Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1TJXA)

Drug Name
CHLORIDE Drug Info
Synonyms
chloride ion; 16887-00-6; Chloride(1-); Chloride anion; Chlorine, ion; UNII-Q32ZN48698; Hydrochloric acid, ion(1-); Chlorid; CHEMBL19429; Cl-; CHEBI:17996; Q32ZN48698; Chlorides; Chloride ions; Chloride (ion); Perchloride; Chlorine anion; Chlorine ion; Chloride (Cl-); Chlorine(1-); Chlorine ion(1-); Chloride ion (1-); Chlorine, ion (Cl1-); AC1L18YJ; Cl(-); CTK0H5734; BDBM26979; VEXZGXHMUGYJMC-UHFFFAOYSA-M; c0884; AKOS015903642; FT-0755769; 3-Carbamoyl-1-ethoxymethylpyridinium chloride; 1-Butoxymethyl-3-carbamoyl-pyridinium
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 3 [1]
Cross-matching ID
PubChem CID
312
ChEBI ID
CHEBI:17996
CAS Number
CAS 16887-00-6
TTD Drug ID
DM1TJXA
INTEDE Drug ID
DR1912

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Candida Cytochrome P450 51 (Candi ERG11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [13]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [13]
Posaconazole DMUL5EW Aspergillosis 1F20 Approved [14]
Ketoconazole DMPZI3Q Blastomycosis 1F22 Approved [15]
Miconazole DMPMYE8 Cutaneous candidiasis 1F23.14 Approved [13]
Oxiconazole DME7KRM Tinea corporis 1F28.Y Approved [16]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [13]
Terconazole DMJ13KI Candidiasis 1F23 Approved [17]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [18]
Tioconazole DMNYPGS Onychomycosis EE12.1 Approved [19]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [21]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [26]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [27]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [21]
Verapamil DMA7PEW Angina pectoris BA40 Approved [28]
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Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [30]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [30]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [30]
Succinic acid DMDWICP Malnutrition 5B50-5B71 Approved [32]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [30]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [33]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [30]
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Drug(s) Affected By Band 3 anion transport protein (SLC4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Adefovir DMM278X N. A. N. A. Approved [38]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [39]
AMG 386 DMQJXL4 Breast cancer 2C60-2C65 Phase 3 [40]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [41]
D-glucose DMMG2TO Discovery agent N.A. Investigative [42]
Selenious acid DMB7GPA N. A. N. A. Investigative [43]
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Drug(s) Affected By Kininogen-1 (KNG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Mepyramine DMB4SFH Allergic rhinitis CA08.0 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [46]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Olanzapine DMPFN6Y Bipolar depression Approved [48]
Indomethacin DMSC4A7 Bursitis Approved [46]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [49]
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Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivacaftor DMZC1HS Cystic fibrosis CA25 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Miglustat DM5J64S Niemann-Pick disease type C Approved [53]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [54]
Milrinone DM8TUPF Congestive heart failure BD10 Approved [51]
Oxidized glutathione DM9EQC0 Breast cancer 2C60-2C65 Approved [55]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
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Drug(s) Affected By Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Testosterone DM7HUNW Hot flushes GA30 Approved [60]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [62]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [63]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [64]
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Drug(s) Affected By Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [66]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [58]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [67]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [68]
Naltrexone DMUL45H Alcohol dependence 6C40.2 Approved [69]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [70]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [41]
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Drug(s) Affected By Chloride anion exchanger (SLC26A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [72]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Morniflumate DM9UTDE Otitis media AA80-AB0Z Approved [5]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Folic Acid DMEMBJC Colorectal carcinoma Approved [75]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [76]
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Drug(s) Affected By Chloride channel protein 2 (CLCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [79]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [80]
Drug(s) Affected By H(+)/Cl(-) exchange transporter 3 (CLCN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Selenium DM25CGV N. A. N. A. Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [73]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Testosterone enanthate DMB6871 N. A. N. A. Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [85]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [86]
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Drug(s) Affected By Proteinase-activated receptor 2 (F2RL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [90]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [86]
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Drug(s) Affected By Secretin (SCT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [94]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [68]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [95]
Pentagastrin DMRCLZB Diagnostic imaging N.A. Approved [96]
AMG 386 DMQJXL4 Breast cancer 2C60-2C65 Phase 3 [97]
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Drug(s) Affected By Pendrin (SLC26A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [98]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [99]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [101]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [41]
IODIDE DM3FZ6P Discovery agent N.A. Investigative [102]
Formic Acid DMNFZC6 Discovery agent N.A. Investigative [103]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Cytochrome P450 51 (Candi ERG11) TTTSOUD CP51_CANAL Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Band 3 anion transport protein (SLC4A1) OT3EFUK8 B3AT_HUMAN Regulation of Drug Effects [4]
Chloride anion exchanger (SLC26A3) OTBNK2U2 S26A3_HUMAN Regulation of Drug Effects [5]
Chloride channel protein 2 (CLCN2) OTBUHK0B CLCN2_HUMAN Regulation of Drug Effects [6]
Cystic fibrosis transmembrane conductance regulator (CFTR) OT6B22QH CFTR_HUMAN Regulation of Drug Effects [7]
Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) OTAOZIGX GBRB2_HUMAN Regulation of Drug Effects [8]
Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3) OT80C3D4 GBRB3_HUMAN Regulation of Drug Effects [8]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Regulation of Drug Effects [9]
Kininogen-1 (KNG1) OT4X9LDE KNG1_HUMAN Regulation of Drug Effects [10]
Pendrin (SLC26A4) OTXUTLVS S26A4_HUMAN Regulation of Drug Effects [11]
Proteinase-activated receptor 2 (F2RL1) OTMRMJ8N PAR2_HUMAN Regulation of Drug Effects [12]

References

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60 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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