi: 10.1016/j.neulet.2014.12.052. Epub 2014 Dec 27.
884 Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease.Brain Behav Immun. 2018 Jul;71:93-107. doi: 10.1016/j.bbi.2018.04.006. Epub 2018 Apr 9.
885 Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases.Aging Cell. 2019 Jun;18(3):e12941. doi: 10.1111/acel.12941. Epub 2019 Mar 5.
886 LDOC1 gene expression in two patients with head and neck squamous cell carcinomas and Parkinson's disease.Tumori. 2012 May-Jun;98(3):86e-88e. doi: 10.1700/1125.12418.
887 Modeling Parkinson's disease in adult Drosophila.J Neurosci Methods. 2019 Jan 1;311:89-94. doi: 10.1016/j.jneumeth.2018.10.018. Epub 2018 Oct 15.
888 Analysis and meta-analysis of five polymorphisms of the LINGO1 and LINGO2 genes in Parkinson's disease and multiple system atrophy in a Chinese population.J Neurol. 2015 Nov;262(11):2478-83. doi: 10.1007/s00415-015-7870-9. Epub 2015 Aug 8.
889 Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons.Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4387-96. doi: 10.1073/pnas.1520387113. Epub 2016 Jul 12.
890 Genetic Analysis of LRRK1 and LRRK2 Variants in Essential Tremor Patients.Genet Test Mol Biomarkers. 2018 Jun;22(6):398-402. doi: 10.1089/gtmb.2017.0277. Epub 2018 May 29.
891 U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16562-7. doi: 10.1073/pnas.1310249110. Epub 2013 Sep 10.
892 Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease.Mol Neurobiol. 2017 May;54(4):2878-2888. doi: 10.1007/s12035-016-9861-y. Epub 2016 Mar 28.
893 Meta-Analysis of Parkinson's Disease and Alzheimer's Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes.J Alzheimers Dis. 2017;56(4):1525-1539. doi: 10.3233/JAD-161032.
894 Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus.Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14280-14289. doi: 10.1073/pnas.1900576116. Epub 2019 Jun 24.
895 The PPARGC1A locus and CNS-specific PGC-1 isoforms are associated with Parkinson's Disease.Neurobiol Dis. 2019 Jan;121:34-46. doi: 10.1016/j.nbd.2018.09.016. Epub 2018 Sep 17.
896 Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease. Chem Res Toxicol. 2011 Oct 17;24(10):1644-52. doi: 10.1021/tx200082h. Epub 2011 Aug 22.
897 Role of microtubule-associated protein 6 glycosylated with Gal-(-1,3)-GalNAc in Parkinson's disease.Aging (Albany NY). 2019 Jul 9;11(13):4597-4610. doi: 10.18632/aging.102072.
898 Impaired set shifting is associated with previous falls in individuals with and without Parkinson's disease.Gait Posture. 2018 May;62:220-226. doi: 10.1016/j.gaitpost.2018.02.027. Epub 2018 Mar 6.
899 Incidence of Mild Cognitive Impairment and Dementia in Parkinson's Disease: The Parkinson's Disease Cognitive Impairment Study.Front Aging Neurosci. 2019 Feb 8;11:21. doi: 10.3389/fnagi.2019.00021. eCollection 2019.
900 Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease.Biol Open. 2019 Oct 15;8(10):bio044347. doi: 10.1242/bio.044347.
901 Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1 transcription. Cell. 2013 Dec 5;155(6):1351-64. doi: 10.1016/j.cell.2013.11.009. Epub 2013 Nov 27.
902 Salidroside protects dopaminergic neurons by regulating the mitochondrial MEF2D-ND6 pathway in the MPTP/MPP(+) -induced model of Parkinson's disease.J Neurochem. 2020 Apr;153(2):276-289. doi: 10.1111/jnc.14868. Epub 2019 Oct 27.
903 AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression.Neuromolecular Med. 2019 Mar;21(1):25-32. doi: 10.1007/s12017-018-8517-7. Epub 2018 Nov 8.
904 Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).Hum Mutat. 2014 Apr;35(4):395-412. doi: 10.1002/humu.22515. Epub 2014 Feb 24.
905 Ferulic acid reinstates mitochondrial dynamics through PGC1 expression modulation in 6-hydroxydopamine lesioned rats.Phytother Res. 2020 Jan;34(1):214-226. doi: 10.1002/ptr.6523. Epub 2019 Oct 27.
906 Midnolin is a confirmed genetic risk factor for Parkinson's disease.Ann Clin Transl Neurol. 2019 Nov;6(11):2205-2211. doi: 10.1002/acn3.50914. Epub 2019 Oct 6.
907 Expression of Aquaporin 1 and Aquaporin 4 in the Temporal Neocortex of Patients with Parkinson's Disease.Brain Pathol. 2017 Mar;27(2):160-168. doi: 10.1111/bpa.12369. Epub 2016 Apr 6.
908 Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease.CNS Neurosci Ther. 2020 May;26(5):527-537. doi: 10.1111/cns.13277. Epub 2019 Dec 8.
909 SH-SY5Y and LUHMES cells display differential sensitivity to MPP+, tunicamycin, and epoxomicin in 2D and 3D cell culture.Biotechnol Prog. 2020 Mar;36(2):e2942. doi: 10.1002/btpr.2942. Epub 2019 Dec 12.
910 Aging, rather than Parkinson's disease, affects the responsiveness of PBMCs to the immunosuppression of bone marrow mesenchymal stem cells.Mol Med Rep. 2019 Jan;19(1):165-176. doi: 10.3892/mmr.2018.9670. Epub 2018 Nov 19.
911 Novel Oxindole-Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection.ACS Chem Neurosci. 2020 Jan 2;11(1):76-85. doi: 10.1021/acschemneuro.9b00619. Epub 2019 Dec 18.
912 Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease.Neurosci Lett. 2010 Dec 17;486(3):228-30. doi: 10.1016/j.neulet.2010.09.059. Epub 2010 Sep 29.
913 MUL1 gene polymorphisms and Parkinson's disease risk.Acta Neurol Scand. 2019 May;139(5):483-487. doi: 10.1111/ane.13081. Epub 2019 Mar 14.
914 Non-SMC condensin I complex, subunit D2 gene polymorphisms are associated with Parkinson's disease: a Han Chinese study.Genome. 2014 May;57(5):253-7. doi: 10.1139/gen-2014-0032. Epub 2014 Aug 11.
915 Acanthopanax senticosus Protects Structure and Function of Mesencephalic Mitochondria in A Mouse Model of Parkinson's Disease.Chin J Integr Med. 2018 Nov;24(11):835-843. doi: 10.1007/s11655-018-2935-5. Epub 2018 Aug 8.
916 Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease.Neurosci Lett. 2015 Feb 5;587:98-101. doi: 10.1016/j.neulet.2014.12.005. Epub 2014 Dec 12.
917 Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson's disease.Neurochem Res. 2011 Aug;36(8):1435-43. doi: 10.1007/s11064-011-0469-3. Epub 2011 Apr 12.
918 A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA.Sci Rep. 2017 Aug 25;7(1):9528. doi: 10.1038/s41598-017-09910-x.
919 Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson's and related diseases.Parkinsonism Relat Disord. 2019 Apr;61:82-87. doi: 10.1016/j.parkreldis.2018.11.021. Epub 2018 Nov 20.
920 Ndfip1 attenuated 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.Neurobiol Aging. 2015 Feb;36(2):1183-93. doi: 10.1016/j.neurobiolaging.2014.10.021. Epub 2014 Oct 18.
921 Astrocyte-specific NDRG2 gene: functions in the brain and neurological diseases.Cell Mol Life Sci. 2020 Jul;77(13):2461-2472. doi: 10.1007/s00018-019-03406-9. Epub 2019 Dec 13.
922 Initiation of neuronal damage by complex I deficiency and oxidative stress in Parkinson's disease.Neurochem Res. 2004 Mar;29(3):569-77. doi: 10.1023/b:nere.0000014827.94562.4b.
923 Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness?.Exp Neurol. 2012 Dec;238(2):89-99. doi: 10.1016/j.expneurol.2012.08.008. Epub 2012 Aug 19.
924 CSF and blood biomarkers for Parkinson's disease.Lancet Neurol. 2019 Jun;18(6):573-586. doi: 10.1016/S1474-4422(19)30024-9. Epub 2019 Apr 10.
925 Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.Neural Plast. 2017;2017:4153076. doi: 10.1155/2017/4153076. Epub 2017 May 28.
926 Nei-like 1 inhibition results in motor dysfunction and promotes inflammation in Parkinson's disease mice model.Biochem Biophys Res Commun. 2020 Jan 1;521(1):245-251. doi: 10.1016/j.bbrc.2019.10.118. Epub 2019 Oct 22.
927 The Neuroprotective Effect of Dimethyl Fumarate in an MPTP-Mouse Model of Parkinson's Disease: Involvement of Reactive Oxygen Species/Nuclear Factor-kB/Nuclear Transcription Factor Related to NF-E2. Antioxid Redox Signal. 2017 Sep 10;27(8):453-471.
928 Understanding the Care Needs and Profile of People Living at Home With Moderate to Advanced Stage Parkinson Disease.J Geriatr Psychiatry Neurol. 2018 Sep;31(5):237-247. doi: 10.1177/0891988718788680. Epub 2018 Jul 16.
929 Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20.
930 Predictive markers for Parkinson's disease using deep neural nets on neuromelanin sensitive MRI.Neuroimage Clin. 2019;22:101748. doi: 10.1016/j.nicl.2019.101748. Epub 2019 Mar 6.
931 Dysregulation of serum NADPH oxidase1 and ferritin levels provides insights into diagnosis of Parkinson's disease.Clin Biochem. 2017 Dec;50(18):1087-1092. doi: 10.1016/j.clinbiochem.2017.09.014. Epub 2017 Sep 20.
932 Pyrosequencing analysis of methylation levels of clock genes in leukocytes from Parkinson's disease patients.Neurosci Lett. 2018 Mar 6;668:115-119. doi: 10.1016/j.neulet.2018.01.027. Epub 2018 Jan 17.
933 Niemann-Pick C disease gene mutations and age-related neurodegenerative disorders.PLoS One. 2013 Dec 30;8(12):e82879. doi: 10.1371/journal.pone.0082879. eCollection 2013.
934 Development of a Parenteral Formulation of NTS-Polyplex Nanoparticles for Clinical Purpose.Pharmaceutics. 2018 Jan 3;10(1):5. doi: 10.3390/pharmaceutics10010005.
935 The association of low levels of nesfatin-1 and glucagon-like peptide-1 with oxidative stress in Parkinson's disease.Neurol Sci. 2019 Dec;40(12):2529-2535. doi: 10.1007/s10072-019-03975-4. Epub 2019 Jul 6.
936 Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease.Acta Neuropathol. 2020 Feb;139(2):319-345. doi: 10.1007/s00401-019-02099-5. Epub 2019 Nov 25.
937 Odor Identification Performance in Idiopathic Parkinson's Disease Is Associated With Gender and the Genetic Variability of the Olfactory Binding Protein.Chem Senses. 2019 May 29;44(5):311-318. doi: 10.1093/chemse/bjz020.
938 Abundant fish protein inhibits -synuclein amyloid formation.Sci Rep. 2018 Apr 3;8(1):5465. doi: 10.1038/s41598-018-23850-0.
939 Altered regulation of serum lysosomal acid hydrolase activities in Parkinson's disease: A potential peripheral biomarker?.Parkinsonism Relat Disord. 2019 Apr;61:132-137. doi: 10.1016/j.parkreldis.2018.10.032. Epub 2018 Nov 2.
940 Transcranial sonography in atypical parkinsonism: How reliable is it in real clinical practice? A multicentre comprehensive study.Parkinsonism Relat Disord. 2019 Nov;68:40-45. doi: 10.1016/j.parkreldis.2019.09.032. Epub 2019 Oct 1.
941 Evidence for encephalopsin immunoreactivity in interneurones and striosomes of the monkey striatum.Exp Brain Res. 2018 Apr;236(4):955-961. doi: 10.1007/s00221-018-5191-9. Epub 2018 Jan 29.
942 Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson's disease.Acta Neuropathol Commun. 2018 Sep 10;6(1):90. doi: 10.1186/s40478-018-0596-z.
943 Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson's disease.Brain Res. 2019 Nov 1;1722:146331. doi: 10.1016/j.brainres.2019.146331. Epub 2019 Jul 10.
944 Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases.Neurobiol Dis. 2007 Aug;27(2):238-47. doi: 10.1016/j.nbd.2007.04.014. Epub 2007 May 18.
945 Exploring white matter microstructure and olfaction dysfunction in early parkinson disease: diffusion MRI reveals new insight.Brain Imaging Behav. 2019 Feb;13(1):210-219. doi: 10.1007/s11682-017-9781-0.
946 Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson's disease.Neurobiol Aging. 2016 Mar;39:217.e13-5. doi: 10.1016/j.neurobiolaging.2015.11.025. Epub 2015 Dec 8.
947 Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells. Neuroscience. 2014 May 16;267:263-76. doi: 10.1016/j.neuroscience.2014.03.001. Epub 2014 Mar 12.
948 Neuropeptidomics: expanding proteomics downwards.Biochem Soc Trans. 2007 Jun;35(Pt 3):588-93. doi: 10.1042/BST0350588.
949 L-dopa co-drugs in nanostructured lipid carriers: A comparative study.Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:168-176. doi: 10.1016/j.msec.2016.11.060. Epub 2016 Nov 18.
950 Clinical findings of autosomal-dominant striatal degeneration and PDE8B mutation screening in parkinsonism and related disorders.Parkinsonism Relat Disord. 2019 Dec;69:94-98. doi: 10.1016/j.parkreldis.2019.11.002. Epub 2019 Nov 5.
951 Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration.PLoS One. 2015 Sep 11;10(9):e0136620. doi: 10.1371/journal.pone.0136620. eCollection 2015.
952 Rapid eye movement behavior disorder in drug-nave patients with Parkinson's disease.J Clin Neurosci. 2019 Jan;59:254-258. doi: 10.1016/j.jocn.2018.07.007. Epub 2018 Oct 9.
953 Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation.Sci Rep. 2019 May 29;9(1):8034. doi: 10.1038/s41598-019-44573-w.
954 Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.J Neurosci Res. 2007 Mar;85(4):798-804. doi: 10.1002/jnr.21164.
955 Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans.Sci Rep. 2019 Oct 23;9(1):15246. doi: 10.1038/s41598-019-51608-9.
956 Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases.J Clin Invest. 2019 Oct 1;129(10):4539-4549. doi: 10.1172/JCI129987.
957 Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson's disease.Acta Neuropathol Commun. 2017 Jan 5;5(1):1. doi: 10.1186/s40478-016-0408-2.
958 Respiratory disturbances in a mouse model of Parkinson's disease.Exp Physiol. 2019 May;104(5):729-739. doi: 10.1113/EP087507. Epub 2019 Mar 7.
959 Overlapping genetic architecture between Parkinson disease and melanoma.Acta Neuropathol. 2020 Feb;139(2):347-364. doi: 10.1007/s00401-019-02110-z. Epub 2019 Dec 16.
960 Reprogramming of a human induced pluripotent stem cell (iPSC) line (IBMSi012-A) from an early-onset Parkinson's disease patient harboring a homozygous p.D331Y mutation in the PLA2G6 gene.Stem Cell Res. 2019 May;37:101432. doi: 10.1016/j.scr.2019.101432. Epub 2019 Apr 5.
961 Plasticity-related gene 3 (LPPR1) and age at diagnosis of Parkinson disease.Neurol Genet. 2018 Oct 5;4(5):e271. doi: 10.1212/NXG.0000000000000271. eCollection 2018 Oct.
962 Retinal Microvascular Impairment in the Early Stages of Parkinson's Disease.Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4115-4122. doi: 10.1167/iovs.17-23230.
963 Genetic analysis of PODXL gene in patients with familial and young-onset Parkinson's disease in a Taiwanese population.Neurobiol Aging. 2019 Dec;84:235.e9-235.e10. doi: 10.1016/j.neurobiolaging.2019.08.027. Epub 2019 Sep 8.
964 Identification of potential diagnostic biomarkers for Parkinson's disease.FEBS Open Bio. 2019 Aug;9(8):1460-1468. doi: 10.1002/2211-5463.12687. Epub 2019 Jul 3.
965 PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.Elife. 2019 Oct 30;8:e50416. doi: 10.7554/eLife.50416.
966 Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease.Exp Neurol. 2018 May;303:95-107. doi: 10.1016/j.expneurol.2018.01.015. Epub 2018 Feb 9.
967 Age affects reinforcement learning through dopamine-based learning imbalance and high decision noise-not through Parkinsonian mechanisms.Neurobiol Aging. 2018 Aug;68:102-113. doi: 10.1016/j.neurobiolaging.2018.04.006. Epub 2018 Apr 19.
968 Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin.ACS Chem Neurosci. 2018 Nov 21;9(11):2701-2712. doi: 10.1021/acschemneuro.8b00144. Epub 2018 Jun 1.
969 PPP2R2B CAG repeat length in the Han Chinese in Taiwan: Association analyses in neurological and psychiatric disorders and potential functional implications.Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):124-9. doi: 10.1002/ajmg.b.30785.
970 Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.Neurosci Lett. 2017 Sep 29;658:114-120. doi: 10.1016/j.neulet.2017.08.029. Epub 2017 Aug 18.
971 Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson's Disease.Neurotox Res. 2018 Feb;33(2):377-387. doi: 10.1007/s12640-017-9800-3. Epub 2017 Aug 24.
972 PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology. Brain. 2014 May;137(Pt 5):1361-73. doi: 10.1093/brain/awu067. Epub 2014 Apr 9.
973 A Novel Small Molecule Supports the Survival of Cultured Dopamine Neurons and May Restore the Dopaminergic Innervation of the Brain in the MPTP Mouse Model of Parkinson's Disease.ACS Chem Neurosci. 2019 Oct 16;10(10):4337-4349. doi: 10.1021/acschemneuro.9b00396. Epub 2019 Sep 11.
974 Use of Overlapping Group LASSO Sparse Deep Belief Network to Discriminate Parkinson's Disease and Normal Control.Front Neurosci. 2019 Apr 29;13:396. doi: 10.3389/fnins.2019.00396. eCollection 2019.
975 Sequencing of the GBA coactivator, Saposin C, in Parkinson disease.Neurobiol Aging. 2018 Dec;72:187.e1-187.e3. doi: 10.1016/j.neurobiolaging.2018.06.034. Epub 2018 Jul 2.
976 PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation.Oncotarget. 2017 Oct 6;9(1):37-53. doi: 10.18632/oncotarget.21554. eCollection 2018 Jan 2.
977 Novel application of the gray-level co-occurrence matrix analysis in the parvalbumin stained hippocampal gyrus dentatus in distinct rat models of Parkinson's disease.Comput Biol Med. 2019 Dec;115:103482. doi: 10.1016/j.compbiomed.2019.103482. Epub 2019 Oct 4.
978 Microarray Analysis of the Molecular Mechanism Involved in Parkinson's Disease.Parkinsons Dis. 2018 Mar 1;2018:1590465. doi: 10.1155/2018/1590465. eCollection 2018.
979 Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease.J Alzheimers Dis. 2018;63(1):157-165. doi: 10.3233/JAD-180023.
980 Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking.PLoS One. 2019 Jan 14;14(1):e0208889. doi: 10.1371/journal.pone.0208889. eCollection 2019.
981 Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease.J Clin Neurol. 2019 Oct;15(4):488-495. doi: 10.3988/jcn.2019.15.4.488.
982 LncRNA HOTAIR targets miR-126-5p to promote the progression of Parkinson's disease through RAB3IP.Biol Chem. 2019 Aug 27;400(9):1217-1228. doi: 10.1515/hsz-2018-0431.
983 Cold-inducible protein RBM3 mediates hypothermic neuroprotection against neurotoxin rotenone via inhibition on MAPK signalling.J Cell Mol Med. 2019 Oct;23(10):7010-7020. doi: 10.1111/jcmm.14588. Epub 2019 Aug 22.
984 Comparison of Quantitative Electroencephalogram During Sleep in Depressed and Non-Depressed Patients with Parkinson's Disease.Med Sci Monit. 2019 Feb 7;25:1046-1052. doi: 10.12659/MSM.913931.
985 The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.PLoS One. 2017 Sep 6;12(9):e0184262. doi: 10.1371/journal.pone.0184262. eCollection 2017.
986 The deficiency of NRSF/REST enhances the pro-inflammatory function of astrocytes in a model of Parkinson's disease.Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165590. doi: 10.1016/j.bbadis.2019.165590. Epub 2019 Nov 7.
987 D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.J Neurosci. 2005 Feb 23;25(8):2157-65. doi: 10.1523/JNEUROSCI.2840-04.2005.
988 Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo.Exp Mol Med. 2018 Feb 9;50(2):e440. doi: 10.1038/emm.2017.261.
989 Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models.Cell Metab. 2019 Dec 3;30(6):1131-1140.e7. doi: 10.1016/j.cmet.2019.08.023. Epub 2019 Sep 26.
990 Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.Neural Regen Res. 2018 Jan;13(1):112-118. doi: 10.4103/1673-5374.224380.
991 c-Jun/Bim Upregulation in Dopaminergic Neurons Promotes Neurodegeneration in the MPTP Mouse Model of Parkinson's Disease.Neuroscience. 2019 Feb 10;399:117-124. doi: 10.1016/j.neuroscience.2018.12.026. Epub 2018 Dec 25.
992 Downregulation of RTN1-C attenuates MPP(+)-induced neuronal injury through inhibition of mGluR5 pathway in SN4741 cells.Brain Res Bull. 2019 Mar;146:1-6. doi: 10.1016/j.brainresbull.2018.11.026. Epub 2018 Dec 3.
993 c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD(+) cleavage activity to inhibit mitochondrial respiration.J Biol Chem. 2018 Dec 7;293(49):18933-18943. doi: 10.1074/jbc.RA118.004578. Epub 2018 Oct 17.
994 The Essential Role of Drp1 and Its Regulation by S-Nitrosylation of Parkin in Dopaminergic Neurodegeneration: Implications for Parkinson's Disease.Antioxid Redox Signal. 2016 Oct 10;25(11):609-622. doi: 10.1089/ars.2016.6634. Epub 2016 Aug 8.
995 No association of FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 polymorphisms with Parkinson's disease in a Chinese Han population.J Neural Transm (Vienna). 2015 Nov;122(11):1547-52. doi: 10.1007/s00702-015-1430-4. Epub 2015 Jul 30.
996 Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing -synuclein and Bax toxicity in yeast.Bioorg Med Chem Lett. 2019 Feb 1;29(3):454-460. doi: 10.1016/j.bmcl.2018.12.028. Epub 2018 Dec 13.
997 The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration.Biol Trace Elem Res. 2019 Mar;188(1):189-195. doi: 10.1007/s12011-018-1521-9. Epub 2018 Sep 18.
998 Selenium speciation analysis in the cerebrospinal fluid of patients with Parkinson's disease.J Trace Elem Med Biol. 2020 Jan;57:126412. doi: 10.1016/j.jtemb.2019.126412. Epub 2019 Sep 24.
999 Meta analysis of the association of rs7702187 SNP in SEMA5A gene with risk of Parkinson's disease.Eur Rev Med Pharmacol Sci. 2014;18(6):900-4.
1000 Modulation of ARTS and XIAP by Parkin Is Associated with Carnosic Acid Protects SH-SY5Y Cells against 6-Hydroxydopamine-Induced Apoptosis.Mol Neurobiol. 2018 Feb;55(2):1786-1794. doi: 10.1007/s12035-017-0443-4. Epub 2017 Feb 21.
1001 miR-185 and SEPT5 Genes May Contribute to Parkinson's Disease Pathophysiology.Oxid Med Cell Longev. 2019 Nov 14;2019:5019815. doi: 10.1155/2019/5019815. eCollection 2019.
1002 The homozygote AA genotype of the alpha1-antichymotrypsin gene may confer protection against early-onset Parkinson's disease in women.Parkinsonism Relat Disord. 2004 Dec;10(8):469-73. doi: 10.1016/j.parkreldis.2004.06.001.
1003 Phase lag index and spectral power as QEEG features for identification of patients with mild cognitive impairment in Parkinson's disease.Clin Neurophysiol. 2019 Oct;130(10):1937-1944. doi: 10.1016/j.clinph.2019.07.017. Epub 2019 Jul 25.
1004 Sestrin2 as Serum Protein Marker and Potential Therapeutic Target for Parkinson's Disease.J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):690-695. doi: 10.1093/gerona/glz234.
1005 Shared Molecular Signatures Across Neurodegenerative Diseases and Herpes Virus Infections Highlights Potential Mechanisms for Maladaptive Innate Immune Responses.Sci Rep. 2019 Jun 19;9(1):8795. doi: 10.1038/s41598-019-45129-8.
1006 ERK/MAP Kinase Activation is Evident in Activated Microglia of the Striatum and Substantia Nigra in an Acute and Chronically-Induced Mouse Model of Parkinson's Disease.Curr Neurovasc Res. 2018;15(4):336-344. doi: 10.2174/1567202616666181123152601.
1007 Phosphoregulation on mitochondria: Integration of cell and organelle responses.CNS Neurosci Ther. 2019 Jul;25(7):837-858. doi: 10.1111/cns.13141. Epub 2019 Apr 25.
1008 Comparative analysis of four disease prediction models of Parkinson's disease.Mol Cell Biochem. 2016 Jan;411(1-2):127-34. doi: 10.1007/s11010-015-2574-0. Epub 2015 Oct 5.
1009 Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation.Cell Death Differ. 2017 Jan;24(1):120-131. doi: 10.1038/cdd.2016.104. Epub 2016 Sep 30.
1010 Signal Alteration of Substantia Nigra on 3.0T Susceptibility-weighted Imaging in Parkinson's Disease and Vascular Parkinsonism.Curr Med Sci. 2019 Oct;39(5):831-835. doi: 10.1007/s11596-019-2113-4. Epub 2019 Oct 14.
1011 Inhibition of nSMase2 Reduces the Transfer of Oligomeric -Synuclein Irrespective of Hypoxia.Front Mol Neurosci. 2019 Aug 28;12:200. doi: 10.3389/fnmol.2019.00200. eCollection 2019.
1012 Abnormal pattern of brain glucose metabolism in Parkinson's disease: replication in three European cohorts.Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):437-450. doi: 10.1007/s00259-019-04570-7. Epub 2019 Nov 25.
1013 Synphilin-1 has neuroprotective effects on MPP(+)-induced Parkinson's disease model cells by inhibiting ROS production and apoptosis.Neurosci Lett. 2019 Jan 18;690:145-150. doi: 10.1016/j.neulet.2018.10.020. Epub 2018 Oct 11.
1014 Transcription factor PITX3 gene in Parkinson's disease.Neurobiol Aging. 2011 Apr;32(4):750-3. doi: 10.1016/j.neurobiolaging.2009.03.015. Epub 2009 Apr 24.
1015 Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease.Hum Mol Genet. 2018 May 1;27(9):1514-1532. doi: 10.1093/hmg/ddy059.
1016 Alzheimer disease associated variants in SORL1 accelerate dementia development in Parkinson disease.Neurosci Lett. 2018 May 1;674:123-126. doi: 10.1016/j.neulet.2018.03.036. Epub 2018 Mar 19.
1017 The Neuroprotective Effect of Steroid Receptor Coactivator-Interacting Protein (SIP) in Astrocyte Model of 1-Methyl-4-Phenylpyridinium (MPP?-Induced Parkinson's Disease.Med Sci Monit. 2019 Aug 3;25:5776-5784. doi: 10.12659/MSM.912106.
1018 SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease.PLoS One. 2010 Feb 8;5(2):e9104. doi: 10.1371/journal.pone.0009104.
1019 Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders.Brain Sci. 2018 Aug 13;8(8):154. doi: 10.3390/brainsci8080154.
1020 Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.Cell Physiol Biochem. 2018;45(2):808-818. doi: 10.1159/000487172. Epub 2018 Jan 31.
1021 The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease.Nat Commun. 2019 Nov 20;10(1):5234. doi: 10.1038/s41467-019-13144-y.
1022 STXBP1 encephalopathy: Connecting neurodevelopmental disorders with -synucleinopathies?.Neurology. 2019 Jul 16;93(3):114-123. doi: 10.1212/WNL.0000000000007786. Epub 2019 Jun 20.
1023 The Synaptic Vesicle Glycoprotein 2: Structure, Function, and Disease Relevance.ACS Chem Neurosci. 2019 Sep 18;10(9):3927-3938. doi: 10.1021/acschemneuro.9b00351. Epub 2019 Aug 23.
1024 Autophagy Activation Is Involved in Acidic Fibroblast Growth Factor Ameliorating Parkinson's Disease via Regulating Tribbles Homologue 3.Front Pharmacol. 2019 Dec 2;10:1428. doi: 10.3389/fphar.2019.01428. eCollection 2019.
1025 6-n-propylthiouracil taste disruption and TAS2R38 nontasting form in Parkinson's disease.Mov Disord. 2018 Aug;33(8):1331-1339. doi: 10.1002/mds.27391. Epub 2018 Mar 24.
1026 A baseline study for detection of Parkinson's disease with 3D-transcranial sonography and uni-lateral reconstruction.J Neurol Sci. 2019 Feb 15;397:16-21. doi: 10.1016/j.jns.2018.12.001. Epub 2018 Dec 3.
1027 Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies.JCI Insight. 2019 Aug 22;4(16):e129719. doi: 10.1172/jci.insight.129719.
1028 Pooled analysis of iron-related genes in Parkinson's disease: association with transferrin.Neurobiol Dis. 2014 Feb;62:172-8. doi: 10.1016/j.nbd.2013.09.019. Epub 2013 Oct 8.
1029 Altered Gut Microbiome in Parkinson's Disease and the Influence of Lipopolysaccharide in a Human -Synuclein Over-Expressing Mouse Model.Front Neurosci. 2019 Aug 7;13:839. doi: 10.3389/fnins.2019.00839. eCollection 2019.
1030 Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation.Autophagy. 2019 Sep;15(9):1495-1505. doi: 10.1080/15548627.2019.1586249. Epub 2019 Mar 19.
1031 Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson's Disease Mouse Model.Front Aging Neurosci. 2018 Jun 1;10:162. doi: 10.3389/fnagi.2018.00162. eCollection 2018.
1032 TMEM106B Effect on cognition in Parkinson disease and frontotemporal dementia.Ann Neurol. 2019 Jun;85(6):801-811. doi: 10.1002/ana.25486.
1033 A replication study of GWAS-genetic risk variants associated with Parkinson's disease in a Spanish population.Neurosci Lett. 2019 Nov 1;712:134425. doi: 10.1016/j.neulet.2019.134425. Epub 2019 Aug 17.
1034 Degradation of alpha-synuclein by dendritic cell factor 1 delays neurodegeneration and extends lifespan in Drosophila.Neurobiol Aging. 2018 Jul;67:67-74. doi: 10.1016/j.neurobiolaging.2018.03.010. Epub 2018 Mar 13.
1035 Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease.Cell Death Dis. 2018 Nov 7;9(11):1122. doi: 10.1038/s41419-018-1154-0.
1036 Wild-type and mutant (G2019S) leucine-rich repeat kinase 2 (LRRK2) associate with subunits of the translocase of outer mitochondrial membrane (TOM) complex.Exp Cell Res. 2019 Feb 15;375(2):72-79. doi: 10.1016/j.yexcr.2018.12.022. Epub 2018 Dec 28.
1037 TOX3 Variants Are Involved in Restless Legs Syndrome and Parkinson's Disease with Opposite Effects.J Mol Neurosci. 2018 Mar;64(3):341-345. doi: 10.1007/s12031-018-1031-4. Epub 2018 Feb 5.
1038 Novel biomolecular information in rotenone-induced cellular model of Parkinson's disease.Gene. 2018 Mar 20;647:244-260. doi: 10.1016/j.gene.2018.01.023. Epub 2018 Jan 10.
1039 Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease.Brain. 2017 Sep 1;140(9):2444-2459. doi: 10.1093/brain/awx202.
1040 Silencing of TRIM10 alleviates apoptosis in cellular model of Parkinson's disease.Biochem Biophys Res Commun. 2019 Oct 20;518(3):451-458. doi: 10.1016/j.bbrc.2019.08.041. Epub 2019 Aug 28.
1041 Parkinson's Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32.Mol Neurobiol. 2018 Apr;55(4):3490-3498. doi: 10.1007/s12035-017-0570-y. Epub 2017 May 15.
1042 Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014.Gut. 2019 Jan;68(1):18-24. doi: 10.1136/gutjnl-2017-315666. Epub 2018 May 21.
1043 New Targets for Parkinson's Disease: Adhesion G Protein-Coupled Receptor B1 is Downregulated by AMP-Activated Protein Kinase Activation.OMICS. 2018 Jul;22(7):493-501. doi: 10.1089/omi.2018.0047.
1044 AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease.Front Cell Neurosci. 2017 Aug 10;11:241. doi: 10.3389/fncel.2017.00241. eCollection 2017.
1045 AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells.Front Cell Neurosci. 2018 Apr 18;12:92. doi: 10.3389/fncel.2018.00092. eCollection 2018.
1046 Acid ceramidase inhibition ameliorates -synuclein accumulation upon loss of GBA1 function.Hum Mol Genet. 2018 Jun 1;27(11):1972-1988. doi: 10.1093/hmg/ddy105.
1047 Extended "Timed Up and Go" assessment as a clinical indicator of cognitive state in Parkinson's disease.J Neurol Sci. 2017 Apr 15;375:86-91. doi: 10.1016/j.jns.2017.01.050. Epub 2017 Jan 17.
1048 Abnormalities of age-related T cell senescence in Parkinson's disease.J Neuroinflammation. 2018 May 28;15(1):166. doi: 10.1186/s12974-018-1206-5.
1049 Gangliosides, -Synuclein, and Parkinson's Disease.Prog Mol Biol Transl Sci. 2018;156:435-454. doi: 10.1016/bs.pmbts.2017.12.009. Epub 2018 Feb 24.
1050 Suppressed microRNA-96 inhibits iNOS expression and dopaminergic neuron apoptosis through inactivating the MAPK signaling pathway by targeting CACNG5 in mice with Parkinson's disease.Mol Med. 2018 Nov 28;24(1):61. doi: 10.1186/s10020-018-0059-9.
1051 Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate.JCI Insight. 2018 Jul 26;3(14):e98202. doi: 10.1172/jci.insight.98202. eCollection 2018 Jul 26.
1052 U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells.Synapse. 2017 Sep;71(9). doi: 10.1002/syn.21980. Epub 2017 Jun 20.
1053 Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Dis Model Mech. 2017 May 1;10(5):619-631. doi: 10.1242/dmm.028035. Epub 2017 Jan 20.
1054 Impairment of mitochondria dynamics by human A53T -synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease.Exp Brain Res. 2017 Mar;235(3):731-742. doi: 10.1007/s00221-016-4836-9. Epub 2016 Nov 19.
1055 Upregulation of Cysteine Protease Cathepsin X in the 6-Hydroxydopamine Model of Parkinson's Disease.Front Mol Neurosci. 2018 Nov 2;11:412. doi: 10.3389/fnmol.2018.00412. eCollection 2018.
1056 A cullin-RING ubiquitin ligase targets exogenous -synuclein and inhibits Lewy body-like pathology.Sci Transl Med. 2019 Jun 5;11(495):eaau6722. doi: 10.1126/scitranslmed.aau6722.
1057 Neuroprotective effects of the gliopeptide ODN in an in vivo model of Parkinson's disease.Cell Mol Life Sci. 2018 Jun;75(11):2075-2091. doi: 10.1007/s00018-017-2727-2. Epub 2017 Dec 20.
1058 Dopamine Transporter Imaging has no Impact on Functional Outcomes in de Novo Probable Parkinson's Disease.J Parkinsons Dis. 2017;7(2):279-287. doi: 10.3233/JPD-160937.
1059 Assessing the sensitivity and specificity of cognitive screening measures for people with Parkinson's disease.NeuroRehabilitation. 2018;43(4):491-500. doi: 10.3233/NRE-182433.
1060 Identification of Critical Genes and miRNAs Associated with the Development of Parkinson's Disease.J Mol Neurosci. 2018 Aug;65(4):527-535. doi: 10.1007/s12031-018-1129-8. Epub 2018 Aug 6.
1061 N400 and emotional word processing in Parkinson's disease.Neuropsychology. 2017 Sep;31(6):585-595. doi: 10.1037/neu0000333. Epub 2017 Mar 13.
1062 Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2735-2740. doi: 10.1073/pnas.1621218114. Epub 2017 Jan 30.
1063 Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia.J Neurochem. 2018 May;145(3):258-270. doi: 10.1111/jnc.14296. Epub 2018 Feb 20.
1064 Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease.Neurosci Bull. 2017 Oct;33(5):510-514. doi: 10.1007/s12264-017-0122-5. Epub 2017 Mar 24.
1065 Glucosylsphingosine Promotes -Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.J Neurosci. 2017 Oct 4;37(40):9617-9631. doi: 10.1523/JNEUROSCI.1525-17.2017. Epub 2017 Aug 28.
1066 Comparison Between Automatic and Visual Scorings of REM Sleep Without Atonia for the Diagnosis of REM Sleep Behavior Disorder in Parkinson Disease.Sleep. 2017 Feb 1;40(2). doi: 10.1093/sleep/zsw060.
1067 Functional lesional neurosurgery for tremor: a systematic review and meta-analysis.J Neurol Neurosurg Psychiatry. 2018 Jul;89(7):717-726. doi: 10.1136/jnnp-2017-316302. Epub 2018 Jan 11.
1068 Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1.J Neurol Sci. 2017 Oct 15;381:176-181. doi: 10.1016/j.jns.2017.08.3235. Epub 2017 Aug 24.
1069 Potential Role of Mic60/Mitofilin in Parkinson's Disease.Front Neurosci. 2019 Jan 25;12:898. doi: 10.3389/fnins.2018.00898. eCollection 2018.
1070 Angiotensin II induces oxidative stress and upregulates neuroprotective signaling from the NRF2 and KLF9 pathway in dopaminergic cells.Free Radic Biol Med. 2018 Dec;129:394-406. doi: 10.1016/j.freeradbiomed.2018.10.409. Epub 2018 Oct 11.
1071 First comprehensive tool for screening pain in Parkinson's disease: the King's Parkinson's Disease Pain Questionnaire.Eur J Neurol. 2018 Oct;25(10):1255-1261. doi: 10.1111/ene.13691. Epub 2018 Jun 22.
1072 LRP10 in autosomal-dominant Parkinson's disease.Mov Disord. 2019 Jun;34(6):912-916. doi: 10.1002/mds.27693. Epub 2019 Apr 9.
1073 Assessment of Safety and Efficacy of Safinamide as a Levodopa Adjunct in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial.JAMA Neurol. 2017 Feb 1;74(2):216-224. doi: 10.1001/jamaneurol.2016.4467.
1074 Comparative assessment of 6-[(18) F]fluoro-L-m-tyrosine and 6-[(18) F]fluoro-L-dopa to evaluate dopaminergic presynaptic integrity in a Parkinson's disease rat model.J Neurochem. 2017 May;141(4):626-635. doi: 10.1111/jnc.14016. Epub 2017 Apr 12.
1075 Progression Rate Associated Peripheral Blood Biomarkers of Parkinson's Disease.J Mol Neurosci. 2018 Jul;65(3):312-318. doi: 10.1007/s12031-018-1102-6. Epub 2018 Jun 23.
1076 NCEH-1 modulates cholesterol metabolism and protects against -synuclein toxicity in a C. elegans model of Parkinson's disease.Hum Mol Genet. 2017 Oct 1;26(19):3823-3836. doi: 10.1093/hmg/ddx269.
1077 Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson's disease model.Cell Death Dis. 2017 Feb 2;8(2):e2574. doi: 10.1038/cddis.2016.454.
1078 Inhibition of microRNA-505 suppressed MPP+?induced cytotoxicity of SHSY5Y cells in an in vitro Parkinson's disease model.Eur J Pharmacol. 2018 Sep 15;835:11-18. doi: 10.1016/j.ejphar.2018.07.023. Epub 2018 Jul 17.
1079 Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders.Curr HIV/AIDS Rep. 2019 Feb;16(1):76-81. doi: 10.1007/s11904-019-00420-1.
1080 Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb.Behav Brain Funct. 2017 Jan 26;13(1):1. doi: 10.1186/s12993-017-0119-2.
1081 The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization.J Biol Chem. 2018 Feb 2;293(5):1642-1650. doi: 10.1074/jbc.RA117.000751. Epub 2017 Dec 6.
1082 Neuroprotective effects of pramipexole transdermal patch in the MPTP-induced mouse model of Parkinson's disease.J Pharmacol Sci. 2018 Sep;138(1):31-37. doi: 10.1016/j.jphs.2018.08.008. Epub 2018 Aug 26.
1083 Clinical variations in Parkinson's disease patients with or without REM sleep behaviour disorder: a meta-analysis.Sci Rep. 2017 Jan 16;7:40779. doi: 10.1038/srep40779.
1084 The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking.Hum Mol Genet. 2017 Feb 15;26(4):729-741. doi: 10.1093/hmg/ddw413.
1085 The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.Stem Cell Reports. 2018 Sep 11;11(3):651-664. doi: 10.1016/j.stemcr.2018.07.014. Epub 2018 Aug 23.
1086 Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain.Brain Res. 2019 Jan 1;1702:85-95. doi: 10.1016/j.brainres.2017.12.029. Epub 2017 Dec 21.
1087 Synapsin III deficiency hampers -synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.Acta Neuropathol. 2018 Oct;136(4):621-639. doi: 10.1007/s00401-018-1892-1. Epub 2018 Jul 25.
1088 Correlation of serum levels and gene expression of tumor necrosis factor--induced protein-8 like-2 with Parkinson disease severity.Metab Brain Dis. 2018 Dec;33(6):1955-1959. doi: 10.1007/s11011-018-0302-7. Epub 2018 Aug 13.
1089 Salusin- mediate neuroprotective effects for Parkinson's disease.Biochem Biophys Res Commun. 2018 Sep 10;503(3):1428-1433. doi: 10.1016/j.bbrc.2018.07.059. Epub 2018 Jul 13.
1090 Effects of Transcranial Direct Current Stimulation (tDCS) Over the Frontal Polar Area on Motor and Executive Functions in Parkinson's Disease; A Pilot Study.Front Aging Neurosci. 2018 Jul 30;10:231. doi: 10.3389/fnagi.2018.00231. eCollection 2018.
1091 The E3Ubiquitin Ligases TRIM17 and TRIM41 Modulate -Synuclein Expression by Regulating ZSCAN21.Cell Rep. 2018 Nov 27;25(9):2484-2496.e9. doi: 10.1016/j.celrep.2018.11.002.