Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4ES8F)

Drug Name
Penbutolol Drug Info
Synonyms
Betapressin; Levatol; Levatolol; Levopenbutol; Lobeta; Paginol; Penbutololum; PENBUTOLOL SULFATE; HOE 893; HOE 893d; Betapressin (TN); Hostabloc (TN); L-Penbutolol; Levatol (TN); Levatolol (TN); Lobeta (TN); Paginol (TN); Penbutolol (INN); Penbutolol [INN:BAN]; Penbutololum [INN-Latin]; Penbutolol Sulfate (2:1); S(-)-Penbutolol; (-)-Penbutolol; (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol; 1-(tert-Butylamino)-3-(o-cyclopentylphenoxy)propan-2-ol
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
37464
ChEBI ID
CHEBI:7954
CAS Number
CAS 38363-40-5
TTD Drug ID
DM4ES8F
INTEDE Drug ID
DR1249
ACDINA Drug ID
D00513

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [6]
Epinephrine DM3KJBC Acute asthma CA23 Approved [7]
Norepinephrine DMOUC09 Alopecia ED70 Approved [8]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [9]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [9]
Metoprolol DMOJ0V6 Acute coronary syndrome BA41 Approved [9]
Timolol DM3NXRU High blood pressure BA00 Approved [10]
Isoproterenol DMK7MEY Atrioventricular block Approved [11]
Betaxolol DM6EUL5 Hypertension BA00-BA04 Approved [12]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [13]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [14]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [15]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [16]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [17]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [18]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [19]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [20]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [21]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [22]
Propranolol DM79NTF Angina pectoris BA40 Approved [23]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [4]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Gefitinib DM15F0X Colon adenocarcinoma Approved [38]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [40]
Selenium DM25CGV N. A. N. A. Approved [41]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [42]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [43]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [4]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [4]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [44]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [45]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [46]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [48]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [51]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [54]
Verapamil DMA7PEW Angina pectoris BA40 Approved [55]
Methysergide DM1EF73 Migraine 8A80 Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [5]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [60]
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Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [4]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [4]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [62]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [65]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [66]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [67]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [69]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [70]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
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Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [4]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [75]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
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Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [4]
Amikacin DM5PDRB Bacteremia 1A73 Approved [4]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [4]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [4]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [4]
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Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Fluoxetine DM3PD2C Bipolar depression Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Antagonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [4]
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Gene/Protein Processing [4]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Gene/Protein Processing [4]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [4]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Gene/Protein Processing [4]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [4]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Gene/Protein Processing [4]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [4]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Gene/Protein Processing [5]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Gene/Protein Processing [4]

References

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58 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
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