Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM16QTM)

Drug Name
CHALCONE Drug Info
Synonyms
Chalcone; (E)-Chalcone; trans-Chalcone; Benzalacetophenone; 614-47-1; 94-41-7; Benzylideneacetophenone; Chalkone; Phenyl styryl ketone; Cinnamophenone; 2-Benzalacetophenone; 2-Benzylideneacetophenone; 1,3-DIPHENYL-2-PROPEN-1-ONE; 1,3-Diphenylpropenone; (2E)-1,3-diphenylprop-2-en-1-one; Styryl phenyl ketone; 3-Phenylacrylophenone; 1-Benzoyl-2-phenylethene; trans-Benzalacetophenone; beta-Benzoylstyrene; Benzylidenecetophenone; Phenyl trans-styryl ketone; 2-Propen-1-one, 1,3-diphenyl-; 1-Benzoyl-1-phenylethene
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
637760
ChEBI ID
CHEBI:48965
CAS Number
CAS 614-47-1
TTD Drug ID
DM16QTM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Monoamine oxidase type B (MAO-B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selegiline Hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [6]
Phenelzine DMHIDUE Depression 6A70-6A7Z Approved [7]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [8]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [9]
Safinamide mesylate DM0J2ZT Parkinson disease 8A00.0 Approved [10]
Rasagiline DM3WKQ4 Parkinson disease 8A00.0 Approved [11]
Sulphadoxine DMZI2UF Malaria 1F40-1F45 Approved [12]
Pargyline DMM0HR1 Hypertension BA00-BA04 Approved [13]
Indeloxazine DMWO3N6 Dementia 6D80-6D86 Approved [14]
Budipine DMODHQI Migraine 8A80 Approved [15]
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Drug(s) Affected By Carbonic anhydrase 1 (CA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [16]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [17]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [18]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [19]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [20]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [17]
Indomethacin DMSC4A7 Bursitis Approved [21]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [22]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [23]
GUAIACOL DMN4E7T N. A. N. A. Phase 3 [19]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [21]
Epinephrine DM3KJBC Acute asthma CA23 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [27]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [28]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [29]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [30]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [18]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [31]
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Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Fructose DM43AN2 Vomiting MD90 Approved [33]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [34]
Estrone DM5T6US Acne vulgaris ED80 Approved [5]
Testosterone DM7HUNW Hot flushes GA30 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [5]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [5]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [5]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Gefitinib DM15F0X Colon adenocarcinoma Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [40]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [41]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [42]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [41]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [43]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [46]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [55]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [58]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [59]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [60]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [61]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [62]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [63]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [65]
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Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [70]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [71]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [75]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [76]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [77]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [40]
Meloxicam DM2AR7L Arthritis FA20 Approved [80]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [81]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [82]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [84]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [85]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Gefitinib DM15F0X Colon adenocarcinoma Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [40]
Selenium DM25CGV N. A. N. A. Approved [89]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [91]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [92]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Gefitinib DM15F0X Colon adenocarcinoma Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [96]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [97]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [98]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [99]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Carbonic anhydrase 1 (CA1) OTNFBVVQ CAH1_HUMAN Gene/Protein Processing [2]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [3]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [3]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Gene/Protein Processing [4]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Drug Response [3]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Gene/Protein Processing [4]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [3]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Protein Interaction/Cellular Processes [5]

References

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37 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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53 P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
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55 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
56 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
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65 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
66 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
67 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
68 Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun. 2009 Sep 11;387(1):109-14. doi: 10.1016/j.bbrc.2009.06.136. Epub 2009 Jul 1.
69 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
70 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
71 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
72 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
73 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
74 An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. Toxicol In Vitro. 2017 Apr;40:11-25. doi: 10.1016/j.tiv.2016.12.005. Epub 2016 Dec 10.
75 Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
76 Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
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