Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2GHCR)

Drug Name
Rebamipide Drug Info
Synonyms
rebamipide; 90098-04-7; Mucosta; Proamipide; 111911-87-6; OPC-12759; Rebamipidum; Pramipide; Rebamipide [INN:JAN]; Rebamipidum [INN-Latin]; Rebamipida [INN-Spanish]; OPC 12759; CCRIS 3585; Rebamipide hydrate; 2-(4-Chlorobenzoylamino)-3-(1,2-dihydro-2-oxo-4-quinolyl)propionic acid; 139344-42-6; 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid; Mucosta hydrate; NCGC00095161-01; Proamipide hydrate; 2-(4-Chlorobenzamido)-3-[2(1H)-quinolinon-4-yl]propionic Acid
Indication
Disease Entry ICD 11 Status REF
Peptic ulcer DA61 Phase 3 [1]
Cross-matching ID
PubChem CID
5042
ChEBI ID
CHEBI:93814
CAS Number
CAS 90098-04-7
TTD Drug ID
DM2GHCR
INTEDE Drug ID
DR1399

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting N-formyl peptide receptor (FPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID22607879CR-(-)-5f DM7OJ5Q Discovery agent N.A. Investigative [8]
fMet-Leu-Phe DMQ391A N. A. N. A. Investigative [9]
pyrazolone, 1 DMLFQKU Discovery agent N.A. Investigative [10]
group E 1682-2106 DMO6IM1 Discovery agent N.A. Investigative [11]
BVT173187 DMULZOP Discovery agent N.A. Investigative [12]
CGEN-855 DM4FMPJ Inflammation 1A00-CA43.1 Investigative [13]
AG-11/03 DMZINUY Discovery agent N.A. Investigative [14]
methionine benzimidazole 6 DMEIP6H Discovery agent N.A. Investigative [15]
AG-09/1 DMW7H28 Discovery agent N.A. Investigative [16]
diamide 7 DM4EX8Y Discovery agent N.A. Investigative [15]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Gefitinib DM15F0X Colon adenocarcinoma Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [29]
Etretinate DM2CZFA Keratosis ED56 Approved [30]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [31]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [32]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [36]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [40]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [41]
Panobinostat DM58WKG Chronic graft versus host disease Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [44]
Testosterone DM7HUNW Hot flushes GA30 Approved [45]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [46]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [47]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [49]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [50]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [54]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [52]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [55]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [56]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [57]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [58]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Verapamil DMA7PEW Angina pectoris BA40 Approved [61]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [62]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [63]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [64]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [63]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [70]
Gefitinib DM15F0X Colon adenocarcinoma Approved [71]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [74]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [66]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [75]
Paclitaxel DMLB81S Breast carcinoma Approved [76]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [77]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [63]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [68]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [81]
Gefitinib DM15F0X Colon adenocarcinoma Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [84]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [88]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [55]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [89]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Verapamil DMA7PEW Angina pectoris BA40 Approved [61]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [90]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [91]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Meloxicam DM2AR7L Arthritis FA20 Approved [94]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [95]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [29]
Selenium DM25CGV N. A. N. A. Approved [98]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [99]
Methotrexate DM2TEOL Anterior urethra cancer Approved [100]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [101]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [104]
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Drug(s) Affected By Aurora kinase B (AURKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [107]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Testosterone DM7HUNW Hot flushes GA30 Approved [110]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [110]
Leflunomide DMR8ONJ Arthritis FA20 Approved [111]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [112]
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Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [115]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [119]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
N-formyl peptide receptor (FPR1) TT5Y4EM FPR1_HUMAN Antagonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Regulation of Drug Effects [5]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Gene/Protein Processing [6]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [6]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [4]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [4]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Gene/Protein Processing [4]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [7]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [4]

References

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3 Involvement of cytochrome P450 in the metabolism of rebamipide by the human liver. Xenobiotica. 2002 Jul;32(7):573-86.
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21 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
22 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
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26 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
27 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
28 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
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30 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
31 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
32 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
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36 Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol Cancer Ther. 2007 Mar;6(3):1031-8. doi: 10.1158/1535-7163.MCT-06-0643. Epub 2007 Mar 5.
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39 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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41 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
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45 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
46 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
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49 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
50 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
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52 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
53 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
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55 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
56 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
57 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
58 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
59 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
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