Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3UZ95)

Drug Name
Bisoprolol Drug Info
Synonyms
Bisocor; Bisoprololum; Cardicor; Concor; Detensiel; Emconcor; Emcor; Euradal; Isoten; Monocor; Soloc; Soprol; Zebeta; Bisoprolol fumerate; Bisoprolol hemifumarate; Bisoprololum [Latin]; CL-297939; Concor (TN); Concore (TN); EMD-33512; Monocor (TN); Zebeta (TN); Bisoprolol (USAN/INN); Bisoprolol [USAN:BAN:INN]; EMD-33-512; (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol; (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol; 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol; 1-[(1-methylethyl)amino]-3-({4-[({2-[(1-methylethyl)oxy]ethyl}oxy)methyl]phenyl}oxy)propan-2-ol; 1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [1]
Malignant essential hypertension BA00 Approved [2]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
2405
ChEBI ID
CHEBI:3127
CAS Number
CAS 66722-44-9
TTD Drug ID
DM3UZ95
INTEDE Drug ID
DR0216
ACDINA Drug ID
D00072

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [9]
Epinephrine DM3KJBC Acute asthma CA23 Approved [10]
Norepinephrine DMOUC09 Alopecia ED70 Approved [11]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [12]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [12]
Metoprolol DMOJ0V6 Acute coronary syndrome BA41 Approved [12]
Timolol DM3NXRU High blood pressure BA00 Approved [13]
Isoproterenol DMK7MEY Atrioventricular block Approved [14]
Betaxolol DM6EUL5 Hypertension BA00-BA04 Approved [15]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [29]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [30]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [31]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [32]
Propranolol DM79NTF Angina pectoris BA40 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [35]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [38]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [39]
Capsaicin DMGMF6V Back pain ME84.Z Approved [40]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [41]
Quinidine DMLPICK N. A. N. A. Approved [42]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [43]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [44]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [45]
Fructose DM43AN2 Vomiting MD90 Approved [8]
Ketoprofen DMRKXPT Bursitis Approved [8]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [47]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [48]
Gefitinib DM15F0X Colon adenocarcinoma Approved [49]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [53]
Gefitinib DM15F0X Colon adenocarcinoma Approved [54]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [55]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [57]
Selenium DM25CGV N. A. N. A. Approved [58]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [59]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [60]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [61]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [62]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [64]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [57]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Gefitinib DM15F0X Colon adenocarcinoma Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [69]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [70]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
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Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [76]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [82]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [83]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [84]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [85]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [86]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [87]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [88]
Cepharanthine DM9Y5JB N. A. N. A. Approved [89]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [90]
Clozapine DMFC71L Schizophrenia 6A20 Approved [91]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [92]
Trifluoperazine DMKBYWI Anxiety Approved [93]
Olanzapine DMPFN6Y Bipolar depression Approved [91]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Antagonist [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [6]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [7]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Drug Response [8]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [7]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [7]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [7]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Gene/Protein Processing [7]

References

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2 Bisoprolol FDA Label
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44 Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
45 A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
46 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
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55 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
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68 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
69 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
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79 Immune regulatory effects of simvastatin on regulatory T cell-mediated tumour immune tolerance. Clin Exp Immunol. 2010 Aug;161(2):298-305. doi: 10.1111/j.1365-2249.2010.04170.x. Epub 2010 May 18.
80 Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. J Appl Physiol (1985). 2007 Nov;103(5):1728-35. doi: 10.1152/japplphysiol.00707.2007. Epub 2007 Aug 23.
81 [Effects of vitamin A on the differentiation, maturation and functions of dendritic cells from cord blood]. Zhonghua Er Ke Za Zhi. 2004 May;42(5):340-3.
82 Zinc induces chemokine and inflammatory cytokine release from human promonocytes. J Hazard Mater. 2011 Nov 30;196:335-41. doi: 10.1016/j.jhazmat.2011.09.035. Epub 2011 Sep 19.
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